Brain tissue expression of ADCYAP1R1 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	211.4	nTPM
FANTOM5:	73.5	Scaled Tags Per Million

Macaque:	39.7	nTPM
Mouse:	93.5	nTPM
Rat:	67.5	nTPM
Pig:	75.5	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	211.4

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 114.0

2301	Female, age 85, both hemispheres	134.7
1984	Male, age 76, both hemispheres	123.8
2090	Male, age 80, both hemispheres	117.5
2188	Female, age 91, both hemispheres	80.0

Dorsal cochlear nucleus
nTPM: 166.4

2802	Male, age 74, right hemisphere	197.9
2370	Male, age 61, both hemispheres	184.5
2058	Male, age 76, both hemispheres	171.9
2378	Male, age 80, both hemispheres	165.6
2187	Female, age 91, both hemispheres	112.0

Dorsal tegmental nucleus
nTPM: 141.8

1936	Male, age 76, left hemisphere	158.2
2326	Male, age 74, both hemispheres	143.6
2083	Male, age 80, both hemispheres	140.7
2358	Male, age 61, both hemispheres	124.6

Dorsolateral tegmental area
nTPM: 125.6

2141	Male, age 76, both hemispheres	178.8
2360	Male, age 74, both hemispheres	138.8
2654	Male, age 80, both hemispheres	135.9
2751	Female, age 85, both hemispheres	113.5
2337	Male, age 61, both hemispheres	61.0

Kolliker-Fuse nucleus
nTPM: 140.2

2315	Male, age 76, right hemisphere	182.6
2163	Male, age 80, both hemispheres	132.3
2793	Female, age 91, left hemisphere	105.7

Lateral lemniscal nuclei
nTPM: 180.1

2036	Male, age 80, both hemispheres	238.3
2169	Male, age 76, both hemispheres	205.7
2746	Female, age 85, left hemisphere	192.3
2453	Male, age 74, right hemisphere	156.0
2320	Female, age 91, left hemisphere	108.2

Lateral parabrachial nucleus
nTPM: 162.7

2139	Female, age 85, right hemisphere	251.8
2013	Male, age 80, both hemispheres	160.1
2790	Male, age 61, both hemispheres	123.8
2792	Male, age 76, both hemispheres	114.9

Lateral vestibular nucleus
nTPM: 147.6

2184	Male, age 76, both hemispheres	155.6
2311	Male, age 80, both hemispheres	139.5

Locus coeruleus
nTPM: 211.4

2317	Female, age 72, unknown	240.6
2014	Male, age 55, unknown	234.1
2123	Female, age 91, both hemispheres	221.7
1980	Male, age 76, both hemispheres	212.3
2162	Male, age 80, both hemispheres	198.2
2788	Male, age 74, unknown	195.7
2720	Male, age 74, both hemispheres	177.4

Medial parabrachial nucleus
nTPM: 124.2

2854	Male, age 80, both hemispheres	137.8
2786	Male, age 76, both hemispheres	136.0
2156	Male, age 61, both hemispheres	128.0
2463	Female, age 85, right hemisphere	120.6
2170	Female, age 91, both hemispheres	98.5

Medial periolivary nuclei
nTPM: 183.5

2171	Female, age 85, both hemispheres	251.7
2063	Male, age 76, both hemispheres	241.9
2791	Male, age 74, right hemisphere	171.5
2081	Male, age 80, both hemispheres	133.9
2458	Female, age 91, both hemispheres	118.3

Motor facial nucleus
nTPM: 189.0

2062	Male, age 76, both hemispheres	262.0
2327	Male, age 80, both hemispheres	222.9
2795	Female, age 91, both hemispheres	217.5
2365	Male, age 74, right hemisphere	157.4
2697	Female, age 85, both hemispheres	154.3
2126	Male, age 61, both hemispheres	119.8

Motor trigeminal nucleus
nTPM: 143.7

2079	Male, age 80, both hemispheres	206.2
2309	Male, age 76, both hemispheres	149.5
2560	Male, age 74, both hemispheres	134.5
2335	Male, age 61, both hemispheres	122.0
2321	Female, age 91, both hemispheres	106.0

Nuclei of the trapezoid body
nTPM: 202.1

2735	Female, age 85, both hemispheres	282.5
1983	Male, age 76, both hemispheres	228.1
2166	Male, age 80, both hemispheres	180.5
2368	Female, age 91, both hemispheres	172.0
2159	Male, age 61, both hemispheres	147.1

Nucleus raphe magnus
nTPM: 184.2

2172	Female, age 85, both hemispheres	261.0
2328	Male, age 80, both hemispheres	191.7
2051	Male, age 76, both hemispheres	184.7
2160	Male, age 61, both hemispheres	182.5
2455	Male, age 74, both hemispheres	169.2
2459	Female, age 91, both hemispheres	116.3

Paramedian reticular nucleus
nTPM: 122.2

2050	Female, age 85, both hemispheres	154.1
2057	Male, age 80, both hemispheres	119.4
2313	Male, age 61, both hemispheres	117.6
2052	Male, age 76, both hemispheres	97.6

