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Gene name
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Tissue Tau score (RNA)
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Brain Tau score (RNA)
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Pig brain Tau score (RNA)
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Reliability score mouse brain
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Cell type Tau score (RNA)
Brain region cell type (scRNA)
Brain region Tau score (scRNA)
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Immune cell Tau score (RNA)
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Immune cell lineage Tau score (RNA)
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Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
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Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
RAS pathway related proteins
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Subclass
Class
Biological process
Molecular function
Disease
Keyword
Chromosome
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
MT
Unmapped
X
Y
External id
Tissue
Any
Adipose tissue
Adrenal gland
Appendix
Bone marrow
Breast
Bronchus
Cartilage
Caudate
Cerebellum
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Cervix
Choroid plexus
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Smooth muscle
Soft tissue
Sole of foot
Spleen
Stomach
Substantia nigra
Testis
Thymus
Thyroid gland
Tonsil
Urinary bladder
Vagina
Cell type
Expression
Antibody panel
Any
Ciliated cells
Kidney
Salivary gland
Sertoli cells
Spermatids
Spermatocytes
Spermatogonia
Tissue
Main location
Patient ID
Annotation
Immunoglobulin genes
Intracellular and membrane
Secreted - unknown location
Secreted in brain
Secreted in female reproductive system
Secreted in male reproductive system
Secreted in other tissues
Secreted to blood
Secreted to digestive system
Secreted to extracellular matrix
Tissue
Any
Adipose tissue
Adrenal gland
Bone marrow
Brain
Breast
Cervix
Choroid plexus
Endometrium
Epididymis
Esophagus
Fallopian tube
Gallbladder
Heart muscle
Intestine
Kidney
Liver
Lung
Lymphoid tissue
Ovary
Pancreas
Parathyroid gland
Pituitary gland
Placenta
Prostate
Retina
Salivary gland
Seminal vesicle
Skeletal muscle
Skin
Smooth muscle
Stomach
Testis
Thyroid gland
Tongue
Urinary bladder
Vagina
Category
Tissue enriched
Group enriched
Tissue enhanced
Low tissue specificity
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Tau score
0-0.1
0.1-0.2
0.2-0.3
0.3-0.4
0.4-0.5
0.5-0.6
0.6-0.7
0.7-0.8
0.8-0.9
0.9-1
Cluster
7:Adipose tissue - Mixed function
26:Adrenal gland - Steroid metabolism
77:Bone marrow - Cell proliferation
6:Bone marrow - Innate immune response
33:Brain - Neuronal signaling
61:Brain - Neuronal signaling
22:Brain - Synaptic signal transduction
5:Brain & Testis - Signal transduction
73:Breast - Lactation
65:Cerebellum - Nervous system development
60:Choroid plexus - Transmembrane transport
8:Ciliated cells - Cilium organization
62:Connective tissue - ECM organization
32:Endocrine & Neural - Unknown function
50:Epididymis - Male reproductive secretion
75:Epithelium - Extracellular exosomes
59:Fallopian tube - Tissue development
12:Heart muscle - Cardiac muscle contraction
30:Heart muscle - Heart development
45:Intestine - Digestion
52:Kidney - Transmembrane transport
55:Kidney & Intestine - Metabolism
83:Liver - Metabolism
69:Liver - Oxidoreductase activity
11:Liver - Plasma proteins
31:Liver - Plasma proteins
37:Liver & Intestine - Lipid metabolism
1:Liver & Kidney - Metabolism
57:Lung - Lung function
36:Lymphoid tissue - Cytokine signaling
70:Lymphoid tissue - Immune response
67:Lymphoid tissue & Bone marrow - Cell proliferation
81:Lymphoid tissue & Bone marrow - Innate immune response
17:Neuronal - Synaptic function
28:Neuronal - Transcription
64:Neuronal - Transcription
19:Non-specific - Basic cellular processes
54:Non-specific - Basic cellular processes
23:Non-specific - Cellular respiration
80:Non-specific - Endocytosis
53:Non-specific - Glycosylation
35:Non-specific - Mitochondria
43:Non-specific - Mitochondrial translation
34:Non-specific - Mixed function
68:Non-specific - Protein processing
18:Non-specific - Ribosome
16:Non-specific - Transcription
40:Non-specific - Transcription
66:Non-specific - Transcription
79:Non-specific - Transcription
3:Non-specific - Unknown function
56:Non-specific - Unknown function
9:Oligodendrocytes - Myelination
15:Pancreas - Proteolysis
24:Parathyroid gland - Vesicular transport
49:Pituitary gland - Hormone signaling
58:Placenta - Pregnancy
76:Retina - Visual perception
39:Retina & Testis - Cilium
38:Salivary gland - Salivary secretion
14:Skeletal muscle - Muscle contraction
2:Skeletal muscle - Striated muscle contraction
13:Skin - Cornification
82:Skin - Keratinization
25:Small intestine - Absorption
41:Smooth muscle tissue - ECM organization
74:Spermatids - Flagellum assembly
47:Spleen - Immune response
29:Squamous epithelium - Innate immune response
27:Squamous epithelium - Keratinization
48:Stomach - Proteolysis
4:Testis - Basic cellular processes
10:Testis - Spermatid development
63:Testis - Spermatid development
20:Testis - Spermatogenesis
42:Testis - Spermatogenesis
44:Testis - Spermatogenesis
46:Testis - Spermatogenesis
78:Testis - Transcription
21:Testis - Unknown function
72:Testis & Skeletal muscle - Protein ubiquitination
71:Thymus - Adaptive immune response
51:Thyroid gland - Unknown function
Reliability
Enhanced
Supported
Approved
Uncertain
Brain region
Any
Amygdala
Basal ganglia
Cerebellum
Cerebral cortex
Choroid plexus
Hippocampal formation
Hypothalamus
Medulla oblongata
Midbrain
Pons
Spinal cord
Thalamus
White matter
Category
Region enriched
Group enriched
Region enhanced
Low region specificity
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Tau score
0-0.1
0.1-0.2
0.2-0.3
0.3-0.4
0.4-0.5
0.5-0.6
0.6-0.7
0.7-0.8
0.8-0.9
0.9-1
Brain region
Any
Amygdala
Basal ganglia
Cerebellum
Cerebral cortex
Hippocampal formation
Hypothalamus
Midbrain
Olfactory bulb
Pons and medulla
Thalamus
White matter
Category
Region enriched
Group enriched
Region enhanced
Low region specificity
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Tau score
0-0.1
0.1-0.2
0.2-0.3
0.3-0.4
0.4-0.5
0.5-0.6
0.6-0.7
0.7-0.8
0.8-0.9
0.9-1
Brain region
Any
Amygdala
Basal ganglia
Cerebellum
Cerebral cortex
Hippocampal formation
Hypothalamus
Medulla oblongata
Midbrain
Olfactory bulb
Pons
Spinal cord
Thalamus
White matter
Category
Region enriched
Group enriched
Region enhanced
Low region specificity
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Tau score
0-0.1
0.1-0.2
0.2-0.3
0.3-0.4
0.4-0.5
0.5-0.6
0.6-0.7
0.7-0.8
0.8-0.9
0.9-1
Cluster
40:Astrocytes - Astrocyte-neuron interactions
19:Astrocytes - Mixed function
39:Astrocytes - Mixed function
46:Brainstem - Mixed function
10:Cerebellum - Nucleic acid binding
32:Cerebral cortex - Mixed function
3:Choroid plexus - Cilium
17:Choroid plexus - Cilium
42:Choroid plexus - Mitochondria
23:Choroid plexus - Mixed function
36:Choroid plexus - Mixed function
47:Endothelial cells - Vasculature
29:Forebrain - Mixed function
43:Hindbrain - Mixed function
49:Hindbrain - Mixed function
56:Hypothalamus - Neuropeptide signaling
8:Immune cells - Immune response
54:Immune cells - T cell receptor
20:Macrophages & Microglia - Immune response
41:Monoamines - Neurotransmitter signalling
1:Neurons - Mixed function
24:Neurons - Mixed function
33:Neurons - Mixed function
37:Neurons - Mixed function
51:Neurons - Mixed function
53:Neurons - Mixed function
2:Neurons - Nucleosome
14:Neurons - Synaptic function
52:Neurons & Synapses - Synaptic function
35:Non-specific - DNA binding
6:Non-specific - Immune response
