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General description of the gene and encoded protein(s) using information from HGNC and Ensembl, as well as predictions made as well as predictions made by the Human Protein Atlas project.
The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.
The main location is characterized by presence in all tested cell lines and/or increased intensity compared to other locations.
Additional locations are characterized by either a markedly lower staining intensity than the main location, or that it is only observed in a subset of the cell lines.
Cytosol and additionally in Nucleoplasm
Cancer prognostic summary
Prognostic marker in renal cancer (unfavourable), ovarian cancer (favourable) and liver cancer (unfavourable)
Brain specificityi
The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.
The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Useful information about the protein provided by UniProt.
Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex ref,ref. Cleaves RIPK1 at 'Asp-325' which is crucial for limiting apoptosis and necroptosis during embryonic development (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase, Protease, Thiol protease
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis, Host-virus interaction
Disease involvementi
Disease related keywords assigned by UniProt combined with Cancer-related genes and FDA approved drug targets
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]...show less
TISSUE ATLASi
The Tissue Atlas contains information regarding the expression profiles of human genes both on the mRNA and protein level. The protein expression data from 44 normal human tissue types is derived from antibody-based protein profiling using immunohistochemistry.
The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.
The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: detected in all, detected in many, detected in some, detected in single and not detected.
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.
"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.
The Brain Atlas explores the protein expression in the mammalian brain by visualization and integration of data from three mammalian species (human, pig and mouse). Transcriptomics data combined with affinity-based protein in situ localization down to single cell detail is here available in a brain-centric sub atlas of the Human Protein Atlas.
The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression profile is based on a combination of data from GTEX and FANTOM5. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category.
The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression profile is based on a combination of data from GTEX and FANTOM5. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category.
The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression profile is based on a combination of data from GTEX and FANTOM5. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category.
Summary of data presented in the Cell Atlas and a representative image of subcellular localization. The Cell Atlas provides RNA expression data derived from RNA sequencing of a large panel of cell lines and protein localization data derived from antibody-based profiling by immunofluorescence confocal microscopy, using a subset of cell lines selected based on RNA expression.
The main location is characterized by presence in all tested cell lines and/or increased intensity compared to other locations. It is highlighted in the illustration to the right. If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively.
Localized to the Cytosol
Additional locationi
Additional locations are characterized by either a markedly lower staining intensity than the main location, or that it is only observed in a subset of the cell lines. They are highlighted in the illustration to the right. If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively.
In addition localized to the Nucleoplasm
Cell line specificityi
The cell lines in the Human Protein Atlas have been analyzed by RNA-seq to estimate the transcript abundance of each protein-coding gene. The RNA-seq data was then used to classify all genes according to their cell line-specific expression into one of six different categories, defined based on the total set of all NX values in all analyzed cell lines.
The Blood Atlas contains single cell type information on genome-wide RNA expression profiles of human protein-coding genes covering various B- and T-cells, monocytes, granulocytes and dendritic cells. In addition, an analysis of the human secretome is presented. including annotation of the genes predicted to be actively secreted to human blood. An analysis of the proteins detected in human blood is also presented.
The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.
The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search.
Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics data set obtained from the PeptideAtlas.
No
PATHOLOGY ATLASi
Summary of data presented in the Pathology Atlas , including mRNA and protein expression data from 17 different forms of human cancer, as well as correlation analysis of mRNA expression and patient survival. To the far left, a representative image of protein expression, based on immunohistochemistry, is shown. Next to it, a representative image of a Kaplan-Meier plot, based on correlation analysis. Images are clickable and redirect to pages with more Pathology Atlas data.
Prognostic marker in renal cancer (unfavourable), ovarian cancer (favourable) and liver cancer (unfavourable)
Cancer specificity (RNA)i
Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected.
Distribution of RNA expression in 17 cancer types is categorized as either detected in single, detected in some, detected in many, detected in all, or not detected.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name
CASP8 (HGNC Symbol)
Synonyms
Casp-8, FLICE, MACH, MCH5
Description
Caspase 8 (HGNC Symbol)
Chromosome
2
Cytoband
q33.1
Chromosome location (bp)
201233443 - 201287711
Number of transcriptsi
Number of protein-coding transcribed from this gene as defined by Ensembl.
