Single cell type - DOCK9 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DOCK9
Gene descriptionⁱ Full gene name according to HGNC.	Dedicator of cytokinesis 9
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	15

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Endothelial cells - Angiogenesis & vascular homeostasis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Esophageal apical cells, Vascular endothelial cells, Oligodendrocytes, Lymphatic endothelial cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.41
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Endothelial cell)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (NK-cell, naive CD4 T-cell, memory CD4 T-cell, MAIT T-cell, naive CD8 T-cell, T-reg, memory CD8 T-cell, gdT-cell)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

Single cell type

Cell type enrichment

Single nuclei - Brain

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nCPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. * Single nuclei Read more
Single cell type groups RNA single cell type group specificity: Cell type enhanced (Apical squamous epithelial cells, Endothelial cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Endothelial cell)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas HPA data, as well as data generated by Monaco et al and Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Group enriched (NK-cell, naive CD4 T-cell, memory CD4 T-cell, MAIT T-cell, naive CD8 T-cell, T-reg, memory CD8 T-cell, gdT-cell)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

DOCK9 is part of cluster 12 Endothelial cells - Angiogenesis & vascular homeostasis with confidenceⁱ 1
216 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
VEGFC	Vascular endothelial growth factor C	0.6862	12
TEK	TEK receptor tyrosine kinase	0.6293	12
NUAK1	NUAK family kinase 1	0.6291	12
FGD5	FYVE, RhoGEF and PH domain containing 5	0.6242	12
GARRE1	Granule associated Rac and RHOG effector 1	0.6198	12
EPB41L4A	Erythrocyte membrane protein band 4.1 like 4A	0.6152	12
ARL15	ADP ribosylation factor like GTPase 15	0.6151	32
SLC5A4	Solute carrier family 5 member 4	0.6041	12
SMAD6	SMAD family member 6	0.5854	12
SHE	Src homology 2 domain containing E	0.5823	12
EFNB2	Ephrin B2	0.5790	12
ADAMTS6	ADAM metallopeptidase with thrombospondin type 1 motif 6	0.5764	12
FAT4	FAT atypical cadherin 4	0.5718	12
PIK3C2B	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta	0.5633	12
RASGRF2	Ras protein specific guanine nucleotide releasing factor 2	0.5619	12

IMMUNE CELLS

DOCK9 is part of cluster 11 T-cells - Unknown function with confidenceⁱ 1
119 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ASDURF	ASNSD1 upstream open reading frame	1.0000	11
ZBTB25	Zinc finger and BTB domain containing 25	1.0000	11
PCMTD2	Protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2	1.0000	11
SLC25A34	Solute carrier family 25 member 34	1.0000	11
ABTB3	Ankyrin repeat and BTB domain containing 3	1.0000	11
SCML4	Scm polycomb group protein like 4	1.0000	11
CCDC61	Coiled-coil domain containing 61	0.9762	11
AAK1	AP2 associated kinase 1	0.9762	11
NIT2	Nitrilase family member 2	0.9762	11
INPP4B	Inositol polyphosphate-4-phosphatase type II B	0.9762	11
ISYNA1	Inositol-3-phosphate synthase 1	0.9762	27
SLC9A3	Solute carrier family 9 member A3	0.9762	43
CLUAP1	Clusterin associated protein 1	0.9762	43
CD40LG	CD40 ligand	0.9762	11
PCSK1N	Proprotein convertase subtilisin/kexin type 1 inhibitor	0.9762	43