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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
p21.31
Chromosome location (bp)
50299890 - 50312381
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Glycosidase, Hydrolase
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Lysosomal storage diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000302[response to reactive oxygen species] GO:0004415[hyalurononglucosaminidase activity] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0005764[lysosome] GO:0005975[carbohydrate metabolic process] GO:0006954[inflammatory response] GO:0008152[metabolic process] GO:0009615[response to virus] GO:0010634[positive regulation of epithelial cell migration] GO:0016787[hydrolase activity] GO:0016798[hydrolase activity, acting on glycosyl bonds] GO:0030207[chondroitin sulfate catabolic process] GO:0030212[hyaluronan metabolic process] GO:0030213[hyaluronan biosynthetic process] GO:0030214[hyaluronan catabolic process] GO:0030307[positive regulation of cell growth] GO:0030308[negative regulation of cell growth] GO:0031410[cytoplasmic vesicle] GO:0036117[hyaluranon cable] GO:0036120[cellular response to platelet-derived growth factor stimulus] GO:0043202[lysosomal lumen] GO:0044344[cellular response to fibroblast growth factor stimulus] GO:0045766[positive regulation of angiogenesis] GO:0045785[positive regulation of cell adhesion] GO:0045927[positive regulation of growth] GO:0046677[response to antibiotic] GO:0050501[hyaluronan synthase activity] GO:0050679[positive regulation of epithelial cell proliferation] GO:0051216[cartilage development] GO:0070062[extracellular exosome] GO:0071347[cellular response to interleukin-1] GO:0071356[cellular response to tumor necrosis factor] GO:0071467[cellular response to pH] GO:0071493[cellular response to UV-B] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1900106[positive regulation of hyaluranon cable assembly]
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Lysosomal storage diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000302[response to reactive oxygen species] GO:0004415[hyalurononglucosaminidase activity] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0005764[lysosome] GO:0005975[carbohydrate metabolic process] GO:0006954[inflammatory response] GO:0008152[metabolic process] GO:0009615[response to virus] GO:0010634[positive regulation of epithelial cell migration] GO:0016787[hydrolase activity] GO:0016798[hydrolase activity, acting on glycosyl bonds] GO:0030207[chondroitin sulfate catabolic process] GO:0030212[hyaluronan metabolic process] GO:0030213[hyaluronan biosynthetic process] GO:0030214[hyaluronan catabolic process] GO:0030307[positive regulation of cell growth] GO:0030308[negative regulation of cell growth] GO:0031410[cytoplasmic vesicle] GO:0036117[hyaluranon cable] GO:0036120[cellular response to platelet-derived growth factor stimulus] GO:0043202[lysosomal lumen] GO:0044344[cellular response to fibroblast growth factor stimulus] GO:0045766[positive regulation of angiogenesis] GO:0045785[positive regulation of cell adhesion] GO:0045927[positive regulation of growth] GO:0046677[response to antibiotic] GO:0050501[hyaluronan synthase activity] GO:0050679[positive regulation of epithelial cell proliferation] GO:0051216[cartilage development] GO:0070062[extracellular exosome] GO:0071347[cellular response to interleukin-1] GO:0071356[cellular response to tumor necrosis factor] GO:0071467[cellular response to pH] GO:0071493[cellular response to UV-B] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1900106[positive regulation of hyaluranon cable assembly]
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Lysosomal storage diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000302[response to reactive oxygen species] GO:0004415[hyalurononglucosaminidase activity] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0005764[lysosome] GO:0005975[carbohydrate metabolic process] GO:0006954[inflammatory response] GO:0008152[metabolic process] GO:0009615[response to virus] GO:0010634[positive regulation of epithelial cell migration] GO:0016787[hydrolase activity] GO:0016798[hydrolase activity, acting on glycosyl bonds] GO:0030207[chondroitin sulfate catabolic process] GO:0030212[hyaluronan metabolic process] GO:0030213[hyaluronan biosynthetic process] GO:0030214[hyaluronan catabolic process] GO:0030307[positive regulation of cell growth] GO:0030308[negative regulation of cell growth] GO:0031410[cytoplasmic vesicle] GO:0036117[hyaluranon cable] GO:0036120[cellular response to platelet-derived growth factor stimulus] GO:0043202[lysosomal lumen] GO:0044344[cellular response to fibroblast growth factor stimulus] GO:0045766[positive regulation of angiogenesis] GO:0045785[positive regulation of cell adhesion] GO:0045927[positive regulation of growth] GO:0046677[response to antibiotic] GO:0050501[hyaluronan synthase activity] GO:0050679[positive regulation of epithelial cell proliferation] GO:0051216[cartilage development] GO:0070062[extracellular exosome] GO:0071347[cellular response to interleukin-1] GO:0071356[cellular response to tumor necrosis factor] GO:0071467[cellular response to pH] GO:0071493[cellular response to UV-B] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1900106[positive regulation of hyaluranon cable assembly]