21:Non-specific - Metabolism
5:Non-specific - Mixed function
18:Non-specific - Mixed function
22:Non-specific - Mixed function
27:Non-specific - Mixed function
34:Non-specific - Mixed function
44:Non-specific - Mixed function
45:Non-specific - Mixed function
48:Non-specific - Mixed function
4:Non-specific - mRNA splicing & Cell cycle
50:Non-specific - Nucleic acid binding
9:Non-specific - Receptor signaling
7:Non-specific - Ribosome
15:Non-specific - Transcription
16:Non-specific - Transcription
25:Non-specific - Transcription
31:Non-specific - Transcription
55:Non-specific - Transcription
12:Non-specific - Vasculature
13:Oligodendrocytes - Mixed function
26:Oligodendrocytes - Mixed function
28:Oligodendrocytes - Mixed function
38:Sub-cortical - Mixed function
30:White matter - Myelination
11:White matter - Signal transduction
Reliability
Supported
Approved
Tissue
Adipose subcutaneous
Adipose visceral
Adrenal gland
Breast
Colon
Heart muscle
Kidney
Liver
Lung
Minor Salivary Gland
Pancreas
Pituitary gland
Prostate
Skeletal muscle
Skin
Spleen
Stomach
Testis
Thyroid gland
Cell type
Enrichment
Very high
High
Moderate
Cell type
Any
Adipocytes
Alveolar cells type 1
Alveolar cells type 2
Astrocytes
B-cells
Basal keratinocytes
Basal prostatic cells
Basal respiratory cells
Basal squamous epithelial cells
Bipolar cells
Breast glandular cells
Breast myoepithelial cells
Cardiomyocytes
Cholangiocytes
Ciliated cells
Club cells
Collecting duct cells
Cone photoreceptor cells
Cytotrophoblasts
Dendritic cells
Distal enterocytes
Distal tubular cells
Ductal cells
Early spermatids
Endometrial stromal cells
Endothelial cells
Enteroendocrine cells
Erythroid cells
Excitatory neurons
Exocrine glandular cells
Extravillous trophoblasts
Fibroblasts
Gastric mucus-secreting cells
Glandular and luminal cells
Granulocytes
Granulosa cells
Hepatocytes
Hofbauer cells
Horizontal cells
Inhibitory neurons
Intestinal goblet cells
Ionocytes
Kupffer cells
Langerhans cells
Late spermatids
Leydig cells
Lymphatic endothelial cells
Macrophages
Melanocytes
Mesothelial cells
Microglial cells
Monocytes
Mucus glandular cells
Muller glia cells
NK-cells
Oligodendrocyte precursor cells
Oligodendrocytes
Oocytes
Ovarian stromal cells
Pancreatic endocrine cells
Paneth cells
Peritubular cells
Plasma cells
Prostatic glandular cells
Proximal enterocytes
Proximal tubular cells
Rod photoreceptor cells
Salivary duct cells
Schwann cells
Secretory cells
Serous glandular cells
Sertoli cells
Skeletal myocytes
Smooth muscle cells
Spermatocytes
Spermatogonia
Squamous epithelial cells
Suprabasal keratinocytes
Syncytiotrophoblasts
T-cells
Undifferentiated cells
Category
Cell type enriched
Group enriched
Cell type enhanced
Low cell type specificity
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Tau score
0-0.1
0.1-0.2
0.2-0.3
0.3-0.4
0.4-0.5
0.5-0.6
0.6-0.7
0.7-0.8
0.8-0.9
0.9-1
Cell type
Any
Amygdala excitatory
Astrocyte
Bergmann glia
Central nervous system macrophage
Cerebellar inhibitory
CGE interneuron
Choroid plexus epithelial cell
Committed oligodendrocyte precursor
Deep-layer corticothalamic and 6b
Deep-layer intratelencephalic
Deep-layer near-projecting
Eccentric medium spiny neuron
Endothelial cell
Ependymal cell
Fibroblast
Hippocampal CA1-3
Hippocampal CA4
Hippocampal dentate gyrus
LAMP5-LHX6 and Chandelier
Leukocyte
Lower rhombic lip
Mammillary body
Medium spiny neuron
MGE interneuron
Midbrain-derived inhibitory
Miscellaneous
Oligodendrocyte
Oligodendrocyte precursor cell
Pericyte
Splatter
Thalamic excitatory
Upper rhombic lip
Upper-layer intratelencephalic
Vascular associated smooth muscle cell
Category
Cell type enriched
Group enriched
Cell type enhanced
Low cell type specificity
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Tau score
0-0.1
0.1-0.2
0.2-0.3
0.3-0.4
0.4-0.5
0.5-0.6
0.6-0.7
0.7-0.8
0.8-0.9
0.9-1
Cell type
Any
Basophil
Classical monocyte
Eosinophil
GdT-cell
Intermediate monocyte
MAIT T-cell
Memory B-cell
Memory CD4 T-cell
Memory CD8 T-cell
Myeloid DC
Naive B-cell
Naive CD4 T-cell
Naive CD8 T-cell
Neutrophil
NK-cell
Non-classical monocyte
Plasmacytoid DC
T-reg
Total PBMC
Category
Immune cell enriched
Group enriched
Immune cell enhanced
Low immune cell specificity
Not detected in immune cells
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Tau score
0-0.1
0.1-0.2
0.2-0.3
0.3-0.4
0.4-0.5
0.5-0.6
0.6-0.7
0.7-0.8
0.8-0.9
0.9-1
Cell lineage
Any
B-cells
Dendritic cells
Granulocytes
Monocytes
NK-cells
T-cells
Category
Lineage enriched
Group enriched
Lineage enhanced
Low lineage specificity
Not detected
Detected in all
Detected in many
Detected in single
Is highest expressed
Tau score
0-0.1
0.1-0.2
0.2-0.3
0.3-0.4
0.4-0.5
0.5-0.6
0.6-0.7
0.7-0.8
0.8-0.9
0.9-1
Cluster
17:B-cells - Immunoglobulins
23:B-cells - Immunoglobulins
34:B-cells - Unknown function
46:Basophils - Proteolysis
32:Basophils - Transcription
41:Basophils - Unknown function
2:Dendritic cells - Unknown function
36:Eosinophils - Protein ubiquitination
22:Eosinophils - Transcription
19:Eosinophils - Unknown function
45:Eosinophils - Unknown function
40:Monocytes - Innate immune response
26:Monocytes - Plasma membrane proteins
38:Monocytes & Neutrophils - Degranulation
37:Monocytes & Neutrophils - Innate immune response
4:Neutrophils - Degranulation
35:Neutrophils - Protein binding
21:Neutrophils - Unknown function
28:Neutrophils - Unknown function
15:NK-cells - Unknown function
33:Non-specific - ATP binding
5:Non-specific - Cell proliferation
16:Non-specific - Cell proliferation
20:Non-specific - DNA binding
30:Non-specific - DNA binding
7:Non-specific - Innate immune response
10:Non-specific - Membrane trafficking
13:Non-specific - Mitochondria
12:Non-specific - Mitochondrial translation
3:Non-specific - Nuclear processes
24:Non-specific - Transcription
43:Non-specific - Transcription & Translation
18:Non-specific - Translation
14:Non-specific - Unknown function
25:Non-specific - Unknown function
29:Non-specific - Unknown function
42:Non-specific - Vesicular transport
44:Plasmacytoid DCs - Plasma membrane proteins
8:Plasmacytoid DCs - Unknown function
6:T-cells - T-cell receptor
31:T-cells - T-cell receptor
39:T-cells - T-cell receptor
1:T-cells - Unknown function
11:T-cells - Unknown function
27:T-cells - Unknown function
9:T-regs - Cell cycle regulation
Cluster
41:Adipocytes & Endothelial cells - Mixed function
72:Alveolar cells - Lung function
47:Astrocytes - Unknown function
73:B-cells - B-cell function
3:Basal prostatic cells - Lipid metabolism
25:Bipolar cells - Visual perception
17:Breast glandular cells - Lactation
68:Cardiomyocytes - Muscle contraction
42:Ciliated cells - Cilium assembly
50:Connective tissue cells - ECM organization
24:Cytotrophoblasts - Mitochondria
28:Dendritic cells - Antigen presentation
21:Early spermatids - Spermatogenesis
18:Early spermatids - Unknown function
9:Endometrial stromal cells - Transcription
5:Enterocytes - Absorption
20:Enteroendocrine cells - Hormone signaling
1:Erythroid cells - Oxygen transport
4:Extravillous trophoblasts - Unknown function
53:Fibroblasts - ECM organization
46:Gastric mucus-secreting cells - Digestion
37:Glandular & Luminal cells - Unknown function
30:Granulocytes - Unknown function
43:Hepatocytes - Metabolism
62:Hepatocytes - Metabolism
71:Horizontal & Bipolar cells - Neuronal signaling
16:Intestinal goblet cells - Mucin production
14:Langerhans cells - Innate immune response
63:Late spermatids - Spermatogenesis
11:Late spermatids - Unknown function
36:Late spermatids - Unknown function
54:Lymphatic endothelial cells - Lymph vessel development
58:Macrophages - Innate immune response
29:Monocytes - Innate immune response
10:Muller glia cells - Visual perception
