Brain tissue expression of EIF1 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	415.3	nTPM
FANTOM5:	1090.9	Scaled Tags Per Million

Macaque:	59.4	nTPM
Pig:	342.6	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - Annotated protein expression
Pending normal tissue analysis

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	415.3

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 378.6

2301	Female, age 85, both hemispheres	442.1
2188	Female, age 91, both hemispheres	387.8
2090	Male, age 80, both hemispheres	366.5
1984	Male, age 76, both hemispheres	317.9

Dorsal cochlear nucleus
nTPM: 379.8

2802	Male, age 74, right hemisphere	433.6
2187	Female, age 91, both hemispheres	413.8
2370	Male, age 61, both hemispheres	382.9
2058	Male, age 76, both hemispheres	344.8
2378	Male, age 80, both hemispheres	324.1

Dorsal tegmental nucleus
nTPM: 355.1

2083	Male, age 80, both hemispheres	432.6
2326	Male, age 74, both hemispheres	370.8
2358	Male, age 61, both hemispheres	340.7
1936	Male, age 76, left hemisphere	276.4

Dorsolateral tegmental area
nTPM: 363.5

2654	Male, age 80, both hemispheres	428.8
2337	Male, age 61, both hemispheres	417.8
2751	Female, age 85, both hemispheres	390.4
2141	Male, age 76, both hemispheres	310.9
2360	Male, age 74, both hemispheres	269.4

Kolliker-Fuse nucleus
nTPM: 415.3

2315	Male, age 76, right hemisphere	463.4
2793	Female, age 91, left hemisphere	421.4
2163	Male, age 80, both hemispheres	361.0

Lateral lemniscal nuclei
nTPM: 341.2

2320	Female, age 91, left hemisphere	361.8
2036	Male, age 80, both hemispheres	358.3
2746	Female, age 85, left hemisphere	356.3
2169	Male, age 76, both hemispheres	343.5
2453	Male, age 74, right hemisphere	286.1

Lateral parabrachial nucleus
nTPM: 400.5

2792	Male, age 76, both hemispheres	529.7
2013	Male, age 80, both hemispheres	376.1
2790	Male, age 61, both hemispheres	352.1
2139	Female, age 85, right hemisphere	344.1

Lateral vestibular nucleus
nTPM: 366.7

2311	Male, age 80, both hemispheres	417.9
2184	Male, age 76, both hemispheres	315.5

Locus coeruleus
nTPM: 308.0

2123	Female, age 91, both hemispheres	353.6
2317	Female, age 72, unknown	342.8
2162	Male, age 80, both hemispheres	314.9
2720	Male, age 74, both hemispheres	307.0
2014	Male, age 55, unknown	301.8
1980	Male, age 76, both hemispheres	272.0
2788	Male, age 74, unknown	264.1

Medial parabrachial nucleus
nTPM: 381.5

2170	Female, age 91, both hemispheres	482.6
2854	Male, age 80, both hemispheres	427.9
2463	Female, age 85, right hemisphere	341.4
2156	Male, age 61, both hemispheres	340.3
2786	Male, age 76, both hemispheres	315.3

Medial periolivary nuclei
nTPM: 327.6

2081	Male, age 80, both hemispheres	341.0
2063	Male, age 76, both hemispheres	336.5
2171	Female, age 85, both hemispheres	326.1
2791	Male, age 74, right hemisphere	322.9
2458	Female, age 91, both hemispheres	311.5

Motor facial nucleus
nTPM: 346.5

2697	Female, age 85, both hemispheres	370.8
2365	Male, age 74, right hemisphere	356.2
2126	Male, age 61, both hemispheres	352.3
2327	Male, age 80, both hemispheres	345.2
2795	Female, age 91, both hemispheres	332.9
2062	Male, age 76, both hemispheres	321.7

Motor trigeminal nucleus
nTPM: 347.4

2335	Male, age 61, both hemispheres	378.4
2560	Male, age 74, both hemispheres	347.1
2321	Female, age 91, both hemispheres	342.8
2079	Male, age 80, both hemispheres	336.1
2309	Male, age 76, both hemispheres	332.5

Nuclei of the trapezoid body
nTPM: 313.6

2159	Male, age 61, both hemispheres	344.5
1983	Male, age 76, both hemispheres	344.4
2166	Male, age 80, both hemispheres	305.0
2368	Female, age 91, both hemispheres	288.6
2735	Female, age 85, both hemispheres	285.6

Nucleus raphe magnus
nTPM: 349.3

2160	Male, age 61, both hemispheres	381.3
2455	Male, age 74, both hemispheres	365.4
2328	Male, age 80, both hemispheres	349.3
2051	Male, age 76, both hemispheres	349.2
2459	Female, age 91, both hemispheres	327.8
2172	Female, age 85, both hemispheres	322.7