Pedunculopontine tegmental nucleus
nTPM: 138.8

1921	Female, age 85, both hemispheres	164.1
2334	Male, age 80, both hemispheres	162.2
2338	Male, age 61, both hemispheres	90.1

Pontine nuclei
nTPM: 141.0

2787	Female, age 85, both hemispheres	244.1
1968	Male, age 76, left hemisphere	184.3
1863	Male, age 55, unknown	169.4
2115	Male, age 80, left hemisphere	148.2
2109	Female, age 72, unknown	116.3
2727	Male, age 61, right hemisphere	116.3
2319	Female, age 91, both hemispheres	88.0
2454	Male, age 74, left hemisphere	61.0

Pontine raphe nucleus
nTPM: 177.0

2122	Female, age 85, midline	181.0
2853	Male, age 76, midline	173.0

Posteroventral cochlear nucleus
nTPM: 111.2

2371	Male, age 61, both hemispheres	175.4
2752	Female, age 85, both hemispheres	140.1
2070	Male, age 76, both hemispheres	133.9
2341	Male, age 80, both hemispheres	63.4
2135	Female, age 91, both hemispheres	42.9

Principal sensory trigeminal nucleus
nTPM: 159.2

2008	Male, age 80, left hemisphere	212.0
2158	Male, age 61, both hemispheres	168.1
2324	Male, age 76, both hemispheres	157.1
2367	Female, age 91, left hemisphere	99.7

Reticular pontine nucleus, caudal
nTPM: 144.2

2092	Male, age 76, both hemispheres	192.5
2332	Male, age 80, right hemisphere	191.8
2457	Female, age 91, both hemispheres	110.8
2559	Male, age 74, both hemispheres	81.5

Reticular pontine nucleus, oral
nTPM: 124.1

2012	Female, age 85, both hemispheres	169.9
2167	Male, age 76, both hemispheres	142.5
1939	Male, age 80, both hemispheres	127.1
2366	Female, age 91, both hemispheres	91.2
2361	Male, age 74, both hemispheres	89.8

Reticulotegmental nucleus
nTPM: 145.6

2325	Male, age 76, both hemispheres	198.7
2333	Male, age 80, both hemispheres	139.7
2322	Female, age 91, both hemispheres	124.6
2452	Male, age 74, both hemispheres	119.6

Spinal trigeminal nucleus, oral
nTPM: 118.9

1978	Male, age 76, both hemispheres	120.8
2737	Female, age 85, both hemispheres	120.0
2164	Male, age 80, both hemispheres	115.9

Subcoeruleus area
nTPM: 163.3

2089	Male, age 76, left hemisphere	206.8
2451	Male, age 74, both hemispheres	176.9
1958	Male, age 80, both hemispheres	166.2
2323	Female, age 91, left hemisphere	160.2
2369	Female, age 85, left hemisphere	106.5

Superior olive
nTPM: 170.2

1875	Female, age 85, both hemispheres	210.7
2329	Male, age 80, right hemisphere	180.4
2020	Male, age 76, both hemispheres	176.5
2364	Male, age 74, right hemisphere	143.5
2561	Female, age 91, both hemispheres	139.6

Ventral periolivary nuclei
nTPM: 206.9

2130	Female, age 85, both hemispheres	284.3
2165	Male, age 80, both hemispheres	230.9
2023	Male, age 76, both hemispheres	163.6
2794	Female, age 91, left hemisphere	149.0

Ventrolateral tegmental area, A5 NE cell group
nTPM: 160.8

1959	Male, age 76, both hemispheres	195.9
2161	Male, age 80, both hemispheres	189.3
2449	Male, age 74, both hemispheres	159.1
2456	Female, age 91, both hemispheres	146.7
2359	Male, age 61, both hemispheres	140.1
2840	Female, age 85, both hemispheres	133.7

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	73.5

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 61.7

FF:10182-103D2	60 years, female	72.1
FF:10165-103B3	76 years, female	51.3

Pons
Scaled Tags Per Million: 73.5

FF:10033-101E6

18-54 years, mixed

73.5

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	39.7

Macaque sample

Sample description

nTPM

Pons
nTPM: 39.7

Samples: 2

Max nTPM: 42.0
Min nTPM: 37.3

Sample A		37.3
Sample B		42.0

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	75.5

Pig sample

Sample description

nTPM

Pons
nTPM: 75.5

Samples: 3

Max nTPM: 83.6
Min nTPM: 71.4

Sample A	Female	71.5
Sample B	Female	83.6
Sample C	Male	71.4

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	93.5

Mouse sample

Sample description

nTPM

Pons
nTPM: 93.5

Samples: 4

Max nTPM: 105.1
Min nTPM: 83.0

Sample A		105.1
Sample B		90.7
Sample C		95.1
Sample D		83.0

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	67.5

Rat sample

Sample description

nTPM

Pons
nTPM: 67.5

Samples: 4

Max nTPM: 68.4
Min nTPM: 66.2

Sample A		68.0
Sample A		66.2
Sample A		68.4
Sample A		67.5