Brain tissue expression of KIF1B in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	301.7	nTPM
FANTOM5:	372.6	Scaled Tags Per Million

Macaque:	235.1	nTPM
Mouse:	244.4	nTPM
Rat:	279.1	nTPM
Pig:	169.9	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	301.7

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 257.8

2301	Female, age 85, both hemispheres	275.3
2188	Female, age 91, both hemispheres	262.5
1984	Male, age 76, both hemispheres	254.1
2090	Male, age 80, both hemispheres	239.2

Dorsal cochlear nucleus
nTPM: 248.2

2802	Male, age 74, right hemisphere	261.4
2187	Female, age 91, both hemispheres	257.2
2370	Male, age 61, both hemispheres	242.6
2058	Male, age 76, both hemispheres	240.9
2378	Male, age 80, both hemispheres	238.6

Dorsal tegmental nucleus
nTPM: 219.8

2083	Male, age 80, both hemispheres	248.8
2326	Male, age 74, both hemispheres	237.7
1936	Male, age 76, left hemisphere	216.7
2358	Male, age 61, both hemispheres	176.1

Dorsolateral tegmental area
nTPM: 224.4

2654	Male, age 80, both hemispheres	260.5
2751	Female, age 85, both hemispheres	257.2
2141	Male, age 76, both hemispheres	227.4
2360	Male, age 74, both hemispheres	218.2
2337	Male, age 61, both hemispheres	159.0

Kolliker-Fuse nucleus
nTPM: 253.1

2793	Female, age 91, left hemisphere	303.0
2163	Male, age 80, both hemispheres	251.4
2315	Male, age 76, right hemisphere	205.0

Lateral lemniscal nuclei
nTPM: 299.3

2036	Male, age 80, both hemispheres	357.5
2169	Male, age 76, both hemispheres	312.0
2320	Female, age 91, left hemisphere	298.3
2746	Female, age 85, left hemisphere	268.9
2453	Male, age 74, right hemisphere	259.7

Lateral parabrachial nucleus
nTPM: 261.5

2792	Male, age 76, both hemispheres	274.7
2139	Female, age 85, right hemisphere	265.2
2013	Male, age 80, both hemispheres	260.5
2790	Male, age 61, both hemispheres	245.7

Lateral vestibular nucleus
nTPM: 246.3

2184	Male, age 76, both hemispheres	253.8
2311	Male, age 80, both hemispheres	238.8

Locus coeruleus
nTPM: 266.9

2014	Male, age 55, unknown	308.0
2317	Female, age 72, unknown	282.4
2788	Male, age 74, unknown	262.1
2123	Female, age 91, both hemispheres	259.5
2162	Male, age 80, both hemispheres	258.1
2720	Male, age 74, both hemispheres	254.5
1980	Male, age 76, both hemispheres	243.6

Medial parabrachial nucleus
nTPM: 250.2

2854	Male, age 80, both hemispheres	264.2
2170	Female, age 91, both hemispheres	260.5
2463	Female, age 85, right hemisphere	252.2
2156	Male, age 61, both hemispheres	237.3
2786	Male, age 76, both hemispheres	236.5

Medial periolivary nuclei
nTPM: 277.5

2063	Male, age 76, both hemispheres	308.4
2171	Female, age 85, both hemispheres	301.9
2458	Female, age 91, both hemispheres	266.0
2791	Male, age 74, right hemisphere	256.8
2081	Male, age 80, both hemispheres	254.5

Motor facial nucleus
nTPM: 284.2

2062	Male, age 76, both hemispheres	307.9
2327	Male, age 80, both hemispheres	300.6
2795	Female, age 91, both hemispheres	289.4
2126	Male, age 61, both hemispheres	278.0
2697	Female, age 85, both hemispheres	269.8
2365	Male, age 74, right hemisphere	259.4

Motor trigeminal nucleus
nTPM: 254.7

2079	Male, age 80, both hemispheres	272.1
2321	Female, age 91, both hemispheres	267.0
2560	Male, age 74, both hemispheres	254.2
2309	Male, age 76, both hemispheres	249.3
2335	Male, age 61, both hemispheres	230.8

Nuclei of the trapezoid body
nTPM: 301.7

2159	Male, age 61, both hemispheres	358.9
2735	Female, age 85, both hemispheres	296.8
2368	Female, age 91, both hemispheres	293.3
2166	Male, age 80, both hemispheres	286.4
1983	Male, age 76, both hemispheres	273.2

Nucleus raphe magnus
nTPM: 293.2

2160	Male, age 61, both hemispheres	356.2
2328	Male, age 80, both hemispheres	298.1
2172	Female, age 85, both hemispheres	293.8
2459	Female, age 91, both hemispheres	284.3
2051	Male, age 76, both hemispheres	266.2
2455	Male, age 74, both hemispheres	260.8

Paramedian reticular nucleus
nTPM: 268.5

2313	Male, age 61, both hemispheres	287.4
2050	Female, age 85, both hemispheres	283.8
2057	Male, age 80, both hemispheres	266.7
2052	Male, age 76, both hemispheres	236.0