Paramedian reticular nucleus
nTPM: 347.7

2050	Female, age 85, both hemispheres	406.4
2057	Male, age 80, both hemispheres	341.8
2313	Male, age 61, both hemispheres	340.9
2052	Male, age 76, both hemispheres	301.5

Pedunculopontine tegmental nucleus
nTPM: 334.7

2334	Male, age 80, both hemispheres	401.1
2338	Male, age 61, both hemispheres	313.6
1921	Female, age 85, both hemispheres	289.4

Pontine nuclei
nTPM: 368.6

2787	Female, age 85, both hemispheres	430.1
2319	Female, age 91, both hemispheres	401.5
1863	Male, age 55, unknown	385.1
2454	Male, age 74, left hemisphere	382.8
2109	Female, age 72, unknown	364.4
2115	Male, age 80, left hemisphere	334.8
2727	Male, age 61, right hemisphere	333.2
1968	Male, age 76, left hemisphere	317.1

Pontine raphe nucleus
nTPM: 358.5

2122	Female, age 85, midline	368.6
2853	Male, age 76, midline	348.3

Posteroventral cochlear nucleus
nTPM: 380.0

2341	Male, age 80, both hemispheres	417.5
2371	Male, age 61, both hemispheres	402.2
2135	Female, age 91, both hemispheres	393.0
2070	Male, age 76, both hemispheres	388.6
2752	Female, age 85, both hemispheres	298.6

Principal sensory trigeminal nucleus
nTPM: 353.0

2367	Female, age 91, left hemisphere	396.4
2324	Male, age 76, both hemispheres	368.3
2158	Male, age 61, both hemispheres	356.7
2008	Male, age 80, left hemisphere	290.6

Reticular pontine nucleus, caudal
nTPM: 356.3

2092	Male, age 76, both hemispheres	377.8
2559	Male, age 74, both hemispheres	362.7
2332	Male, age 80, right hemisphere	362.2
2457	Female, age 91, both hemispheres	322.6

Reticular pontine nucleus, oral
nTPM: 358.2

1939	Male, age 80, both hemispheres	385.1
2012	Female, age 85, both hemispheres	376.0
2167	Male, age 76, both hemispheres	345.0
2366	Female, age 91, both hemispheres	343.1
2361	Male, age 74, both hemispheres	341.7

Reticulotegmental nucleus
nTPM: 366.9

2322	Female, age 91, both hemispheres	415.7
2333	Male, age 80, both hemispheres	383.9
2452	Male, age 74, both hemispheres	358.3
2325	Male, age 76, both hemispheres	309.9

Spinal trigeminal nucleus, oral
nTPM: 320.1

2164	Male, age 80, both hemispheres	386.0
1978	Male, age 76, both hemispheres	292.1
2737	Female, age 85, both hemispheres	282.1

Subcoeruleus area
nTPM: 357.6

2369	Female, age 85, left hemisphere	437.4
2323	Female, age 91, left hemisphere	377.6
1958	Male, age 80, both hemispheres	366.9
2451	Male, age 74, both hemispheres	323.7
2089	Male, age 76, left hemisphere	282.7

Superior olive
nTPM: 351.3

2329	Male, age 80, right hemisphere	365.7
2364	Male, age 74, right hemisphere	359.3
1875	Female, age 85, both hemispheres	352.2
2020	Male, age 76, both hemispheres	345.0
2561	Female, age 91, both hemispheres	334.2

Ventral periolivary nuclei
nTPM: 327.0

2023	Male, age 76, both hemispheres	366.0
2165	Male, age 80, both hemispheres	337.8
2130	Female, age 85, both hemispheres	318.4
2794	Female, age 91, left hemisphere	285.7

Ventrolateral tegmental area, A5 NE cell group
nTPM: 338.3

2840	Female, age 85, both hemispheres	386.7
2161	Male, age 80, both hemispheres	349.2
2449	Male, age 74, both hemispheres	341.6
2359	Male, age 61, both hemispheres	339.3
2456	Female, age 91, both hemispheres	309.4
1959	Male, age 76, both hemispheres	303.8

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	1090.9

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 1090.9

FF:10165-103B3	76 years, female	1191.9
FF:10182-103D2	60 years, female	990.0

Pons
Scaled Tags Per Million: 629.8

FF:10033-101E6

18-54 years, mixed

629.8

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	59.4

Macaque sample

Sample description

nTPM

Pons
nTPM: 59.4

Samples: 2

Max nTPM: 72.2
Min nTPM: 46.6

Sample A		72.2
Sample B		46.6

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	342.6

Pig sample

Sample description

nTPM

Pons
nTPM: 342.5

Samples: 3

Max nTPM: 385.9
Min nTPM: 275.8

Sample A	Female	365.9
Sample B	Female	275.8
Sample C	Male	385.9