Brain tissue expression of MORF4L1 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	391.8	nTPM
FANTOM5:	215.0	Scaled Tags Per Million

Macaque:	345.7	nTPM
Mouse:	266.8	nTPM
Rat:	227.2	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
Show allShow less

This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
Show allShow less

This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	391.8

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 300.8

2188	Female, age 91, both hemispheres	333.6
2301	Female, age 85, both hemispheres	299.3
2090	Male, age 80, both hemispheres	293.5
1984	Male, age 76, both hemispheres	276.5

Dorsal cochlear nucleus
nTPM: 302.6

2187	Female, age 91, both hemispheres	348.4
2802	Male, age 74, right hemisphere	339.6
2058	Male, age 76, both hemispheres	285.3
2378	Male, age 80, both hemispheres	276.7
2370	Male, age 61, both hemispheres	263.1

Dorsal tegmental nucleus
nTPM: 320.6

2083	Male, age 80, both hemispheres	372.8
2358	Male, age 61, both hemispheres	318.9
2326	Male, age 74, both hemispheres	305.6
1936	Male, age 76, left hemisphere	285.0

Dorsolateral tegmental area
nTPM: 316.5

2654	Male, age 80, both hemispheres	378.5
2751	Female, age 85, both hemispheres	344.2
2141	Male, age 76, both hemispheres	315.1
2337	Male, age 61, both hemispheres	286.5
2360	Male, age 74, both hemispheres	258.4

Kolliker-Fuse nucleus
nTPM: 337.6

2163	Male, age 80, both hemispheres	377.0
2793	Female, age 91, left hemisphere	343.7
2315	Male, age 76, right hemisphere	292.0

Lateral lemniscal nuclei
nTPM: 302.2

2169	Male, age 76, both hemispheres	401.1
2746	Female, age 85, left hemisphere	305.7
2453	Male, age 74, right hemisphere	295.2
2320	Female, age 91, left hemisphere	254.5
2036	Male, age 80, both hemispheres	254.4

Lateral parabrachial nucleus
nTPM: 314.7

2139	Female, age 85, right hemisphere	351.0
2792	Male, age 76, both hemispheres	319.4
2013	Male, age 80, both hemispheres	304.6
2790	Male, age 61, both hemispheres	283.9

Lateral vestibular nucleus
nTPM: 345.9

2184	Male, age 76, both hemispheres	347.1
2311	Male, age 80, both hemispheres	344.7

Locus coeruleus
nTPM: 385.1

2014	Male, age 55, unknown	427.5
2123	Female, age 91, both hemispheres	426.3
2788	Male, age 74, unknown	422.6
2720	Male, age 74, both hemispheres	415.7
2162	Male, age 80, both hemispheres	357.8
2317	Female, age 72, unknown	343.4
1980	Male, age 76, both hemispheres	302.2

Medial parabrachial nucleus
nTPM: 334.5

2854	Male, age 80, both hemispheres	397.2
2170	Female, age 91, both hemispheres	396.7
2156	Male, age 61, both hemispheres	298.7
2786	Male, age 76, both hemispheres	298.0
2463	Female, age 85, right hemisphere	281.7

Medial periolivary nuclei
nTPM: 330.0

2171	Female, age 85, both hemispheres	409.2
2063	Male, age 76, both hemispheres	355.1
2791	Male, age 74, right hemisphere	339.3
2458	Female, age 91, both hemispheres	275.2
2081	Male, age 80, both hemispheres	271.2

Motor facial nucleus
nTPM: 342.1

2697	Female, age 85, both hemispheres	411.4
2062	Male, age 76, both hemispheres	380.9
2365	Male, age 74, right hemisphere	336.5
2126	Male, age 61, both hemispheres	330.9
2795	Female, age 91, both hemispheres	305.4
2327	Male, age 80, both hemispheres	287.1

Motor trigeminal nucleus
nTPM: 291.1

2335	Male, age 61, both hemispheres	302.5
2309	Male, age 76, both hemispheres	296.4
2560	Male, age 74, both hemispheres	293.0
2079	Male, age 80, both hemispheres	283.8
2321	Female, age 91, both hemispheres	279.9

Nuclei of the trapezoid body
nTPM: 328.4

2159	Male, age 61, both hemispheres	404.4
1983	Male, age 76, both hemispheres	372.4
2735	Female, age 85, both hemispheres	344.6
2166	Male, age 80, both hemispheres	278.7
2368	Female, age 91, both hemispheres	241.9

Nucleus raphe magnus
nTPM: 357.8

2160	Male, age 61, both hemispheres	478.4
2172	Female, age 85, both hemispheres	397.5
2051	Male, age 76, both hemispheres	359.3
2455	Male, age 74, both hemispheres	340.6
2328	Male, age 80, both hemispheres	309.8
2459	Female, age 91, both hemispheres	261.2

