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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes FDA approved drug targets RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q31.3
Chromosome location (bp)
142592178 - 142698070
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 1,2. Can induce angiogenesis 3....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Angiogenesis, Differentiation
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001525[angiogenesis] GO:0001759[organ induction] GO:0001934[positive regulation of protein phosphorylation] GO:0005104[fibroblast growth factor receptor binding] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005938[cell cortex] GO:0007165[signal transduction] GO:0008083[growth factor activity] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008543[fibroblast growth factor receptor signaling pathway] GO:0009653[anatomical structure morphogenesis] GO:0009887[animal organ morphogenesis] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0030154[cell differentiation] GO:0030324[lung development] GO:0030334[regulation of cell migration] GO:0030335[positive regulation of cell migration] GO:0030544[Hsp70 protein binding] GO:0031012[extracellular matrix] GO:0032148[activation of protein kinase B activity] GO:0034605[cellular response to heat] GO:0042060[wound healing] GO:0043406[positive regulation of MAP kinase activity] GO:0044548[S100 protein binding] GO:0045542[positive regulation of cholesterol biosynthetic process] GO:0045766[positive regulation of angiogenesis] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050673[epithelial cell proliferation] GO:0050679[positive regulation of epithelial cell proliferation] GO:0051781[positive regulation of cell division] GO:0060681[branch elongation involved in ureteric bud branching] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0072163[mesonephric epithelium development] GO:1901509[regulation of endothelial tube morphogenesis] GO:1902533[positive regulation of intracellular signal transduction] GO:1903672[positive regulation of sprouting angiogenesis] GO:2000347[positive regulation of hepatocyte proliferation] GO:2000544[regulation of endothelial cell chemotaxis to fibroblast growth factor]
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525[angiogenesis] GO:0001934[positive regulation of protein phosphorylation] GO:0005104[fibroblast growth factor receptor binding] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005938[cell cortex] GO:0007165[signal transduction] GO:0008083[growth factor activity] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008543[fibroblast growth factor receptor signaling pathway] GO:0009653[anatomical structure morphogenesis] GO:0009887[animal organ morphogenesis] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0030154[cell differentiation] GO:0030324[lung development] GO:0030334[regulation of cell migration] GO:0030335[positive regulation of cell migration] GO:0032148[activation of protein kinase B activity] GO:0034605[cellular response to heat] GO:0042060[wound healing] GO:0043406[positive regulation of MAP kinase activity] GO:0044548[S100 protein binding] GO:0045542[positive regulation of cholesterol biosynthetic process] GO:0045766[positive regulation of angiogenesis] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050679[positive regulation of epithelial cell proliferation] GO:0051781[positive regulation of cell division] GO:0060681[branch elongation involved in ureteric bud branching] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0072163[mesonephric epithelium development] GO:1901509[regulation of endothelial tube morphogenesis] GO:1902533[positive regulation of intracellular signal transduction] GO:1903672[positive regulation of sprouting angiogenesis] GO:2000544[regulation of endothelial cell chemotaxis to fibroblast growth factor]
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525[angiogenesis] GO:0001934[positive regulation of protein phosphorylation] GO:0005104[fibroblast growth factor receptor binding] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005938[cell cortex] GO:0007165[signal transduction] GO:0008083[growth factor activity] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008543[fibroblast growth factor receptor signaling pathway] GO:0009653[anatomical structure morphogenesis] GO:0009887[animal organ morphogenesis] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0030154[cell differentiation] GO:0030324[lung development] GO:0030334[regulation of cell migration] GO:0030335[positive regulation of cell migration] GO:0032148[activation of protein kinase B activity] GO:0034605[cellular response to heat] GO:0042060[wound healing] GO:0043406[positive regulation of MAP kinase activity] GO:0044548[S100 protein binding] GO:0045542[positive regulation of cholesterol biosynthetic process] GO:0045766[positive regulation of angiogenesis] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050679[positive regulation of epithelial cell proliferation] GO:0051781[positive regulation of cell division] GO:0060681[branch elongation involved in ureteric bud branching] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0072163[mesonephric epithelium development] GO:1901509[regulation of endothelial tube morphogenesis] GO:1902533[positive regulation of intracellular signal transduction] GO:1903672[positive regulation of sprouting angiogenesis] GO:2000544[regulation of endothelial cell chemotaxis to fibroblast growth factor]
