Brain tissue expression of ABCB1 in medulla oblongata

MEDULLA OBLONGATA - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	30.8	nTPM
FANTOM5:	45.5	Scaled Tags Per Million

Mouse:	11.6	nTPM
Rat:	19.0	nTPM
Pig:	2.3	nTPM

MEDULLA OBLONGATA - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - MEDULLA OBLONGATA, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1) ETV1+ Z...
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1) ETV1+ Z...
	c-4	Unassigned
	c-5	Excitatory (VGLUT1) ETV1+ Z...
	c-6	Inhibitory (GAD1/2) SLC6A5+
	c-7	Unassigned
	c-8	Excitatory (VGLUT1) ETV1+ Z...
	c-9	Excitatory (VGLUT1/2)
	c-10	Inhibitory (GAD1/2) SLC6A5+
	c-11	Inhibitory (GAD1/2) SLC6A5+...
	c-12	Excitatory (VGLUT2)
	c-13	Excitatory (VGLUT2)
	c-14	Inhibitory (GAD1/2) SLC6A5+...
	c-15	Inhibitory (GAD1/2) SLC6A5+...
	c-16	SST+ CALB1+ EBF1+
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2) SLC6A5+...
	c-19	Inhibitory (GAD1/2) SLC6A5+...
	c-20	SST+ TAC3+ GRP+ SOX5+
	c-21	Inhibitory (GAD1/2) PVALB+ ...
	c-22	Inferior olive Excitatory (...
	c-23	Excitatory (VGLUT2)
	c-24	Excitatory (VGLUT2) TFAP2B+...
	c-25	Excitatory (VGLUT2)
	c-26	EBF1+ CALB1+
	c-27	SST+ TRH+ CALB1+
	c-28	Excitatory (VGLUT2) EBF1+
	c-29	Excitatory (VGLUT2) TH+ TFA...
	c-30	Monoaminergic Excitatory (V...
	c-31	Inhibitory (GAD1/2) PENK+ E...
	c-32	Excitatory (VGLUT2) SST+ TA...
	c-33	Inhibitory (GAD1/2) SLC6A5+
	c-34	Excitatory (VGLUT2) PVALB+
	c-35	Inhibitory (GAD2) SLC6A5+ N
	c-36	Excitatory (VGLUT2) GAL+ NO
	c-37	Serotonergic TPH2+ SLC6A4+
	c-38	Excitatory (VGLUT2) SLC5A7+...
	c-39	Cholinergic CHAT+ SLC5A7+ T...
	c-40	Excitatory (VGLUT2) MEIS2+
	c-41	Inhibitory (GAD1/2) SLC6A5+
	c-42	Inhibitory (GAD1/2) RORB+ K
	c-43	Inhibitory (GAD1/2) PENK+ ...
	c-44	LMX1A+
	c-45	Excitatory (VGLUT2) SST+ TA
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - MEDULLA OBLONGATA, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocytes
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Microglia
	c-7	Oligodendrocyte progenitor ...
	c-8	Oligodendrocytes
	c-9	Astrocytes (TTR+ CD44+)
	c-10	Oligodendrocytes
	c-11	Choroid plexus epithelial c...
	c-12	Astrocytes (TTR+ CD44+)
	c-13	Astrocytes (CD44+)
	c-14	Ependymal cells
	c-15	Astrocytes (TTR+ CD44+)
	c-16	Fibroblasts
	c-17	Astrocytes (TTR+ CD44+)
	c-18	Vascular endothelial cells
	c-19	Microglia
	c-20	Pericytes
	c-21	Lymphocytes
	c-22	Bergmann glia
	c-23	Macrophages
	c-24	Vascular smooth muscle cell
	c-25	Astrocyte & neuron doublets
	c-26	Ependymal cell & neuron dou...
	c-27	Immature oligodendrocytes
	c-28	Myelinating schwann cells
	c-29	Monocytes
	c-30	Oligodendrocyte progenitor ...
	c-31	Fibroblasts (BNC2+ KCNMA1+ ...
	c-32	Ependymal cell & oligodendr...
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

MEDULLA OBLONGATA - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	30.8

Sample id

Sample description

nTPM

Area postrema
nTPM: 22.1

2306	Male, age 80, both hemispheres	27.6
2799	Male, age 61, both hemispheres	19.5
2054	Male, age 76, both hemispheres	19.3

