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BETA
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  • RAPGEF4
BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS
MEDULLA OBLONGATA MIDBRAIN PONS SPINAL CORD THALAMUS
ANTIBODIES
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MIDBRAIN - Expression summary
Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units. Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set. If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas HPA, Genotype-Tissue Expression GTEx portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets. The mRNA expression levels in pig brain are based on RNA-seq data generated by the Human Protein Atlas, and for mouse brain HPA data and in situ hybridization generated by the Allen brain atlas dataset are reported.

Scroll down to view mRNA expression data in more detail.

Consensus:31.2 nTPM
HPA Brain:66.9 nTPM
GTEx:31.2 nTPM
FANTOM5:7.3 Scaled Tags Per Million
Macaque:55.2 nTPM
Mouse:90.3 nTPM
Rat:60.0 nTPM
Pig:32.5 nTPM
MIDBRAIN - SINGLE NUCLEI RNA EXPRESSIONi

RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right).

- UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon

- The BAR CHART shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.


SINGLE NUCLEI BRAIN - MIDBRAIN, NEURONSi

RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right).

- UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon

- The BAR CHART shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

Cell type color
Cluster color
Colored according to cell type group
Colored according to clusters
Read count filter: 0
 
Cluster Cell type Expression (nCPM)
0 830
c-1 Inhibitory (GAD1/2) RORB+ K
c-2 Excitatory (VGLUT1) ETV1+ Z...
c-3 Inhibitory (GAD1/2) RORB+ K
c-4 Inhibitory (GAD1/2) RORB+ K
c-5 Unassigned
c-6 Tectum Excitatory (VGLUT2)
c-7 Inhibitory (GAD1/2)
c-8 Inhibitory (GAD1/2) TFAP2B+
c-9 Excitatory (VGLUT2)
c-10 Excitatory (VGLUT2)
c-11 Tectum Inhibitory (GAD1/2)
c-12 Excitatory (VGLUT2) TFAP2B+
c-13 Excitatory (VGLUT2)
c-14 Excitatory (VGLUT2)
c-15 Tectum Excitatory (VGLUT2)
c-16 Excitatory (VGLUT2)
c-17 Inhibitory (GAD1/2)
c-18 Excitatory (VGLUT2)
c-19 Inhibitory (GAD1/2)
c-20 Inhibitory (GAD1/2)
c-21 Excitatory (VGLUT2)
c-22 Excitatory (VGLUT2)
c-23 Inhibitory (GAD1/2) TFAP2B+
c-24 Inhibitory (GAD1/2)
c-25 Excitatory (VGLUT2) CRH+ CA...
c-26 Inhibitory (GAD1/2) SST+
c-27 Inhibitory (GAD1/2) NPY+
c-28 Inhibitory (GAD1/2) RORB+ K
c-29 Excitatory (VGLUT2) TFAP2B+
c-30 Excitatory (VGLUT2)
c-31 Dopaminergic TH+ LMX1A+ SLC...
c-32 Inhibitory (GAD1/2) PVALB+
c-33 Tegmentum Excitatory (VGLUT...
c-34 Excitatory (VGLUT2) LMX1A+
c-35 Tegmentum Inhibitory (GAD2)...
c-36 TPH2+
c-37 Inhibitory (GAD1/2) CXCL14+
c-38 Excitatory (VGLUT1) SATB2+
c-39 Inhibitory (GAD1/2) RORB+ K
c-40 Excitatory (VGLUT2) MEIS2+
c-41 Inhibitory (GAD1/2) TFAP2B+
c-42 Excitatory (VGLUT2)
c-43 Excitatory (VGLUT1)
c-44 SN Monoaminergic Inhibitory...
c-45 Inhibitory (GAD1/2)
c-46 Excitatory (VGLUT1) GRP+
c-47 Inhibitory (GAD1/2) PVALB+ ...
c-48 Excitatory (VGLUT1)
c-49 Inhibitory (GAD1/2) LAMP5+
c-50 Excitatory (VGLUT2) KIT+
c-51 Excitatory (VGLUT1) SLC5A7+
c-52 Inhibitory (GAD1/2) NOS1+ G...
Show allShow less
This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - MIDBRAIN, NON-NEURONALi

RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right).

- UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon

- The BAR CHART shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

Cell type color
Cluster color
Colored according to cell type group
Colored according to clusters
Read count filter: 0
 
Cluster Cell type Expression (nCPM)
0 700
c-1 Oligodendrocytes
c-2 Oligodendrocytes
c-3 Microglia
c-4 Oligodendrocytes
c-5 Oligodendrocyte progenitor ...
c-6 Astrocytes
c-7 Oligodendrocytes
c-8 Oligodendrocytes
c-9 Oligodendrocytes
c-10 Oligodendrocytes
c-11 Oligodendrocytes
c-12 Astrocytes
c-13 Fibroblasts
c-14 NK-cells & T-cells
c-15 Macrophages
c-16 Ependymal cells
c-17 Capillary endothelial cells
c-18 Pericytes
c-19 Oligodendrocyte progenitor ...
c-20 Immature oligodendrocytes
c-21 Vascular smooth muscle cell
c-22 Oligodendrocyte progenitor ...
c-23 B-cells & Monocytes doublet
c-24 Arterial endothelial cells
c-25 CD44+ Mural cells
c-26 Bergmann glia
c-27 Oligodendrocytes & Lymphocy
c-28 Macrophages & Monocytes
Show allShow less
This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

MIDBRAIN - HPA Brain RNA-seq
Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

66.9
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 31.1
2828 Female, age 72, unknown 43.6
2019 Male, age 18, unknown 43.3
2219 Male, age 76, both hemispheres 38.5
2411 Female, age 72, unknown 31.8
1870 Female, age 42, unknown 30.4
1827 Male, age 72, unknown 29.1
1833 Male, age 53, unknown 27.2
1830 Male, age 51, unknown 25.2
2666 Male, age 74, left hemisphere 24.5
2586 Male, age 75, left hemisphere 17.9
Dorsal raphe nucleus
nTPM: 19.8
2750 Male, age 76, both hemispheres 24.9
2298 Female, age 72, unknown 20.4
2047 Male, age 72, unknown 18.8
1828 Male, age 53, unknown 17.4
2016 Female, age 72, unknown 17.4
Inferior colliculus
nTPM: 39.6
2097 Female, age 72, unknown 46.5
1848 Female, age 42, unknown 43.3
1890 Male, age 53, unknown 37.0
2849 Male, age 72, unknown 31.5
Median raphe nucleus
nTPM: 27.4
2220 Male, age 76, midline 27.4
Periaquaductal grey, anterior
nTPM: 27.8
1795 Male, age 51, unknown 36.8
2502 Female, age 75, unknown 23.6
1947 Male, age 18, unknown 23.0
Periaquaductal grey, dorsal
nTPM: 28.7
1831 Male, age 72, unknown 34.6
2464 Female, age 72, unknown 31.2
1840 Male, age 53, unknown 28.3
2850 Male, age 76, both hemispheres 20.9
Periaquaductal grey, lateral
nTPM: 20.3
2053 Male, age 18, unknown 25.9
2140 Male, age 76, both hemispheres 20.3
2272 Male, age 74, both hemispheres 14.8
Pretectal area
nTPM: 66.9
2667 Female, age 75, unknown 171.6
1944 Female, age 72, unknown 102.5
1816 Male, age 51, unknown 93.1
1815 Male, age 53, unknown 92.2
2007 Male, age 72, unknown 74.3
1817 Female, age 42, unknown 68.3
2273 Male, age 74, both hemispheres 32.2
2316 Male, age 76, right hemisphere 29.7
2224 Female, age 72, unknown 28.6
2825 Male, age 18, unknown 22.1
2407 Male, age 75, both hemispheres 21.1
Red nucleus
nTPM: 24.7
2785 Male, age 18, unknown 46.0
1954 Female, age 42, unknown 31.9
1821 Female, age 72, unknown 28.0
2823 Male, age 76, right hemisphere 27.4
1904 Male, age 53, unknown 25.2
2227 Male, age 72, unknown 22.7
2503 Female, age 72, unknown 22.4
1865 Male, age 51, unknown 22.0
2584 Male, age 75, left hemisphere 21.9
2769 Male, age 72, unknown 21.6
2588 Male, age 74, left hemisphere 16.1
2725 Female, age 75, unknown 11.3
Substantia nigra
nTPM: 40.7
1889 Female, age 72, unknown 74.0
2665 Male, age 74, both hemispheres 54.5
2409 Female, age 72, unknown 47.4
1916 Female, age 42, unknown 44.2
2241 Male, age 72, unknown 42.3
1941 Male, age 53, unknown 40.6
1851 Male, age 51, unknown 39.0
2699 Male, age 18, unknown 23.2
2583 Male, age 75, right hemisphere 23.1
2590 Female, age 75, unknown 18.7
Superior colliculus
nTPM: 50.2
2087 Female, age 72, unknown 133.7
1913 Female, age 42, unknown 65.5
2668 Female, age 75, unknown 61.6
2261 Male, age 18, unknown 54.4
1895 Male, age 76, right hemisphere 43.5
1796 Male, age 53, unknown 35.5
1995 Male, age 72, unknown 34.0
1839 Male, age 51, unknown 30.6
2587 Male, age 74, left hemisphere 24.6
2664 Male, age 75, both hemispheres 18.7
Ventral tegmental area
nTPM: 35.2
1915 Female, age 42, unknown 45.7
2223 Female, age 72, unknown 44.3
2410 Female, age 72, unknown 36.7
2218 Male, age 76, both hemispheres 32.2
2021 Male, age 53, unknown 27.3
1942 Male, age 51, unknown 25.0

