Brain tissue expression of RPS11 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	796.8	nTPM
FANTOM5:	187.4	Scaled Tags Per Million

Mouse:	202.0	nTPM
Pig:	287.7	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
Show allShow less

This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
Show allShow less

This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	796.8

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 796.8

2090	Male, age 80, both hemispheres	909.1
2188	Female, age 91, both hemispheres	857.0
2301	Female, age 85, both hemispheres	794.8
1984	Male, age 76, both hemispheres	626.4

Dorsal cochlear nucleus
nTPM: 721.4

2187	Female, age 91, both hemispheres	818.3
2802	Male, age 74, right hemisphere	800.0
2378	Male, age 80, both hemispheres	708.9
2370	Male, age 61, both hemispheres	684.1
2058	Male, age 76, both hemispheres	595.6

Dorsal tegmental nucleus
nTPM: 787.9

2358	Male, age 61, both hemispheres	848.9
2326	Male, age 74, both hemispheres	825.6
2083	Male, age 80, both hemispheres	806.5
1936	Male, age 76, left hemisphere	670.7

Dorsolateral tegmental area
nTPM: 756.9

2337	Male, age 61, both hemispheres	966.4
2654	Male, age 80, both hemispheres	870.0
2751	Female, age 85, both hemispheres	695.4
2141	Male, age 76, both hemispheres	630.8
2360	Male, age 74, both hemispheres	621.9

Kolliker-Fuse nucleus
nTPM: 791.2

2315	Male, age 76, right hemisphere	891.0
2793	Female, age 91, left hemisphere	791.6
2163	Male, age 80, both hemispheres	691.0

Lateral lemniscal nuclei
nTPM: 570.2

2746	Female, age 85, left hemisphere	612.4
2169	Male, age 76, both hemispheres	594.7
2320	Female, age 91, left hemisphere	593.9
2453	Male, age 74, right hemisphere	526.9
2036	Male, age 80, both hemispheres	523.2

Lateral parabrachial nucleus
nTPM: 795.8

2792	Male, age 76, both hemispheres	976.0
2013	Male, age 80, both hemispheres	852.6
2139	Female, age 85, right hemisphere	717.1
2790	Male, age 61, both hemispheres	637.7

Lateral vestibular nucleus
nTPM: 741.4

2311	Male, age 80, both hemispheres	873.8
2184	Male, age 76, both hemispheres	609.0

Locus coeruleus
nTPM: 628.4

2720	Male, age 74, both hemispheres	775.2
2123	Female, age 91, both hemispheres	700.8
2162	Male, age 80, both hemispheres	686.8
2317	Female, age 72, unknown	599.5
2014	Male, age 55, unknown	579.6
1980	Male, age 76, both hemispheres	577.3
2788	Male, age 74, unknown	479.5

Medial parabrachial nucleus
nTPM: 731.4

2170	Female, age 91, both hemispheres	821.3
2854	Male, age 80, both hemispheres	761.8
2156	Male, age 61, both hemispheres	708.9
2786	Male, age 76, both hemispheres	687.5
2463	Female, age 85, right hemisphere	677.8

Medial periolivary nuclei
nTPM: 625.8

2081	Male, age 80, both hemispheres	730.5
2063	Male, age 76, both hemispheres	667.2
2458	Female, age 91, both hemispheres	640.0
2791	Male, age 74, right hemisphere	579.0
2171	Female, age 85, both hemispheres	512.2

Motor facial nucleus
nTPM: 635.1

2126	Male, age 61, both hemispheres	742.8
2697	Female, age 85, both hemispheres	676.1
2795	Female, age 91, both hemispheres	668.5
2365	Male, age 74, right hemisphere	647.8
2062	Male, age 76, both hemispheres	607.4
2327	Male, age 80, both hemispheres	468.1

Motor trigeminal nucleus
nTPM: 664.2

2335	Male, age 61, both hemispheres	751.3
2321	Female, age 91, both hemispheres	680.1
2309	Male, age 76, both hemispheres	677.2
2560	Male, age 74, both hemispheres	632.4
2079	Male, age 80, both hemispheres	579.9

Nuclei of the trapezoid body
nTPM: 601.4

1983	Male, age 76, both hemispheres	762.5
2166	Male, age 80, both hemispheres	643.1
2159	Male, age 61, both hemispheres	567.4
2368	Female, age 91, both hemispheres	539.6
2735	Female, age 85, both hemispheres	494.6

Nucleus raphe magnus
nTPM: 575.2

2051	Male, age 76, both hemispheres	628.9
2459	Female, age 91, both hemispheres	602.6
2455	Male, age 74, both hemispheres	592.3
2328	Male, age 80, both hemispheres	574.1
2172	Female, age 85, both hemispheres	543.4
2160	Male, age 61, both hemispheres	510.2