Dorsal medullary reticular nucleus
nTPM: 24.4

2373	Male, age 61, both hemispheres	32.6
2040	Female, age 85, both hemispheres	21.0
2088	Male, age 76, both hemispheres	19.7

Dorsal motor vagal complex
nTPM: 22.5

2797	Male, age 61, both hemispheres	47.0
2807	Female, age 85, both hemispheres	24.3
2844	Male, age 55, unknown	22.8
2185	Male, age 76, both hemispheres	22.3
2133	Female, age 91, both hemispheres	17.7
2643	Male, age 74, both hemispheres	17.7
2000	Male, age 74, unknown	14.4
2813	Female, age 72, unknown	14.1

Gigantocellular reticular nuclei, medullary
nTPM: 28.8

2387	Female, age 91, both hemispheres	38.5
2310	Male, age 80, both hemispheres	33.4
1876	Female, age 85, both hemispheres	28.2
2314	Male, age 61, both hemispheres	26.2
2462	Male, age 74, both hemispheres	23.8
2022	Male, age 76, right hemisphere	22.4

Gigantocellular reticular nuclei, pars
nTPM: 26.4

2706	Male, age 80, both hemispheres	35.9
2330	Male, age 80, both hemispheres	32.8
2336	Male, age 61, both hemispheres	28.2
2084	Female, age 85, both hemispheres	19.2
2168	Male, age 76, both hemispheres	16.0

Inferior olive
nTPM: 30.2

2379	Male, age 80, both hemispheres	41.4
2178	Male, age 61, both hemispheres	33.3
2628	Female, age 91, both hemispheres	29.5
2563	Male, age 74, both hemispheres	25.3
2085	Female, age 85, both hemispheres	21.5

Lateral medullary reticular nucleus
nTPM: 18.5

2374	Male, age 61, both hemispheres	24.8
2190	Female, age 85, both hemispheres	24.4
2804	Female, age 91, both hemispheres	20.4
2044	Male, age 76, both hemispheres	17.7
2852	Male, age 80, both hemispheres	14.6
2305	Male, age 74, both hemispheres	9.2

Medial olivary nucleus
nTPM: 17.2

2138	Female, age 91, both hemispheres	22.2
2851	Male, age 80, both hemispheres	19.4
1962	Male, age 76, both hemispheres	14.3
1943	Male, age 61, both hemispheres	12.8

Medial vestibular nucleus
nTPM: 23.4

2624	Male, age 61, both hemispheres	28.4
2093	Male, age 80, both hemispheres	27.6
2803	Female, age 91, both hemispheres	27.0
2743	Female, age 85, both hemispheres	20.4
2801	Male, age 74, both hemispheres	18.8
2134	Male, age 76, both hemispheres	18.4

Motor hypoglossal nucleus
nTPM: 22.0

2461	Male, age 61, both hemispheres	26.8
2125	Female, age 91, both hemispheres	23.2
2132	Female, age 85, both hemispheres	21.7
2182	Male, age 80, both hemispheres	20.7
2277	Male, age 76, both hemispheres	17.8

Nucleus ambiguus
nTPM: 16.7

2096	Female, age 85, both hemispheres	20.6
2071	Male, age 76, both hemispheres	12.8

Nucleus cuneatus
nTPM: 30.8

2562	Male, age 61, both hemispheres	38.9
2805	Female, age 91, both hemispheres	38.4
2376	Male, age 61, both hemispheres	37.2
2381	Male, age 80, both hemispheres	31.2
2808	Female, age 85, both hemispheres	28.5
2564	Male, age 74, both hemispheres	28.2
2380	Male, age 80, both hemispheres	27.8
2131	Male, age 76, both hemispheres	23.8
2100	Male, age 76, both hemispheres	23.4

Nucleus gracilis
nTPM: 25.8

2299	Female, age 85, both hemispheres	33.7
2382	Male, age 80, both hemispheres	28.7
2627	Male, age 74, both hemispheres	15.1

