Brain tissue expression of CDC14B in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	49.8	nTPM
FANTOM5:	24.0	Scaled Tags Per Million

Rat:	8.2	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	49.8

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 40.7

2188	Female, age 91, both hemispheres	56.0
2090	Male, age 80, both hemispheres	41.7
2301	Female, age 85, both hemispheres	39.2
1984	Male, age 76, both hemispheres	25.8

Dorsal cochlear nucleus
nTPM: 38.6

2802	Male, age 74, right hemisphere	41.8
2187	Female, age 91, both hemispheres	40.1
2378	Male, age 80, both hemispheres	38.6
2370	Male, age 61, both hemispheres	37.7
2058	Male, age 76, both hemispheres	34.8

Dorsal tegmental nucleus
nTPM: 41.6

2083	Male, age 80, both hemispheres	54.0
2326	Male, age 74, both hemispheres	43.5
1936	Male, age 76, left hemisphere	40.7
2358	Male, age 61, both hemispheres	28.0

Dorsolateral tegmental area
nTPM: 43.2

2654	Male, age 80, both hemispheres	59.9
2751	Female, age 85, both hemispheres	48.9
2337	Male, age 61, both hemispheres	46.5
2360	Male, age 74, both hemispheres	31.1
2141	Male, age 76, both hemispheres	29.6

Kolliker-Fuse nucleus
nTPM: 42.5

2793	Female, age 91, left hemisphere	45.9
2315	Male, age 76, right hemisphere	42.9
2163	Male, age 80, both hemispheres	38.6

Lateral lemniscal nuclei
nTPM: 39.8

2320	Female, age 91, left hemisphere	49.2
2036	Male, age 80, both hemispheres	45.3
2453	Male, age 74, right hemisphere	39.4
2746	Female, age 85, left hemisphere	36.5
2169	Male, age 76, both hemispheres	28.9

Lateral parabrachial nucleus
nTPM: 42.1

2792	Male, age 76, both hemispheres	56.6
2013	Male, age 80, both hemispheres	41.9
2790	Male, age 61, both hemispheres	37.9
2139	Female, age 85, right hemisphere	31.8

Lateral vestibular nucleus
nTPM: 35.3

2311	Male, age 80, both hemispheres	37.4
2184	Male, age 76, both hemispheres	33.2

Locus coeruleus
nTPM: 29.2

2720	Male, age 74, both hemispheres	32.5
2162	Male, age 80, both hemispheres	31.2
2317	Female, age 72, unknown	30.2
2014	Male, age 55, unknown	29.7
1980	Male, age 76, both hemispheres	28.0
2788	Male, age 74, unknown	28.0
2123	Female, age 91, both hemispheres	24.5

Medial parabrachial nucleus
nTPM: 41.4

2786	Male, age 76, both hemispheres	46.2
2463	Female, age 85, right hemisphere	44.4
2170	Female, age 91, both hemispheres	41.8
2156	Male, age 61, both hemispheres	38.2
2854	Male, age 80, both hemispheres	36.4

Medial periolivary nuclei
nTPM: 36.0

2081	Male, age 80, both hemispheres	49.8
2458	Female, age 91, both hemispheres	48.3
2791	Male, age 74, right hemisphere	30.5
2171	Female, age 85, both hemispheres	26.4
2063	Male, age 76, both hemispheres	24.8

Motor facial nucleus
nTPM: 34.4

2126	Male, age 61, both hemispheres	44.4
2795	Female, age 91, both hemispheres	39.1
2697	Female, age 85, both hemispheres	38.3
2327	Male, age 80, both hemispheres	31.9
2365	Male, age 74, right hemisphere	27.9
2062	Male, age 76, both hemispheres	24.7

Motor trigeminal nucleus
nTPM: 43.7

2321	Female, age 91, both hemispheres	51.6
2309	Male, age 76, both hemispheres	50.4
2560	Male, age 74, both hemispheres	42.8
2079	Male, age 80, both hemispheres	37.7
2335	Male, age 61, both hemispheres	35.9

Nuclei of the trapezoid body
nTPM: 36.5

2166	Male, age 80, both hemispheres	47.6
2368	Female, age 91, both hemispheres	43.6
2159	Male, age 61, both hemispheres	34.3
1983	Male, age 76, both hemispheres	30.4
2735	Female, age 85, both hemispheres	26.8

Nucleus raphe magnus
nTPM: 33.2

2459	Female, age 91, both hemispheres	51.0
2328	Male, age 80, both hemispheres	39.7
2051	Male, age 76, both hemispheres	33.8
2455	Male, age 74, both hemispheres	30.8
2160	Male, age 61, both hemispheres	22.7
2172	Female, age 85, both hemispheres	21.3