8:Neurons - Neuronal signaling
34:Neurons - Neuronal signaling
69:Neurons - Neuronal signaling
65:Neurons - Synaptic function
74:Neutrophils - Degranulation
19:NK-cells - Adaptive immune response
78:NK-cells & T-cells - Immune system & Transcription
39:Non-specific - Basic cellular processes
52:Non-specific - Cell proliferation
33:Non-specific - DNA binding
15:Non-specific - Mixed function
45:Non-specific - Mixed function
64:Non-specific - Ribosome
49:Non-specific - Transcription
55:Non-specific - Transcription
80:Non-specific - Transcription
76:Oligodendrocyte precursor - Unknown function
51:Oligodendrocytes - Unknown function
44:Oocytes - Unknown function
6:Ovarian stromal cells - Transcription
60:Pancreatic exocrine cells - Proteolysis
66:Photoreceptor cells - Visual perception
23:Plasma cells - Humoral immune response
61:Plasma cells - Immunoglobulins & histones
77:Plasma cells - Protein processing
57:Platelets - Hemostasis
40:Prostatic glandular cells - Transcription
22:Proximal enterocytes - Digestion
56:Proximal tubular cells - Amino acid metabolism
38:Proximal tubular cells - Transmembrane transport
35:Respiratory epithelial cells - Unknown function
26:Schwann cells & Melanocytes - Mixed function
75:Serous glandular cells - Salivary secretion
2:Skeletal myocytes - Muscle contraction
32:Smooth muscle cells - Muscle contraction
48:Smooth muscle cells - Signal transduction
13:Spermatids - Transcription
31:Spermatocytes - Spermatogenesis
70:Spermatocytes & Spermatids - Spermatid development
79:Spermatocytes & Spermatogonia - Spermatogenesis
67:Spermatogonia - Spermatogenesis
12:Squamous epithelial cells - Keratinization
59:Suprabasal keratinocytes - Cornification
27:Syncytiotrophoblasts - Pregnancy
7:T-cells - T-cell receptor
Location
Acrosome
Actin filaments
Aggresome
Annulus
Basal body
Calyx
Cell Junctions
Centriolar satellite
Centrosome
Cleavage furrow
Connecting piece
Cytokinetic bridge
Cytoplasmic bodies
Cytosol
End piece
Endoplasmic reticulum
Endosomes
Equatorial segment
Flagellar centriole
Focal adhesion sites
Golgi apparatus
Intermediate filaments
Kinetochore
Lipid droplets
Lysosomes
Microtubule ends
Microtubules
Mid piece
Midbody
Midbody ring
Mitochondria
Mitotic chromosome
Mitotic spindle
Nuclear bodies
Nuclear membrane
Nuclear speckles
Nucleoli
Nucleoli fibrillar center
Nucleoli rim
Nucleoplasm
Perinuclear theca
Peroxisomes
Plasma membrane
Primary cilium
Primary cilium tip
Primary cilium transition zone
Principal piece
Rods & Rings
Vesicles
Searches
Enhanced
Supported
Approved
Uncertain
Single cell variation
CCD protein mitotic structure
CCD protein interphase
Cell cycle dependent protein
Cell cycle independent protein
Cell cycle dependent transcript
Cell cycle independent transcript
Multilocalizing
Localizing 1
Localizing 2
Localizing 3
Localizing 4
Localizing 5
Localizing 6
Main location
Additional location
Location
Any
Acrosome
Actin filaments
Aggresome
Annulus
Basal body
Calyx
Cell Junctions
Centriolar satellite
Centrosome
Cleavage furrow
Connecting piece
Cytokinetic bridge
Cytoplasmic bodies
Cytosol
End piece
Endoplasmic reticulum
Endosomes
Equatorial segment
Flagellar centriole
Focal adhesion sites
Golgi apparatus
Intermediate filaments
Kinetochore
Lipid droplets
Lysosomes
Microtubule ends
Microtubules
Mid piece
Midbody
Midbody ring
Mitochondria
Mitotic chromosome
Mitotic spindle
Nuclear bodies
Nuclear membrane
Nuclear speckles
Nucleoli
Nucleoli fibrillar center
Nucleoli rim
Nucleoplasm
Perinuclear theca
Peroxisomes
Plasma membrane
Primary cilium
Primary cilium tip
Primary cilium transition zone
Principal piece
Rods & Rings
Vesicles
Cell line
Any
A-431
A-549
AF22
ASC52telo
BJ [Human fibroblast]
CACO-2
EFO-21
FHDF/TERT166
GAMG
HaCaT
HAP1
HBEC3-KT
HBF/TERT88
HDLM-2
HEK293
HEL
HeLa
Hep-G2
HTCEpi
HTEC/SVTERT24-B
HTERT-HME1
HTERT-RPE1
HTERT-RPE1 (serum starved)
HUVEC/TERT2
JURKAT
K-562
LHCN-M2
MCF-7
NB4
OE19
PC-3
PODO/SVTERT152
PODO/TERT256
REH
Rh30
RPTEC/TERT1
RT-4
SH-SY5Y
SiHa
SK-MEL-30
Sperm
SuSa
THP-1
U-251MG
U2OS
Class
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
Type
Protein
Rna
Phase
G1
S
G2
Reliability
Enhanced
Supported
Approved
Uncertain
Cancer
Bladder Urothelial Carcinoma
Breast Invasive Carcinoma
Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma
Colon Adenocarcinoma
Glioblastoma Multiforme
Head and Neck Squamous Cell Carcinoma
Kidney Chromophobe
Kidney Renal Clear Cell Carcinoma
Kidney Renal Papillary Cell Carcinoma
Liver Hepatocellular Carcinoma
Lung Adenocarcinoma
Lung Squamous Cell Carcinoma
Ovary Serous Cystadenocarcinoma
Pancreatic Adenocarcinoma
Prostate Adenocarcinoma
Rectum Adenocarcinoma
Skin Cuteneous Melanoma
Stomach Adenocarcinoma
Testicular Germ Cell Tumor
Thyroid Carcinoma
Uterine Corpus Endometrial Carcinoma
Prognosis
Favorable - potential prognostic
Favorable - validated prognostic
Unfavorable - potential prognostic
Unfavorable - validated prognostic
Cancer
Any
Bladder Urothelial Carcinoma
Breast Invasive Carcinoma
Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma
Colon Adenocarcinoma
Glioblastoma Multiforme
Head and Neck Squamous Cell Carcinoma
Kidney Chromophobe
Kidney Renal Clear Cell Carcinoma
Kidney Renal Papillary Cell Carcinoma
Liver Hepatocellular Carcinoma
Lung Adenocarcinoma
Lung Squamous Cell Carcinoma
Ovary Serous Cystadenocarcinoma
Pancreatic Adenocarcinoma
Prostate Adenocarcinoma
Rectum Adenocarcinoma
Skin Cuteneous Melanoma
Stomach Adenocarcinoma
Testicular Germ Cell Tumor
Thyroid Carcinoma
Uterine Corpus Endometrial Carcinoma
Category
Cancer enriched
Group enriched
Cancer enhanced
Low cancer specificity
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Cancer
Any
Adrenocortical cancer
Bile duct cancer
Bladder cancer
Bone cancer
Brain cancer
Breast cancer
Cervical cancer
Colorectal cancer
Esophageal cancer
Gallbladder cancer
Gastric cancer
Head and neck cancer
Kidney cancer
Leukemia
Liver cancer
Lung cancer
Lymphoma
Myeloma
Neuroblastoma
Non-cancerous
Ovarian cancer
Pancreatic cancer
Prostate cancer
Rhabdoid
Sarcoma
Skin cancer
Testis cancer
Thyroid cancer
Uncategorized
Uterine cancer
Category
Cancer enriched
Group enriched
Cancer enhanced
Low cancer specificity
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Tau score
0-0.1
0.1-0.2
0.2-0.3
0.3-0.4
0.4-0.5
0.5-0.6
0.6-0.7
0.7-0.8
0.8-0.9
0.9-1
Cluster
48:Adipocytes & Endothelial cells - Angiogenesis
61:BICR 18 - Protein kinases
12:Bone cancer - Neuronal signaling
27:Breast cancer - Unknown function
10:Ciliated cells - Ion channel activity
44:Connective tissue cells - ECM organization
64:Connective tissue cells - ECM organization
70:DU4475 - Unknown function
49:HMC-1 - Innate immune response
15:Kidney cancer - Membrane components
47:Leukemia - Hemostasis
6:Leukemia - Signal transduction
59:Leukemia - T-cell receptor
7:Liver cancer - Metabolism
18:Liver cancer - Metabolism
21:Lymphoma - Adaptive immune response
46:Lymphoma - Humoral immune response
55:Lymphoma - Immune response
71:Lymphoma - Inflammatory response
50:Lymphoma - Unknown function
2:Mucus-secreting cells - Unknown function
14:Myeloid leukemia - Innate immune response
20:Myeloma - Immune response
51:Myeloma - Immunoglobulins
17:Neuroblastoma - Neuronal signaling
11:Neuronal - Sensory perception
72:Neuronal - Signal transduction
1:Neuronal - Visual perception
31:Non-specific - Antiviral immune response
8:Non-specific - Basic cellular processes
43:Non-specific - Basic cellular processes
68:Non-specific - Cell cycle regulation
32:Non-specific - Cell proliferation
30:Non-specific - Gene expression regulation
52:Non-specific - Mitochondria
66:Non-specific - Mitochondria
26:Non-specific - Mitochondria & RNA binding
13:Non-specific - Mixed function
36:Non-specific - mRNA processing
37:Non-specific - mRNA processing