Nucleus raphe obscurus
nTPM: 18.2

2800	Male, age 61, midline	23.2
2845	Female, age 85, midline	20.9
2142	Male, age 76, midline	10.6

Nucleus raphe pallidus
nTPM: 14.9

2183	Male, age 80, midline	20.1
2145	Male, age 76, midline	18.1
1924	Male, age 61, midline	6.5

Nucleus tractus solitarii
nTPM: 20.8

2144	Female, age 91, right hemisphere	22.8
2656	Male, age 76, both hemispheres	20.6
2307	Male, age 80, both hemispheres	20.4
2191	Female, age 85, both hemispheres	19.3

Parvicellular reticular nuclei
nTPM: 22.7

2558	Male, age 74, both hemispheres	26.9
2119	Male, age 80, both hemispheres	21.6
2095	Male, age 76, both hemispheres	19.7

Parvicellular reticular nuclei, medullary
nTPM: 24.0

2091	Female, age 85, both hemispheres	26.6
2181	Male, age 80, left hemisphere	23.2
2189	Female, age 91, both hemispheres	22.4

Peritrigeminal nucleus
nTPM: 17.0

2179	Male, age 61, both hemispheres	21.2
2136	Male, age 76, both hemispheres	17.7
2067	Female, age 85, both hemispheres	12.0

Prepositus hypoglossal nucleus
nTPM: 24.1

2855	Female, age 85, right hemisphere	24.1
2086	Male, age 80, both hemispheres	24.0

Spinal trigeminal nucleus, caudal
nTPM: 20.1

2390	Female, age 91, both hemispheres	25.3
2312	Male, age 61, both hemispheres	23.0
2308	Male, age 80, both hemispheres	20.8
2447	Male, age 76, both hemispheres	20.0
2642	Male, age 74, both hemispheres	11.1

Spinal trigeminal nucleus, interpolar
nTPM: 22.7

2625	Male, age 61, both hemispheres	29.4
2389	Female, age 91, both hemispheres	22.4
2066	Male, age 76, right hemisphere	21.7
2033	Male, age 80, both hemispheres	20.9
2386	Female, age 85, both hemispheres	19.4

Spinal vestibular nucleus
nTPM: 23.6

2796	Male, age 61, both hemispheres	33.8
2384	Male, age 74, both hemispheres	28.6
2806	Female, age 85, both hemispheres	21.9
2186	Female, age 91, both hemispheres	21.0
2780	Male, age 80, both hemispheres	19.5
2748	Male, age 76, both hemispheres	16.9

Superior vestibular nucleus
nTPM: 16.0

2015	Male, age 80, both hemispheres	19.3
2383	Male, age 74, both hemispheres	15.2
2061	Male, age 76, both hemispheres	13.4

Ventral medullary reticular nucleus
nTPM: 25.0

2372	Male, age 61, both hemispheres	33.9
2060	Male, age 76, both hemispheres	16.2

Ventrolateral medulla, A1-C1 cell groups
nTPM: 22.0

2118	Male, age 80, both hemispheres	27.9
2180	Male, age 61, both hemispheres	25.0
2302	Female, age 91, both hemispheres	20.9
2741	Female, age 85, both hemispheres	20.9
1986	Male, age 76, both hemispheres	15.2

MEDULLA OBLONGATA - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	45.5

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Medulla oblongata
Scaled Tags Per Million: 45.5

FF:10155-103A2	76 years, female	56.0
FF:10038-101F2	18-64 years, mixed	40.9
FF:10174-103C3	60 years, female	39.5

MEDULLA OBLONGATA - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	2.3

Pig sample

Sample description

nTPM

Medulla oblongata
nTPM: 10.0

Samples: 4

Max nTPM: 12.2
Min nTPM: 7.7

Sample A	Female	7.7
Sample B	Female	9.8
Sample C	Male	12.2
Sample D	Male	10.4

MEDULLA OBLONGATA - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	11.6

Mouse sample

Sample description

nTPM

Medulla oblongata
nTPM: 1.0

Samples: 4

Max nTPM: 1.0
Min nTPM: 0.9

Sample A		1.0
Sample B		0.9
Sample C		1.0
Sample D		1.0

MEDULLA OBLONGATA - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	19.0

Rat sample

Sample description

nTPM

Medulla oblongata
nTPM: 19.0

Samples: 4

Max nTPM: 20.8
Min nTPM: 16.0

Sample A		18.6
Sample A		20.8
Sample A		16.0
Sample A		20.6