Single cell type - CYP2J2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CYP2J2
Gene descriptionⁱ Full gene name according to HGNC.	Cytochrome P450 family 2 subfamily J member 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Cardiomyocytes - Cardiac muscle contraction & structure (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Syncytiotrophoblasts, Cardiomyocytes, Esophageal apical cells, Enterocytes, Bergmann glia, Cytotrophoblasts, Migrating cytotrophoblasts, Respiratory secretory cells, Myonuclei, Oligodendrocytes, Hepatocytes)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.75
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Cell type enhanced (Bergmann glia, Oligodendrocyte, Astrocyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enhanced (naive CD4 T-cell, naive CD8 T-cell)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

Single cell type

Cell type enrichment

Single nuclei - Brain

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nCPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. * Single nuclei Read more
Single cell type groups RNA single cell type group specificity: Cell type enhanced (Trophoblast cells, Myocytes, Apical squamous epithelial cells, Enterocytes, Glial cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Cell type enhanced (Bergmann glia, Oligodendrocyte, Astrocyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas HPA data, as well as data generated by Monaco et al and Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enhanced (naive CD4 T-cell, naive CD8 T-cell)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

CYP2J2 is part of cluster 60 Cardiomyocytes - Cardiac muscle contraction & structure with confidenceⁱ 1
246 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ARGFX	Arginine-fifty homeobox	0.5868	60
MYOZ2	Myozenin 2	0.5735	60
MYH6	Myosin heavy chain 6	0.5494	60
PKD2L2	Polycystin 2 like 2, transient receptor potential cation channel	0.5179	60
CSRP3	Cysteine and glycine rich protein 3	0.4995	55
OR6C4	Olfactory receptor family 6 subfamily C member 4	0.4975	60
STRADB	STE20 related adaptor beta	0.4921	60
FREM3	FRAS1 related extracellular matrix 3	0.4850	60
CBR4	Carbonyl reductase 4	0.4847	60
CDIN1	CDAN1 interacting nuclease 1	0.4838	60
RBM20	RNA binding motif protein 20	0.4797	60
AKAP6	A-kinase anchoring protein 6	0.4789	46
RNF207	Ring finger protein 207	0.4788	60
TECRL	Trans-2,3-enoyl-CoA reductase like	0.4774	55
NRAP	Nebulin related anchoring protein	0.4747	55

IMMUNE CELLS

CYP2J2 is part of cluster 30 Non-specific - DNA binding with confidenceⁱ 0.99
263 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PPT2	Palmitoyl-protein thioesterase 2	1.0000	30
NT5C1B	5'-nucleotidase, cytosolic IB	1.0000	30
TSPYL2	TSPY like 2	1.0000	30
OR3A2	Olfactory receptor family 3 subfamily A member 2	0.9762	30
FBXL22	F-box and leucine rich repeat protein 22	0.9762	30
NUCB2	Nucleobindin 2	0.9762	30
C5orf34	Chromosome 5 open reading frame 34	0.9524	30
C8orf88	Chromosome 8 open reading frame 88	0.9524	30
GAL3ST4	Galactose-3-O-sulfotransferase 4	0.9524	30
RBIS	Ribosomal biogenesis factor	0.9524	30
PTPRM	Protein tyrosine phosphatase receptor type M	0.9524	30
SNRPN	Small nuclear ribonucleoprotein polypeptide N	0.9524	30
USP9Y	Ubiquitin specific peptidase 9 Y-linked	0.9524	30
TMIGD2	Transmembrane and immunoglobulin domain containing 2	0.9286	30
SALL2	Spalt like transcription factor 2	0.9286	30