Paramedian reticular nucleus
nTPM: 391.8

2050	Female, age 85, both hemispheres	464.9
2313	Male, age 61, both hemispheres	376.1
2052	Male, age 76, both hemispheres	372.9
2057	Male, age 80, both hemispheres	353.3

Pedunculopontine tegmental nucleus
nTPM: 368.2

2334	Male, age 80, both hemispheres	380.3
2338	Male, age 61, both hemispheres	363.5
1921	Female, age 85, both hemispheres	360.8

Pontine nuclei
nTPM: 342.4

1863	Male, age 55, unknown	411.4
2727	Male, age 61, right hemisphere	407.3
2787	Female, age 85, both hemispheres	380.9
1968	Male, age 76, left hemisphere	344.2
2109	Female, age 72, unknown	336.7
2454	Male, age 74, left hemisphere	327.0
2319	Female, age 91, both hemispheres	287.0
2115	Male, age 80, left hemisphere	244.4

Pontine raphe nucleus
nTPM: 369.1

2853	Male, age 76, midline	371.9
2122	Female, age 85, midline	366.3

Posteroventral cochlear nucleus
nTPM: 305.1

2752	Female, age 85, both hemispheres	370.5
2070	Male, age 76, both hemispheres	312.6
2341	Male, age 80, both hemispheres	310.1
2135	Female, age 91, both hemispheres	270.2
2371	Male, age 61, both hemispheres	262.1

Principal sensory trigeminal nucleus
nTPM: 334.9

2158	Male, age 61, both hemispheres	389.2
2324	Male, age 76, both hemispheres	340.9
2008	Male, age 80, left hemisphere	328.7
2367	Female, age 91, left hemisphere	280.9

Reticular pontine nucleus, caudal
nTPM: 320.8

2092	Male, age 76, both hemispheres	343.0
2559	Male, age 74, both hemispheres	320.2
2457	Female, age 91, both hemispheres	317.1
2332	Male, age 80, right hemisphere	303.0

Reticular pontine nucleus, oral
nTPM: 353.7

2361	Male, age 74, both hemispheres	415.2
1939	Male, age 80, both hemispheres	368.6
2012	Female, age 85, both hemispheres	359.6
2167	Male, age 76, both hemispheres	326.9
2366	Female, age 91, both hemispheres	297.9

Reticulotegmental nucleus
nTPM: 336.2

2322	Female, age 91, both hemispheres	370.0
2325	Male, age 76, both hemispheres	357.4
2333	Male, age 80, both hemispheres	321.9
2452	Male, age 74, both hemispheres	295.2

Spinal trigeminal nucleus, oral
nTPM: 322.1

2164	Male, age 80, both hemispheres	358.2
2737	Female, age 85, both hemispheres	326.2
1978	Male, age 76, both hemispheres	282.0

Subcoeruleus area
nTPM: 318.1

1958	Male, age 80, both hemispheres	385.6
2323	Female, age 91, left hemisphere	384.2
2369	Female, age 85, left hemisphere	314.8
2089	Male, age 76, left hemisphere	263.2
2451	Male, age 74, both hemispheres	242.6

Superior olive
nTPM: 324.1

1875	Female, age 85, both hemispheres	393.9
2020	Male, age 76, both hemispheres	339.4
2364	Male, age 74, right hemisphere	309.3
2329	Male, age 80, right hemisphere	291.1
2561	Female, age 91, both hemispheres	286.6

Ventral periolivary nuclei
nTPM: 331.2

2130	Female, age 85, both hemispheres	353.8
2023	Male, age 76, both hemispheres	348.8
2165	Male, age 80, both hemispheres	348.2
2794	Female, age 91, left hemisphere	274.2

Ventrolateral tegmental area, A5 NE cell group
nTPM: 329.1

2840	Female, age 85, both hemispheres	430.5
2359	Male, age 61, both hemispheres	348.6
2449	Male, age 74, both hemispheres	340.7
1959	Male, age 76, both hemispheres	323.4
2161	Male, age 80, both hemispheres	287.8
2456	Female, age 91, both hemispheres	243.8

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	215.0

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 214.4

FF:10182-103D2	60 years, female	242.7
FF:10165-103B3	76 years, female	186.1

Pons
Scaled Tags Per Million: 215.0

FF:10033-101E6

18-54 years, mixed

215.0

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	345.7

Macaque sample

Sample description

nTPM

Pons
nTPM: 345.8

Samples: 2

Max nTPM: 349.4
Min nTPM: 342.1

Sample A		349.4
Sample B		342.1

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	266.8

Mouse sample

Sample description

nTPM

Pons
nTPM: 266.8

Samples: 4

Max nTPM: 282.4
Min nTPM: 250.7

Sample A		276.9
Sample B		250.7
Sample C		282.4
Sample D		257.2

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	227.2

Rat sample

Sample description

nTPM

Pons
nTPM: 227.2

Samples: 4

Max nTPM: 234.7
Min nTPM: 217.4

Sample A		227.7
Sample A		234.7
Sample A		217.4
Sample A		229.1