On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units. Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set. If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.
h
m
l
n
Endocrine cells:
Medium
Endothelial cells:
Medium
Enterocytes:
Medium
Enterocytes - Microvilli:
Not detected
Fibroblasts:
Medium
Goblet cells:
Medium
Mucosal lymphoid cells:
Medium
Peripheral nerve/ganglion:
High
RNA expressioni
A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas HPA, Genotype-Tissue Expression GTEx portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets. The mRNA expression levels in pig brain are based on RNA-seq data generated by the Human Protein Atlas, and for mouse brain HPA data and in situ hybridization generated by the Allen brain atlas dataset are reported.
Scroll down to view mRNA expression data in more detail.
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.
Ascending and descending describe two types of gradient, based on difference in staining intensity between enterocytes in crypts and apical enterocytes.
Ascending - the staining intensity is stronger in apical enterocytes (towards the lumen) compared to enterocytes in the crypts (gland based)
Descending - the staining is weaker in apical enterocytes compared to enterocytes in crypts
Antibody HPA045423
Antibody CAB011536
Endocrine cells
-
Medium
Endothelial cells
-
Medium
Enterocytes
-
Medium
Enterocytes - Microvilli
-
Not detected
Fibroblasts
-
Medium
Glandular cells
Low
-
Goblet cells
-
Medium
Mucosal lymphoid cells
-
Medium
Peripheral nerve/ganglion
-
High
RECTUM - HPA RNA-seqi
The RNA-seq details section shows detailed information about the individual samples used for the transcript profiling and results of the RNA-seq analysis.
Information about each individual sample is listed below, including gender, age, a tissue section image and estimated fractions of cell types. nTPM (normalized transcripts per million) values give a quantification of the gene abundance which is comparable between different genes and samples.
Average nTPMi
Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.
254.2
Male, age 67
Rectum sample 333 nTPM: 248.1
Cell types%
Glandular cells:
20
Smooth muscle cells:
10
Other cell types:
70
Male, age 69
Rectum sample 334 nTPM: 134
Cell types%
Glandular cells:
15
Smooth muscle cells:
40
Other cell types:
45
Male, age 82
Rectum sample 335 nTPM: 308.9
Cell types%
Glandular cells:
35
Smooth muscle cells:
5
Other cell types:
60
Male, age 63
Rectum sample 338 nTPM: 325.8
Cell types%
Glandular cells:
55
Smooth muscle cells:
5
Other cell types:
40
RECTUM - Macaque RNA-seq
Max subtype nTPMi
Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.
176.8
Macaque sample
Sample description
nTPM
Rectum nTPM: 176.8
Samples: 3
Max nTPM: 193.8
Min nTPM: 151.3
Sample A
193.8
Sample B
185.3
Sample C
151.3
RECTUM - Pig RNA-seqi
RNA-seq data obtained from pig brain is reported as nTPM. Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.
Max subtype nTPMi
Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.
829.6
Pig sample
Sample description
nTPM
Rectum nTPM: 829.7
Samples: 4
Max nTPM: 1155.4
Min nTPM: 555.6
Sample A
Female
881.0
Sample B
Female
555.6
Sample C
Male
726.6
Sample D
Male
1155.4
RECTUM - Rat RNA-seq
Max subtype nTPMi
Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.
395.2
Rat sample
Sample description
nTPM
Rectum nTPM: 395.2
Samples: 4
Max nTPM: 450.7
Min nTPM: 346.9
Sample A
381.3
Sample B
346.9
Sample A
450.7
Sample A
401.8
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