22:Non-specific - mRNA splicing & Cell cycle
28:Non-specific - Nuclear processes
45:Non-specific - Nuclear processes
58:Non-specific - Nuclear processes
41:Non-specific - Nucleosome assembly
62:Non-specific - Plasma proteins
63:Non-specific - Protein processing
25:Non-specific - Ribosome
56:Non-specific - Sensory perception
4:Non-specific - Transcription
23:Non-specific - Transcription
38:Non-specific - Transcription
39:Non-specific - Transcription
54:Non-specific - Transcription
19:Non-specific - Unknown function
24:Non-specific - Unknown function
29:Non-specific - Unknown function
40:Non-specific - Unknown function
42:Non-specific - Unknown function
65:Non-specific - Unknown function
67:Non-specific - Unknown function
60:Prostate cancer - Unknown function
3:Rhabdoid - Membrane components
5:Rhabdoid - Unknown function
35:RS4;11 - Unknown function
33:Sarcoma - Muscle contraction
69:Skin cancer - ECM organization
9:Skin cancer - Melanin biosynthesis
53:Squamous epithelial cells - Keratinization
57:Stomach & Colon cancer - Digestion
34:Testis cancer - Unknown function
16:Thyroid cancer - Neuronal signaling
Variants
Alphamissense population
Alphamissense clinical
Experimental Population
Experimental clinical
Interacting gene (ensg_id)
Type
Consensus
IntAct
BioGrid
OpenCell
BioPlex
Number of interactions
1
2
3
4
5
6-10
11-20
21-30
31-40
41-50
51-75
76-100
101-200
>200
Pathway
Acyl-CoA hydrolysis
Acylglycerides metabolism
Alanine; aspartate and glutamate metabolism
Amino sugar and nucleotide sugar metabolism
Aminoacyl-tRNA biosynthesis
Androgen metabolism
Arachidonic acid metabolism
Arginine and proline metabolism
Ascorbate and aldarate metabolism
Beta oxidation of branched-chain fatty acids (mitochondrial)
Beta oxidation of di-unsaturated fatty acids (n-6) (mitochondrial)
Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)
Beta oxidation of even-chain fatty acids (mitochondrial)
Beta oxidation of even-chain fatty acids (peroxisomal)
Beta oxidation of odd-chain fatty acids (mitochondrial)
Beta oxidation of phytanic acid (peroxisomal)
Beta oxidation of poly-unsaturated fatty acids (mitochondrial)
Beta oxidation of unsaturated fatty acids (n-7) (mitochondrial)
Beta oxidation of unsaturated fatty acids (n-7) (peroxisomal)
Beta oxidation of unsaturated fatty acids (n-9) (mitochondrial)
Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal)
Beta-alanine metabolism
Bile acid biosynthesis
Bile acid recycling
Biopterin metabolism
Biotin metabolism
Blood group biosynthesis
Butanoate metabolism
C5-branched dibasic acid metabolism
Carnitine shuttle (cytosolic)
Carnitine shuttle (endoplasmic reticular)
Carnitine shuttle (mitochondrial)
Carnitine shuttle (peroxisomal)
Cholesterol biosynthesis 1 (Bloch pathway)
Cholesterol biosynthesis 2
Cholesterol biosynthesis 3 (Kandustch-Russell pathway)
Cholesterol metabolism
Chondroitin / heparan sulfate biosynthesis
Chondroitin sulfate degradation
CoA synthesis
Cysteine and methionine metabolism
Drug metabolism
Eicosanoid metabolism
Estrogen metabolism
Ether lipid metabolism
Fatty acid activation (cytosolic)
Fatty acid activation (endoplasmic reticular)
Fatty acid biosynthesis
Fatty acid biosynthesis (even-chain)
Fatty acid biosynthesis (odd-chain)
Fatty acid biosynthesis (unsaturated)
Fatty acid desaturation (even-chain)
Fatty acid desaturation (odd-chain)
Fatty acid elongation (even-chain)
Fatty acid elongation (odd-chain)
Fatty acid oxidation
Folate metabolism
Formation and hydrolysis of cholesterol esters
Fructose and mannose metabolism
Galactose metabolism
Glucocorticoid biosynthesis
Glutathione metabolism
Glycerolipid metabolism
Glycerophospholipid metabolism
Glycine; serine and threonine metabolism
Glycolysis / Gluconeogenesis
Glycosphingolipid biosynthesis-ganglio series
Glycosphingolipid biosynthesis-globo series
Glycosphingolipid biosynthesis-lacto and neolacto series
Glycosphingolipid metabolism
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
Heme degradation
Heme synthesis
Heparan sulfate degradation
Histidine metabolism
Inositol phosphate metabolism
Isolated
Keratan sulfate biosynthesis
Keratan sulfate degradation
Leukotriene metabolism
Linoleate metabolism
Lipoic acid metabolism
Lysine metabolism
Metabolism of other amino acids
Miscellaneous
N-glycan metabolism
Nicotinate and nicotinamide metabolism
Nucleotide metabolism
O-glycan metabolism
Omega-3 fatty acid metabolism
Omega-6 fatty acid metabolism
Oxidative phosphorylation
Pantothenate and CoA biosynthesis
Pentose and glucuronate interconversions
Pentose phosphate pathway
Phenylalanine metabolism
Phenylalanine; tyrosine and tryptophan biosynthesis
Phosphatidylinositol phosphate metabolism
Pool reactions
Porphyrin metabolism
Propanoate metabolism
Prostaglandin biosynthesis
Protein assembly
Protein degradation
Protein modification
Purine metabolism
Pyrimidine metabolism
Pyruvate metabolism
Retinol metabolism
Riboflavin metabolism
ROS detoxification
Serotonin and melatonin biosynthesis
Sphingolipid metabolism
Starch and sucrose metabolism
Steroid metabolism
Sulfur metabolism
Terpenoid backbone biosynthesis
Thiamine metabolism
Transport reactions
Tricarboxylic acid cycle and glyoxylate/dicarboxylate metabolism
Tryptophan metabolism
Tyrosine metabolism
Ubiquinone synthesis
Urea cycle
Valine; leucine; and isoleucine metabolism
Vitamin A metabolism
Vitamin B12 metabolism
Vitamin B2 metabolism
Vitamin B6 metabolism
Vitamin C metabolism
Vitamin D metabolism
Vitamin E metabolism
Xenobiotics metabolism
Category
Evidence at protein level
Evidence at transcript level
No human protein/transcript evidence
Score
Evidence at protein level
Evidence at transcript level
No human protein/transcript evidence
Score
Evidence at protein level
Evidence at transcript level
No human protein/transcript evidence
Score
Evidence at protein level
Evidence at transcript level
No human protein/transcript evidence
Validation
Supported
Approved
Uncertain
Validation
Enhanced - Capture
Enhanced - Genetic
Enhanced - Independent
Enhanced - Orthogonal
Enhanced - Recombinant
Supported
Approved
Uncertain
Validation
Enhanced - Independent
Enhanced - Orthogonal
Supported
Approved
Uncertain
Validation
Enhanced - Genetic
Enhanced - Independent
Enhanced - Recombinant
Supported
Approved
Uncertain
Antibodies
Yes
No
Data type
Tissue - Immunohistochemistry
Tissue - GTEx transcriptomics
Tissue - FANTOM transcriptomics
Tissue - Expression clustering
Brain
Brain - Expression clustering
Single cell - Expression clustering
Subcellular
Cancer - Immunohistochemistry
Cancer - Mass spectrometry
Blood - conc. immunoassay
Blood - conc. mass spectrometry
Blood - Detected pea
Blood - Expression clustering
Disease - PEA
Disease - Mass spectrometry
Cell line - Mass spectrometry
Cell line - Expression clustering
Structure
Interaction
Metabolic
Column
Gene
Position
Tissue specific score
Prognostic
Reliability (IF)
Reliability (IH)
Add
Cancel
Immune cell
Expression cluster
Immune cell expression cluster
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Metabolic proteins
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Localized to mitochondria
,
Genes tissue enriched in brain (RNA)
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Field
All
Gene name
Protein class
Uniprot keyword
Chromosome
External id
Tissue expression (IHC)
Multiplex tissue (IHC)
Patient ID (IHC)
Secretome annotation
Tissue category (RNA)
Tissue Tau score (RNA)
Tissue expression cluster (RNA)
Reliability score tissue (IHC)
Brain region category (RNA)
Brain Tau score (RNA)
Mouse brain category (RNA)
Mouse brain Tau score (RNA)
Pig brain category (RNA)
Pig brain Tau score (RNA)
Brain expression cluster (RNA)
Reliability score mouse brain
Cell type enrichment (RNA)
