Brain tissue expression of STARD7 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	89.8	nTPM
FANTOM5:	59.3	Scaled Tags Per Million

Macaque:	51.6	nTPM
Mouse:	29.7	nTPM
Rat:	55.1	nTPM
Pig:	34.3	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	89.8

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 73.8

2090	Male, age 80, both hemispheres	82.3
2188	Female, age 91, both hemispheres	76.3
1984	Male, age 76, both hemispheres	69.7
2301	Female, age 85, both hemispheres	67.1

Dorsal cochlear nucleus
nTPM: 89.8

2802	Male, age 74, right hemisphere	116.2
2378	Male, age 80, both hemispheres	92.8
2370	Male, age 61, both hemispheres	81.9
2187	Female, age 91, both hemispheres	79.1
2058	Male, age 76, both hemispheres	79.0

Dorsal tegmental nucleus
nTPM: 78.0

2083	Male, age 80, both hemispheres	88.2
2326	Male, age 74, both hemispheres	83.4
1936	Male, age 76, left hemisphere	75.2
2358	Male, age 61, both hemispheres	65.3

Dorsolateral tegmental area
nTPM: 80.3

2751	Female, age 85, both hemispheres	90.8
2654	Male, age 80, both hemispheres	89.6
2360	Male, age 74, both hemispheres	76.9
2141	Male, age 76, both hemispheres	75.6
2337	Male, age 61, both hemispheres	68.7

Kolliker-Fuse nucleus
nTPM: 85.0

2315	Male, age 76, right hemisphere	99.8
2163	Male, age 80, both hemispheres	79.6
2793	Female, age 91, left hemisphere	75.5

Lateral lemniscal nuclei
nTPM: 73.6

2746	Female, age 85, left hemisphere	84.4
2453	Male, age 74, right hemisphere	72.8
2320	Female, age 91, left hemisphere	72.1
2036	Male, age 80, both hemispheres	69.9
2169	Male, age 76, both hemispheres	68.6

Lateral parabrachial nucleus
nTPM: 77.4

2013	Male, age 80, both hemispheres	86.5
2139	Female, age 85, right hemisphere	82.4
2792	Male, age 76, both hemispheres	77.2
2790	Male, age 61, both hemispheres	63.6

Lateral vestibular nucleus
nTPM: 77.4

2311	Male, age 80, both hemispheres	78.3
2184	Male, age 76, both hemispheres	76.5

Locus coeruleus
nTPM: 82.4

2014	Male, age 55, unknown	96.4
2317	Female, age 72, unknown	91.9
2123	Female, age 91, both hemispheres	86.0
1980	Male, age 76, both hemispheres	81.3
2788	Male, age 74, unknown	78.4
2162	Male, age 80, both hemispheres	76.2
2720	Male, age 74, both hemispheres	66.7

Medial parabrachial nucleus
nTPM: 75.8

2463	Female, age 85, right hemisphere	89.1
2170	Female, age 91, both hemispheres	81.2
2854	Male, age 80, both hemispheres	71.9
2786	Male, age 76, both hemispheres	71.0
2156	Male, age 61, both hemispheres	65.6

Medial periolivary nuclei
nTPM: 75.0

2791	Male, age 74, right hemisphere	83.4
2063	Male, age 76, both hemispheres	79.8
2081	Male, age 80, both hemispheres	76.1
2171	Female, age 85, both hemispheres	71.1
2458	Female, age 91, both hemispheres	64.5

Motor facial nucleus
nTPM: 72.3

2795	Female, age 91, both hemispheres	83.4
2062	Male, age 76, both hemispheres	82.8
2365	Male, age 74, right hemisphere	78.3
2126	Male, age 61, both hemispheres	72.6
2697	Female, age 85, both hemispheres	59.6
2327	Male, age 80, both hemispheres	57.0

Motor trigeminal nucleus
nTPM: 68.3

2309	Male, age 76, both hemispheres	73.3
2560	Male, age 74, both hemispheres	71.6
2079	Male, age 80, both hemispheres	67.3
2335	Male, age 61, both hemispheres	66.3
2321	Female, age 91, both hemispheres	62.9

Nuclei of the trapezoid body
nTPM: 74.0

1983	Male, age 76, both hemispheres	80.4
2159	Male, age 61, both hemispheres	75.5
2368	Female, age 91, both hemispheres	75.2
2735	Female, age 85, both hemispheres	72.7
2166	Male, age 80, both hemispheres	66.3

Nucleus raphe magnus
nTPM: 71.2

2051	Male, age 76, both hemispheres	79.2
2455	Male, age 74, both hemispheres	76.9
2160	Male, age 61, both hemispheres	71.8
2459	Female, age 91, both hemispheres	68.8
2328	Male, age 80, both hemispheres	67.9
2172	Female, age 85, both hemispheres	62.6

Paramedian reticular nucleus
nTPM: 76.5

2057	Male, age 80, both hemispheres	86.3
2050	Female, age 85, both hemispheres	75.0
2313	Male, age 61, both hemispheres	73.2
2052	Male, age 76, both hemispheres	71.6

