Protein interactions - CTSS - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CTSS
Synonyms
Gene descriptionⁱ Full gene name according to HGNC.	Cathepsin S
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Monocytes & Neutrophils - Inflammatory signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (cDC, Colonocytes, Hofbauer cells, Kupffer cells, Macrophages, Monocyte progenitors, monocytes, Neutrophil progenitors, Neutrophils)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Lymphoid tissue - Immune response (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (Bone marrow, Lymphoid tissue)
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Vesicles
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	1
Cytoband	q21.3
Chromosome location (bp)	150730079 - 150765957
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9
Ensembl	ENSG00000163131 (version 109)
Entrez gene	1520
HGNC	HGNC:2545
UniProt	P25774
GeneCards	CTSS

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

Filter menu »

e.g. Brain enriched, Localized to mitochondria, Lymphoid tissue - Immune response

Field

Cluster

Cell type

Category

Cluster

Pathway

Consensus

IntAct

BioGrid

OpenCell

BioPlex

Highlight:

Off

Subcell location

Predicted location

Cell type specificity

Protein class

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ACTN1	8	26	56	7	0
ACTN4	10	14	45	18	1
AIF1L	0	0	13	6	0
BAG2	17	15	52	7	69
BAG5	5	13	34	2	0
CALR	7	64	44	3	7
CALU	1	0	22	2	0
CKAP4	9	2	65	12	25
CNPY2	1	2	3	0	3
CNPY3	0	10	3	1	24
COLGALT1	1	1	8	2	4
CPD	1	0	23	1	4
DDOST	26	6	54	108	0
DNAJB11	10	7	53	5	10
DNAJC10	0	0	20	1	0
DNAJC3	0	0	19	0	15
EMC1	12	1	30	15	0
ERLIN2	8	5	44	10	3
ERO1A	2	6	10	0	0
ERP29	0	16	7	2	1
FKBP10	0	2	3	1	4
GANAB	1	0	22	4	0
GXYLT1	0	0	3	0	0
HLA-A	2	4	46	0	3
HSD17B12	1	5	21	8	4
HSP90B1	8	5	79	16	7
HYOU1	2	2	42	1	7
IKBIP	1	8	6	4	0
IPO4	5	7	32	3	0
LMAN1	3	4	33	5	4
LRPAP1	6	7	11	2	11
MANF	0	2	4	1	11
MESD	0	52	2	0	10
MINPP1	0	1	1	0	4
MYO1B	3	2	26	13	0
MYO6	12	6	57	15	0
NUCB2	2	2	9	0	0
NUP210	1	2	11	10	1
OS9	6	6	31	2	0
P4HA1	1	2	27	21	0
PDIA3	7	8	50	1	2
PDIA4	4	8	60	2	14
PFKL	1	4	24	0	0
PHB1	2	7	130	1	0
PLD3	0	3	23	0	0
PLOD1	2	1	10	3	10
PLOD3	5	12	10	1	13
POFUT1	0	0	3	0	0
PON2	1	1	7	2	0
PRDX4	3	6	19	3	0
PRKDC	11	13	143	17	1
RALY	8	6	51	16	0
RBM11	3	26	6	0	8
RCN1	0	19	13	9	0
RPN1	33	10	135	65	3
RPN2	33	3	99	60	2
SDF2L1	5	3	15	3	122
SEC61A1	7	3	33	20	0
SEL1L	5	5	23	1	16
SELENOF	1	1	2	4	0
SERPINH1	0	27	23	4	0
SLC25A11	0	8	20	0	2
STT3A	6	8	19	7	0
STT3B	15	5	28	54	3
TMED10	17	8	25	101	20
TOR1AIP1	2	7	22	0	8
TP53	123	166	704	5	0
TPM4	1	3	21	0	0
TTC17	0	0	1	0	30
UBR4	0	1	30	0	0
UGGT1	0	0	12	2	0
UGGT2	1	2	5	1	10
WDR1	2	2	25	5	0
XPO5	2	3	13	0	25
YARS1	0	11	8	0	0
Show allShow less

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene CTSS is associated with 15 reactions in 1 different subsystems, and present in the compartments: Lysosome. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Protein degradation	Cytosol, Lysosome, Mitochondria	20	49	15

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CTSS-201	P25774		Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	331 aa 37.5 kDa	Yes	0
CTSS-202		A0A804DAZ0	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	255 aa 29.5 kDa	Yes	0
CTSS-207		A0A7P0T8H4	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	309 aa 35 kDa	Yes	0
CTSS-208		A0A7P0T7Z6	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	220 aa 25 kDa	Yes	0
CTSS-209		A0A7P0T904	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	240 aa 26.7 kDa	Yes	0
CTSS-210	P25774		Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	281 aa 31.6 kDa	Yes	0
CTSS-211		A0A7P0T8A1	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	215 aa 24.5 kDa	Yes	0
CTSS-214		A0A7P0TAQ0	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	272 aa 30.4 kDa	No	0
CTSS-218		A0A7P0T8U1	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	267 aa 30.3 kDa	Yes	0
Show allShow less