Brain tissue expression of DLG1 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	107.9	nTPM
FANTOM5:	117.6	Scaled Tags Per Million

Macaque:	77.4	nTPM
Mouse:	39.7	nTPM
Rat:	44.8	nTPM
Pig:	43.8	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	107.9

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 101.4

2301	Female, age 85, both hemispheres	113.7
2188	Female, age 91, both hemispheres	111.4
2090	Male, age 80, both hemispheres	106.2
1984	Male, age 76, both hemispheres	74.2

Dorsal cochlear nucleus
nTPM: 89.0

2378	Male, age 80, both hemispheres	100.4
2187	Female, age 91, both hemispheres	96.0
2802	Male, age 74, right hemisphere	88.3
2058	Male, age 76, both hemispheres	80.4
2370	Male, age 61, both hemispheres	79.6

Dorsal tegmental nucleus
nTPM: 80.4

2083	Male, age 80, both hemispheres	96.3
2326	Male, age 74, both hemispheres	83.5
1936	Male, age 76, left hemisphere	73.6
2358	Male, age 61, both hemispheres	68.2

Dorsolateral tegmental area
nTPM: 82.8

2751	Female, age 85, both hemispheres	106.7
2654	Male, age 80, both hemispheres	89.5
2360	Male, age 74, both hemispheres	75.9
2337	Male, age 61, both hemispheres	75.0
2141	Male, age 76, both hemispheres	66.9

Kolliker-Fuse nucleus
nTPM: 92.8

2793	Female, age 91, left hemisphere	130.5
2163	Male, age 80, both hemispheres	81.7
2315	Male, age 76, right hemisphere	66.2

Lateral lemniscal nuclei
nTPM: 95.7

2320	Female, age 91, left hemisphere	120.6
2036	Male, age 80, both hemispheres	104.2
2453	Male, age 74, right hemisphere	93.1
2746	Female, age 85, left hemisphere	90.3
2169	Male, age 76, both hemispheres	70.5

Lateral parabrachial nucleus
nTPM: 96.4

2792	Male, age 76, both hemispheres	110.9
2013	Male, age 80, both hemispheres	108.9
2790	Male, age 61, both hemispheres	86.4
2139	Female, age 85, right hemisphere	79.5

Lateral vestibular nucleus
nTPM: 84.1

2184	Male, age 76, both hemispheres	85.2
2311	Male, age 80, both hemispheres	83.1

Locus coeruleus
nTPM: 59.9

2720	Male, age 74, both hemispheres	73.1
2788	Male, age 74, unknown	64.5
2162	Male, age 80, both hemispheres	61.2
2014	Male, age 55, unknown	60.0
1980	Male, age 76, both hemispheres	56.5
2317	Female, age 72, unknown	54.8
2123	Female, age 91, both hemispheres	49.2

Medial parabrachial nucleus
nTPM: 86.9

2170	Female, age 91, both hemispheres	92.4
2854	Male, age 80, both hemispheres	90.8
2786	Male, age 76, both hemispheres	89.0
2463	Female, age 85, right hemisphere	86.6
2156	Male, age 61, both hemispheres	75.6

Medial periolivary nuclei
nTPM: 85.4

2458	Female, age 91, both hemispheres	108.5
2081	Male, age 80, both hemispheres	106.4
2791	Male, age 74, right hemisphere	79.2
2063	Male, age 76, both hemispheres	67.3
2171	Female, age 85, both hemispheres	65.5

Motor facial nucleus
nTPM: 83.2

2697	Female, age 85, both hemispheres	105.4
2365	Male, age 74, right hemisphere	89.0
2126	Male, age 61, both hemispheres	83.2
2795	Female, age 91, both hemispheres	81.6
2327	Male, age 80, both hemispheres	79.6
2062	Male, age 76, both hemispheres	60.6

Motor trigeminal nucleus
nTPM: 89.5

2321	Female, age 91, both hemispheres	107.0
2560	Male, age 74, both hemispheres	100.8
2079	Male, age 80, both hemispheres	83.2
2309	Male, age 76, both hemispheres	82.5
2335	Male, age 61, both hemispheres	73.9

Nuclei of the trapezoid body
nTPM: 78.3

2166	Male, age 80, both hemispheres	102.7
2368	Female, age 91, both hemispheres	93.4
2159	Male, age 61, both hemispheres	70.2
1983	Male, age 76, both hemispheres	64.2
2735	Female, age 85, both hemispheres	61.0

Nucleus raphe magnus
nTPM: 79.4

2459	Female, age 91, both hemispheres	100.0
2328	Male, age 80, both hemispheres	88.2
2051	Male, age 76, both hemispheres	81.9
2455	Male, age 74, both hemispheres	79.6
2172	Female, age 85, both hemispheres	70.0
2160	Male, age 61, both hemispheres	56.4

Paramedian reticular nucleus
nTPM: 88.2

2052	Male, age 76, both hemispheres	100.3
2057	Male, age 80, both hemispheres	92.2
2050	Female, age 85, both hemispheres	88.2
2313	Male, age 61, both hemispheres	72.3