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525[angiogenesis] GO:0001934[positive regulation of protein phosphorylation] GO:0005104[fibroblast growth factor receptor binding] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005938[cell cortex] GO:0007165[signal transduction] GO:0008083[growth factor activity] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008543[fibroblast growth factor receptor signaling pathway] GO:0009653[anatomical structure morphogenesis] GO:0009887[animal organ morphogenesis] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0030154[cell differentiation] GO:0030324[lung development] GO:0030334[regulation of cell migration] GO:0030335[positive regulation of cell migration] GO:0032148[activation of protein kinase B activity] GO:0034605[cellular response to heat] GO:0042060[wound healing] GO:0043406[positive regulation of MAP kinase activity] GO:0044548[S100 protein binding] GO:0045542[positive regulation of cholesterol biosynthetic process] GO:0045766[positive regulation of angiogenesis] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050679[positive regulation of epithelial cell proliferation] GO:0051781[positive regulation of cell division] GO:0060681[branch elongation involved in ureteric bud branching] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0072163[mesonephric epithelium development] GO:1901509[regulation of endothelial tube morphogenesis] GO:1902533[positive regulation of intracellular signal transduction] GO:1903672[positive regulation of sprouting angiogenesis] GO:2000544[regulation of endothelial cell chemotaxis to fibroblast growth factor]
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Protein evidence (Ezkurdia et al 2014)
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Protein evidence (Ezkurdia et al 2014)
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Protein evidence (Ezkurdia et al 2014)
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525[angiogenesis] GO:0001934[positive regulation of protein phosphorylation] GO:0005104[fibroblast growth factor receptor binding] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005938[cell cortex] GO:0007165[signal transduction] GO:0008083[growth factor activity] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008543[fibroblast growth factor receptor signaling pathway] GO:0009653[anatomical structure morphogenesis] GO:0009887[animal organ morphogenesis] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0030154[cell differentiation] GO:0030324[lung development] GO:0030334[regulation of cell migration] GO:0030335[positive regulation of cell migration] GO:0032148[activation of protein kinase B activity] GO:0034605[cellular response to heat] GO:0042060[wound healing] GO:0043406[positive regulation of MAP kinase activity] GO:0044548[S100 protein binding] GO:0045542[positive regulation of cholesterol biosynthetic process] GO:0045766[positive regulation of angiogenesis] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050679[positive regulation of epithelial cell proliferation] GO:0051781[positive regulation of cell division] GO:0060681[branch elongation involved in ureteric bud branching] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0072163[mesonephric epithelium development] GO:1901509[regulation of endothelial tube morphogenesis] GO:1902533[positive regulation of intracellular signal transduction] GO:1903672[positive regulation of sprouting angiogenesis] GO:2000544[regulation of endothelial cell chemotaxis to fibroblast growth factor]
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525[angiogenesis] GO:0001934[positive regulation of protein phosphorylation] GO:0005104[fibroblast growth factor receptor binding] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005938[cell cortex] GO:0007165[signal transduction] GO:0008083[growth factor activity] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008543[fibroblast growth factor receptor signaling pathway] GO:0009653[anatomical structure morphogenesis] GO:0009887[animal organ morphogenesis] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0030154[cell differentiation] GO:0030324[lung development] GO:0030334[regulation of cell migration] GO:0030335[positive regulation of cell migration] GO:0032148[activation of protein kinase B activity] GO:0034605[cellular response to heat] GO:0042060[wound healing] GO:0043406[positive regulation of MAP kinase activity] GO:0044548[S100 protein binding] GO:0045542[positive regulation of cholesterol biosynthetic process] GO:0045766[positive regulation of angiogenesis] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050679[positive regulation of epithelial cell proliferation] GO:0051781[positive regulation of cell division] GO:0060681[branch elongation involved in ureteric bud branching] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0072163[mesonephric epithelium development] GO:1901509[regulation of endothelial tube morphogenesis] GO:1902533[positive regulation of intracellular signal transduction] GO:1903672[positive regulation of sprouting angiogenesis] GO:2000544[regulation of endothelial cell chemotaxis to fibroblast growth factor]
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525[angiogenesis] GO:0001934[positive regulation of protein phosphorylation] GO:0005104[fibroblast growth factor receptor binding] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005938[cell cortex] GO:0007165[signal transduction] GO:0008083[growth factor activity] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008543[fibroblast growth factor receptor signaling pathway] GO:0009653[anatomical structure morphogenesis] GO:0009887[animal organ morphogenesis] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0030154[cell differentiation] GO:0030324[lung development] GO:0030334[regulation of cell migration] GO:0030335[positive regulation of cell migration] GO:0032148[activation of protein kinase B activity] GO:0034605[cellular response to heat] GO:0042060[wound healing] GO:0043406[positive regulation of MAP kinase activity] GO:0044548[S100 protein binding] GO:0045542[positive regulation of cholesterol biosynthetic process] GO:0045766[positive regulation of angiogenesis] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050679[positive regulation of epithelial cell proliferation] GO:0051781[positive regulation of cell division] GO:0060681[branch elongation involved in ureteric bud branching] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0072163[mesonephric epithelium development] GO:1901509[regulation of endothelial tube morphogenesis] GO:1902533[positive regulation of intracellular signal transduction] GO:1903672[positive regulation of sprouting angiogenesis] GO:2000544[regulation of endothelial cell chemotaxis to fibroblast growth factor]
