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BETA
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  • LRRTM2
BRAIN MIDBRAIN Show tissue menu
AMYGDALA BASAL GANGLIA CEREBELLUM CEREBRAL CORTEX HIPPOCAMPAL FORMATION HYPOTHALAMUS
MEDULLA OBLONGATA MIDBRAIN PONS SPINAL CORD THALAMUS
Brain proteome
Midbrain
Methods
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MIDBRAIN - Expression summary
Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units. Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set. If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas HPA, Genotype-Tissue Expression GTEx portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets. The mRNA expression levels in pig brain are based on RNA-seq data generated by the Human Protein Atlas, and for mouse brain HPA data and in situ hybridization generated by the Allen brain atlas dataset are reported.

Scroll down to view mRNA expression data in more detail.

Consensus:3.7 nTPM
HPA Brain:33.4 nTPM
GTEx:3.7 nTPM
FANTOM5:24.5 Scaled Tags Per Million
Macaque:34.2 nTPM
Mouse:17.8 nTPM
Rat:21.1 nTPM
Pig:42.2 nTPM
MIDBRAIN - SINGLE NUCLEI RNA EXPRESSIONi

RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right).

- UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon

- The BAR CHART shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.


SINGLE NUCLEI BRAIN - MIDBRAIN, NEURONSi

RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right).

- UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon

- The BAR CHART shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

Cell type color
Cluster color
Colored according to cell type group
Colored according to clusters
Read count filter: 0
 
Cluster Cell type Expression (nCPM)
0 100
c-1 Inhibitory (GAD1/2) RORB+ K
c-2 Excitatory (VGLUT1) ETV1+ Z...
c-3 Inhibitory (GAD1/2) RORB+ K
c-4 Inhibitory (GAD1/2) RORB+ K
c-5 Unassigned
c-6 Tectum Excitatory (VGLUT2)
c-7 Inhibitory (GAD1/2)
c-8 Inhibitory (GAD1/2) TFAP2B+
c-9 Excitatory (VGLUT2)
c-10 Excitatory (VGLUT2)
c-11 Tectum Inhibitory (GAD1/2)
c-12 Excitatory (VGLUT2) TFAP2B+
c-13 Excitatory (VGLUT2)
c-14 Excitatory (VGLUT2)
c-15 Tectum Excitatory (VGLUT2)
c-16 Excitatory (VGLUT2)
c-17 Inhibitory (GAD1/2)
c-18 Excitatory (VGLUT2)
c-19 Inhibitory (GAD1/2)
c-20 Inhibitory (GAD1/2)
c-21 Excitatory (VGLUT2)
c-22 Excitatory (VGLUT2)
c-23 Inhibitory (GAD1/2) TFAP2B+
c-24 Inhibitory (GAD1/2)
c-25 Excitatory (VGLUT2) CRH+ CA...
c-26 Inhibitory (GAD1/2) SST+
c-27 Inhibitory (GAD1/2) NPY+
c-28 Inhibitory (GAD1/2) RORB+ K
c-29 Excitatory (VGLUT2) TFAP2B+
c-30 Excitatory (VGLUT2)
c-31 Dopaminergic TH+ LMX1A+ SLC...
c-32 Inhibitory (GAD1/2) PVALB+
c-33 Tegmentum Excitatory (VGLUT...
c-34 Excitatory (VGLUT2) LMX1A+
c-35 Tegmentum Inhibitory (GAD2)...
c-36 TPH2+
c-37 Inhibitory (GAD1/2) CXCL14+
c-38 Excitatory (VGLUT1) SATB2+
c-39 Inhibitory (GAD1/2) RORB+ K
c-40 Excitatory (VGLUT2) MEIS2+
c-41 Inhibitory (GAD1/2) TFAP2B+
c-42 Excitatory (VGLUT2)
c-43 Excitatory (VGLUT1)
c-44 SN Monoaminergic Inhibitory...
c-45 Inhibitory (GAD1/2)
c-46 Excitatory (VGLUT1) GRP+
c-47 Inhibitory (GAD1/2) PVALB+ ...
c-48 Excitatory (VGLUT1)
c-49 Inhibitory (GAD1/2) LAMP5+
c-50 Excitatory (VGLUT2) KIT+
c-51 Excitatory (VGLUT1) SLC5A7+
c-52 Inhibitory (GAD1/2) NOS1+ G...
Show allShow less
This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - MIDBRAIN, NON-NEURONALi

RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right).

- UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)*100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon

- The BAR CHART shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

Cell type color
Cluster color
Colored according to cell type group
Colored according to clusters
Read count filter: 0
 
Cluster Cell type Expression (nCPM)
0 110
c-1 Oligodendrocytes
c-2 Oligodendrocytes
c-3 Microglia
c-4 Oligodendrocytes
c-5 Oligodendrocyte progenitor ...
c-6 Astrocytes
c-7 Oligodendrocytes
c-8 Oligodendrocytes
c-9 Oligodendrocytes
c-10 Oligodendrocytes
c-11 Oligodendrocytes
c-12 Astrocytes
c-13 Fibroblasts
c-14 NK-cells & T-cells
c-15 Macrophages
c-16 Ependymal cells
c-17 Capillary endothelial cells
c-18 Pericytes
c-19 Oligodendrocyte progenitor ...
c-20 Immature oligodendrocytes
c-21 Vascular smooth muscle cell
c-22 Oligodendrocyte progenitor ...
c-23 B-cells & Monocytes doublet
c-24 Arterial endothelial cells
c-25 CD44+ Mural cells
c-26 Bergmann glia
c-27 Oligodendrocytes & Lymphocy
c-28 Macrophages & Monocytes
Show allShow less
This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

MIDBRAIN - Annotated protein expression
Pending normal tissue analysis

MIDBRAIN - HPA Brain RNA-seq
Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

33.4
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 22.7
1827 Male, age 72, unknown 30.4
2666 Male, age 74, left hemisphere 25.6
2411 Female, age 72, unknown 24.0
2219 Male, age 76, both hemispheres 23.9
1833 Male, age 53, unknown 23.6
1870 Female, age 42, unknown 23.0
2828 Female, age 72, unknown 22.9
2019 Male, age 18, unknown 18.9
1830 Male, age 51, unknown 18.5
2586 Male, age 75, left hemisphere 16.6
Dorsal raphe nucleus
nTPM: 20.4
2750 Male, age 76, both hemispheres 23.9
2298 Female, age 72, unknown 22.8
1828 Male, age 53, unknown 20.6
2047 Male, age 72, unknown 19.1
2016 Female, age 72, unknown 15.5
Inferior colliculus
nTPM: 21.7
1848 Female, age 42, unknown 25.3
2097 Female, age 72, unknown 24.2
2849 Male, age 72, unknown 21.0
1890 Male, age 53, unknown 16.2
Median raphe nucleus
nTPM: 26.2
2220 Male, age 76, midline 26.2
Periaquaductal grey, anterior
nTPM: 29.8
1947 Male, age 18, unknown 39.3
1795 Male, age 51, unknown 28.3
2502 Female, age 75, unknown 21.9
Periaquaductal grey, dorsal
nTPM: 22.1
1840 Male, age 53, unknown 25.1
1831 Male, age 72, unknown 23.5
2464 Female, age 72, unknown 22.8
2850 Male, age 76, both hemispheres 17.0
Periaquaductal grey, lateral
nTPM: 22.6
2053 Male, age 18, unknown 27.3
2272 Male, age 74, both hemispheres 23.4
2140 Male, age 76, both hemispheres 17.1
Pretectal area
nTPM: 33.4
1816 Male, age 51, unknown 58.0
1944 Female, age 72, unknown 56.9
1815 Male, age 53, unknown 39.1
2007 Male, age 72, unknown 31.9
1817 Female, age 42, unknown 31.7
2667 Female, age 75, unknown 29.7
2224 Female, age 72, unknown 27.1
2825 Male, age 18, unknown 26.7
2316 Male, age 76, right hemisphere 24.2
2407 Male, age 75, both hemispheres 22.3
2273 Male, age 74, both hemispheres 19.7
Red nucleus
nTPM: 20.9
2823 Male, age 76, right hemisphere 26.2
2503 Female, age 72, unknown 24.7
1821 Female, age 72, unknown 22.7
1904 Male, age 53, unknown 21.7
2584 Male, age 75, left hemisphere 21.6
2785 Male, age 18, unknown 21.2
1865 Male, age 51, unknown 20.7
1954 Female, age 42, unknown 20.4
2725 Female, age 75, unknown 20.4
2588 Male, age 74, left hemisphere 18.7
2769 Male, age 72, unknown 16.6
2227 Male, age 72, unknown 16.3
Substantia nigra
nTPM: 21.4
1889 Female, age 72, unknown 28.6
2409 Female, age 72, unknown 27.2
2590 Female, age 75, unknown 25.9
2241 Male, age 72, unknown 23.6
2583 Male, age 75, right hemisphere 20.2
1851 Male, age 51, unknown 19.5
1941 Male, age 53, unknown 18.7
2665 Male, age 74, both hemispheres 18.5
1916 Female, age 42, unknown 18.1
2699 Male, age 18, unknown 13.8
Superior colliculus
nTPM: 31.2
2087 Female, age 72, unknown 48.6
2261 Male, age 18, unknown 37.0
2668 Female, age 75, unknown 34.8
1913 Female, age 42, unknown 34.5
1895 Male, age 76, right hemisphere 32.8
1796 Male, age 53, unknown 32.4
1995 Male, age 72, unknown 30.9
2587 Male, age 74, left hemisphere 21.6
1839 Male, age 51, unknown 21.2
2664 Male, age 75, both hemispheres 18.3
Ventral tegmental area
nTPM: 20.7
2410 Female, age 72, unknown 26.4
2218 Male, age 76, both hemispheres 24.4
1942 Male, age 51, unknown 20.8
1915 Female, age 42, unknown 17.9
2021 Male, age 53, unknown 17.3
2223 Female, age 72, unknown 17.2

