Protein interactions - UBA1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	UBA1
Synonyms	A1S9T, CFAP124, GXP1, POC20, UBE1, UBE1X
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquitin like modifier activating enzyme 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Essential proteins Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - RNA processing (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Esophageal apical cells)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Basic cellular processes (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm In addition localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	X
Cytoband	p11.3
Chromosome location (bp)	47190861 - 47215128
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8
Ensembl	ENSG00000130985 (version 109)
Entrez gene	7317
HGNC	HGNC:12469
UniProt	P22314
GeneCards	UBA1

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Basic cellular processes

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
BIRC3	12	10	58	0	3
GAN	4	6	15	1	9
UBE2K	18	61	35	3	0
UBE2L3	11	11	58	1	0
UBE2N	17	26	66	2	0

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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
BIRC3	12	10	58	0	3
GAN	4	6	15	1	9
HTT	36	666	56	0	0
MAGEC2	1	11	7	0	0
OTUB1	12	42	54	0	6
STUB1	26	57	192	0	20
TRAF4	11	74	34	0	0
UBE2N	17	26	66	2	0
WWP2	18	52	140	1	1

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
AIMP2	9	33	60	0	2
AP1B1	5	3	30	3	0
AP1G1	2	2	24	3	0
AP1M1	6	67	20	0	6
ARHGAP1	2	3	14	1	9
ARHGAP24	0	1	12	0	0
BIRC3	12	10	58	0	3
BRCA1	36	39	311	3	0
BRD4	4	6	490	0	2
CDC34	2	5	24	0	4
CIAPIN1	3	6	6	2	0
CUL3	40	45	771	2	0
EDEM3	0	0	9	0	26
EEF1E1	3	2	12	3	3
EPHB4	2	5	10	0	7
FH	1	10	9	0	0
FUS	14	28	150	6	0
GAN	4	6	15	1	9
GARS1	0	4	31	0	0
HSD17B10	5	5	44	3	0
HSP90AB1	65	146	187	22	19
HSPA1A	1	7	318	0	0
IARS1	6	1	37	17	8
KCNA3	2	2	98	0	0
LARS1	9	2	23	7	8
MAPT	11	19	188	0	0
MYC	66	90	1269	2	0
NMD3	1	1	6	6	3
PRKN	11	11	1405	0	0
PRNP	9	17	294	0	0
PSMD14	13	9	101	3	8
RAD21	9	10	46	7	7
RAD23A	9	42	37	1	5
RIPK4	8	7	30	2	0
TP53	123	166	704	5	0
TRIP13	11	72	19	0	6
UBC	35	59	463	4	0
UBE2A	3	17	28	2	1
UBE2B	3	6	18	0	0
UBE2C	0	2	12	1	0
UBE2D1	34	40	123	0	0
UBE2D2	33	41	130	0	4
UBE2D3	23	26	121	0	0
UBE2D4	25	40	34	0	2
UBE2E1	7	8	47	0	6
UBE2E2	9	17	33	0	2
UBE2E3	14	25	36	0	2
UBE2G1	0	3	7	1	1
UBE2G2	3	3	9	2	0
UBE2H	2	9	32	0	0
UBE2J1	3	34	15	0	9
UBE2J2	0	7	4	0	6
UBE2K	18	61	35	3	0
UBE2L3	11	11	58	1	0
UBE2L6	9	13	17	0	1
UBE2M	6	7	64	6	0
UBE2N	17	26	66	2	0
UBE2Q2	0	2	1	0	2
UBE2R2	0	4	5	3	1
UBE2S	1	2	24	0	3
UBE2T	0	2	11	0	0
UBE2W	8	15	19	0	0
UBE2Z	1	10	5	0	0
UBTD2	1	11	5	0	2
USP11	5	7	95	0	2
YWHAE	235	123	383	324	12
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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ABCD3	4	3	20	7	2
DENND4A	7	4	8	14	0
FRA10AC1	4	8	4	1	0
KPNA2	31	37	85	43	7
MKRN2	1	9	24	1	1
MZT2B	3	1	7	5	4
NEDD1	9	1	35	4	20
NUDT16L1	1	14	4	3	2
TUBG2	1	0	1	2	15
TUBGCP2	3	1	16	2	12
TUBGCP4	3	12	10	4	0
TUBGCP6	0	0	7	1	0
UBE2K	18	61	35	3	0
UBE2L3	11	11	58	1	0
UBE2N	17	26	66	2	0
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene UBA1 is associated with 1 reactions in 1 different subsystems, and present in the compartments: Cytosol. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Isolated	Cytosol, Mitochondria, Peroxisome, Endoplasmic reticulum, Extracellular, Nucleus, Golgi apparatus	524	320	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UBA1-201	P22314	A0A024R1A3	Enzymes Metabolic proteins Predicted membrane proteins Plasma proteins Cancer-related genes Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	1058 aa 117.8 kDa	No	1
UBA1-202		Q5JRR6	Metabolic proteins Predicted membrane proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	506 aa 56.9 kDa	No	1
UBA1-203	P22314	A0A024R1A3	Enzymes Metabolic proteins Predicted membrane proteins Plasma proteins Cancer-related genes Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	1058 aa 117.8 kDa	No	1
UBA1-204		Q5JRR9	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	270 aa 29.2 kDa	No	0
UBA1-205		Q5JRS1	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	173 aa 18.6 kDa	No	0
UBA1-206		Q5JRS0	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	284 aa 30.8 kDa	No	0
UBA1-207		Q5JRS2	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	234 aa 25.1 kDa	No	0
UBA1-208		Q5JRS3	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	195 aa 20.7 kDa	No	0
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