Single cell type - ENSG00000111780 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ENSG00000111780
Gene descriptionⁱ Full gene name according to HGNC.	Novel protein
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Intestinal epithelial cells - Intestinal epi homeostasis & respiration (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Enterocytes, Colonocytes, Enteric transient amplifying cells, Enteric stem cells, Goblet cells, Parietal cells, Cardiomyocytes, Epididymal clear cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.70
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

Single cell type

Single nuclei - Brain

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nCPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. * Single nuclei Read more
Single cell type groups RNA single cell type group specificity: Cell type enhanced (Enterocytes, Proliferating cells)

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas HPA data, as well as data generated by Monaco et al and Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ENSG00000111780 is part of cluster 54 Intestinal epithelial cells - Intestinal epi homeostasis & respiration with confidenceⁱ 1
107 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CDX2	Caudal type homeobox 2	0.7473	54
CDX1	Caudal type homeobox 1	0.7392	54
ISX	Intestine specific homeobox	0.7091	54
CHP2	Calcineurin like EF-hand protein 2	0.6885	1
MICOS10	Mitochondrial contact site and cristae organizing system subunit 10	0.6781	15
PIGR	Polymeric immunoglobulin receptor	0.6746	54
NDUFV2	NADH:ubiquinone oxidoreductase core subunit V2	0.6648	15
PRAC1	PRAC1 small nuclear protein	0.6575	54
B3GNT7	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7	0.6524	54
HOXB13	Homeobox B13	0.6495	54
NOX1	NADPH oxidase 1	0.6467	54
NXPE4	Neurexophilin and PC-esterase domain family member 4	0.6394	54
TACO1	Translational activator of cytochrome c oxidase I	0.6316	15
CDH17	Cadherin 17	0.6172	45
ENSG00000267261	Novel protein	0.6157	15

IMMUNE CELLS

ENSG00000111780 is part of cluster 12 Non-specific - Mitochondrial translation with confidenceⁱ 0.99
566 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
MDP1	Magnesium dependent phosphatase 1	1.0000	12
PACC1	Proton activated chloride channel 1	0.9762	12
NDUFS3	NADH:ubiquinone oxidoreductase core subunit S3	0.9762	12
RNLS	Renalase, FAD dependent amine oxidase	0.9762	12
BAP1	BRCA1 associated protein 1	0.9762	29
RANBP10	RAN binding protein 10	0.9762	29
PTPMT1	Protein tyrosine phosphatase mitochondrial 1	0.9762	12
NDUFS8	NADH:ubiquinone oxidoreductase core subunit S8	0.9524	12
METTL26	Methyltransferase like 26	0.9524	12
GNL2	G protein nucleolar 2	0.9524	12
TMEM147	Transmembrane protein 147	0.9524	12
FAHD1	Fumarylacetoacetate hydrolase domain containing 1	0.9524	12
ZNF555	Zinc finger protein 555	0.9524	29
SELENOH	Selenoprotein H	0.9524	12
TOMM6	Translocase of outer mitochondrial membrane 6	0.9524	12