MIDBRAIN - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.

Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

3.7
GTEx sample id Sample description nTPM
Brain - Substantia nigra
Average nTPM: 3.7
Samples: 183

Max nTPM: 12.9
Min nTPM: 0.7
Std nTPM: 1.8
Median nTPM: 3.4
GTEX-WVLH-0011-R2A-SM-3MJFJ 50-59 years, male 12.9
GTEX-1PIIG-0011-R2b-SM-F648W 30-39 years, male 10.1
GTEX-ZAB4-0011-R2a-SM-4RGNP 40-49 years, male 8.8
GTEX-13SLX-0011-R2b-SM-5S2VP 50-59 years, female 8.6
GTEX-1MJK2-0011-R2b-SM-EXUS5 50-59 years, male 8.5
GTEX-QDT8-0011-R2A-SM-32PKQ 30-39 years, female 7.7
GTEX-WL46-0011-R2A-SM-3LK6O 50-59 years, male 7.6
GTEX-1HB9E-0011-R2b-SM-A96RW 50-59 years, male 7.5
GTEX-1HT8W-0011-R2a-SM-CMKH9 30-39 years, male 7.5
GTEX-15ER7-0011-R2a-SM-6M46O 20-29 years, female 7.4
GTEX-1J8Q2-0011-R2b-SM-EAZ2X 60-69 years, male 7.3
GTEX-Z93S-0011-R2a-SM-4RGNG 50-59 years, male 7.3
GTEX-1JN1M-0011-R2b-SM-G9EPE 60-69 years, female 7.2
GTEX-117XS-0011-R2b-SM-GI4VT 60-69 years, male 7.0
GTEX-WHSE-0011-R2A-SM-3P5ZL 20-29 years, male 6.8
GTEX-12WSH-0011-R2a-SM-5GU68 50-59 years, male 6.5
GTEX-1LH75-0011-R2b-SM-EYYWQ 50-59 years, female 5.9
GTEX-1B8L1-0011-R2a-SM-9OSVL 60-69 years, male 5.8
GTEX-11GSP-0011-R2b-SM-9QEGE 60-69 years, female 5.7
GTEX-13OW7-0011-R2b-SM-H6Q8E 50-59 years, male 5.6
GTEX-1EMGI-0011-R2b-SM-9OSVS 60-69 years, male 5.6
GTEX-13OVJ-0011-R2b-SM-5L3GP 50-59 years, female 5.5
GTEX-14C5O-0011-R2a-SM-5ZZV2 60-69 years, male 5.5
GTEX-1313W-0011-R2a-SM-5EGLF 50-59 years, female 5.4
GTEX-1LSVX-0011-R2a-SM-G8OL9 60-69 years, male 5.4
GTEX-1N2EF-0011-R2b-SM-F6482 60-69 years, male 5.4
GTEX-NPJ7-0011-R2a-SM-2I3GF 60-69 years, female 5.4
GTEX-ZAJG-0011-R2a-SM-GNTAX 50-59 years, female 5.4
GTEX-11ZTS-0011-R2b-SM-5BC75 60-69 years, female 5.3
GTEX-131XH-0011-R2b-SM-5DUVY 50-59 years, male 5.2
GTEX-1GN73-0011-R2a-SM-CJI2V 60-69 years, male 5.2
GTEX-1IKJJ-0011-R2b-SM-ARZLJ 60-69 years, male 5.2
