Brain tissue expression of ABLIM1 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	167.5	nTPM
FANTOM5:	150.5	Scaled Tags Per Million

Macaque:	70.4	nTPM
Mouse:	51.4	nTPM
Rat:	46.8	nTPM
Pig:	104.5	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	167.5

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 152.1

1984	Male, age 76, both hemispheres	283.3
2090	Male, age 80, both hemispheres	117.0
2301	Female, age 85, both hemispheres	116.5
2188	Female, age 91, both hemispheres	91.5

Dorsal cochlear nucleus
nTPM: 140.2

2370	Male, age 61, both hemispheres	161.2
2802	Male, age 74, right hemisphere	154.8
2378	Male, age 80, both hemispheres	141.8
2058	Male, age 76, both hemispheres	134.8
2187	Female, age 91, both hemispheres	108.3

Dorsal tegmental nucleus
nTPM: 140.2

2358	Male, age 61, both hemispheres	199.0
1936	Male, age 76, left hemisphere	129.2
2083	Male, age 80, both hemispheres	121.1
2326	Male, age 74, both hemispheres	111.3

Dorsolateral tegmental area
nTPM: 118.0

2141	Male, age 76, both hemispheres	128.1
2360	Male, age 74, both hemispheres	123.1
2654	Male, age 80, both hemispheres	122.2
2337	Male, age 61, both hemispheres	118.6
2751	Female, age 85, both hemispheres	98.0

Kolliker-Fuse nucleus
nTPM: 167.5

2315	Male, age 76, right hemisphere	277.4
2163	Male, age 80, both hemispheres	134.2
2793	Female, age 91, left hemisphere	90.9

Lateral lemniscal nuclei
nTPM: 116.1

2169	Male, age 76, both hemispheres	135.6
2036	Male, age 80, both hemispheres	129.4
2746	Female, age 85, left hemisphere	119.2
2453	Male, age 74, right hemisphere	114.2
2320	Female, age 91, left hemisphere	82.1

Lateral parabrachial nucleus
nTPM: 142.0

2139	Female, age 85, right hemisphere	164.1
2792	Male, age 76, both hemispheres	157.4
2013	Male, age 80, both hemispheres	123.9
2790	Male, age 61, both hemispheres	122.8

Lateral vestibular nucleus
nTPM: 128.7

2184	Male, age 76, both hemispheres	131.7
2311	Male, age 80, both hemispheres	125.7

Locus coeruleus
nTPM: 136.6

2014	Male, age 55, unknown	149.2
2788	Male, age 74, unknown	146.8
2317	Female, age 72, unknown	142.6
1980	Male, age 76, both hemispheres	136.0
2123	Female, age 91, both hemispheres	132.3
2162	Male, age 80, both hemispheres	128.9
2720	Male, age 74, both hemispheres	120.8

Medial parabrachial nucleus
nTPM: 134.9

2463	Female, age 85, right hemisphere	196.7
2156	Male, age 61, both hemispheres	140.5
2854	Male, age 80, both hemispheres	122.9
2786	Male, age 76, both hemispheres	113.9
2170	Female, age 91, both hemispheres	100.7

Medial periolivary nuclei
nTPM: 125.1

2171	Female, age 85, both hemispheres	164.1
2063	Male, age 76, both hemispheres	143.6
2791	Male, age 74, right hemisphere	123.4
2081	Male, age 80, both hemispheres	104.8
2458	Female, age 91, both hemispheres	89.8

Motor facial nucleus
nTPM: 129.4

2795	Female, age 91, both hemispheres	146.8
2062	Male, age 76, both hemispheres	145.0
2327	Male, age 80, both hemispheres	133.4
2365	Male, age 74, right hemisphere	118.7
2126	Male, age 61, both hemispheres	116.6
2697	Female, age 85, both hemispheres	115.9

Motor trigeminal nucleus
nTPM: 106.9

2335	Male, age 61, both hemispheres	129.0
2079	Male, age 80, both hemispheres	122.0
2309	Male, age 76, both hemispheres	107.5
2560	Male, age 74, both hemispheres	89.5
2321	Female, age 91, both hemispheres	86.6

Nuclei of the trapezoid body
nTPM: 135.0

2735	Female, age 85, both hemispheres	146.1
1983	Male, age 76, both hemispheres	140.6
2159	Male, age 61, both hemispheres	140.0
2368	Female, age 91, both hemispheres	127.1
2166	Male, age 80, both hemispheres	121.2

Nucleus raphe magnus
nTPM: 131.3

2172	Female, age 85, both hemispheres	142.3
2160	Male, age 61, both hemispheres	140.0
2051	Male, age 76, both hemispheres	139.3
2455	Male, age 74, both hemispheres	136.1
2328	Male, age 80, both hemispheres	135.4
2459	Female, age 91, both hemispheres	94.6

Paramedian reticular nucleus
nTPM: 130.2

2050	Female, age 85, both hemispheres	137.2
2057	Male, age 80, both hemispheres	134.2
2313	Male, age 61, both hemispheres	127.5
2052	Male, age 76, both hemispheres	122.0

