Protein interactions - QARS1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	QARS1
Synonyms	QARS
Gene descriptionⁱ Full gene name according to HGNC.	Glutaminyl-tRNA synthetase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Essential proteins Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Intestinal epithelial cells - Intestinal epi homeostasis & respiration (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Cytotrophoblasts, Early spermatids, Esophageal apical cells, Late spermatids)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Basic cellular processes (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	49095932 - 49105130
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	15
Ensembl	ENSG00000172053 (version 109)
Entrez gene	5859
HGNC	HGNC:9751
UniProt	P47897
GeneCards	QARS1

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Basic cellular processes

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
AIMP1	3	2	26	11	3
AIMP2	9	33	60	0	2
CALCOCO2	21	118	59	0	5
DARS1	4	3	28	13	3
EEF1E1	3	2	12	3	3
EPRS1	6	7	47	9	4
IARS1	6	1	37	17	8
LARS1	9	2	23	7	8
MARS1	4	1	24	16	4
RNF11	17	154	28	0	1
TRAF2	53	240	125	2	0
ZRANB1	35	112	197	0	1
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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ACTN2	10	66	19	9	1
B9D2	5	10	5	0	7
BIRC7	6	25	8	0	6
CALCOCO2	21	118	59	0	5
COG6	2	49	11	0	0
DNM2	9	27	21	8	0
EDC3	13	13	22	12	15
EFHC2	3	79	3	0	0
ESS2	3	11	9	1	5
FAM161A	3	118	4	0	0
FAM83A	0	23	0	0	0
GPBP1	1	11	2	1	0
GRN	3	218	12	0	0
GSTZ1	0	6	1	0	0
HES7	0	4	0	0	0
HMG20A	11	53	27	11	7
HSPB1	30	139	105	3	4
HTT	36	666	56	0	0
IK	11	21	18	7	4
KLC3	7	32	10	5	0
LGALS9B	1	7	1	0	0
LGALS9C	0	23	0	0	5
LNX1	12	334	34	0	0
LZTS1	1	73	3	2	0
LZTS2	21	178	46	4	7
MCCD1	0	21	0	0	0
MESD	0	52	2	0	10
NAB2	1	62	2	0	18
NEBL	1	29	3	0	0
NFKBID	0	83	0	0	0
PICK1	10	276	36	0	9
PRDM6	0	48	1	0	0
PTPN21	2	17	16	3	1
RNF11	17	154	28	0	1
SF3B4	29	40	49	28	7
SHLD1	1	6	3	0	0
SORBS3	4	88	7	0	0
SP7	1	7	5	0	0
SPDYE4	3	12	9	0	0
SPRED2	2	38	6	0	8
TCF12	10	31	28	0	0
TGM7	0	15	0	0	0
TLE5	9	107	28	0	8
TRAF2	53	240	125	2	0
TRAF4	11	74	34	0	0
TRIM27	20	235	63	0	0
TRIP13	11	72	19	0	6
USHBP1	8	162	12	0	0
VPS37B	6	22	9	8	2
WFS1	0	316	2	2	20
XIAP	27	42	84	2	8
ZMYND12	0	66	0	0	0
ZRANB1	35	112	197	0	1
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Predicted location

Cell type specificity

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ACE2	10	13	278	0	0
AIMP1	3	2	26	11	3
AIMP2	9	33	60	0	2
ANLN	1	0	568	2	0
CALCOCO2	21	118	59	0	5
CAPZB	100	6	133	666	0
CCNF	4	4	624	0	1
CFTR	34	103	236	0	0
CTSL	1	2	40	0	7
CUL3	40	45	771	2	0
DARS1	4	3	28	13	3
EEF1E1	3	2	12	3	3
EPRS1	6	7	47	9	4
GARS1	0	4	31	0	0
GSK3B	27	30	186	8	0
HSPA8	65	45	457	29	101
IARS1	6	1	37	17	8
KARS1	3	4	31	8	0
LARS1	9	2	23	7	8
MAPRE1	54	37	93	198	4
MARS1	4	1	24	16	4
MYC	66	90	1269	2	0
PRKN	11	11	1405	0	0
RARS1	3	4	20	9	0
RNF11	17	154	28	0	1
STAU1	32	13	371	39	0
TOP3B	3	10	95	5	0
TRAF2	53	240	125	2	0
ZRANB1	35	112	197	0	1
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Subcell location

Predicted location

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
AIMP1	3	2	26	11	3
AIMP2	9	33	60	0	2
COMTD1	1	0	4	0	105
DARS1	4	3	28	13	3
EEF1E1	3	2	12	3	3
EPRS1	6	7	47	9	4
IARS1	6	1	37	17	8
LARS1	9	2	23	7	8
MARS1	4	1	24	16	4
PDCL	10	5	13	9	20

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene QARS1 is associated with 1 reactions in 1 different subsystems, and present in the compartments: Cytosol. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Aminoacyl-tRNA biosynthesis	Cytosol	21	66	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
QARS1-201	P47897		Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	775 aa 87.8 kDa	No	0
QARS1-202	P47897		Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	764 aa 86.6 kDa	No	0
QARS1-206		C9J165	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	339 aa 38.1 kDa	No	0
QARS1-207		H7C0R3	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	253 aa 28.6 kDa	No	0
QARS1-209		B4DDN1	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	630 aa 71.7 kDa	No	0
QARS1-210		A0A0U1RRC8	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	91 aa 10.1 kDa	No	0
QARS1-228		A0A0U1RQQ5	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	194 aa 22.6 kDa	No	0
QARS1-230		A0A0U1RQJ6	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	96 aa 10.9 kDa	No	0
QARS1-231		A0A0U1RQM8	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	173 aa 19.1 kDa	No	0
QARS1-237		A0A0U1RQE9	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	187 aa 20.8 kDa	No	0
QARS1-238		A0A0U1RRI9	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	182 aa 20.3 kDa	No	0
QARS1-240		A0A0U1RQL2	Metabolic proteins Predicted membrane proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	191 aa 21.4 kDa	No	1
QARS1-242		A0A0U1RQT0	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	342 aa 38.5 kDa	No	0
QARS1-245		A0A0U1RR66	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	173 aa 19.5 kDa	No	0
QARS1-246		A0A0U1RRJ7	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	68 aa 7.7 kDa	No	0
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