Brain tissue expression of DDT in pons - The Human Protein Atlas

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:

72.9

nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	72.9

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 60.0

2188	Female, age 91, both hemispheres	67.3
2090	Male, age 80, both hemispheres	62.1
1984	Male, age 76, both hemispheres	57.1
2301	Female, age 85, both hemispheres	53.4

Dorsal cochlear nucleus
nTPM: 60.2

2058	Male, age 76, both hemispheres	65.7
2187	Female, age 91, both hemispheres	65.1
2370	Male, age 61, both hemispheres	59.8
2378	Male, age 80, both hemispheres	55.9
2802	Male, age 74, right hemisphere	54.6

Dorsal tegmental nucleus
nTPM: 60.6

2083	Male, age 80, both hemispheres	68.7
1936	Male, age 76, left hemisphere	61.5
2358	Male, age 61, both hemispheres	59.1
2326	Male, age 74, both hemispheres	52.8

Dorsolateral tegmental area
nTPM: 64.7

2751	Female, age 85, both hemispheres	71.4
2337	Male, age 61, both hemispheres	70.5
2654	Male, age 80, both hemispheres	68.1
2360	Male, age 74, both hemispheres	59.0
2141	Male, age 76, both hemispheres	54.2

Kolliker-Fuse nucleus
nTPM: 67.2

2315	Male, age 76, right hemisphere	76.3
2163	Male, age 80, both hemispheres	72.2
2793	Female, age 91, left hemisphere	53.0

Lateral lemniscal nuclei
nTPM: 59.9

2169	Male, age 76, both hemispheres	70.9
2746	Female, age 85, left hemisphere	68.9
2036	Male, age 80, both hemispheres	55.9
2453	Male, age 74, right hemisphere	55.3
2320	Female, age 91, left hemisphere	48.7

Lateral parabrachial nucleus
nTPM: 65.1

2139	Female, age 85, right hemisphere	75.1
2013	Male, age 80, both hemispheres	70.6
2792	Male, age 76, both hemispheres	57.4
2790	Male, age 61, both hemispheres	57.2

Lateral vestibular nucleus
nTPM: 65.8

2184	Male, age 76, both hemispheres	75.1
2311	Male, age 80, both hemispheres	56.5

Locus coeruleus
nTPM: 69.6

2123	Female, age 91, both hemispheres	84.3
2014	Male, age 55, unknown	79.7
1980	Male, age 76, both hemispheres	77.9
2317	Female, age 72, unknown	69.8
2162	Male, age 80, both hemispheres	64.4
2720	Male, age 74, both hemispheres	59.8
2788	Male, age 74, unknown	51.4

Medial parabrachial nucleus
nTPM: 67.0

2170	Female, age 91, both hemispheres	85.3
2463	Female, age 85, right hemisphere	72.3
2156	Male, age 61, both hemispheres	61.7
2786	Male, age 76, both hemispheres	58.3
2854	Male, age 80, both hemispheres	57.5

Medial periolivary nuclei
nTPM: 64.2

2063	Male, age 76, both hemispheres	81.2
2171	Female, age 85, both hemispheres	74.9
2791	Male, age 74, right hemisphere	67.8
2081	Male, age 80, both hemispheres	55.7
2458	Female, age 91, both hemispheres	41.2

Motor facial nucleus
nTPM: 60.9

2062	Male, age 76, both hemispheres	88.8
2365	Male, age 74, right hemisphere	70.3
2126	Male, age 61, both hemispheres	67.0
2697	Female, age 85, both hemispheres	51.9
2795	Female, age 91, both hemispheres	48.8
2327	Male, age 80, both hemispheres	38.3

Motor trigeminal nucleus
nTPM: 59.4

2335	Male, age 61, both hemispheres	72.1
2560	Male, age 74, both hemispheres	60.7
2309	Male, age 76, both hemispheres	56.3
2079	Male, age 80, both hemispheres	56.2
2321	Female, age 91, both hemispheres	51.6

Nuclei of the trapezoid body
nTPM: 71.7

1983	Male, age 76, both hemispheres	86.5
2159	Male, age 61, both hemispheres	83.9
2735	Female, age 85, both hemispheres	79.9
2166	Male, age 80, both hemispheres	60.2
2368	Female, age 91, both hemispheres	48.2