Cell type category (scRNA)
Cell type Tau score (RNA)
Brain region cell type (scRNA)
Brain region Tau score (scRNA)
Immune cell category (RNA)
Immune cell Tau score (RNA)
Immune cell lineage category (RNA)
Immune cell lineage Tau score (RNA)
Immune cell expression cluster (RNA)
Single cell type expression cluster (RNA)
Subcellular location (ICC)
Subcellular location - cell line (ICC)
Predicted location
Subcellular Cell Cycle Peak Phase
Reliability score cells (ICC)
Prognostic cancer
Cancer category (RNA)
Cell line category (RNA)
Celline Tau score (RNA)
Cell line expression cluster (RNA)
Protein sequence variants
Protein interaction
Protein interaction count
Metabolic pathway
Evidence summary
UniProt evidence
NeXtProt evidence
HPA evidence
Protein array (PA)
Western blot (WB)
Immunohistochemistry (IHC)
Immunocytochemistry (ICC)
With antibodies
Has data
Sort by
Term
Gene name
Class
Blood group antigen proteins
Cancer-related genes
Candidate cardiovascular disease genes
CD markers
Citric acid cycle related proteins
Disease related genes
Enzymes
FDA approved drug targets
G-protein coupled receptors
Human disease related genes
Immunoglobulin genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Nuclear receptors
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
RAS pathway related proteins
Ribosomal proteins
RNA polymerase related proteins
T-cell receptor genes
Transcription factors
Transporters
Voltage-gated ion channels
Subclass
Class
Biological process
Molecular function
Disease
Keyword
Chromosome
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
MT
Unmapped
X
Y
External id
Tissue
Any
Adipose tissue
Adrenal gland
Appendix
Bone marrow
Breast
Bronchus
Cartilage
Caudate
Cerebellum
Cerebral cortex
Cervix
Choroid plexus
Colon
Dorsal raphe
Duodenum
Endometrium
Epididymis
Esophagus
Eye
Fallopian tube
Gallbladder
Hair
Heart muscle
Hippocampus
Hypothalamus
Kidney
Lactating breast
Liver
Lung
Lymph node
Nasopharynx
Oral mucosa
Ovary
Pancreas
Parathyroid gland
Pituitary gland
Placenta
Prostate
Rectum
Retina
Salivary gland
Seminal vesicle
Skeletal muscle
Skin
Small intestine
Smooth muscle
Soft tissue
Sole of foot
Spleen
Stomach
Substantia nigra
Testis
Thymus
Thyroid gland
Tonsil
Urinary bladder
Vagina
Cell type
Expression
Antibody panel
Any
Ciliated cells
Kidney
Salivary gland
Sertoli cells
Spermatids
Spermatocytes
Spermatogonia
Tissue
Main location
Patient ID
Annotation
Immunoglobulin genes
Intracellular and membrane
Secreted - unknown location
Secreted in brain
Secreted in female reproductive system
Secreted in male reproductive system
Secreted in other tissues
Secreted to blood
Secreted to digestive system
Secreted to extracellular matrix
Tissue
Any
Adipose tissue
Adrenal gland
Bone marrow
Brain
Breast
Cervix
Choroid plexus
Endometrium
Epididymis
Esophagus
Fallopian tube
Gallbladder
Heart muscle
Intestine
Kidney
Liver
Lung
Lymphoid tissue
Ovary
Pancreas
Parathyroid gland
Pituitary gland
Placenta
Prostate
Retina
Salivary gland
Seminal vesicle
Skeletal muscle
Skin
Smooth muscle
Stomach
Testis
Thyroid gland
Tongue
Urinary bladder
Vagina
Category
Tissue enriched
Group enriched
Tissue enhanced
Low tissue specificity
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Tau score
0-0.1
0.1-0.2
0.2-0.3
0.3-0.4
0.4-0.5
0.5-0.6
0.6-0.7
0.7-0.8
0.8-0.9
0.9-1
Cluster
7:Adipose tissue - Mixed function
26:Adrenal gland - Steroid metabolism
77:Bone marrow - Cell proliferation
6:Bone marrow - Innate immune response
33:Brain - Neuronal signaling
61:Brain - Neuronal signaling
22:Brain - Synaptic signal transduction
5:Brain & Testis - Signal transduction
73:Breast - Lactation
65:Cerebellum - Nervous system development
60:Choroid plexus - Transmembrane transport
8:Ciliated cells - Cilium organization
62:Connective tissue - ECM organization
32:Endocrine & Neural - Unknown function
50:Epididymis - Male reproductive secretion
75:Epithelium - Extracellular exosomes
59:Fallopian tube - Tissue development
12:Heart muscle - Cardiac muscle contraction
30:Heart muscle - Heart development
45:Intestine - Digestion
52:Kidney - Transmembrane transport
55:Kidney & Intestine - Metabolism
83:Liver - Metabolism
69:Liver - Oxidoreductase activity
11:Liver - Plasma proteins
31:Liver - Plasma proteins
37:Liver & Intestine - Lipid metabolism
1:Liver & Kidney - Metabolism
57:Lung - Lung function
36:Lymphoid tissue - Cytokine signaling
70:Lymphoid tissue - Immune response
67:Lymphoid tissue & Bone marrow - Cell proliferation
81:Lymphoid tissue & Bone marrow - Innate immune response
17:Neuronal - Synaptic function
28:Neuronal - Transcription
64:Neuronal - Transcription
19:Non-specific - Basic cellular processes
54:Non-specific - Basic cellular processes
23:Non-specific - Cellular respiration
80:Non-specific - Endocytosis
53:Non-specific - Glycosylation
35:Non-specific - Mitochondria
43:Non-specific - Mitochondrial translation
34:Non-specific - Mixed function
68:Non-specific - Protein processing
18:Non-specific - Ribosome
16:Non-specific - Transcription
40:Non-specific - Transcription
66:Non-specific - Transcription
79:Non-specific - Transcription
3:Non-specific - Unknown function
56:Non-specific - Unknown function
9:Oligodendrocytes - Myelination
15:Pancreas - Proteolysis
24:Parathyroid gland - Vesicular transport
49:Pituitary gland - Hormone signaling
58:Placenta - Pregnancy
76:Retina - Visual perception
39:Retina & Testis - Cilium
38:Salivary gland - Salivary secretion
14:Skeletal muscle - Muscle contraction
2:Skeletal muscle - Striated muscle contraction
13:Skin - Cornification
82:Skin - Keratinization
25:Small intestine - Absorption
41:Smooth muscle tissue - ECM organization
74:Spermatids - Flagellum assembly
47:Spleen - Immune response
29:Squamous epithelium - Innate immune response
27:Squamous epithelium - Keratinization
48:Stomach - Proteolysis
4:Testis - Basic cellular processes
10:Testis - Spermatid development
63:Testis - Spermatid development
20:Testis - Spermatogenesis
42:Testis - Spermatogenesis
44:Testis - Spermatogenesis
46:Testis - Spermatogenesis
78:Testis - Transcription
21:Testis - Unknown function
72:Testis & Skeletal muscle - Protein ubiquitination
71:Thymus - Adaptive immune response
51:Thyroid gland - Unknown function
Reliability
Enhanced
Supported
Approved
Uncertain
Brain region
Any
Amygdala
Basal ganglia
Cerebellum
Cerebral cortex
Choroid plexus
Hippocampal formation
Hypothalamus
Medulla oblongata
Midbrain
Pons
Spinal cord
Thalamus
White matter
Category
Region enriched
Group enriched
Region enhanced
Low region specificity
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Tau score
0-0.1
0.1-0.2
0.2-0.3
0.3-0.4
0.4-0.5
0.5-0.6
0.6-0.7
0.7-0.8
0.8-0.9
0.9-1
Brain region
Any
Amygdala
Basal ganglia
Cerebellum
Cerebral cortex
Hippocampal formation
Hypothalamus
Midbrain
Olfactory bulb
Pons and medulla
Thalamus
White matter
Category
Region enriched
Group enriched
Region enhanced
Low region specificity
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Tau score
0-0.1
0.1-0.2
0.2-0.3
0.3-0.4
0.4-0.5
0.5-0.6
0.6-0.7
0.7-0.8
0.8-0.9
0.9-1
Brain region
Any
Amygdala
Basal ganglia
Cerebellum
Cerebral cortex
Hippocampal formation
Hypothalamus
Medulla oblongata
Midbrain
Olfactory bulb
Pons
Spinal cord
Thalamus
White matter
Category
Region enriched
Group enriched
Region enhanced
Low region specificity
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Tau score
0-0.1
0.1-0.2
0.2-0.3
0.3-0.4
0.4-0.5
0.5-0.6
0.6-0.7
0.7-0.8
0.8-0.9
0.9-1
Cluster
40:Astrocytes - Astrocyte-neuron interactions
19:Astrocytes - Mixed function
39:Astrocytes - Mixed function
46:Brainstem - Mixed function
10:Cerebellum - Nucleic acid binding
32:Cerebral cortex - Mixed function
3:Choroid plexus - Cilium
17:Choroid plexus - Cilium
