Single cell type - MPP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MPP2
Gene descriptionⁱ Full gene name according to HGNC.	MAGUK p55 scaffold protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	19

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Retinal bipolar cells - Synaptic signal transduction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Retinal bipolar cells, Early spermatids, Oligodendrocytes, Choroid plexus epithelial cells, Corticotrophs, Early primary spermatocytes, Retinal horizontal cells, Late spermatids, Retinal pigment epithelial cells, Cardiomyocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.72
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

Single cell type

Cell type enrichment

Single nuclei - Brain

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nCPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. * Single nuclei Read more
Single cell type groups RNA single cell type group specificity: Cell type enhanced (Neuronal cells, Spermatogenic cell types, Glial cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas HPA data, as well as data generated by Monaco et al and Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Not detected in immune cells
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

MPP2 is part of cluster 86 Retinal bipolar cells - Synaptic signal transduction with confidenceⁱ 1
272 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IFNL3	Interferon lambda 3	0.5403	86
GPRIN1	G protein regulated inducer of neurite outgrowth 1	0.5271	86
GABRB3	Gamma-aminobutyric acid type A receptor subunit beta3	0.5082	86
TACR3	Tachykinin receptor 3	0.4948	86
NRXN3	Neurexin 3	0.4867	86
LRFN1	Leucine rich repeat and fibronectin type III domain containing 1	0.4862	86
LACTBL1	Lactamase beta like 1	0.4829	86
SLC25A22	Solute carrier family 25 member 22	0.4822	86
AMIGO1	Adhesion molecule with Ig like domain 1	0.4813	86
ZNF804B	Zinc finger protein 804B	0.4759	86
GABRA5	Gamma-aminobutyric acid type A receptor subunit alpha5	0.4757	86
KIF1A	Kinesin family member 1A	0.4752	86
NEUROD4	Neuronal differentiation 4	0.4738	86
SORCS2	Sortilin related VPS10 domain containing receptor 2	0.4706	86
TRPC7	Transient receptor potential cation channel subfamily C member 7	0.4697	86

IMMUNE CELLS

MPP2 is part of cluster 3 Non-specific - Nuclear processes with confidenceⁱ 0.96
471 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
STMN3	Stathmin 3	0.9762	3
HSF2	Heat shock transcription factor 2	0.9762	43
BNIP3	BCL2 interacting protein 3	0.9762	3
PRRT3	Proline rich transmembrane protein 3	0.9762	43
GSTM3	Glutathione S-transferase mu 3	0.9762	43
NAE1	NEDD8 activating enzyme E1 subunit 1	0.9762	3
USP20	Ubiquitin specific peptidase 20	0.9524	3
SLC29A2	Solute carrier family 29 member 2	0.9524	11
C15orf40	Chromosome 15 open reading frame 40	0.9524	3
NR2F6	Nuclear receptor subfamily 2 group F member 6	0.9524	3
TMEM177	Transmembrane protein 177	0.9524	43
WDR89	WD repeat domain 89	0.9524	43
CACNA2D2	Calcium voltage-gated channel auxiliary subunit alpha2delta 2	0.9524	11
LY9	Lymphocyte antigen 9	0.9524	11
CISH	Cytokine inducible SH2 containing protein	0.9524	11