Pedunculopontine tegmental nucleus
nTPM: 136.0

1921	Female, age 85, both hemispheres	158.7
2338	Male, age 61, both hemispheres	129.6
2334	Male, age 80, both hemispheres	119.8

Pontine nuclei
nTPM: 116.1

1863	Male, age 55, unknown	148.1
2787	Female, age 85, both hemispheres	145.0
1968	Male, age 76, left hemisphere	127.7
2109	Female, age 72, unknown	125.4
2727	Male, age 61, right hemisphere	119.8
2115	Male, age 80, left hemisphere	107.0
2319	Female, age 91, both hemispheres	82.7
2454	Male, age 74, left hemisphere	73.0

Pontine raphe nucleus
nTPM: 120.6

2122	Female, age 85, midline	123.0
2853	Male, age 76, midline	118.2

Posteroventral cochlear nucleus
nTPM: 114.7

2371	Male, age 61, both hemispheres	155.8
2752	Female, age 85, both hemispheres	120.6
2070	Male, age 76, both hemispheres	119.3
2341	Male, age 80, both hemispheres	104.5
2135	Female, age 91, both hemispheres	73.3

Principal sensory trigeminal nucleus
nTPM: 122.9

2324	Male, age 76, both hemispheres	143.3
2158	Male, age 61, both hemispheres	136.1
2008	Male, age 80, left hemisphere	131.9
2367	Female, age 91, left hemisphere	80.6

Reticular pontine nucleus, caudal
nTPM: 110.6

2092	Male, age 76, both hemispheres	140.8
2332	Male, age 80, right hemisphere	128.1
2559	Male, age 74, both hemispheres	89.4
2457	Female, age 91, both hemispheres	84.0

Reticular pontine nucleus, oral
nTPM: 102.0

2012	Female, age 85, both hemispheres	126.0
1939	Male, age 80, both hemispheres	120.6
2167	Male, age 76, both hemispheres	100.8
2366	Female, age 91, both hemispheres	88.4
2361	Male, age 74, both hemispheres	74.2

Reticulotegmental nucleus
nTPM: 121.6

2333	Male, age 80, both hemispheres	140.0
2325	Male, age 76, both hemispheres	130.4
2322	Female, age 91, both hemispheres	110.9
2452	Male, age 74, both hemispheres	105.2

Spinal trigeminal nucleus, oral
nTPM: 134.1

2737	Female, age 85, both hemispheres	169.8
2164	Male, age 80, both hemispheres	124.1
1978	Male, age 76, both hemispheres	108.5

Subcoeruleus area
nTPM: 111.1

1958	Male, age 80, both hemispheres	126.9
2089	Male, age 76, left hemisphere	117.9
2323	Female, age 91, left hemisphere	109.5
2451	Male, age 74, both hemispheres	103.8
2369	Female, age 85, left hemisphere	97.2

Superior olive
nTPM: 118.0

1875	Female, age 85, both hemispheres	129.3
2364	Male, age 74, right hemisphere	126.9
2020	Male, age 76, both hemispheres	119.3
2329	Male, age 80, right hemisphere	119.3
2561	Female, age 91, both hemispheres	95.4

Ventral periolivary nuclei
nTPM: 130.8

2130	Female, age 85, both hemispheres	161.4
2165	Male, age 80, both hemispheres	144.6
2023	Male, age 76, both hemispheres	117.7
2794	Female, age 91, left hemisphere	99.5

Ventrolateral tegmental area, A5 NE cell group
nTPM: 124.3

2840	Female, age 85, both hemispheres	140.1
2359	Male, age 61, both hemispheres	139.9
1959	Male, age 76, both hemispheres	133.3
2161	Male, age 80, both hemispheres	129.1
2449	Male, age 74, both hemispheres	103.4
2456	Female, age 91, both hemispheres	100.1

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	150.5

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 150.5

FF:10182-103D2	60 years, female	196.5
FF:10165-103B3	76 years, female	104.4

Pons
Scaled Tags Per Million: 139.3

FF:10033-101E6

18-54 years, mixed

139.3

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	70.4

Macaque sample

Sample description

nTPM

Pons
nTPM: 70.4

Samples: 2

Max nTPM: 80.6
Min nTPM: 60.1

Sample A		60.1
Sample B		80.6

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	104.5

Pig sample

Sample description

nTPM

Pons
nTPM: 104.5

Samples: 3

Max nTPM: 106.2
Min nTPM: 102.9

Sample A	Female	104.5
Sample B	Female	106.2
Sample C	Male	102.9

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	51.4

Mouse sample

Sample description

nTPM

Pons
nTPM: 51.4

Samples: 4

Max nTPM: 61.4
Min nTPM: 42.7

Sample A		43.2
Sample B		61.4
Sample C		42.7
Sample D		58.3

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	46.8

Rat sample

Sample description

nTPM

Pons
nTPM: 46.8

Samples: 4

Max nTPM: 49.3
Min nTPM: 44.2

Sample A		44.2
Sample A		49.3
Sample A		46.7
Sample A		47.1