Protein interactions - ACAA2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ACAA2
Synonyms	DSAEC
Gene descriptionⁱ Full gene name according to HGNC.	Acetyl-CoA acyltransferase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Colonocytes & Enterocytes - Gastrointestinal absorption & barrier (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Cholangiocytes, Colonocytes, Enteric transient amplifying cells, Enterocytes, Hepatocytes, Late spermatids)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Liver & Kidney - Metabolism (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (Liver)
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Mitochondria In addition localized to the Basal body, Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	18
Cytoband	q21.1
Chromosome location (bp)	49782164 - 49813953
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6
Ensembl	ENSG00000167315 (version 109)
Entrez gene	10449
HGNC	HGNC:83
UniProt	P42765
GeneCards	ACAA2

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Liver & Kidney - Metabolism

Field

Cluster

Cell type

Category

Cluster

Pathway

Consensus

IntAct

BioGrid

OpenCell

BioPlex

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Subcell location

Predicted location

Cell type specificity

Protein class

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Interaction:

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Confidence

Antibodies

Interactor

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
TRMT61B	3	4	28	0	6

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Subcell location

Predicted location

Cell type specificity

Protein class

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ACAT1	0	0	12	1	2
AK2	0	7	7	2	0
CFL1	7	14	44	6	4
CLPP	2	19	211	0	5
PAFAH1B1	16	17	30	20	2
PGD	0	0	7	0	0
PRKN	11	11	1405	0	0
TRMT61B	3	4	28	0	6
UCHL3	1	2	19	0	0
UQCRFS1	2	1	21	0	34

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CLIP1	7	2	13	48	0

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Predicted location

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
AARS2	2	1	26	0	6
ACAD10	0	0	2	0	24
ACSF2	0	17	0	0	27
ACSF3	1	6	3	0	19
BCKDHA	2	2	10	0	18
CYP24A1	0	0	0	0	35
DARS2	2	13	9	1	29
DBT	2	6	12	0	21
ERCC3	12	15	24	3	38
HARS2	3	1	9	0	49
LARS2	2	0	5	0	27
MCCC1	2	2	5	0	25
MGME1	0	2	2	0	30
MVK	0	3	1	1	6
NARS2	0	0	3	0	13
PCP4	0	2	0	0	25
PINK1	16	16	64	0	99
POLG	2	1	8	0	17
PPOX	0	0	1	0	26
SARAF	0	2	3	0	102
TMEM70	0	2	2	0	12
TMLHE	0	0	1	0	28
TRMT61B	3	4	28	0	6
YARS2	8	2	10	2	86
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene ACAA2 is associated with 99 reactions in 14 different subsystems, and present in the compartments: Cytosol, Mitochondria. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Fatty acid oxidation	Cytosol, Endoplasmic reticulum, Peroxisome, Mitochondria, Extracellular	70	358	12
Beta oxidation of unsaturated fatty acids (n-9) (mitochondrial)	Mitochondria	12	30	5
Beta oxidation of odd-chain fatty acids (mitochondrial)	Mitochondria	11	47	9
Beta oxidation of even-chain fatty acids (mitochondrial)	Mitochondria	14	66	30
Arachidonic acid metabolism	Cytosol, Peroxisome, Endoplasmic reticulum, Extracellular, Nucleus, Mitochondria, Golgi apparatus	107	88	6
Beta oxidation of di-unsaturated fatty acids (n-6) (mitochondrial)	Mitochondria	13	28	4
Vitamin E metabolism	Mitochondria, Cytosol, Endoplasmic reticulum	55	68	13
Omega-6 fatty acid metabolism	Cytosol, Mitochondria, Peroxisome	38	56	1
Valine, leucine, and isoleucine metabolism	Mitochondria, Cytosol, Peroxisome	68	71	1
Beta oxidation of poly-unsaturated fatty acids (mitochondrial)	Mitochondria	8	34	6
Leukotriene metabolism	Peroxisome, Mitochondria, Cytosol, Endoplasmic reticulum, Nucleus, Extracellular	199	105	4
Beta oxidation of unsaturated fatty acids (n-7) (mitochondrial)	Mitochondria	12	26	4
Beta oxidation of branched-chain fatty acids (mitochondrial)	Mitochondria	9	23	3
Transport reactions	Cytosol, Extracellular, Lysosome, Peroxisome, Mitochondria, Golgi apparatus, Endoplasmic reticulum, Nucleus, Inner mitochondria	563	1599	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACAA2-201	P42765		Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	397 aa 41.9 kDa	No	0
ACAA2-202		K7EJB1	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	84 aa 8.9 kDa	No	0
ACAA2-203		K7ER88	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	72 aa 7.6 kDa	No	0
ACAA2-204		K7EJ68	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	124 aa 13.5 kDa	No	0
ACAA2-205		A0A0B4J2A4	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	394 aa 41.6 kDa	No	0
ACAA2-206		K7EME0	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	342 aa 36.3 kDa	No	0
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