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.

Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

31.2
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 31.2
Samples: 183

Max nTPM: 322.1
Min nTPM: 4.1
Std nTPM: 33.4
Median nTPM: 23.9
GTEX-QVJO-0011-R2A-SM-2S1QK 60-69 years, female 322.1
GTEX-WVLH-0011-R2A-SM-3MJFJ 50-59 years, male 224.0
GTEX-1MCQQ-0011-R2a-SM-F649V 60-69 years, male 162.1
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 113.3
GTEX-WL46-0011-R2A-SM-3LK6O 50-59 years, male 95.4
GTEX-1RQED-0011-R2a-SM-F3K5T 60-69 years, male 86.1
GTEX-1MJK2-0011-R2b-SM-EXUS5 50-59 years, male 84.4
GTEX-1PWST-0011-R2b-SM-F3K5I 70-79 years, male 79.4
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 76.7
GTEX-1PIIG-0011-R2b-SM-F648W 30-39 years, male 76.1
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 75.7
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 74.6
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 72.0
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 71.4
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 67.6
GTEX-1I19N-0011-R2b-SM-GPRYG 70-79 years, male 61.4
GTEX-12696-0011-R2b-SM-GHWPY 60-69 years, male 60.1
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 57.9
GTEX-1R9K4-0011-R2b-SM-G8LLF 60-69 years, male 57.6
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 53.0
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 51.6
GTEX-13OVL-0011-R2b-SM-H65ZN 50-59 years, male 51.5
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 51.4
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 50.2
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 49.7
GTEX-11NUK-0011-R2a-SM-GINAO 50-59 years, male 49.6
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 49.5
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 46.4
GTEX-ZZPT-0011-R2a-SM-GNTB1 50-59 years, male 40.9
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 40.7
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 40.6
GTEX-1JMQJ-0011-R2a-SM-F6493 50-59 years, male 39.8
GTEX-117XS-0011-R2b-SM-GI4VT 60-69 years, male 39.7
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 38.8
GTEX-ZAK1-0011-R2a-SM-GPRX1 50-59 years, female 38.1
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 37.8
GTEX-1QMI2-0011-R2b-SM-F648R 60-69 years, male 37.4
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 37.3
GTEX-1PPGY-0011-R2b-SM-F33YW 60-69 years, male 35.8
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 34.6
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 34.5
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 34.4
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 34.2
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 34.2
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 33.9
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 33.5
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 33.4
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 33.3
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 33.3
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 33.1
GTEX-16GPK-0011-R2a-SM-GRR1F 60-69 years, male 33.1
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 33.0
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 32.6
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 31.8
GTEX-1R9PO-0011-R2a-SM-F2TBH 60-69 years, female 31.8
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 31.5
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 31.3
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 30.7
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 30.5
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 29.8
GTEX-1LG7Y-0011-R2b-SM-G8LMM 50-59 years, male 29.4
GTEX-11TTK-0011-R2b-SM-GJ3PU 60-69 years, female 29.0
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 28.9
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 28.8
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 28.7
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 28.6
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 28.5
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 28.0
GTEX-1KD4Q-0011-R2a-SM-F649I 40-49 years, male 27.9
GTEX-13OW7-0011-R2b-SM-H6Q8E 50-59 years, male 27.8
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 27.8
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 27.7
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 27.7
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 27.6
GTEX-1JMPZ-0011-R2a-SM-G8LLS 30-39 years, male 27.6
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 27.3
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 26.9
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 26.5
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 26.2
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 25.8
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 25.7
GTEX-111FC-0011-R2a-SM-GIN8S 60-69 years, male 25.6
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 25.6
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 25.5
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 25.3
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 25.3
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 24.5
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 24.4
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 24.3
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 24.3
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 24.1