Pedunculopontine tegmental nucleus
nTPM: 233.1

2334	Male, age 80, both hemispheres	258.8
1921	Female, age 85, both hemispheres	248.5
2338	Male, age 61, both hemispheres	192.1

Pontine nuclei
nTPM: 297.7

2727	Male, age 61, right hemisphere	367.0
1863	Male, age 55, unknown	344.6
2109	Female, age 72, unknown	302.8
1968	Male, age 76, left hemisphere	288.9
2454	Male, age 74, left hemisphere	282.2
2787	Female, age 85, both hemispheres	278.7
2319	Female, age 91, both hemispheres	273.6
2115	Male, age 80, left hemisphere	243.6

Pontine raphe nucleus
nTPM: 251.7

2122	Female, age 85, midline	269.7
2853	Male, age 76, midline	233.6

Posteroventral cochlear nucleus
nTPM: 251.0

2070	Male, age 76, both hemispheres	256.5
2371	Male, age 61, both hemispheres	254.1
2135	Female, age 91, both hemispheres	251.1
2752	Female, age 85, both hemispheres	250.3
2341	Male, age 80, both hemispheres	243.2

Principal sensory trigeminal nucleus
nTPM: 284.2

2158	Male, age 61, both hemispheres	334.9
2008	Male, age 80, left hemisphere	280.4
2367	Female, age 91, left hemisphere	274.8
2324	Male, age 76, both hemispheres	246.8

Reticular pontine nucleus, caudal
nTPM: 275.0

2332	Male, age 80, right hemisphere	309.3
2092	Male, age 76, both hemispheres	280.2
2457	Female, age 91, both hemispheres	262.4
2559	Male, age 74, both hemispheres	248.0

Reticular pontine nucleus, oral
nTPM: 266.9

2366	Female, age 91, both hemispheres	289.8
2012	Female, age 85, both hemispheres	282.0
2361	Male, age 74, both hemispheres	272.3
1939	Male, age 80, both hemispheres	252.3
2167	Male, age 76, both hemispheres	238.3

Reticulotegmental nucleus
nTPM: 267.5

2322	Female, age 91, both hemispheres	279.0
2333	Male, age 80, both hemispheres	274.5
2325	Male, age 76, both hemispheres	259.9
2452	Male, age 74, both hemispheres	256.6

Spinal trigeminal nucleus, oral
nTPM: 237.9

2164	Male, age 80, both hemispheres	244.9
2737	Female, age 85, both hemispheres	235.8
1978	Male, age 76, both hemispheres	233.0

Subcoeruleus area
nTPM: 259.8

2089	Male, age 76, left hemisphere	285.3
2369	Female, age 85, left hemisphere	265.2
1958	Male, age 80, both hemispheres	261.9
2323	Female, age 91, left hemisphere	252.8
2451	Male, age 74, both hemispheres	233.9

Superior olive
nTPM: 284.4

2329	Male, age 80, right hemisphere	304.4
1875	Female, age 85, both hemispheres	300.4
2020	Male, age 76, both hemispheres	296.2
2561	Female, age 91, both hemispheres	266.7
2364	Male, age 74, right hemisphere	254.2

Ventral periolivary nuclei
nTPM: 293.9

2023	Male, age 76, both hemispheres	309.3
2130	Female, age 85, both hemispheres	301.4
2165	Male, age 80, both hemispheres	299.7
2794	Female, age 91, left hemisphere	265.3

Ventrolateral tegmental area, A5 NE cell group
nTPM: 262.2

1959	Male, age 76, both hemispheres	283.8
2456	Female, age 91, both hemispheres	276.1
2161	Male, age 80, both hemispheres	269.0
2840	Female, age 85, both hemispheres	255.6
2449	Male, age 74, both hemispheres	252.2
2359	Male, age 61, both hemispheres	236.6

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	372.6

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 309.1

FF:10182-103D2	60 years, female	322.8
FF:10165-103B3	76 years, female	295.5

Pons
Scaled Tags Per Million: 372.6

FF:10033-101E6

18-54 years, mixed

372.6

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	235.1

Macaque sample

Sample description

nTPM

Pons
nTPM: 235.1

Samples: 2

Max nTPM: 282.5
Min nTPM: 187.7

Sample A		282.5
Sample B		187.7

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	169.9

Pig sample

Sample description

nTPM

Pons
nTPM: 169.9

Samples: 3

Max nTPM: 176.9
Min nTPM: 164.9

Sample A	Female	176.9
Sample B	Female	164.9
Sample C	Male	167.8

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	244.4

Mouse sample

Sample description

nTPM

Pons
nTPM: 244.4

Samples: 4

Max nTPM: 259.8
Min nTPM: 232.2

Sample A		259.8
Sample B		232.2
Sample C		247.2
Sample D		238.4

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	279.1

Rat sample

Sample description

nTPM

Pons
nTPM: 279.1

Samples: 4

Max nTPM: 290.5
Min nTPM: 272.6

Sample A		290.5
Sample A		272.6
Sample A		272.9
Sample A		280.3