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525[angiogenesis] GO:0001934[positive regulation of protein phosphorylation] GO:0005104[fibroblast growth factor receptor binding] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005938[cell cortex] GO:0007165[signal transduction] GO:0008083[growth factor activity] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008543[fibroblast growth factor receptor signaling pathway] GO:0009653[anatomical structure morphogenesis] GO:0009887[animal organ morphogenesis] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0030154[cell differentiation] GO:0030324[lung development] GO:0030334[regulation of cell migration] GO:0030335[positive regulation of cell migration] GO:0032148[activation of protein kinase B activity] GO:0034605[cellular response to heat] GO:0042060[wound healing] GO:0043406[positive regulation of MAP kinase activity] GO:0044548[S100 protein binding] GO:0045542[positive regulation of cholesterol biosynthetic process] GO:0045766[positive regulation of angiogenesis] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050679[positive regulation of epithelial cell proliferation] GO:0051781[positive regulation of cell division] GO:0060681[branch elongation involved in ureteric bud branching] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0072163[mesonephric epithelium development] GO:1901509[regulation of endothelial tube morphogenesis] GO:1902533[positive regulation of intracellular signal transduction] GO:1903672[positive regulation of sprouting angiogenesis] GO:2000544[regulation of endothelial cell chemotaxis to fibroblast growth factor]
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525[angiogenesis] GO:0001934[positive regulation of protein phosphorylation] GO:0005104[fibroblast growth factor receptor binding] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005938[cell cortex] GO:0007165[signal transduction] GO:0008083[growth factor activity] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008543[fibroblast growth factor receptor signaling pathway] GO:0009653[anatomical structure morphogenesis] GO:0009887[animal organ morphogenesis] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0030154[cell differentiation] GO:0030324[lung development] GO:0030334[regulation of cell migration] GO:0030335[positive regulation of cell migration] GO:0032148[activation of protein kinase B activity] GO:0034605[cellular response to heat] GO:0042060[wound healing] GO:0043406[positive regulation of MAP kinase activity] GO:0044548[S100 protein binding] GO:0045542[positive regulation of cholesterol biosynthetic process] GO:0045766[positive regulation of angiogenesis] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050679[positive regulation of epithelial cell proliferation] GO:0051781[positive regulation of cell division] GO:0060681[branch elongation involved in ureteric bud branching] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0072163[mesonephric epithelium development] GO:1901509[regulation of endothelial tube morphogenesis] GO:1902533[positive regulation of intracellular signal transduction] GO:1903672[positive regulation of sprouting angiogenesis] GO:2000544[regulation of endothelial cell chemotaxis to fibroblast growth factor]
Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525[angiogenesis] GO:0001934[positive regulation of protein phosphorylation] GO:0005104[fibroblast growth factor receptor binding] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005938[cell cortex] GO:0007165[signal transduction] GO:0008083[growth factor activity] GO:0008201[heparin binding] GO:0008284[positive regulation of cell population proliferation] GO:0008543[fibroblast growth factor receptor signaling pathway] GO:0009653[anatomical structure morphogenesis] GO:0009887[animal organ morphogenesis] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0030154[cell differentiation] GO:0030324[lung development] GO:0030334[regulation of cell migration] GO:0030335[positive regulation of cell migration] GO:0032148[activation of protein kinase B activity] GO:0034605[cellular response to heat] GO:0042060[wound healing] GO:0043406[positive regulation of MAP kinase activity] GO:0044548[S100 protein binding] GO:0045542[positive regulation of cholesterol biosynthetic process] GO:0045766[positive regulation of angiogenesis] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0050679[positive regulation of epithelial cell proliferation] GO:0051781[positive regulation of cell division] GO:0060681[branch elongation involved in ureteric bud branching] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0072163[mesonephric epithelium development] GO:1901509[regulation of endothelial tube morphogenesis] GO:1902533[positive regulation of intracellular signal transduction] GO:1903672[positive regulation of sprouting angiogenesis] GO:2000544[regulation of endothelial cell chemotaxis to fibroblast growth factor]