Paramedian reticular nucleus
nTPM: 40.6

2052	Male, age 76, both hemispheres	47.1
2057	Male, age 80, both hemispheres	41.2
2313	Male, age 61, both hemispheres	38.6
2050	Female, age 85, both hemispheres	35.3

Pedunculopontine tegmental nucleus
nTPM: 36.5

2334	Male, age 80, both hemispheres	41.2
2338	Male, age 61, both hemispheres	38.0
1921	Female, age 85, both hemispheres	30.3

Pontine nuclei
nTPM: 42.8

2115	Male, age 80, left hemisphere	54.2
2319	Female, age 91, both hemispheres	50.4
2454	Male, age 74, left hemisphere	50.2
1968	Male, age 76, left hemisphere	43.4
2109	Female, age 72, unknown	42.4
1863	Male, age 55, unknown	36.5
2727	Male, age 61, right hemisphere	33.8
2787	Female, age 85, both hemispheres	31.4

Pontine raphe nucleus
nTPM: 32.7

2122	Female, age 85, midline	35.5
2853	Male, age 76, midline	29.8

Posteroventral cochlear nucleus
nTPM: 49.8

2135	Female, age 91, both hemispheres	58.8
2341	Male, age 80, both hemispheres	57.4
2070	Male, age 76, both hemispheres	49.0
2371	Male, age 61, both hemispheres	46.8
2752	Female, age 85, both hemispheres	36.9

Principal sensory trigeminal nucleus
nTPM: 36.2

2367	Female, age 91, left hemisphere	46.4
2324	Male, age 76, both hemispheres	36.7
2008	Male, age 80, left hemisphere	33.0
2158	Male, age 61, both hemispheres	28.8

Reticular pontine nucleus, caudal
nTPM: 44.2

2457	Female, age 91, both hemispheres	50.6
2559	Male, age 74, both hemispheres	48.0
2092	Male, age 76, both hemispheres	40.8
2332	Male, age 80, right hemisphere	37.5

Reticular pontine nucleus, oral
nTPM: 45.0

2366	Female, age 91, both hemispheres	58.6
1939	Male, age 80, both hemispheres	48.2
2167	Male, age 76, both hemispheres	41.3
2012	Female, age 85, both hemispheres	39.6
2361	Male, age 74, both hemispheres	37.5

Reticulotegmental nucleus
nTPM: 41.7

2452	Male, age 74, both hemispheres	46.8
2322	Female, age 91, both hemispheres	42.9
2333	Male, age 80, both hemispheres	42.0
2325	Male, age 76, both hemispheres	35.0

Spinal trigeminal nucleus, oral
nTPM: 38.0

1978	Male, age 76, both hemispheres	41.9
2164	Male, age 80, both hemispheres	40.3
2737	Female, age 85, both hemispheres	31.8

Subcoeruleus area
nTPM: 40.0

2369	Female, age 85, left hemisphere	55.2
2451	Male, age 74, both hemispheres	47.2
1958	Male, age 80, both hemispheres	36.6
2089	Male, age 76, left hemisphere	34.7
2323	Female, age 91, left hemisphere	26.1

Superior olive
nTPM: 39.7

2020	Male, age 76, both hemispheres	49.9
2561	Female, age 91, both hemispheres	48.7
2329	Male, age 80, right hemisphere	42.6
1875	Female, age 85, both hemispheres	30.3
2364	Male, age 74, right hemisphere	27.1

Ventral periolivary nuclei
nTPM: 36.0

2023	Male, age 76, both hemispheres	54.9
2794	Female, age 91, left hemisphere	39.3
2165	Male, age 80, both hemispheres	31.5
2130	Female, age 85, both hemispheres	18.2

Ventrolateral tegmental area, A5 NE cell group
nTPM: 37.1

2456	Female, age 91, both hemispheres	49.9
2161	Male, age 80, both hemispheres	35.9
2840	Female, age 85, both hemispheres	35.7
1959	Male, age 76, both hemispheres	35.2
2359	Male, age 61, both hemispheres	34.8
2449	Male, age 74, both hemispheres	30.9

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	24.0

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 24.0

FF:10182-103D2	60 years, female	28.7
FF:10165-103B3	76 years, female	19.2

Pons
Scaled Tags Per Million: 21.5

FF:10033-101E6

18-54 years, mixed

21.5

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	8.2

Rat sample

Sample description

nTPM

Pons
nTPM: 8.2

Samples: 4

Max nTPM: 8.8
Min nTPM: 7.1

Sample A		7.1
Sample A		8.5
Sample A		8.3
Sample A		8.8