42:Choroid plexus - Mitochondria
23:Choroid plexus - Mixed function
36:Choroid plexus - Mixed function
47:Endothelial cells - Vasculature
29:Forebrain - Mixed function
43:Hindbrain - Mixed function
49:Hindbrain - Mixed function
56:Hypothalamus - Neuropeptide signaling
8:Immune cells - Immune response
54:Immune cells - T cell receptor
20:Macrophages & Microglia - Immune response
41:Monoamines - Neurotransmitter signalling
1:Neurons - Mixed function
24:Neurons - Mixed function
33:Neurons - Mixed function
37:Neurons - Mixed function
51:Neurons - Mixed function
53:Neurons - Mixed function
2:Neurons - Nucleosome
14:Neurons - Synaptic function
52:Neurons & Synapses - Synaptic function
35:Non-specific - DNA binding
6:Non-specific - Immune response
21:Non-specific - Metabolism
5:Non-specific - Mixed function
18:Non-specific - Mixed function
22:Non-specific - Mixed function
27:Non-specific - Mixed function
34:Non-specific - Mixed function
44:Non-specific - Mixed function
45:Non-specific - Mixed function
48:Non-specific - Mixed function
4:Non-specific - mRNA splicing & Cell cycle
50:Non-specific - Nucleic acid binding
9:Non-specific - Receptor signaling
7:Non-specific - Ribosome
15:Non-specific - Transcription
16:Non-specific - Transcription
25:Non-specific - Transcription
31:Non-specific - Transcription
55:Non-specific - Transcription
12:Non-specific - Vasculature
13:Oligodendrocytes - Mixed function
26:Oligodendrocytes - Mixed function
28:Oligodendrocytes - Mixed function
38:Sub-cortical - Mixed function
30:White matter - Myelination
11:White matter - Signal transduction
Reliability
Supported
Approved
Tissue
Adipose subcutaneous
Adipose visceral
Adrenal gland
Breast
Colon
Heart muscle
Kidney
Liver
Lung
Minor Salivary Gland
Pancreas
Pituitary gland
Prostate
Skeletal muscle
Skin
Spleen
Stomach
Testis
Thyroid gland
Cell type
Enrichment
Very high
High
Moderate
Cell type
Any
Adipocytes
Alveolar cells type 1
Alveolar cells type 2
Astrocytes
B-cells
Basal keratinocytes
Basal prostatic cells
Basal respiratory cells
Basal squamous epithelial cells
Bipolar cells
Breast glandular cells
Breast myoepithelial cells
Cardiomyocytes
Cholangiocytes
Ciliated cells
Club cells
Collecting duct cells
Cone photoreceptor cells
Cytotrophoblasts
Dendritic cells
Distal enterocytes
Distal tubular cells
Ductal cells
Early spermatids
Endometrial stromal cells
Endothelial cells
Enteroendocrine cells
Erythroid cells
Excitatory neurons
Exocrine glandular cells
Extravillous trophoblasts
Fibroblasts
Gastric mucus-secreting cells
Glandular and luminal cells
Granulocytes
Granulosa cells
Hepatocytes
Hofbauer cells
Horizontal cells
Inhibitory neurons
Intestinal goblet cells
Ionocytes
Kupffer cells
Langerhans cells
Late spermatids
Leydig cells
Lymphatic endothelial cells
Macrophages
Melanocytes
Mesothelial cells
Microglial cells
Monocytes
Mucus glandular cells
Muller glia cells
NK-cells
Oligodendrocyte precursor cells
Oligodendrocytes
Oocytes
Ovarian stromal cells
Pancreatic endocrine cells
Paneth cells
Peritubular cells
Plasma cells
Prostatic glandular cells
Proximal enterocytes
Proximal tubular cells
Rod photoreceptor cells
Salivary duct cells
Schwann cells
Secretory cells
Serous glandular cells
Sertoli cells
Skeletal myocytes
Smooth muscle cells
Spermatocytes
Spermatogonia
Squamous epithelial cells
Suprabasal keratinocytes
Syncytiotrophoblasts
T-cells
Undifferentiated cells
Category
Cell type enriched
Group enriched
Cell type enhanced
Low cell type specificity
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Tau score
0-0.1
0.1-0.2
0.2-0.3
0.3-0.4
0.4-0.5
0.5-0.6
0.6-0.7
0.7-0.8
0.8-0.9
0.9-1
Cell type
Any
Amygdala excitatory
Astrocyte
Bergmann glia
Central nervous system macrophage
Cerebellar inhibitory
CGE interneuron
Choroid plexus epithelial cell
Committed oligodendrocyte precursor
Deep-layer corticothalamic and 6b
Deep-layer intratelencephalic
Deep-layer near-projecting
Eccentric medium spiny neuron
Endothelial cell
Ependymal cell
Fibroblast
Hippocampal CA1-3
Hippocampal CA4
Hippocampal dentate gyrus
LAMP5-LHX6 and Chandelier
Leukocyte
Lower rhombic lip
Mammillary body
Medium spiny neuron
MGE interneuron
Midbrain-derived inhibitory
Miscellaneous
Oligodendrocyte
Oligodendrocyte precursor cell
Pericyte
Splatter
Thalamic excitatory
Upper rhombic lip
Upper-layer intratelencephalic
Vascular associated smooth muscle cell
Category
Cell type enriched
Group enriched
Cell type enhanced
Low cell type specificity
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Tau score
0-0.1
0.1-0.2
0.2-0.3
0.3-0.4
0.4-0.5
0.5-0.6
0.6-0.7
0.7-0.8
0.8-0.9
0.9-1
Cell type
Any
Basophil
Classical monocyte
Eosinophil
GdT-cell
Intermediate monocyte
MAIT T-cell
Memory B-cell
Memory CD4 T-cell
Memory CD8 T-cell
Myeloid DC
Naive B-cell
Naive CD4 T-cell
Naive CD8 T-cell
Neutrophil
NK-cell
Non-classical monocyte
Plasmacytoid DC
T-reg
Total PBMC
Category
Immune cell enriched
Group enriched
Immune cell enhanced
Low immune cell specificity
Not detected in immune cells
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Tau score
0-0.1
0.1-0.2
0.2-0.3
0.3-0.4
0.4-0.5
0.5-0.6
0.6-0.7
0.7-0.8
0.8-0.9
0.9-1
Cell lineage
Any
B-cells
Dendritic cells
Granulocytes
Monocytes
NK-cells
T-cells
Category
Lineage enriched
Group enriched
Lineage enhanced
Low lineage specificity
Not detected
Detected in all
Detected in many
Detected in single
Is highest expressed
Tau score
0-0.1
0.1-0.2
0.2-0.3
0.3-0.4
0.4-0.5
0.5-0.6
0.6-0.7
0.7-0.8
0.8-0.9
0.9-1
Cluster
17:B-cells - Immunoglobulins
23:B-cells - Immunoglobulins
34:B-cells - Unknown function
46:Basophils - Proteolysis
32:Basophils - Transcription
41:Basophils - Unknown function
2:Dendritic cells - Unknown function
36:Eosinophils - Protein ubiquitination
22:Eosinophils - Transcription
19:Eosinophils - Unknown function
45:Eosinophils - Unknown function
40:Monocytes - Innate immune response
26:Monocytes - Plasma membrane proteins
38:Monocytes & Neutrophils - Degranulation
37:Monocytes & Neutrophils - Innate immune response
4:Neutrophils - Degranulation
35:Neutrophils - Protein binding
21:Neutrophils - Unknown function
28:Neutrophils - Unknown function
15:NK-cells - Unknown function
33:Non-specific - ATP binding
5:Non-specific - Cell proliferation
16:Non-specific - Cell proliferation
20:Non-specific - DNA binding
30:Non-specific - DNA binding
7:Non-specific - Innate immune response
10:Non-specific - Membrane trafficking
13:Non-specific - Mitochondria
12:Non-specific - Mitochondrial translation
3:Non-specific - Nuclear processes
24:Non-specific - Transcription
43:Non-specific - Transcription & Translation
18:Non-specific - Translation
14:Non-specific - Unknown function
25:Non-specific - Unknown function
29:Non-specific - Unknown function
42:Non-specific - Vesicular transport
44:Plasmacytoid DCs - Plasma membrane proteins
8:Plasmacytoid DCs - Unknown function
6:T-cells - T-cell receptor
31:T-cells - T-cell receptor
39:T-cells - T-cell receptor
1:T-cells - Unknown function
11:T-cells - Unknown function
27:T-cells - Unknown function
9:T-regs - Cell cycle regulation
Cluster
41:Adipocytes & Endothelial cells - Mixed function
72:Alveolar cells - Lung function
47:Astrocytes - Unknown function
73:B-cells - B-cell function
3:Basal prostatic cells - Lipid metabolism
25:Bipolar cells - Visual perception
17:Breast glandular cells - Lactation
68:Cardiomyocytes - Muscle contraction
42:Ciliated cells - Cilium assembly
50:Connective tissue cells - ECM organization
24:Cytotrophoblasts - Mitochondria
28:Dendritic cells - Antigen presentation
21:Early spermatids - Spermatogenesis
18:Early spermatids - Unknown function
9:Endometrial stromal cells - Transcription
5:Enterocytes - Absorption
20:Enteroendocrine cells - Hormone signaling
1:Erythroid cells - Oxygen transport
