Brain tissue expression of RASA4 in medulla oblongata

MEDULLA OBLONGATA - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:

39.4

nTPM

MEDULLA OBLONGATA - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - MEDULLA OBLONGATA, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1) ETV1+ Z...
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1) ETV1+ Z...
	c-4	Unassigned
	c-5	Excitatory (VGLUT1) ETV1+ Z...
	c-6	Inhibitory (GAD1/2) SLC6A5+
	c-7	Unassigned
	c-8	Excitatory (VGLUT1) ETV1+ Z...
	c-9	Excitatory (VGLUT1/2)
	c-10	Inhibitory (GAD1/2) SLC6A5+
	c-11	Inhibitory (GAD1/2) SLC6A5+...
	c-12	Excitatory (VGLUT2)
	c-13	Excitatory (VGLUT2)
	c-14	Inhibitory (GAD1/2) SLC6A5+...
	c-15	Inhibitory (GAD1/2) SLC6A5+...
	c-16	SST+ CALB1+ EBF1+
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2) SLC6A5+...
	c-19	Inhibitory (GAD1/2) SLC6A5+...
	c-20	SST+ TAC3+ GRP+ SOX5+
	c-21	Inhibitory (GAD1/2) PVALB+ ...
	c-22	Inferior olive Excitatory (...
	c-23	Excitatory (VGLUT2)
	c-24	Excitatory (VGLUT2) TFAP2B+...
	c-25	Excitatory (VGLUT2)
	c-26	EBF1+ CALB1+
	c-27	SST+ TRH+ CALB1+
	c-28	Excitatory (VGLUT2) EBF1+
	c-29	Excitatory (VGLUT2) TH+ TFA...
	c-30	Monoaminergic Excitatory (V...
	c-31	Inhibitory (GAD1/2) PENK+ E...
	c-32	Excitatory (VGLUT2) SST+ TA...
	c-33	Inhibitory (GAD1/2) SLC6A5+
	c-34	Excitatory (VGLUT2) PVALB+
	c-35	Inhibitory (GAD2) SLC6A5+ N
	c-36	Excitatory (VGLUT2) GAL+ NO
	c-37	Serotonergic TPH2+ SLC6A4+
	c-38	Excitatory (VGLUT2) SLC5A7+...
	c-39	Cholinergic CHAT+ SLC5A7+ T...
	c-40	Excitatory (VGLUT2) MEIS2+
	c-41	Inhibitory (GAD1/2) SLC6A5+
	c-42	Inhibitory (GAD1/2) RORB+ K
	c-43	Inhibitory (GAD1/2) PENK+ ...
	c-44	LMX1A+
	c-45	Excitatory (VGLUT2) SST+ TA
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - MEDULLA OBLONGATA, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocytes
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Microglia
	c-7	Oligodendrocyte progenitor ...
	c-8	Oligodendrocytes
	c-9	Astrocytes (TTR+ CD44+)
	c-10	Oligodendrocytes
	c-11	Choroid plexus epithelial c...
	c-12	Astrocytes (TTR+ CD44+)
	c-13	Astrocytes (CD44+)
	c-14	Ependymal cells
	c-15	Astrocytes (TTR+ CD44+)
	c-16	Fibroblasts
	c-17	Astrocytes (TTR+ CD44+)
	c-18	Vascular endothelial cells
	c-19	Microglia
	c-20	Pericytes
	c-21	Lymphocytes
	c-22	Bergmann glia
	c-23	Macrophages
	c-24	Vascular smooth muscle cell
	c-25	Astrocyte & neuron doublets
	c-26	Ependymal cell & neuron dou...
	c-27	Immature oligodendrocytes
	c-28	Myelinating schwann cells
	c-29	Monocytes
	c-30	Oligodendrocyte progenitor ...
	c-31	Fibroblasts (BNC2+ KCNMA1+ ...
	c-32	Ependymal cell & oligodendr...
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

MEDULLA OBLONGATA - Annotated protein expression
Pending normal tissue analysis

MEDULLA OBLONGATA - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	39.4

Sample id

Sample description

nTPM

Area postrema
nTPM: 36.4

2306	Male, age 80, both hemispheres	42.6
2799	Male, age 61, both hemispheres	40.4
2054	Male, age 76, both hemispheres	26.2

Dorsal medullary reticular nucleus
nTPM: 25.8

2088	Male, age 76, both hemispheres	31.4
2373	Male, age 61, both hemispheres	26.5
2040	Female, age 85, both hemispheres	19.4

Dorsal motor vagal complex
nTPM: 39.4

2643	Male, age 74, both hemispheres	51.2
2807	Female, age 85, both hemispheres	48.9
2185	Male, age 76, both hemispheres	45.6
2797	Male, age 61, both hemispheres	37.0
2813	Female, age 72, unknown	37.0
2844	Male, age 55, unknown	37.0
2000	Male, age 74, unknown	29.6
2133	Female, age 91, both hemispheres	28.8

Gigantocellular reticular nuclei, medullary
nTPM: 23.9

2314	Male, age 61, both hemispheres	32.0
2310	Male, age 80, both hemispheres	26.6
2462	Male, age 74, both hemispheres	24.9
2022	Male, age 76, right hemisphere	21.6
2387	Female, age 91, both hemispheres	20.4
1876	Female, age 85, both hemispheres	17.6

Gigantocellular reticular nuclei, pars
nTPM: 27.8

2330	Male, age 80, both hemispheres	33.3
2336	Male, age 61, both hemispheres	29.8
2706	Male, age 80, both hemispheres	28.4
2084	Female, age 85, both hemispheres	25.0
2168	Male, age 76, both hemispheres	22.5

