Protein interactions - PAFAH1B1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PAFAH1B1
Synonyms	LIS1, MDCR, MDS, NudF, PAFAH
Gene descriptionⁱ Full gene name according to HGNC.	Platelet activating factor acetylhydrolase 1b regulatory subunit 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Essential proteins Human disease related genes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Elongating spermatids - Sperm cell metabolism & fertilization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Late spermatids, Neutrophils)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Basic cellular processes (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Centrosome In addition localized to the Mid piece
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	17
Cytoband	p13.3
Chromosome location (bp)	2593210 - 2685615
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11
Ensembl	ENSG00000007168 (version 109)
Entrez gene	5048
HGNC	HGNC:8574
UniProt	P43034
GeneCards	PAFAH1B1

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Basic cellular processes

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CLIP1	7	2	13	48	0
DCTN1	21	15	110	22	0
DISC1	31	105	42	0	0
DYNC1H1	17	37	61	33	1
DYNC1I2	15	6	43	13	0
DYNC1LI1	16	4	28	34	9
DYNLL1	104	60	142	117	7
HSP90AA1	51	57	369	23	0
MAPRE1	54	37	93	198	4
NDE1	3	5	8	0	0
NDEL1	17	63	28	3	0
NUDCD3	8	16	19	1	15
PAFAH1B2	2	3	4	0	2
PAFAH1B3	3	8	4	0	2
YWHAG	254	271	433	222	13
YWHAH	130	36	395	144	6
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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
DCTN1	21	15	110	22	0
DISC1	31	105	42	0	0
DYNC1H1	17	37	61	33	1
DYNC1I2	15	6	43	13	0
DYNC1LI1	16	4	28	34	9
DYNLRB2	0	7	0	0	0
DYNLT1	11	36	29	16	3
DYNLT3	4	8	7	4	1
GID8	12	17	17	4	33
HSP90AA1	51	57	369	23	0
MAPRE1	54	37	93	198	4
NDE1	3	5	8	0	0
NDEL1	17	63	28	3	0
NUDCD2	3	8	8	3	0
NUDCD3	8	16	19	1	15
PAFAH1B2	2	3	4	0	2
PAFAH1B3	3	8	4	0	2
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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ACAA2	1	0	10	1	24
ASNS	0	2	11	1	0
CCSER2	1	2	11	0	0
CLIP1	7	2	13	48	0
CUL4A	7	10	138	0	0
CUL4B	6	11	169	4	0
DCTN1	21	15	110	22	0
DCX	1	14	6	0	0
DDB1	39	22	173	64	9
DISC1	31	105	42	0	0
DYNC1H1	17	37	61	33	1
DYNC1I1	4	4	17	1	0
DYNC1I2	15	6	43	13	0
DYNC1LI1	16	4	28	34	9
DYNLL1	104	60	142	117	7
HSP90AA1	51	57	369	23	0
KATNA1	2	2	9	1	4
KATNB1	5	3	11	0	6
MAPRE1	54	37	93	198	4
NDE1	3	5	8	0	0
NDEL1	17	63	28	3	0
NUDC	6	14	32	4	4
NUDCD3	8	16	19	1	15
PAFAH1B2	2	3	4	0	2
PAFAH1B3	3	8	4	0	2
PDE4D	1	6	12	0	0
PRKN	11	11	1405	0	0
RACK1	56	99	144	208	1
YWHAG	254	271	433	222	13
YWHAH	130	36	395	144	6
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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ACTB	77	27	195	111	34
ACTG1	30	15	75	116	0
CAPZB	100	6	133	666	0
CLASP1	11	5	17	33	0
CLASP2	10	4	19	23	0
CLIP1	7	2	13	48	0
DYNC1H1	17	37	61	33	1
DYNC1I2	15	6	43	13	0
DYNC1LI1	16	4	28	34	9
DYNC1LI2	6	1	17	8	2
DYNLL1	104	60	142	117	7
DYNLL2	83	51	99	102	3
MAPRE1	54	37	93	198	4
SAR1B	3	3	3	126	11
TUBB4B	14	1	52	93	13
YWHAB	183	93	337	245	0
YWHAE	235	123	383	324	12
YWHAG	254	271	433	222	13
YWHAH	130	36	395	144	6
YWHAZ	222	164	348	324	8
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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
PAFAH1B2	2	3	4	0	2
PAFAH1B3	3	8	4	0	2

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene PAFAH1B1 is associated with 2 reactions in 1 different subsystems, and present in the compartments: Cytosol. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Glycerophospholipid metabolism	Cytosol, Nucleus, Extracellular, Peroxisome, Mitochondria, Endoplasmic reticulum, Golgi apparatus	106	96	2

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PAFAH1B1-202	P43034		Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes Human disease related genes Mapped to neXtProt Essential proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	410 aa 46.6 kDa	No	0
PAFAH1B1-208		I3L3N5	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	208 aa 23.7 kDa	No	0
PAFAH1B1-211		I3L495	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	82 aa 9.6 kDa	No	0
PAFAH1B1-214		A0A6Q8PFU3	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	428 aa 48.8 kDa	No	0
PAFAH1B1-215		A0A6Q8PFT2	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	345 aa 38.9 kDa	No	0
PAFAH1B1-217	P43034		Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes Human disease related genes Mapped to neXtProt Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	410 aa 46.6 kDa	No	0
PAFAH1B1-218	P43034		Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes Human disease related genes Mapped to neXtProt Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	410 aa 46.6 kDa	No	0
PAFAH1B1-220	P43034		Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes Human disease related genes Mapped to neXtProt Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	410 aa 46.6 kDa	No	0
PAFAH1B1-226	P43034		Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes Human disease related genes Mapped to neXtProt Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	410 aa 46.6 kDa	No	0
PAFAH1B1-227	P43034		Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes Human disease related genes Mapped to neXtProt Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	410 aa 46.6 kDa	No	0
PAFAH1B1-229		A0A6Q8PFT2	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	345 aa 38.9 kDa	No	0
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