Pedunculopontine tegmental nucleus
nTPM: 75.6

2334	Male, age 80, both hemispheres	86.4
1921	Female, age 85, both hemispheres	82.7
2338	Male, age 61, both hemispheres	57.7

Pontine nuclei
nTPM: 76.0

2109	Female, age 72, unknown	80.4
1863	Male, age 55, unknown	80.2
2727	Male, age 61, right hemisphere	80.2
2115	Male, age 80, left hemisphere	76.4
2319	Female, age 91, both hemispheres	74.9
2787	Female, age 85, both hemispheres	73.8
1968	Male, age 76, left hemisphere	71.6
2454	Male, age 74, left hemisphere	70.7

Pontine raphe nucleus
nTPM: 74.7

2853	Male, age 76, midline	78.8
2122	Female, age 85, midline	70.6

Posteroventral cochlear nucleus
nTPM: 81.2

2752	Female, age 85, both hemispheres	85.3
2341	Male, age 80, both hemispheres	82.9
2371	Male, age 61, both hemispheres	81.7
2135	Female, age 91, both hemispheres	81.2
2070	Male, age 76, both hemispheres	74.9

Principal sensory trigeminal nucleus
nTPM: 72.5

2324	Male, age 76, both hemispheres	76.3
2367	Female, age 91, left hemisphere	74.0
2158	Male, age 61, both hemispheres	71.0
2008	Male, age 80, left hemisphere	68.6

Reticular pontine nucleus, caudal
nTPM: 73.2

2457	Female, age 91, both hemispheres	77.9
2559	Male, age 74, both hemispheres	76.8
2092	Male, age 76, both hemispheres	75.5
2332	Male, age 80, right hemisphere	62.7

Reticular pontine nucleus, oral
nTPM: 75.3

1939	Male, age 80, both hemispheres	86.3
2012	Female, age 85, both hemispheres	81.8
2167	Male, age 76, both hemispheres	77.1
2366	Female, age 91, both hemispheres	71.1
2361	Male, age 74, both hemispheres	60.1

Reticulotegmental nucleus
nTPM: 79.7

2452	Male, age 74, both hemispheres	82.5
2333	Male, age 80, both hemispheres	80.8
2322	Female, age 91, both hemispheres	80.3
2325	Male, age 76, both hemispheres	75.1

Spinal trigeminal nucleus, oral
nTPM: 78.2

2164	Male, age 80, both hemispheres	79.4
2737	Female, age 85, both hemispheres	79.0
1978	Male, age 76, both hemispheres	76.0

Subcoeruleus area
nTPM: 77.2

2369	Female, age 85, left hemisphere	91.9
2451	Male, age 74, both hemispheres	85.0
2323	Female, age 91, left hemisphere	76.2
1958	Male, age 80, both hemispheres	74.7
2089	Male, age 76, left hemisphere	58.0

Superior olive
nTPM: 70.7

2364	Male, age 74, right hemisphere	83.4
1875	Female, age 85, both hemispheres	72.0
2020	Male, age 76, both hemispheres	72.0
2329	Male, age 80, right hemisphere	64.8
2561	Female, age 91, both hemispheres	61.3

Ventral periolivary nuclei
nTPM: 68.4

2023	Male, age 76, both hemispheres	74.4
2165	Male, age 80, both hemispheres	73.7
2130	Female, age 85, both hemispheres	64.8
2794	Female, age 91, left hemisphere	60.8

Ventrolateral tegmental area, A5 NE cell group
nTPM: 72.3

2840	Female, age 85, both hemispheres	78.7
2161	Male, age 80, both hemispheres	75.1
2456	Female, age 91, both hemispheres	75.0
2449	Male, age 74, both hemispheres	71.8
1959	Male, age 76, both hemispheres	67.5
2359	Male, age 61, both hemispheres	65.9

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	59.3

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 56.7

FF:10165-103B3	76 years, female	80.0
FF:10182-103D2	60 years, female	33.4

Pons
Scaled Tags Per Million: 59.3

FF:10033-101E6

18-54 years, mixed

59.3

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	51.6

Macaque sample

Sample description

nTPM

Pons
nTPM: 51.7

Samples: 2

Max nTPM: 58.9
Min nTPM: 44.4

Sample A		58.9
Sample B		44.4

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	34.3

Pig sample

Sample description

nTPM

Pons
nTPM: 34.3

Samples: 3

Max nTPM: 37.9
Min nTPM: 29.6

Sample A	Female	37.9
Sample B	Female	29.6
Sample C	Male	35.5

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	29.7

Mouse sample

Sample description

nTPM

Pons
nTPM: 29.7

Samples: 4

Max nTPM: 31.0
Min nTPM: 29.1

Sample A		31.0
Sample B		29.1
Sample C		29.2
Sample D		29.4

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	55.1

Rat sample

Sample description

nTPM

Pons
nTPM: 55.2

Samples: 4

Max nTPM: 55.8
Min nTPM: 54.0

Sample A		55.8
Sample A		54.0
Sample A		55.0
Sample A		55.8