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WDR37
HPA
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  • SUMMARY

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  • STRUCT & INT

  • WDR37
SINGLE CELL SINGLE CELL TYPES TISSUE CELL TYPE SINGLE NUCLEI BRAIN IMMUNE CELLS EXPRESSION CLUSTER TISSUES Show tissue menu
ADIPOSE TISSUE ADRENAL GLAND BONE MARROW BRAIN BREAST BRONCHUS COLON ENDOMETRIUM ESOPHAGUS EYE
FALLOPIAN TUBE HEART MUSCLE KIDNEY LIVER LUNG LYMPH NODE OVARY PANCREAS PBMC PITUITARY GLAND
PLACENTA PROSTATE RECTUM SALIVARY GLAND SKELETAL MUSCLE SKIN SMALL INTESTINE SPLEEN STOMACH TESTIS
THYMUS THYROID GLAND TONGUE VASCULAR
Single cell type
Tabula sapiens
Tissue cell type
Cell type proteome
Cell type enrichment
Brain cells
Immune cells
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

WDR37
Gene descriptioni

Full gene name according to HGNC.

WD repeat domain 37
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Disease related genes
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Intracellular
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

9
HUMAN PROTEIN ATLAS INFORMATIONi

Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.

Single cell type expression clusteri

The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.

Early spermatids - Spermatogenesis (mainly)
Single cell type specificityi

The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.

Cell type enhanced (Early spermatids, Late spermatids)
Tau specificity scorei

Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.

0.51
Brain cluster specificityi

The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.

Low cell type specificity
Immune cell specificityi

The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.

Low immune cell specificity
Protein evidencei

Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.

Evidence at protein level
ASSAYSi

Overview of the different datasets included in the Single Cell resource.

Single cell type
Cell type enrichment
Single nuclei - Brain
Immune cells
Expression clustering
SINGLE CELL TYPESi

A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.

Single cell types
RNA single cell type specificity: Cell type enhanced (Early spermatids, Late spermatids)
TISSUE CELL TYPEi

The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.

Core cell typesi

The core cell type table displays data for a panel of eight cell types that are found in many tissues.

Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there.

Category
Alphabetical
Enrichment
Tissue specific cell typesi

This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues.

An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINi

A summary of normalized single nuclei RNA (nTPM) from the brain single nuclei. Color-coding is based on cell type groups (as defined in the single cell type data representing the whole body), in this case separated into the main cell categories of neuron, glial cells, endothelial cells, fibroblasts and muscle cell (vascular smooth muscle cells and pericytes).

The data is based on Siletti K et al. (2023) public data.

Single nuclei cluster types
RNA brain cluster specificity: Low cell type specificity
IMMUNE CELL TYPE EXPRESSION (RNA)i

Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.

HPA dataseti

The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC).

Lineage
Expression
Alphabetical
Immune cell type specificity: Low immune cell specificity
Monaco dataseti

The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al.

Lineage
Expression
Alphabetical
Schmiedel dataseti

Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset.

Lineage
Expression
Alphabetical
EXPRESSION CLUSTERING & CORRELATIONi

The RNA data was used to cluster genes according to their expression across samples. The resulting clusters have been manually annotated to describe common features in terms of function and specificity. The annotation of the cluster is displayed together with a confidence score of the gene's assignment to the cluster. The confidence is calculated as the fraction of times the gene was assigned to this cluster in repeated calculations and is reported between 0 to 1, where 1 is the highest possible confidence. The clustering results are shown in a UMAP, where the cluster this gene was assigned to is highlighted as a colored area in which most of the cluster genes reside. A table shows the 15 most similar genes in terms of expression profile.

SINGLE CELL TYPE
WDR37 is part of cluster 21 Early spermatids - Spermatogenesis with confidencei

Confidence is the fraction of times a gene was assigned to the cluster in repeated clustering, and therefore reflects how strongly associated it is to the cluster. A confidence of 1 indicates that the gene was assigned to this cluster in all repeated clusterings.

1
337 genes in cluster
Go to interactive expression cluster page
15 nearest neighbours based on single cell RNA expression
Neighbouri

Gene name according to HGNC.

Descriptioni

Gene description according to HGNC.

Correlationi

Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.

Clusteri

ID of the expression cluster of the neighboring gene.

DNTT DNA nucleotidylexotransferase 0.6693 11
DEFB135 Defensin beta 135 0.6660 21
TRIM11 Tripartite motif containing 11 0.6296 21
AGAP6 ArfGAP with GTPase domain, ankyrin repeat and PH domain 6 0.6284 21
TANGO6 Transport and golgi organization 6 homolog 0.6257 21
FANCC FA complementation group C 0.6202 21
MARCHF8 Membrane associated ring-CH-type finger 8 0.6117 21
ZNF707 Zinc finger protein 707 0.6004 21
SERP2 Stress associated endoplasmic reticulum protein family member 2 0.5894 21
DXO Decapping exoribonuclease 0.5883 21
AOC2 Amine oxidase copper containing 2 0.5882 21
ARID2 AT-rich interaction domain 2 0.5819 21
LRRIQ4 Leucine rich repeats and IQ motif containing 4 0.5774 21
IFNL4 Interferon lambda 4 (gene/pseudogene) 0.5766 21
ARRDC5 Arrestin domain containing 5 0.5696 21
IMMUNE CELLS
WDR37 is part of cluster 15 NK-cells - Unknown function with confidencei

Confidence is the fraction of times a gene was assigned to the cluster in repeated clustering, and therefore reflects how strongly associated it is to the cluster. A confidence of 1 indicates that the gene was assigned to this cluster in all repeated clusterings.

0.8
158 genes in cluster
Go to interactive expression cluster page
15 nearest neighbours based on single cell RNA expression
Neighbouri

Gene name according to HGNC.

Descriptioni

Gene description according to HGNC.

Correlationi

Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.

Clusteri

ID of the expression cluster of the neighboring gene.

DTD1 D-aminoacyl-tRNA deacylase 1 0.9524 15
GPR65 G protein-coupled receptor 65 0.9524 5
GNAI1 G protein subunit alpha i1 0.9286 5
ZNF550 Zinc finger protein 550 0.9048 15
P2RY11 Purinergic receptor P2Y11 0.9048 15
ATXN2 Ataxin 2 0.9048 5
CMC1 C-X9-C motif containing 1 0.9048 15
EFHC2 EF-hand domain containing 2 0.9048 5
SEMA4C Semaphorin 4C 0.9048 5
STIM1 Stromal interaction molecule 1 0.9048 33
ZC3H18 Zinc finger CCCH-type containing 18 0.9048 5
PCNX4 Pecanex 4 0.9048 15
IL18R1 Interleukin 18 receptor 1 0.9048 15
ANKMY2 Ankyrin repeat and MYND domain containing 2 0.9048 15
CLASP1 Cytoplasmic linker associated protein 1 0.9048 15
 

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