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COX10
HPA
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  • COX10
SINGLE CELL SINGLE CELL TYPES TISSUE CELL TYPE SINGLE NUCLEI BRAIN IMMUNE CELLS EXPRESSION CLUSTER TISSUES Show tissue menu
ADIPOSE TISSUE ADRENAL GLAND BONE MARROW BRAIN BREAST BRONCHUS COLON ENDOMETRIUM ESOPHAGUS EYE
FALLOPIAN TUBE HEART MUSCLE KIDNEY LIVER LUNG LYMPH NODE OVARY PANCREAS PBMC PITUITARY GLAND
PLACENTA PROSTATE RECTUM SALIVARY GLAND SKELETAL MUSCLE SKIN SMALL INTESTINE SPLEEN STOMACH TESTIS
THYMUS THYROID GLAND TONGUE VASCULAR
Single cell type
Tabula sapiens
Tissue cell type
Cell type proteome
Cell type enrichment
Brain cells
Immune cells
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

COX10
Gene descriptioni

Full gene name according to HGNC.

Cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Disease related genes
Enzymes
Human disease related genes
Metabolic proteins
Potential drug targets
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Membrane, Intracellular
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

2
HUMAN PROTEIN ATLAS INFORMATIONi

Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.

Single cell type expression clusteri

The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.

Cardiomyocytes - Muscle contraction (mainly)
Single cell type specificityi

The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.

Cell type enhanced (Cardiomyocytes, Late spermatids)
Tau specificity scorei

Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.

0.49
Brain cluster specificityi

The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.

Low cell type specificity
Immune cell specificityi

The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.

Low immune cell specificity
Protein evidencei

Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.

Evidence at protein level
ASSAYSi

Overview of the different datasets included in the Single Cell resource.

Single cell type
Cell type enrichment
Single nuclei - Brain
Immune cells
Expression clustering
SINGLE CELL TYPESi

A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.

Single cell types
RNA single cell type specificity: Cell type enhanced (Cardiomyocytes, Late spermatids)
TISSUE CELL TYPEi

The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.

Core cell typesi

The core cell type table displays data for a panel of eight cell types that are found in many tissues.

Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there.

Category
Alphabetical
Enrichment
Tissue specific cell typesi

This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues.

An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINi

A summary of normalized single nuclei RNA (nTPM) from the brain single nuclei. Color-coding is based on cell type groups (as defined in the single cell type data representing the whole body), in this case separated into the main cell categories of neuron, glial cells, endothelial cells, fibroblasts and muscle cell (vascular smooth muscle cells and pericytes).

The data is based on Siletti K et al. (2023) public data.

Single nuclei cluster types
RNA brain cluster specificity: Low cell type specificity
IMMUNE CELL TYPE EXPRESSION (RNA)i

Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.

HPA dataseti

The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC).

Lineage
Expression
Alphabetical
Immune cell type specificity: Low immune cell specificity
Monaco dataseti

The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al.

Lineage
Expression
Alphabetical
Schmiedel dataseti

Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset.

Lineage
Expression
Alphabetical
EXPRESSION CLUSTERING & CORRELATIONi

The RNA data was used to cluster genes according to their expression across samples. The resulting clusters have been manually annotated to describe common features in terms of function and specificity. The annotation of the cluster is displayed together with a confidence score of the gene's assignment to the cluster. The confidence is calculated as the fraction of times the gene was assigned to this cluster in repeated calculations and is reported between 0 to 1, where 1 is the highest possible confidence. The clustering results are shown in a UMAP, where the cluster this gene was assigned to is highlighted as a colored area in which most of the cluster genes reside. A table shows the 15 most similar genes in terms of expression profile.

SINGLE CELL TYPE
COX10 is part of cluster 68 Cardiomyocytes - Muscle contraction with confidencei

Confidence is the fraction of times a gene was assigned to the cluster in repeated clustering, and therefore reflects how strongly associated it is to the cluster. A confidence of 1 indicates that the gene was assigned to this cluster in all repeated clusterings.

1
262 genes in cluster
Go to interactive expression cluster page
15 nearest neighbours based on single cell RNA expression
Neighbouri

Gene name according to HGNC.

Descriptioni

Gene description according to HGNC.

Correlationi

Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.

Clusteri

ID of the expression cluster of the neighboring gene.

LRRC49 Leucine rich repeat containing 49 0.6780 68
OPA1 OPA1 mitochondrial dynamin like GTPase 0.5929 68
MIPEP Mitochondrial intermediate peptidase 0.5777 68
NDUFS1 NADH:ubiquinone oxidoreductase core subunit S1 0.5664 68
NEBL Nebulette 0.5622 68
DCUN1D2 Defective in cullin neddylation 1 domain containing 2 0.5570 68
HADHB Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta 0.5569 68
RBM20 RNA binding motif protein 20 0.5542 68
DNMT3A DNA methyltransferase 3 alpha 0.5394 68
GPR22 G protein-coupled receptor 22 0.5358 68
FSD2 Fibronectin type III and SPRY domain containing 2 0.5308 68
ETFDH Electron transfer flavoprotein dehydrogenase 0.5307 68
ATP5ME ATP synthase membrane subunit e 0.5284 68
SCN5A Sodium voltage-gated channel alpha subunit 5 0.5275 68
PAM Peptidylglycine alpha-amidating monooxygenase 0.5251 68
IMMUNE CELLS
COX10 is part of cluster 12 Non-specific - Mitochondrial translation with confidencei

Confidence is the fraction of times a gene was assigned to the cluster in repeated clustering, and therefore reflects how strongly associated it is to the cluster. A confidence of 1 indicates that the gene was assigned to this cluster in all repeated clusterings.

0.99
566 genes in cluster
Go to interactive expression cluster page
15 nearest neighbours based on single cell RNA expression
Neighbouri

Gene name according to HGNC.

Descriptioni

Gene description according to HGNC.

Correlationi

Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.

Clusteri

ID of the expression cluster of the neighboring gene.

PYM1 PYM homolog 1, exon junction complex associated factor 1.0000 12
EDC4 Enhancer of mRNA decapping 4 0.9762 12
AIFM1 Apoptosis inducing factor mitochondria associated 1 0.9762 12
RAN RAN, member RAS oncogene family 0.9762 12
CMAS Cytidine monophosphate N-acetylneuraminic acid synthetase 0.9762 12
DOLK Dolichol kinase 0.9524 12
PTBP1 Polypyrimidine tract binding protein 1 0.9524 12
COX11 Cytochrome c oxidase copper chaperone COX11 0.9524 12
HPRT1 Hypoxanthine phosphoribosyltransferase 1 0.9524 12
MMS19 MMS19 homolog, cytosolic iron-sulfur assembly component 0.9524 12
SNRPA1 Small nuclear ribonucleoprotein polypeptide A' 0.9524 12
EXOSC3 Exosome component 3 0.9524 12
PDCD5 Programmed cell death 5 0.9524 12
DNAJC17 DnaJ heat shock protein family (Hsp40) member C17 0.9524 12
SART3 Spliceosome associated factor 3, U4/U6 recycling protein 0.9524 12
 

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