Pedunculopontine tegmental nucleus
nTPM: 82.0

2334	Male, age 80, both hemispheres	84.8
2338	Male, age 61, both hemispheres	81.4
1921	Female, age 85, both hemispheres	79.8

Pontine nuclei
nTPM: 89.6

2454	Male, age 74, left hemisphere	118.9
2115	Male, age 80, left hemisphere	111.2
2319	Female, age 91, both hemispheres	107.6
2109	Female, age 72, unknown	86.5
1863	Male, age 55, unknown	84.0
1968	Male, age 76, left hemisphere	72.7
2787	Female, age 85, both hemispheres	70.1
2727	Male, age 61, right hemisphere	65.6

Pontine raphe nucleus
nTPM: 75.6

2122	Female, age 85, midline	77.6
2853	Male, age 76, midline	73.6

Posteroventral cochlear nucleus
nTPM: 99.8

2341	Male, age 80, both hemispheres	132.5
2135	Female, age 91, both hemispheres	114.7
2371	Male, age 61, both hemispheres	89.5
2070	Male, age 76, both hemispheres	81.3
2752	Female, age 85, both hemispheres	80.8

Principal sensory trigeminal nucleus
nTPM: 81.5

2367	Female, age 91, left hemisphere	111.4
2008	Male, age 80, left hemisphere	76.6
2324	Male, age 76, both hemispheres	75.9
2158	Male, age 61, both hemispheres	61.9

Reticular pontine nucleus, caudal
nTPM: 85.5

2559	Male, age 74, both hemispheres	100.4
2457	Female, age 91, both hemispheres	88.6
2332	Male, age 80, right hemisphere	76.7
2092	Male, age 76, both hemispheres	76.5

Reticular pontine nucleus, oral
nTPM: 107.9

2366	Female, age 91, both hemispheres	136.5
2361	Male, age 74, both hemispheres	112.6
1939	Male, age 80, both hemispheres	100.8
2167	Male, age 76, both hemispheres	94.9
2012	Female, age 85, both hemispheres	94.5

Reticulotegmental nucleus
nTPM: 85.8

2452	Male, age 74, both hemispheres	95.1
2322	Female, age 91, both hemispheres	91.3
2333	Male, age 80, both hemispheres	86.2
2325	Male, age 76, both hemispheres	70.7

Spinal trigeminal nucleus, oral
nTPM: 78.1

2164	Male, age 80, both hemispheres	82.9
1978	Male, age 76, both hemispheres	80.8
2737	Female, age 85, both hemispheres	70.7

Subcoeruleus area
nTPM: 87.8

2369	Female, age 85, left hemisphere	126.0
2451	Male, age 74, both hemispheres	86.8
1958	Male, age 80, both hemispheres	84.8
2089	Male, age 76, left hemisphere	76.7
2323	Female, age 91, left hemisphere	65.0

Superior olive
nTPM: 97.0

2561	Female, age 91, both hemispheres	109.7
2329	Male, age 80, right hemisphere	101.5
2020	Male, age 76, both hemispheres	95.7
1875	Female, age 85, both hemispheres	91.5
2364	Male, age 74, right hemisphere	86.8

Ventral periolivary nuclei
nTPM: 84.1

2794	Female, age 91, left hemisphere	96.8
2023	Male, age 76, both hemispheres	89.5
2165	Male, age 80, both hemispheres	78.8
2130	Female, age 85, both hemispheres	71.4

Ventrolateral tegmental area, A5 NE cell group
nTPM: 92.7

2840	Female, age 85, both hemispheres	105.8
2456	Female, age 91, both hemispheres	105.6
2161	Male, age 80, both hemispheres	90.9
2449	Male, age 74, both hemispheres	88.6
2359	Male, age 61, both hemispheres	83.9
1959	Male, age 76, both hemispheres	81.1

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	117.6

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 74.4

FF:10165-103B3	76 years, female	84.2
FF:10182-103D2	60 years, female	64.5

Pons
Scaled Tags Per Million: 117.6

FF:10033-101E6

18-54 years, mixed

117.6

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	77.4

Macaque sample

Sample description

nTPM

Pons
nTPM: 77.4

Samples: 2

Max nTPM: 84.5
Min nTPM: 70.2

Sample A		84.5
Sample B		70.2

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	43.8

Pig sample

Sample description

nTPM

Pons
nTPM: 43.8

Samples: 3

Max nTPM: 49.3
Min nTPM: 39.2

Sample A	Female	42.8
Sample B	Female	39.2
Sample C	Male	49.3

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	39.7

Mouse sample

Sample description

nTPM

Pons
nTPM: 39.7

Samples: 4

Max nTPM: 41.4
Min nTPM: 37.4

Sample A		41.4
Sample B		40.1
Sample C		37.4
Sample D		39.9

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	44.8

Rat sample

Sample description

nTPM

Pons
nTPM: 44.8

Samples: 4

Max nTPM: 48.0
Min nTPM: 42.8

Sample A		43.0
Sample A		45.5
Sample A		48.0
Sample A		42.8