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas)
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GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007166 [cell surface receptor signaling pathway] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0016032 [viral process] GO:0016787 [hydrolase activity] GO:0030101 [natural killer cell activation] GO:0030225 [macrophage differentiation] GO:0031264 [death-inducing signaling complex] GO:0031265 [CD95 death-inducing signaling complex] GO:0031625 [ubiquitin protein ligase binding] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034612 [response to tumor necrosis factor] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0035877 [death effector domain binding] GO:0036462 [TRAIL-activated apoptotic signaling pathway] GO:0039650 [suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process] GO:0042110 [T cell activation] GO:0042113 [B cell activation] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045651 [positive regulation of macrophage differentiation] GO:0045862 [positive regulation of proteolysis] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0060544 [regulation of necroptotic process] GO:0060715 [syncytiotrophoblast cell differentiation involved in labyrinthine layer development] GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway] GO:0071260 [cellular response to mechanical stimulus] GO:0071550 [death-inducing signaling complex assembly] GO:0097110 [scaffold protein binding] GO:0097153 [cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097194 [execution phase of apoptosis] GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097200 [cysteine-type endopeptidase activity involved in execution phase of apoptosis] GO:0097202 [activation of cysteine-type endopeptidase activity] GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097342 [ripoptosome] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas)
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GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007166 [cell surface receptor signaling pathway] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0016032 [viral process] GO:0016787 [hydrolase activity] GO:0030101 [natural killer cell activation] GO:0030225 [macrophage differentiation] GO:0031264 [death-inducing signaling complex] GO:0031265 [CD95 death-inducing signaling complex] GO:0031625 [ubiquitin protein ligase binding] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034612 [response to tumor necrosis factor] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0035877 [death effector domain binding] GO:0036462 [TRAIL-activated apoptotic signaling pathway] GO:0039650 [suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process] GO:0042110 [T cell activation] GO:0042113 [B cell activation] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045651 [positive regulation of macrophage differentiation] GO:0045862 [positive regulation of proteolysis] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0060544 [regulation of necroptotic process] GO:0060715 [syncytiotrophoblast cell differentiation involved in labyrinthine layer development] GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway] GO:0071260 [cellular response to mechanical stimulus] GO:0071550 [death-inducing signaling complex assembly] GO:0097110 [scaffold protein binding] GO:0097153 [cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097194 [execution phase of apoptosis] GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097200 [cysteine-type endopeptidase activity involved in execution phase of apoptosis] GO:0097202 [activation of cysteine-type endopeptidase activity] GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097342 [ripoptosome] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas)
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GO:0004197 [cysteine-type endopeptidase activity] GO:0005123 [death receptor binding] GO:0005164 [tumor necrosis factor receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007166 [cell surface receptor signaling pathway] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0009409 [response to cold] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0016032 [viral process] GO:0016787 [hydrolase activity] GO:0030101 [natural killer cell activation] GO:0030225 [macrophage differentiation] GO:0031264 [death-inducing signaling complex] GO:0031265 [CD95 death-inducing signaling complex] GO:0031625 [ubiquitin protein ligase binding] GO:0032025 [response to cobalt ion] GO:0032355 [response to estradiol] GO:0032496 [response to lipopolysaccharide] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034612 [response to tumor necrosis factor] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0035877 [death effector domain binding] GO:0036462 [TRAIL-activated apoptotic signaling pathway] GO:0039650 [suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process] GO:0042110 [T cell activation] GO:0042113 [B cell activation] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043005 [neuron projection] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0044297 [cell body] GO:0045121 [membrane raft] GO:0045471 [response to ethanol] GO:0045651 [positive regulation of macrophage differentiation] GO:0045862 [positive regulation of proteolysis] GO:0046677 [response to antibiotic] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0060544 [regulation of necroptotic process] GO:0060715 [syncytiotrophoblast cell differentiation involved in labyrinthine layer development] GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway] GO:0071260 [cellular response to mechanical stimulus] GO:0071407 [cellular response to organic cyclic compound] GO:0071550 [death-inducing signaling complex assembly] GO:0097110 [scaffold protein binding] GO:0097153 [cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097194 [execution phase of apoptosis] GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097200 [cysteine-type endopeptidase activity involved in execution phase of apoptosis] GO:0097202 [activation of cysteine-type endopeptidase activity] GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097342 [ripoptosome] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1901216 [positive regulation of neuron death] GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas)
