Protein interactions - PDIA3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PDIA3
Synonyms	ERp57, ERp60, ERp61, GRP57, GRP58, HsT17083, P58, PI-PLC
Gene descriptionⁱ Full gene name according to HGNC.	Protein disulfide isomerase family A member 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Secretory pathway (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Epididymal principal cells, Extravillous trophoblasts, Syncytiotrophoblasts)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Epididymis - Mixed function (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (Thyroid gland)
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Endoplasmic reticulum
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	15
Cytoband	q15.3
Chromosome location (bp)	43746394 - 43773279
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10
Ensembl	ENSG00000167004 (version 109)
Entrez gene	2923
HGNC	HGNC:4606
UniProt	P30101
GeneCards	PDIA3

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Epididymis - Mixed function

Field

Cluster

Cell type

Category

Cluster

Pathway

Consensus

IntAct

BioGrid

OpenCell

BioPlex

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Interaction:

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Antibodies

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
APP	44	313	141	1	0
CALR	7	64	44	3	7
CANX	130	8	242	381	24
CFTR	34	103	236	0	0
CLU	4	9	35	2	0
ERO1A	2	6	10	0	0
TAP1	5	17	9	0	24

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Predicted location

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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
APP	44	313	141	1	0
CALR	7	64	44	3	7
CFTR	34	103	236	0	0
CLU	4	9	35	2	0
COL1A1	1	23	7	0	13
ERO1A	2	6	10	0	0
STIM1	6	21	29	4	13
TAP1	5	17	9	0	24

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Subcell location

Predicted location

Cell type specificity

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ACE2	10	13	278	0	0
AGR2	3	64	227	0	2
ANXA5	0	5	12	1	1
APP	44	313	141	1	0
ATG16L1	7	9	90	0	0
BAG1	6	8	37	0	0
CALR	7	64	44	3	7
CALR3	1	0	50	0	6
CANX	130	8	242	381	24
CCNF	4	4	624	0	1
CDC25A	6	7	29	2	0
CFTR	34	103	236	0	0
CLU	4	9	35	2	0
CNDP2	0	1	6	2	1
COX4I1	2	5	105	2	1
CTSB	3	5	65	0	1
CTSS	0	0	75	0	0
DPP4	0	6	137	0	0
EFEMP1	2	27	13	0	0
EFTUD2	54	15	181	46	30
ERO1A	2	6	10	0	0
FLNA	7	18	86	6	0
H3C15	2	28	41	0	1
HMGB1	14	21	61	0	1
HMGB2	10	11	24	66	0
HSPA1A	1	7	318	0	0
HSPA5	38	32	268	25	86
HSPA8	65	45	457	29	101
HSPD1	20	38	139	11	45
KNL1	5	4	17	4	0
LGALS9	7	0	24	0	33
LOXL2	1	4	7	0	29
MARCKS	0	0	21	0	0
MTOR	21	21	78	13	17
MYC	66	90	1269	2	0
NAA50	2	5	5	0	0
PDIA4	4	8	60	2	14
PGM1	0	1	12	2	0
PLD3	0	3	23	0	0
PPIB	1	17	26	1	0
PPP1R3D	1	3	4	1	3
PRKN	11	11	1405	0	0
PTPRO	0	1	34	0	0
RICTOR	11	6	76	9	0
SOD1	5	51	62	0	1
STAT3	25	59	107	0	0
TAP1	5	17	9	0	24
TAPBP	1	2	3	0	0
VCP	57	56	348	43	5
ZGRF1	0	3	2	1	0
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Highlight:

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Subcell location

Predicted location

Cell type specificity

Protein class

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CANX	130	8	242	381	24

Highlight:

Off

Subcell location

Predicted location

Cell type specificity

Protein class

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CD1B	0	1	0	0	20
IDS	0	1	0	0	60

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene PDIA3 is associated with 1 reactions in 1 different subsystems, and present in the compartments: Cytosol. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Isolated	Cytosol, Mitochondria, Peroxisome, Endoplasmic reticulum, Extracellular, Nucleus, Golgi apparatus	524	320	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDIA3-201	P30101	V9HVY3	Enzymes Metabolic proteins Transporters Predicted intracellular proteins Plasma proteins Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	505 aa 56.8 kDa	Yes	0
PDIA3-207		A0A8I5KS72	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	477 aa 53.6 kDa	Yes	0
PDIA3-210		A0A8I5KPY2	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	416 aa 46.6 kDa	Yes	0
PDIA3-212		A0A8I5KNU9	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	462 aa 51.8 kDa	Yes	0
PDIA3-215		A0A8I5KTA1	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	116 aa 13.2 kDa	No	0
PDIA3-222		A0A8I5QJM1	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	159 aa 17.1 kDa	Yes	0
PDIA3-223		A0A8I5QKQ5	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	456 aa 51 kDa	Yes	0
PDIA3-224		A0A8I5KT88	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	512 aa 57.7 kDa	Yes	0
PDIA3-229		A0A8I5KW00	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	453 aa 50.6 kDa	Yes	0
PDIA3-230		A0A8I5KW33	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	487 aa 54.6 kDa	Yes	0
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