Protein interactions - DNMT1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DNMT1
Synonyms	CXXC9, DNMT, MCMT
Gene descriptionⁱ Full gene name according to HGNC.	DNA methyltransferase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Essential proteins FDA approved drug targets Human disease related genes Metabolic proteins Plasma proteins Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Cytotrophoblasts - Basic cellular functions (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Cytotrophoblasts, Early primary spermatocytes, Erythrocyte progenitors, Megakaryocyte progenitors, Migrating cytotrophoblasts, Monocyte progenitors, Syncytiotrophoblasts)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Lymphoid tissue - Adaptive immune response (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	10133342 - 10231286
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	13
Ensembl	ENSG00000130816 (version 109)
Entrez gene	1786
HGNC	HGNC:2976
UniProt	P26358
GeneCards	DNMT1

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Lymphoid tissue - Adaptive immune response

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
AKT1	53	143	197	2	4
DCAF5	2	3	8	1	23
EED	12	12	66	6	0
EZH2	16	16	236	7	0
L3MBTL3	1	24	15	3	0
NRIP1	9	15	29	2	1
PARP1	80	28	281	158	1
PICK1	10	276	36	0	9
SETD7	7	17	21	0	0
SIRT1	34	48	126	0	17
UHRF1	4	3	54	4	6
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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
AKT1	53	143	197	2	4
CTNNB1	47	85	285	13	13
DCAF5	2	3	8	1	23
EED	12	12	66	6	0
EZH2	16	16	236	7	0
L3MBTL3	1	24	15	3	0
NRIP1	9	15	29	2	1
PARP1	80	28	281	158	1
PICK1	10	276	36	0	9
SETD7	7	17	21	0	0
SIRT1	34	48	126	0	17
UHRF1	4	3	54	4	6
YWHAZ	222	164	348	324	8
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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ACE2	10	13	278	0	0
AKT1	53	143	197	2	4
APEX1	2	4	71	1	0
BRAP	3	5	14	0	1
BRD4	4	6	490	0	2
CBX5	29	59	88	9	24
CHD4	13	3	188	17	0
CHEK1	7	10	52	7	1
CUL3	40	45	771	2	0
CUL4B	6	11	169	4	0
DAXX	37	79	88	0	0
DCAF5	2	3	8	1	23
DDB1	39	22	173	64	9
DMAP1	14	27	40	4	25
DNMT3A	6	14	35	1	1
DNMT3B	6	6	28	0	0
EED	12	12	66	6	0
EHMT2	10	29	57	0	0
EZH2	16	16	236	7	0
FBP1	2	6	12	0	4
H3-4	6	22	109	0	0
H3C1	26	53	300	0	14
H4C1	32	56	356	0	5
HDAC1	104	65	375	76	42
HDAC2	68	19	227	88	12
HELLS	2	2	27	1	0
KAT5	17	180	88	3	0
KDM1A	61	88	154	9	0
L3MBTL3	1	24	15	3	0
LASP1	1	22	12	0	0
MECP2	8	34	97	9	0
MTA1	13	23	68	0	8
MTA2	14	6	84	17	9
MYC	66	90	1269	2	0
NR2C1	0	0	21	0	0
NR2C2	2	2	35	0	0
NRIP1	9	15	29	2	1
PARP1	80	28	281	158	1
PCLAF	1	1	6	0	2
PCNA	34	37	150	10	14
PHF20L1	2	24	7	0	3
PICK1	10	276	36	0	9
PRKN	11	11	1405	0	0
RB1	32	36	147	2	1
RUNX1	3	7	48	0	0
RUNX1T1	2	4	21	0	0
SETD7	7	17	21	0	0
SIRT1	34	48	126	0	17
SNAI1	9	29	57	0	0
STAT3	25	59	107	0	0
STK4	23	17	947	24	7
SUV39H1	32	52	53	2	8
SUZ12	8	6	79	10	4
TP53	123	166	704	5	0
TRIM28	109	24	346	68	94
UBB	2	36	30	5	16
UHRF1	4	3	54	4	6
UHRF2	6	6	29	0	0
USP7	28	28	212	7	11
ZNF263	2	12	12	0	0
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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
YWHAZ	222	164	348	324	8

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene DNMT1 is associated with 3 reactions in 2 different subsystems, and present in the compartments: Cytosol, Nucleus. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Cysteine and methionine metabolism	Cytosol, Mitochondria, Nucleus, Extracellular	43	74	2
Metabolism of other amino acids	Cytosol, Peroxisome, Nucleus, Endoplasmic reticulum	28	53	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DNMT1-201	P26358		Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Transcription factors Disease related genes FDA approved drug targets Human disease related genes Mapped to neXtProt Essential proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	1616 aa 183.2 kDa	No	0
DNMT1-202	P26358		Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Transcription factors Disease related genes FDA approved drug targets Human disease related genes Mapped to neXtProt Essential proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	1632 aa 184.8 kDa	No	0
DNMT1-209		K7EKC3	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	25 aa 2.7 kDa	No	0
DNMT1-213		K7EJL0	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	255 aa 28.3 kDa	No	0
DNMT1-215		K7ENQ6	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	119 aa 13.6 kDa	No	0
DNMT1-221		K7ER10	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	77 aa 8.5 kDa	No	0
DNMT1-225		K7ERQ1	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	71 aa 7.8 kDa	No	0
DNMT1-226		K7ELB1	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	94 aa 10.4 kDa	No	0
DNMT1-230		A0A7I2YQQ0	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	1613 aa 182.4 kDa	No	0
DNMT1-241		A0A7I2V5D0	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	1655 aa 187.1 kDa	No	0
DNMT1-247		A0A7I2V490	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	1658 aa 187.3 kDa	No	0
DNMT1-251		A0A7I2YQA8	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	1577 aa 179.2 kDa	No	0
DNMT1-252		A0A7I2V5F1	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	1580 aa 179.4 kDa	No	0
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