Show all
GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007166 [cell surface receptor signaling pathway] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0016032 [viral process] GO:0016787 [hydrolase activity] GO:0030101 [natural killer cell activation] GO:0030225 [macrophage differentiation] GO:0031264 [death-inducing signaling complex] GO:0031265 [CD95 death-inducing signaling complex] GO:0031625 [ubiquitin protein ligase binding] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034612 [response to tumor necrosis factor] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0035877 [death effector domain binding] GO:0036462 [TRAIL-activated apoptotic signaling pathway] GO:0039650 [suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process] GO:0042110 [T cell activation] GO:0042113 [B cell activation] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045651 [positive regulation of macrophage differentiation] GO:0045862 [positive regulation of proteolysis] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0060544 [regulation of necroptotic process] GO:0060715 [syncytiotrophoblast cell differentiation involved in labyrinthine layer development] GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway] GO:0071260 [cellular response to mechanical stimulus] GO:0071550 [death-inducing signaling complex assembly] GO:0097110 [scaffold protein binding] GO:0097153 [cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097194 [execution phase of apoptosis] GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097200 [cysteine-type endopeptidase activity involved in execution phase of apoptosis] GO:0097202 [activation of cysteine-type endopeptidase activity] GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097342 [ripoptosome] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas)
Show all
GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007166 [cell surface receptor signaling pathway] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0016032 [viral process] GO:0016787 [hydrolase activity] GO:0030101 [natural killer cell activation] GO:0030225 [macrophage differentiation] GO:0031264 [death-inducing signaling complex] GO:0031265 [CD95 death-inducing signaling complex] GO:0031625 [ubiquitin protein ligase binding] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034612 [response to tumor necrosis factor] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0035877 [death effector domain binding] GO:0036462 [TRAIL-activated apoptotic signaling pathway] GO:0039650 [suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process] GO:0042110 [T cell activation] GO:0042113 [B cell activation] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045651 [positive regulation of macrophage differentiation] GO:0045862 [positive regulation of proteolysis] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0060544 [regulation of necroptotic process] GO:0060715 [syncytiotrophoblast cell differentiation involved in labyrinthine layer development] GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway] GO:0071260 [cellular response to mechanical stimulus] GO:0071550 [death-inducing signaling complex assembly] GO:0097110 [scaffold protein binding] GO:0097153 [cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097194 [execution phase of apoptosis] GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097200 [cysteine-type endopeptidase activity involved in execution phase of apoptosis] GO:0097202 [activation of cysteine-type endopeptidase activity] GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097342 [ripoptosome] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas)
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GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0007166 [cell surface receptor signaling pathway] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0016032 [viral process] GO:0016787 [hydrolase activity] GO:0030101 [natural killer cell activation] GO:0030225 [macrophage differentiation] GO:0031264 [death-inducing signaling complex] GO:0031265 [CD95 death-inducing signaling complex] GO:0031625 [ubiquitin protein ligase binding] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034612 [response to tumor necrosis factor] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0035877 [death effector domain binding] GO:0036462 [TRAIL-activated apoptotic signaling pathway] GO:0039650 [suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process] GO:0042110 [T cell activation] GO:0042113 [B cell activation] GO:0042802 [identical protein binding] GO:0042981 [regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0045651 [positive regulation of macrophage differentiation] GO:0045862 [positive regulation of proteolysis] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0060544 [regulation of necroptotic process] GO:0060715 [syncytiotrophoblast cell differentiation involved in labyrinthine layer development] GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway] GO:0071260 [cellular response to mechanical stimulus] GO:0071550 [death-inducing signaling complex assembly] GO:0097110 [scaffold protein binding] GO:0097153 [cysteine-type endopeptidase activity involved in apoptotic process] GO:0097190 [apoptotic signaling pathway] GO:0097191 [extrinsic apoptotic signaling pathway] GO:0097194 [execution phase of apoptosis] GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097200 [cysteine-type endopeptidase activity involved in execution phase of apoptosis] GO:0097202 [activation of cysteine-type endopeptidase activity] GO:0097296 [activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway] GO:0097342 [ripoptosome] GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] GO:1902041 [regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors]
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