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Lysosomal storage diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302[response to reactive oxygen species] GO:0004415[hyalurononglucosaminidase activity] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0005764[lysosome] GO:0005975[carbohydrate metabolic process] GO:0006954[inflammatory response] GO:0008152[metabolic process] GO:0009615[response to virus] GO:0010634[positive regulation of epithelial cell migration] GO:0016787[hydrolase activity] GO:0016798[hydrolase activity, acting on glycosyl bonds] GO:0030207[chondroitin sulfate catabolic process] GO:0030212[hyaluronan metabolic process] GO:0030213[hyaluronan biosynthetic process] GO:0030214[hyaluronan catabolic process] GO:0030307[positive regulation of cell growth] GO:0030308[negative regulation of cell growth] GO:0031410[cytoplasmic vesicle] GO:0036117[hyaluranon cable] GO:0036120[cellular response to platelet-derived growth factor stimulus] GO:0043202[lysosomal lumen] GO:0044344[cellular response to fibroblast growth factor stimulus] GO:0045766[positive regulation of angiogenesis] GO:0045785[positive regulation of cell adhesion] GO:0045927[positive regulation of growth] GO:0046677[response to antibiotic] GO:0050501[hyaluronan synthase activity] GO:0050679[positive regulation of epithelial cell proliferation] GO:0051216[cartilage development] GO:0052757[chondroitin hydrolase activity] GO:0060272[embryonic skeletal joint morphogenesis] GO:0070062[extracellular exosome] GO:0071347[cellular response to interleukin-1] GO:0071356[cellular response to tumor necrosis factor] GO:0071467[cellular response to pH] GO:0071493[cellular response to UV-B] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1900106[positive regulation of hyaluranon cable assembly]
Enzymes ENZYME proteins Hydrolases Metabolic proteins MEMSAT3 predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Lysosomal storage diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302[response to reactive oxygen species] GO:0004415[hyalurononglucosaminidase activity] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0005764[lysosome] GO:0005975[carbohydrate metabolic process] GO:0006954[inflammatory response] GO:0008152[metabolic process] GO:0009615[response to virus] GO:0010634[positive regulation of epithelial cell migration] GO:0016787[hydrolase activity] GO:0016798[hydrolase activity, acting on glycosyl bonds] GO:0030207[chondroitin sulfate catabolic process] GO:0030212[hyaluronan metabolic process] GO:0030213[hyaluronan biosynthetic process] GO:0030214[hyaluronan catabolic process] GO:0030307[positive regulation of cell growth] GO:0030308[negative regulation of cell growth] GO:0031410[cytoplasmic vesicle] GO:0036117[hyaluranon cable] GO:0036120[cellular response to platelet-derived growth factor stimulus] GO:0043202[lysosomal lumen] GO:0044344[cellular response to fibroblast growth factor stimulus] GO:0045766[positive regulation of angiogenesis] GO:0045785[positive regulation of cell adhesion] GO:0045927[positive regulation of growth] GO:0046677[response to antibiotic] GO:0050501[hyaluronan synthase activity] GO:0050679[positive regulation of epithelial cell proliferation] GO:0051216[cartilage development] GO:0070062[extracellular exosome] GO:0071347[cellular response to interleukin-1] GO:0071356[cellular response to tumor necrosis factor] GO:0071467[cellular response to pH] GO:0071493[cellular response to UV-B] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1900106[positive regulation of hyaluranon cable assembly]
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Congenital disorders of glycan/glycoprotein metabolism Lysosomal storage diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000302[response to reactive oxygen species] GO:0004415[hyalurononglucosaminidase activity] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0005764[lysosome] GO:0005975[carbohydrate metabolic process] GO:0006954[inflammatory response] GO:0008152[metabolic process] GO:0009615[response to virus] GO:0010634[positive regulation of epithelial cell migration] GO:0016787[hydrolase activity] GO:0016798[hydrolase activity, acting on glycosyl bonds] GO:0030207[chondroitin sulfate catabolic process] GO:0030212[hyaluronan metabolic process] GO:0030213[hyaluronan biosynthetic process] GO:0030214[hyaluronan catabolic process] GO:0030307[positive regulation of cell growth] GO:0030308[negative regulation of cell growth] GO:0031410[cytoplasmic vesicle] GO:0036117[hyaluranon cable] GO:0036120[cellular response to platelet-derived growth factor stimulus] GO:0043202[lysosomal lumen] GO:0044344[cellular response to fibroblast growth factor stimulus] GO:0045766[positive regulation of angiogenesis] GO:0045785[positive regulation of cell adhesion] GO:0045927[positive regulation of growth] GO:0046677[response to antibiotic] GO:0050501[hyaluronan synthase activity] GO:0050679[positive regulation of epithelial cell proliferation] GO:0051216[cartilage development] GO:0070062[extracellular exosome] GO:0071347[cellular response to interleukin-1] GO:0071356[cellular response to tumor necrosis factor] GO:0071467[cellular response to pH] GO:0071493[cellular response to UV-B] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1900106[positive regulation of hyaluranon cable assembly]