4:Extravillous trophoblasts - Unknown function
53:Fibroblasts - ECM organization
46:Gastric mucus-secreting cells - Digestion
37:Glandular & Luminal cells - Unknown function
30:Granulocytes - Unknown function
43:Hepatocytes - Metabolism
62:Hepatocytes - Metabolism
71:Horizontal & Bipolar cells - Neuronal signaling
16:Intestinal goblet cells - Mucin production
14:Langerhans cells - Innate immune response
63:Late spermatids - Spermatogenesis
11:Late spermatids - Unknown function
36:Late spermatids - Unknown function
54:Lymphatic endothelial cells - Lymph vessel development
58:Macrophages - Innate immune response
29:Monocytes - Innate immune response
10:Muller glia cells - Visual perception
8:Neurons - Neuronal signaling
34:Neurons - Neuronal signaling
69:Neurons - Neuronal signaling
65:Neurons - Synaptic function
74:Neutrophils - Degranulation
19:NK-cells - Adaptive immune response
78:NK-cells & T-cells - Immune system & Transcription
39:Non-specific - Basic cellular processes
52:Non-specific - Cell proliferation
33:Non-specific - DNA binding
15:Non-specific - Mixed function
45:Non-specific - Mixed function
64:Non-specific - Ribosome
49:Non-specific - Transcription
55:Non-specific - Transcription
80:Non-specific - Transcription
76:Oligodendrocyte precursor - Unknown function
51:Oligodendrocytes - Unknown function
44:Oocytes - Unknown function
6:Ovarian stromal cells - Transcription
60:Pancreatic exocrine cells - Proteolysis
66:Photoreceptor cells - Visual perception
23:Plasma cells - Humoral immune response
61:Plasma cells - Immunoglobulins & histones
77:Plasma cells - Protein processing
57:Platelets - Hemostasis
40:Prostatic glandular cells - Transcription
22:Proximal enterocytes - Digestion
56:Proximal tubular cells - Amino acid metabolism
38:Proximal tubular cells - Transmembrane transport
35:Respiratory epithelial cells - Unknown function
26:Schwann cells & Melanocytes - Mixed function
75:Serous glandular cells - Salivary secretion
2:Skeletal myocytes - Muscle contraction
32:Smooth muscle cells - Muscle contraction
48:Smooth muscle cells - Signal transduction
13:Spermatids - Transcription
31:Spermatocytes - Spermatogenesis
70:Spermatocytes & Spermatids - Spermatid development
79:Spermatocytes & Spermatogonia - Spermatogenesis
67:Spermatogonia - Spermatogenesis
12:Squamous epithelial cells - Keratinization
59:Suprabasal keratinocytes - Cornification
27:Syncytiotrophoblasts - Pregnancy
7:T-cells - T-cell receptor
Location
Acrosome
Actin filaments
Aggresome
Annulus
Basal body
Calyx
Cell Junctions
Centriolar satellite
Centrosome
Cleavage furrow
Connecting piece
Cytokinetic bridge
Cytoplasmic bodies
Cytosol
End piece
Endoplasmic reticulum
Endosomes
Equatorial segment
Flagellar centriole
Focal adhesion sites
Golgi apparatus
Intermediate filaments
Kinetochore
Lipid droplets
Lysosomes
Microtubule ends
Microtubules
Mid piece
Midbody
Midbody ring
Mitochondria
Mitotic chromosome
Mitotic spindle
Nuclear bodies
Nuclear membrane
Nuclear speckles
Nucleoli
Nucleoli fibrillar center
Nucleoli rim
Nucleoplasm
Perinuclear theca
Peroxisomes
Plasma membrane
Primary cilium
Primary cilium tip
Primary cilium transition zone
Principal piece
Rods & Rings
Vesicles
Searches
Enhanced
Supported
Approved
Uncertain
Single cell variation
CCD protein mitotic structure
CCD protein interphase
Cell cycle dependent protein
Cell cycle independent protein
Cell cycle dependent transcript
Cell cycle independent transcript
Multilocalizing
Localizing 1
Localizing 2
Localizing 3
Localizing 4
Localizing 5
Localizing 6
Main location
Additional location
Location
Any
Acrosome
Actin filaments
Aggresome
Annulus
Basal body
Calyx
Cell Junctions
Centriolar satellite
Centrosome
Cleavage furrow
Connecting piece
Cytokinetic bridge
Cytoplasmic bodies
Cytosol
End piece
Endoplasmic reticulum
Endosomes
Equatorial segment
Flagellar centriole
Focal adhesion sites
Golgi apparatus
Intermediate filaments
Kinetochore
Lipid droplets
Lysosomes
Microtubule ends
Microtubules
Mid piece
Midbody
Midbody ring
Mitochondria
Mitotic chromosome
Mitotic spindle
Nuclear bodies
Nuclear membrane
Nuclear speckles
Nucleoli
Nucleoli fibrillar center
Nucleoli rim
Nucleoplasm
Perinuclear theca
Peroxisomes
Plasma membrane
Primary cilium
Primary cilium tip
Primary cilium transition zone
Principal piece
Rods & Rings
Vesicles
Cell line
Any
A-431
A-549
AF22
ASC52telo
BJ [Human fibroblast]
CACO-2
EFO-21
FHDF/TERT166
GAMG
HaCaT
HAP1
HBEC3-KT
HBF/TERT88
HDLM-2
HEK293
HEL
HeLa
Hep-G2
HTCEpi
HTEC/SVTERT24-B
HTERT-HME1
HTERT-RPE1
HTERT-RPE1 (serum starved)
HUVEC/TERT2
JURKAT
K-562
LHCN-M2
MCF-7
NB4
OE19
PC-3
PODO/SVTERT152
PODO/TERT256
REH
Rh30
RPTEC/TERT1
RT-4
SH-SY5Y
SiHa
SK-MEL-30
Sperm
SuSa
THP-1
U-251MG
U2OS
Class
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
Type
Protein
Rna
Phase
G1
S
G2
Reliability
Enhanced
Supported
Approved
Uncertain
Cancer
Bladder Urothelial Carcinoma
Breast Invasive Carcinoma
Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma
Colon Adenocarcinoma
Glioblastoma Multiforme
Head and Neck Squamous Cell Carcinoma
Kidney Chromophobe
Kidney Renal Clear Cell Carcinoma
Kidney Renal Papillary Cell Carcinoma
Liver Hepatocellular Carcinoma
Lung Adenocarcinoma
Lung Squamous Cell Carcinoma
Ovary Serous Cystadenocarcinoma
Pancreatic Adenocarcinoma
Prostate Adenocarcinoma
Rectum Adenocarcinoma
Skin Cuteneous Melanoma
Stomach Adenocarcinoma
Testicular Germ Cell Tumor
Thyroid Carcinoma
Uterine Corpus Endometrial Carcinoma
Prognosis
Favorable - potential prognostic
Favorable - validated prognostic
Unfavorable - potential prognostic
Unfavorable - validated prognostic
Cancer
Any
Bladder Urothelial Carcinoma
Breast Invasive Carcinoma
Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma
Colon Adenocarcinoma
Glioblastoma Multiforme
Head and Neck Squamous Cell Carcinoma
Kidney Chromophobe
Kidney Renal Clear Cell Carcinoma
Kidney Renal Papillary Cell Carcinoma
Liver Hepatocellular Carcinoma
Lung Adenocarcinoma
Lung Squamous Cell Carcinoma
Ovary Serous Cystadenocarcinoma
Pancreatic Adenocarcinoma
Prostate Adenocarcinoma
Rectum Adenocarcinoma
Skin Cuteneous Melanoma
Stomach Adenocarcinoma
Testicular Germ Cell Tumor
Thyroid Carcinoma
Uterine Corpus Endometrial Carcinoma
Category
Cancer enriched
Group enriched
Cancer enhanced
Low cancer specificity
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Cancer
Any
Adrenocortical cancer
Bile duct cancer
Bladder cancer
Bone cancer
Brain cancer
Breast cancer
Cervical cancer
Colorectal cancer
Esophageal cancer
Gallbladder cancer
Gastric cancer
Head and neck cancer
Kidney cancer
Leukemia
Liver cancer
Lung cancer
Lymphoma
Myeloma
Neuroblastoma
Non-cancerous
Ovarian cancer
Pancreatic cancer
Prostate cancer
Rhabdoid
Sarcoma
Skin cancer
Testis cancer
Thyroid cancer
Uncategorized
Uterine cancer
Category
Cancer enriched
Group enriched
Cancer enhanced
Low cancer specificity
Not detected
Detected in all
Detected in many
Detected in some
Detected in single
Is highest expressed
Tau score
0-0.1
0.1-0.2
0.2-0.3
0.3-0.4
0.4-0.5
0.5-0.6
0.6-0.7
0.7-0.8
0.8-0.9
0.9-1
Cluster
48:Adipocytes & Endothelial cells - Angiogenesis
61:BICR 18 - Protein kinases
12:Bone cancer - Neuronal signaling
27:Breast cancer - Unknown function
10:Ciliated cells - Ion channel activity
44:Connective tissue cells - ECM organization
64:Connective tissue cells - ECM organization
70:DU4475 - Unknown function
49:HMC-1 - Innate immune response
15:Kidney cancer - Membrane components
47:Leukemia - Hemostasis
6:Leukemia - Signal transduction
59:Leukemia - T-cell receptor
7:Liver cancer - Metabolism
18:Liver cancer - Metabolism
21:Lymphoma - Adaptive immune response
46:Lymphoma - Humoral immune response
55:Lymphoma - Immune response
71:Lymphoma - Inflammatory response