Nucleus raphe magnus
nTPM: 65.7

2160	Male, age 61, both hemispheres	99.7
2172	Female, age 85, both hemispheres	75.4
2051	Male, age 76, both hemispheres	65.9
2455	Male, age 74, both hemispheres	61.3
2328	Male, age 80, both hemispheres	52.0
2459	Female, age 91, both hemispheres	39.8

Paramedian reticular nucleus
nTPM: 72.9

2057	Male, age 80, both hemispheres	85.3
2050	Female, age 85, both hemispheres	78.3
2313	Male, age 61, both hemispheres	71.9
2052	Male, age 76, both hemispheres	56.2

Pedunculopontine tegmental nucleus
nTPM: 61.5

2334	Male, age 80, both hemispheres	68.4
1921	Female, age 85, both hemispheres	59.7
2338	Male, age 61, both hemispheres	56.3

Pontine nuclei
nTPM: 72.1

2787	Female, age 85, both hemispheres	93.3
2727	Male, age 61, right hemisphere	88.6
1968	Male, age 76, left hemisphere	82.3
1863	Male, age 55, unknown	74.3
2109	Female, age 72, unknown	68.3
2454	Male, age 74, left hemisphere	61.9
2115	Male, age 80, left hemisphere	54.8
2319	Female, age 91, both hemispheres	53.4

Pontine raphe nucleus
nTPM: 65.9

2122	Female, age 85, midline	70.0
2853	Male, age 76, midline	61.8

Posteroventral cochlear nucleus
nTPM: 65.6

2752	Female, age 85, both hemispheres	76.6
2135	Female, age 91, both hemispheres	67.9
2070	Male, age 76, both hemispheres	63.4
2341	Male, age 80, both hemispheres	60.1
2371	Male, age 61, both hemispheres	59.8

Principal sensory trigeminal nucleus
nTPM: 67.9

2158	Male, age 61, both hemispheres	88.3
2324	Male, age 76, both hemispheres	67.9
2008	Male, age 80, left hemisphere	65.3
2367	Female, age 91, left hemisphere	50.1

Reticular pontine nucleus, caudal
nTPM: 61.4

2092	Male, age 76, both hemispheres	71.8
2559	Male, age 74, both hemispheres	65.9
2457	Female, age 91, both hemispheres	58.0
2332	Male, age 80, right hemisphere	49.9

Reticular pontine nucleus, oral
nTPM: 71.4

2361	Male, age 74, both hemispheres	93.4
1939	Male, age 80, both hemispheres	76.2
2012	Female, age 85, both hemispheres	70.1
2167	Male, age 76, both hemispheres	64.5
2366	Female, age 91, both hemispheres	52.6

Reticulotegmental nucleus
nTPM: 61.6

2325	Male, age 76, both hemispheres	67.0
2452	Male, age 74, both hemispheres	62.2
2322	Female, age 91, both hemispheres	60.1
2333	Male, age 80, both hemispheres	57.3

Spinal trigeminal nucleus, oral
nTPM: 65.8

2164	Male, age 80, both hemispheres	69.0
2737	Female, age 85, both hemispheres	67.8
1978	Male, age 76, both hemispheres	60.7

Subcoeruleus area
nTPM: 62.2

2369	Female, age 85, left hemisphere	67.0
2451	Male, age 74, both hemispheres	65.4
1958	Male, age 80, both hemispheres	62.7
2323	Female, age 91, left hemisphere	58.6
2089	Male, age 76, left hemisphere	57.5

Superior olive
nTPM: 63.5

1875	Female, age 85, both hemispheres	76.0
2364	Male, age 74, right hemisphere	73.1
2020	Male, age 76, both hemispheres	69.6
2329	Male, age 80, right hemisphere	52.3
2561	Female, age 91, both hemispheres	46.6

Ventral periolivary nuclei
nTPM: 57.0

2130	Female, age 85, both hemispheres	63.9
2165	Male, age 80, both hemispheres	62.0
2023	Male, age 76, both hemispheres	60.5
2794	Female, age 91, left hemisphere	41.3

Ventrolateral tegmental area, A5 NE cell group
nTPM: 59.1

1959	Male, age 76, both hemispheres	65.6
2359	Male, age 61, both hemispheres	64.2
2449	Male, age 74, both hemispheres	62.6
2840	Female, age 85, both hemispheres	61.0
2161	Male, age 80, both hemispheres	53.1
2456	Female, age 91, both hemispheres	48.3