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 23.9
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 23.2
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 22.9
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 22.5
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 22.3
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 22.1
GTEX-1LSVX-0011-R2a-SM-G8OL9 60-69 years, male 22.0
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 21.8
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 21.7
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 21.6
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 21.5
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 21.4
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 21.3
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 21.1
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 20.9
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 20.8
GTEX-1N2EE-0011-R2a-SM-F649F 60-69 years, male 20.7
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 20.2
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 20.2
GTEX-1192X-0011-R2b-SM-GI4VV 50-59 years, male 20.1
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 19.8
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 18.9
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 18.8
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 18.7
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 18.7
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 18.6
GTEX-1KD5A-0011-R2b-SM-G9EPP 50-59 years, male 18.2
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 18.2
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 18.1
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 17.9
GTEX-1NV8Z-0011-R2b-SM-F648N 60-69 years, male 17.9
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 17.8
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 17.6
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 17.6
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 17.6
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 17.5
GTEX-15G19-0011-R2b-SM-H6Q7S 60-69 years, male 17.4
GTEX-15SHU-0011-R2a-SM-GPRXS 40-49 years, female 17.3
GTEX-1IDJH-0011-R2a-SM-GPI9D 70-79 years, male 17.3
GTEX-1N2EF-0011-R2b-SM-F6482 60-69 years, male 17.0
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 16.9
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 16.9
GTEX-1JJ6O-0011-R2a-SM-EY5ZO 60-69 years, male 16.8
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 16.4
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 16.3
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 16.0
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 15.9
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 15.2
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 15.2
GTEX-1POEN-0011-R2b-SM-G8LLP 30-39 years, female 15.1
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 15.1
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 15.0
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 14.4
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 14.4
GTEX-1RQEC-0011-R2b-SM-EY5ZT 60-69 years, male 14.4
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 14.0
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 13.9
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 13.8
GTEX-1KWVE-0011-R2a-SM-G8OLX 30-39 years, male 13.7
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 13.4
GTEX-ZAJG-0011-R2a-SM-GNTAX 50-59 years, female 13.1
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 13.0
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 12.9
GTEX-ZYY3-0011-R2a-SM-GNTB2 60-69 years, female 12.8
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 12.7
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 12.7
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 12.3
GTEX-1RDX4-0011-R2b-SM-F649Z 50-59 years, female 11.9
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 11.3
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 11.3
GTEX-1O9I2-0011-R2b-SM-F3K53 50-59 years, male 11.1
GTEX-1117F-0011-R2b-SM-GI4VL 60-69 years, female 10.9
GTEX-X4EP-0011-R2B-SM-3P625 60-69 years, female 10.7
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 10.5
GTEX-RN5K-0011-R2A-SM-GQ1CA 50-59 years, female 9.8
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 9.7
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 9.7
GTEX-1HBPH-0011-R2a-SM-GQ1DS 40-49 years, female 9.6
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 9.3
GTEX-1P4AB-0011-R2a-SM-F649K 50-59 years, male 8.3
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 8.0
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 7.8
GTEX-1JN1M-0011-R2b-SM-G9EPE 60-69 years, female 7.8
GTEX-1LKK1-0011-R2b-SM-G8OLT 50-59 years, female 6.7
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 6.1
GTEX-1CB4J-0011-R2a-SM-9WG5N 60-69 years, male 5.9
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 5.9
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 5.8
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 5.7
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 5.5
GTEX-1N5O9-0011-R2a-SM-G8LM1 60-69 years, male 4.4
GTEX-1NV5F-0011-R2a-SM-G8LME 60-69 years, female 4.1
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MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Max subtype Scaled Tags Per Millioni

Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.

7.3
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 7.3
FF:10158-103A5 76 years, female 7.3

MIDBRAIN - Macaque RNA-seq
Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

55.2
Macaque sample Sample description nTPM
Substantia nigra
nTPM: 48.6
Samples: 1

Max nTPM: 48.6
Min nTPM: 48.6
Sample A 48.6
Midbrain
nTPM: 44.1
Samples: 1

Max nTPM: 44.1
Min nTPM: 44.1
Sample A 44.1
Superior colliculi
nTPM: 55.2
Samples: 1

Max nTPM: 55.2
Min nTPM: 55.2
Sample A 55.2

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM. Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.

Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

32.5
Pig sample Sample description nTPM
Substantia nigra
nTPM: 18.2
Samples: 3

Max nTPM: 20.1
Min nTPM: 15.5
Sample A Female 20.1
Sample B Female 15.5
Sample C Male 18.9
Midbrain
nTPM: 32.5
Samples: 3

Max nTPM: 40.9
Min nTPM: 17.9
Sample B Female 17.9
Sample C Male 40.9
Sample D Male 38.7
Periaqueductal gray
nTPM: 15.3
Samples: 3

Max nTPM: 16.6
Min nTPM: 14.2
Sample B Female 15.2
Sample C Male 16.6
Sample D Male 14.2
Superior colliculi
nTPM: 30.0
Samples: 4

Max nTPM: 33.0
Min nTPM: 21.7
Sample A Female 33.0
Sample B Female 21.7
Sample C Male 32.7
Sample D Male 32.5

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM. Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.

Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

90.3
Mouse sample Sample description nTPM
Midbrain
nTPM: 90.3
Samples: 4

Max nTPM: 95.3
Min nTPM: 87.1
Sample A 95.3
Sample B 87.1
Sample C 88.7
Sample D 90.0

MIDBRAIN - Rat RNA-seq
Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

60.0
Rat sample Sample description nTPM
Midbrain
nTPM: 60.0
Samples: 4

Max nTPM: 62.0
Min nTPM: 57.8
Sample A 62.0
Sample A 58.9
Sample A 57.8
Sample A 61.2

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