Inferior olive
nTPM: 37.8

2379	Male, age 80, both hemispheres	48.9
2563	Male, age 74, both hemispheres	37.4
2178	Male, age 61, both hemispheres	35.8
2085	Female, age 85, both hemispheres	34.9
2628	Female, age 91, both hemispheres	32.1

Lateral medullary reticular nucleus
nTPM: 32.7

2804	Female, age 91, both hemispheres	39.2
2852	Male, age 80, both hemispheres	36.1
2374	Male, age 61, both hemispheres	34.8
2305	Male, age 74, both hemispheres	33.7
2190	Female, age 85, both hemispheres	28.0
2044	Male, age 76, both hemispheres	24.6

Medial olivary nucleus
nTPM: 31.5

1943	Male, age 61, both hemispheres	35.4
2138	Female, age 91, both hemispheres	33.4
2851	Male, age 80, both hemispheres	32.8
1962	Male, age 76, both hemispheres	24.5

Medial vestibular nucleus
nTPM: 23.3

2624	Male, age 61, both hemispheres	27.1
2801	Male, age 74, both hemispheres	26.7
2743	Female, age 85, both hemispheres	24.6
2093	Male, age 80, both hemispheres	20.9
2803	Female, age 91, both hemispheres	20.8
2134	Male, age 76, both hemispheres	19.6

Motor hypoglossal nucleus
nTPM: 26.4

2277	Male, age 76, both hemispheres	39.9
2182	Male, age 80, both hemispheres	30.3
2125	Female, age 91, both hemispheres	22.2
2132	Female, age 85, both hemispheres	21.1
2461	Male, age 61, both hemispheres	18.8

Nucleus ambiguus
nTPM: 35.9

2096	Female, age 85, both hemispheres	36.2
2071	Male, age 76, both hemispheres	35.6

Nucleus cuneatus
nTPM: 34.8

2564	Male, age 74, both hemispheres	42.8
2805	Female, age 91, both hemispheres	41.1
2808	Female, age 85, both hemispheres	37.5
2131	Male, age 76, both hemispheres	33.8
2381	Male, age 80, both hemispheres	32.8
2100	Male, age 76, both hemispheres	32.5
2376	Male, age 61, both hemispheres	32.3
2380	Male, age 80, both hemispheres	31.4
2562	Male, age 61, both hemispheres	29.4

Nucleus gracilis
nTPM: 36.4

2299	Female, age 85, both hemispheres	45.9
2627	Male, age 74, both hemispheres	34.4
2382	Male, age 80, both hemispheres	28.8

Nucleus raphe obscurus
nTPM: 27.8

2142	Male, age 76, midline	32.4
2845	Female, age 85, midline	26.2
2800	Male, age 61, midline	24.9

Nucleus raphe pallidus
nTPM: 28.5

1924	Male, age 61, midline	29.3
2183	Male, age 80, midline	29.3
2145	Male, age 76, midline	27.0

Nucleus tractus solitarii
nTPM: 37.9

2307	Male, age 80, both hemispheres	52.7
2191	Female, age 85, both hemispheres	41.3
2656	Male, age 76, both hemispheres	32.2
2144	Female, age 91, right hemisphere	25.4

Parvicellular reticular nuclei
nTPM: 26.3

2119	Male, age 80, both hemispheres	28.5
2095	Male, age 76, both hemispheres	26.1
2558	Male, age 74, both hemispheres	24.3

Parvicellular reticular nuclei, medullary
nTPM: 27.3

2181	Male, age 80, left hemisphere	30.6
2091	Female, age 85, both hemispheres	27.1
2189	Female, age 91, both hemispheres	24.1

Peritrigeminal nucleus
nTPM: 26.4

2067	Female, age 85, both hemispheres	28.5
2136	Male, age 76, both hemispheres	26.8
2179	Male, age 61, both hemispheres	23.9

Prepositus hypoglossal nucleus
nTPM: 28.0

2086	Male, age 80, both hemispheres	35.2
2855	Female, age 85, right hemisphere	20.7

Spinal trigeminal nucleus, caudal
nTPM: 33.0

2642	Male, age 74, both hemispheres	41.5
2312	Male, age 61, both hemispheres	34.4
2308	Male, age 80, both hemispheres	32.2
2447	Male, age 76, both hemispheres	31.7
2390	Female, age 91, both hemispheres	25.0

Spinal trigeminal nucleus, interpolar
nTPM: 24.1

2386	Female, age 85, both hemispheres	25.6
2033	Male, age 80, both hemispheres	24.4
2625	Male, age 61, both hemispheres	24.1
2389	Female, age 91, both hemispheres	23.4
2066	Male, age 76, right hemisphere	23.1

Spinal vestibular nucleus
nTPM: 26.2

2796	Male, age 61, both hemispheres	32.2
2780	Male, age 80, both hemispheres	29.8
2384	Male, age 74, both hemispheres	28.0
2186	Female, age 91, both hemispheres	23.0
2806	Female, age 85, both hemispheres	22.0
2748	Male, age 76, both hemispheres	21.9

Superior vestibular nucleus
nTPM: 32.3

2061	Male, age 76, both hemispheres	40.0
2015	Male, age 80, both hemispheres	29.7
2383	Male, age 74, both hemispheres	27.1

Ventral medullary reticular nucleus
nTPM: 25.0

2372	Male, age 61, both hemispheres	29.4
2060	Male, age 76, both hemispheres	20.6

Ventrolateral medulla, A1-C1 cell groups
nTPM: 30.0

2302	Female, age 91, both hemispheres	35.5
2118	Male, age 80, both hemispheres	32.2
2180	Male, age 61, both hemispheres	31.0
1986	Male, age 76, both hemispheres	27.2
2741	Female, age 85, both hemispheres	24.0