50:Lymphoma - Unknown function
2:Mucus-secreting cells - Unknown function
14:Myeloid leukemia - Innate immune response
20:Myeloma - Immune response
51:Myeloma - Immunoglobulins
17:Neuroblastoma - Neuronal signaling
11:Neuronal - Sensory perception
72:Neuronal - Signal transduction
1:Neuronal - Visual perception
31:Non-specific - Antiviral immune response
8:Non-specific - Basic cellular processes
43:Non-specific - Basic cellular processes
68:Non-specific - Cell cycle regulation
32:Non-specific - Cell proliferation
30:Non-specific - Gene expression regulation
52:Non-specific - Mitochondria
66:Non-specific - Mitochondria
26:Non-specific - Mitochondria & RNA binding
13:Non-specific - Mixed function
36:Non-specific - mRNA processing
37:Non-specific - mRNA processing
22:Non-specific - mRNA splicing & Cell cycle
28:Non-specific - Nuclear processes
45:Non-specific - Nuclear processes
58:Non-specific - Nuclear processes
41:Non-specific - Nucleosome assembly
62:Non-specific - Plasma proteins
63:Non-specific - Protein processing
25:Non-specific - Ribosome
56:Non-specific - Sensory perception
4:Non-specific - Transcription
23:Non-specific - Transcription
38:Non-specific - Transcription
39:Non-specific - Transcription
54:Non-specific - Transcription
19:Non-specific - Unknown function
24:Non-specific - Unknown function
29:Non-specific - Unknown function
40:Non-specific - Unknown function
42:Non-specific - Unknown function
65:Non-specific - Unknown function
67:Non-specific - Unknown function
60:Prostate cancer - Unknown function
3:Rhabdoid - Membrane components
5:Rhabdoid - Unknown function
35:RS4;11 - Unknown function
33:Sarcoma - Muscle contraction
69:Skin cancer - ECM organization
9:Skin cancer - Melanin biosynthesis
53:Squamous epithelial cells - Keratinization
57:Stomach & Colon cancer - Digestion
34:Testis cancer - Unknown function
16:Thyroid cancer - Neuronal signaling
Variants
Alphamissense population
Alphamissense clinical
Experimental Population
Experimental clinical
Interacting gene (ensg_id)
Type
Consensus
IntAct
BioGrid
OpenCell
BioPlex
Number of interactions
1
2
3
4
5
6-10
11-20
21-30
31-40
41-50
51-75
76-100
101-200
>200
Pathway
Acyl-CoA hydrolysis
Acylglycerides metabolism
Alanine; aspartate and glutamate metabolism
Amino sugar and nucleotide sugar metabolism
Aminoacyl-tRNA biosynthesis
Androgen metabolism
Arachidonic acid metabolism
Arginine and proline metabolism
Ascorbate and aldarate metabolism
Beta oxidation of branched-chain fatty acids (mitochondrial)
Beta oxidation of di-unsaturated fatty acids (n-6) (mitochondrial)
Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)
Beta oxidation of even-chain fatty acids (mitochondrial)
Beta oxidation of even-chain fatty acids (peroxisomal)
Beta oxidation of odd-chain fatty acids (mitochondrial)
Beta oxidation of phytanic acid (peroxisomal)
Beta oxidation of poly-unsaturated fatty acids (mitochondrial)
Beta oxidation of unsaturated fatty acids (n-7) (mitochondrial)
Beta oxidation of unsaturated fatty acids (n-7) (peroxisomal)
Beta oxidation of unsaturated fatty acids (n-9) (mitochondrial)
Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal)
Beta-alanine metabolism
Bile acid biosynthesis
Bile acid recycling
Biopterin metabolism
Biotin metabolism
Blood group biosynthesis
Butanoate metabolism
C5-branched dibasic acid metabolism
Carnitine shuttle (cytosolic)
Carnitine shuttle (endoplasmic reticular)
Carnitine shuttle (mitochondrial)
Carnitine shuttle (peroxisomal)
Cholesterol biosynthesis 1 (Bloch pathway)
Cholesterol biosynthesis 2
Cholesterol biosynthesis 3 (Kandustch-Russell pathway)
Cholesterol metabolism
Chondroitin / heparan sulfate biosynthesis
Chondroitin sulfate degradation
CoA synthesis
Cysteine and methionine metabolism
Drug metabolism
Eicosanoid metabolism
Estrogen metabolism
Ether lipid metabolism
Fatty acid activation (cytosolic)
Fatty acid activation (endoplasmic reticular)
Fatty acid biosynthesis
Fatty acid biosynthesis (even-chain)
Fatty acid biosynthesis (odd-chain)
Fatty acid biosynthesis (unsaturated)
Fatty acid desaturation (even-chain)
Fatty acid desaturation (odd-chain)
Fatty acid elongation (even-chain)
Fatty acid elongation (odd-chain)
Fatty acid oxidation
Folate metabolism
Formation and hydrolysis of cholesterol esters
Fructose and mannose metabolism
Galactose metabolism
Glucocorticoid biosynthesis
Glutathione metabolism
Glycerolipid metabolism
Glycerophospholipid metabolism
Glycine; serine and threonine metabolism
Glycolysis / Gluconeogenesis
Glycosphingolipid biosynthesis-ganglio series
Glycosphingolipid biosynthesis-globo series
Glycosphingolipid biosynthesis-lacto and neolacto series
Glycosphingolipid metabolism
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
Heme degradation
Heme synthesis
Heparan sulfate degradation
Histidine metabolism
Inositol phosphate metabolism
Isolated
Keratan sulfate biosynthesis
Keratan sulfate degradation
Leukotriene metabolism
Linoleate metabolism
Lipoic acid metabolism
Lysine metabolism
Metabolism of other amino acids
Miscellaneous
N-glycan metabolism
Nicotinate and nicotinamide metabolism
Nucleotide metabolism
O-glycan metabolism
Omega-3 fatty acid metabolism
Omega-6 fatty acid metabolism
Oxidative phosphorylation
Pantothenate and CoA biosynthesis
Pentose and glucuronate interconversions
Pentose phosphate pathway
Phenylalanine metabolism
Phenylalanine; tyrosine and tryptophan biosynthesis
Phosphatidylinositol phosphate metabolism
Pool reactions
Porphyrin metabolism
Propanoate metabolism
Prostaglandin biosynthesis
Protein assembly
Protein degradation
Protein modification
Purine metabolism
Pyrimidine metabolism
Pyruvate metabolism
Retinol metabolism
Riboflavin metabolism
ROS detoxification
Serotonin and melatonin biosynthesis
Sphingolipid metabolism
Starch and sucrose metabolism
Steroid metabolism
Sulfur metabolism
Terpenoid backbone biosynthesis
Thiamine metabolism
Transport reactions
Tricarboxylic acid cycle and glyoxylate/dicarboxylate metabolism
Tryptophan metabolism
Tyrosine metabolism
Ubiquinone synthesis
Urea cycle
Valine; leucine; and isoleucine metabolism
Vitamin A metabolism
Vitamin B12 metabolism
Vitamin B2 metabolism
Vitamin B6 metabolism
Vitamin C metabolism
Vitamin D metabolism
Vitamin E metabolism
Xenobiotics metabolism
Category
Evidence at protein level
Evidence at transcript level
No human protein/transcript evidence
Score
Evidence at protein level
Evidence at transcript level
No human protein/transcript evidence
Score
Evidence at protein level
Evidence at transcript level
No human protein/transcript evidence
Score
Evidence at protein level
Evidence at transcript level
No human protein/transcript evidence
Validation
Supported
Approved
Uncertain
Validation
Enhanced - Capture
Enhanced - Genetic
Enhanced - Independent
Enhanced - Orthogonal
Enhanced - Recombinant
Supported
Approved
Uncertain
Validation
Enhanced - Independent
Enhanced - Orthogonal
Supported
Approved
Uncertain
Validation
Enhanced - Genetic
Enhanced - Independent
Enhanced - Recombinant
Supported
Approved
Uncertain
Antibodies
Yes
No
Data type
Tissue - Immunohistochemistry
Tissue - GTEx transcriptomics
Tissue - FANTOM transcriptomics
Tissue - Expression clustering
Brain
Brain - Expression clustering
Single cell - Expression clustering
Subcellular
Cancer - Immunohistochemistry
Cancer - Mass spectrometry
Blood - conc. immunoassay
Blood - conc. mass spectrometry
Blood - Detected pea
Blood - Expression clustering
Disease - PEA
Disease - Mass spectrometry
Cell line - Mass spectrometry
Cell line - Expression clustering
Structure
Interaction
Metabolic
Column
Gene
Position
Tissue specific score
Prognostic
Reliability (IF)
Reliability (IH)
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