Protein interactions - LARS1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LARS1
Synonyms	FLJ10595, FLJ21788, HSPC192, LARS, LEUS, RNTLS
Gene descriptionⁱ Full gene name according to HGNC.	Leucyl-tRNA synthetase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Essential proteins Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - RNA processing (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Basic cellular processes (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nuclear bodies, Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	5
Cytoband	q32
Chromosome location (bp)	146110566 - 146182696
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11
Ensembl	ENSG00000133706 (version 109)
Entrez gene	51520
HGNC	HGNC:6512
UniProt	Q9P2J5
GeneCards	LARS1

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Basic cellular processes

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
AIMP1	3	2	26	11	3
AIMP2	9	33	60	0	2
DARS1	4	3	28	13	3
EEF1E1	3	2	12	3	3
EPRS1	6	7	47	9	4
IARS1	6	1	37	17	8
MARS1	4	1	24	16	4
QARS1	12	53	29	0	10
RARS1	3	4	20	9	0

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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
RARS1	3	4	20	9	0
RRAGD	6	3	10	0	4

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
AIMP1	3	2	26	11	3
AIMP2	9	33	60	0	2
ATP5ME	2	4	11	0	5
CCT8	18	8	72	25	20
CDC42	30	33	160	15	1
CUL3	40	45	771	2	0
DARS1	4	3	28	13	3
EEF1E1	3	2	12	3	3
EEF1G	10	9	49	11	9
EPRS1	6	7	47	9	4
GARS1	0	4	31	0	0
HSPA8	65	45	457	29	101
HSPD1	20	38	139	11	45
IARS1	6	1	37	17	8
KARS1	3	4	31	8	0
MAD2L2	7	32	145	0	2
MARS1	4	1	24	16	4
PRKN	11	11	1405	0	0
QARS1	12	53	29	0	10
RARS1	3	4	20	9	0
STAU1	32	13	371	39	0
UBA1	5	9	66	15	0
VARS1	4	3	21	0	7
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Predicted location

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ATG13	8	9	18	137	0
CAPRIN1	16	3	49	135	0
CAPZB	100	6	133	666	0
EMC9	5	2	6	128	4
NCAPH	7	4	21	131	2
PSPC1	20	5	33	270	0
RPS16	102	5	139	295	47

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Subcell location

Predicted location

Cell type specificity

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
AIMP1	3	2	26	11	3
AIMP2	9	33	60	0	2
DARS1	4	3	28	13	3
EEF1E1	3	2	12	3	3
EPRS1	6	7	47	9	4
IARS1	6	1	37	17	8
MARS1	4	1	24	16	4
QARS1	12	53	29	0	10

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene LARS1 is associated with 1 reactions in 1 different subsystems, and present in the compartments: Cytosol. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Aminoacyl-tRNA biosynthesis	Cytosol	21	66	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LARS1-201	Q9P2J5		Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	485 aa 55.3 kDa	No	0
LARS1-202	Q9P2J5		Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	1176 aa 134.5 kDa	No	0
LARS1-209	Q9P2J5		Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	1122 aa 128 kDa	No	0
LARS1-213		A0A6I8PS05	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	1049 aa 119.8 kDa	No	0
LARS1-215	Q9P2J5		Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	1122 aa 128 kDa	No	0
LARS1-217		A0A6I8PLB3	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	1024 aa 117.1 kDa	No	0
LARS1-219		A0A6I8PL42	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	1130 aa 129.2 kDa	No	0
LARS1-220		A0A6I8PRS0	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	1121 aa 127.9 kDa	No	0
LARS1-221		A0A6I8PIT3	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	1164 aa 133.1 kDa	No	0
LARS1-225		A0A6I8PIV1	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	1175 aa 134.3 kDa	No	0
LARS1-228		B4DER1	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	1149 aa 131.5 kDa	No	0
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