Paramedian reticular nucleus
nTPM: 667.9

2052	Male, age 76, both hemispheres	716.5
2057	Male, age 80, both hemispheres	676.1
2313	Male, age 61, both hemispheres	658.0
2050	Female, age 85, both hemispheres	621.0

Pedunculopontine tegmental nucleus
nTPM: 740.0

2338	Male, age 61, both hemispheres	879.7
2334	Male, age 80, both hemispheres	762.4
1921	Female, age 85, both hemispheres	578.1

Pontine nuclei
nTPM: 663.8

2319	Female, age 91, both hemispheres	783.6
1863	Male, age 55, unknown	700.0
2115	Male, age 80, left hemisphere	696.0
1968	Male, age 76, left hemisphere	675.2
2454	Male, age 74, left hemisphere	665.7
2787	Female, age 85, both hemispheres	647.6
2109	Female, age 72, unknown	634.9
2727	Male, age 61, right hemisphere	507.7

Pontine raphe nucleus
nTPM: 602.1

2853	Male, age 76, midline	607.4
2122	Female, age 85, midline	596.8

Posteroventral cochlear nucleus
nTPM: 790.5

2135	Female, age 91, both hemispheres	930.7
2341	Male, age 80, both hemispheres	911.7
2371	Male, age 61, both hemispheres	745.4
2070	Male, age 76, both hemispheres	711.7
2752	Female, age 85, both hemispheres	652.8

Principal sensory trigeminal nucleus
nTPM: 592.4

2367	Female, age 91, left hemisphere	689.5
2324	Male, age 76, both hemispheres	608.7
2158	Male, age 61, both hemispheres	574.4
2008	Male, age 80, left hemisphere	496.9

Reticular pontine nucleus, caudal
nTPM: 644.9

2092	Male, age 76, both hemispheres	722.1
2559	Male, age 74, both hemispheres	693.9
2457	Female, age 91, both hemispheres	680.8
2332	Male, age 80, right hemisphere	483.0

Reticular pontine nucleus, oral
nTPM: 670.8

2366	Female, age 91, both hemispheres	801.7
1939	Male, age 80, both hemispheres	737.0
2167	Male, age 76, both hemispheres	718.1
2012	Female, age 85, both hemispheres	557.9
2361	Male, age 74, both hemispheres	539.3

Reticulotegmental nucleus
nTPM: 679.0

2452	Male, age 74, both hemispheres	757.4
2322	Female, age 91, both hemispheres	697.5
2333	Male, age 80, both hemispheres	665.1
2325	Male, age 76, both hemispheres	596.1

Spinal trigeminal nucleus, oral
nTPM: 623.0

2164	Male, age 80, both hemispheres	681.8
1978	Male, age 76, both hemispheres	617.1
2737	Female, age 85, both hemispheres	570.0

Subcoeruleus area
nTPM: 677.8

2451	Male, age 74, both hemispheres	791.7
2369	Female, age 85, left hemisphere	731.9
1958	Male, age 80, both hemispheres	663.1
2323	Female, age 91, left hemisphere	633.4
2089	Male, age 76, left hemisphere	568.9

Superior olive
nTPM: 618.6

2020	Male, age 76, both hemispheres	735.6
2561	Female, age 91, both hemispheres	667.7
2364	Male, age 74, right hemisphere	609.5
2329	Male, age 80, right hemisphere	545.4
1875	Female, age 85, both hemispheres	534.6

Ventral periolivary nuclei
nTPM: 638.2

2023	Male, age 76, both hemispheres	761.0
2794	Female, age 91, left hemisphere	648.9
2165	Male, age 80, both hemispheres	578.2
2130	Female, age 85, both hemispheres	564.6

Ventrolateral tegmental area, A5 NE cell group
nTPM: 649.9

2359	Male, age 61, both hemispheres	707.7
2840	Female, age 85, both hemispheres	704.7
2161	Male, age 80, both hemispheres	676.1
1959	Male, age 76, both hemispheres	661.8
2456	Female, age 91, both hemispheres	605.3
2449	Male, age 74, both hemispheres	543.9

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	187.4

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 187.4

FF:10165-103B3	76 years, female	192.1
FF:10182-103D2	60 years, female	182.8

Pons
Scaled Tags Per Million: 69.3

FF:10033-101E6

18-54 years, mixed

69.3

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	287.7

Pig sample

Sample description

nTPM

Pons
nTPM: 287.7

Samples: 3

Max nTPM: 355.6
Min nTPM: 206.0

Sample A	Female	301.6
Sample B	Female	206.0
Sample C	Male	355.6

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	202.0

Mouse sample

Sample description

nTPM

Pons
nTPM: 202.0

Samples: 4

Max nTPM: 212.2
Min nTPM: 178.0

Sample A		178.0
Sample B		212.2
Sample C		210.4
Sample D		207.4