GTEX-13OW6-0011-R2a-SM-5L3HG 50-59 years, male 5.1
GTEX-1B933-0011-R2b-SM-7IGNM 50-59 years, female 5.1
GTEX-Q2AG-0011-R2A-SM-2HMIT 40-49 years, female 5.1
GTEX-QMR6-0011-R2A-SM-32PKV 50-59 years, male 5.1
GTEX-145LS-0011-R2a-SM-5PNZI 60-69 years, female 5.0
GTEX-16Z82-0011-R2b-SM-79OK9 60-69 years, male 5.0
GTEX-S7SE-0011-R2A-SM-2XCDC 50-59 years, male 5.0
GTEX-12ZZX-0011-R2a-SM-5EGLG 40-49 years, female 4.9
GTEX-1LSNL-0011-R2a-SM-EZ6MK 50-59 years, male 4.9
GTEX-1H1DG-0011-R2a-SM-ADEIQ 70-79 years, male 4.8
GTEX-XLM4-0011-R2B-SM-4AT5Z 60-69 years, male 4.8
GTEX-1HFI6-0011-R2a-SM-CMKH5 40-49 years, male 4.7
GTEX-1POEN-0011-R2b-SM-G8LLP 30-39 years, female 4.6
GTEX-1R9PO-0011-R2a-SM-F2TBH 60-69 years, female 4.6
GTEX-QVJO-0011-R2A-SM-2S1QK 60-69 years, female 4.6
GTEX-11NUK-0011-R2a-SM-GINAO 50-59 years, male 4.5
GTEX-1B8SG-0011-R2b-SM-79OOT 50-59 years, male 4.5
GTEX-11DZ1-0011-R2a-SM-DNZZM 50-59 years, male 4.4
GTEX-14JG1-0011-R2a-SM-5ZZVE 40-49 years, male 4.4
GTEX-T6MN-0011-R2A-SM-32QOW 50-59 years, male 4.4
GTEX-1B996-0011-R2a-SM-7IGON 60-69 years, male 4.3
GTEX-1NV5F-0011-R2a-SM-G8LME 60-69 years, female 4.3
GTEX-RU72-0011-R2A-SM-2TF6O 50-59 years, female 4.3
GTEX-111FC-0011-R2a-SM-GIN8S 60-69 years, male 4.2
GTEX-1E1VI-0011-R2a-SM-9QEGS 50-59 years, male 4.2
GTEX-1HSMO-0011-R2a-SM-CL553 60-69 years, male 4.2
GTEX-T2IS-0011-R2A-SM-32QPF 20-29 years, female 4.2
GTEX-15CHQ-0011-R2b-SM-6AJAD 60-69 years, male 4.1
GTEX-15SHU-0011-R2a-SM-GPRXS 40-49 years, female 4.1
GTEX-1I1GS-0011-R2b-SM-CMKHG 60-69 years, male 4.1
GTEX-X585-0011-R2B-SM-46MVF 50-59 years, male 4.1
GTEX-1445S-0011-R2b-SM-5PNUH 60-69 years, male 4.0
GTEX-147GR-0011-R2b-SM-5S2RQ 60-69 years, male 4.0
GTEX-1MCQQ-0011-R2a-SM-F649V 60-69 years, male 4.0
GTEX-ZAK1-0011-R2a-SM-GPRX1 50-59 years, female 4.0
GTEX-15DYW-0011-R2b-SM-7KUKY 60-69 years, female 3.9
GTEX-1CB4G-0011-R2a-SM-9QEGQ 60-69 years, male 3.9
GTEX-1I1GV-0011-R2a-SM-ARZLF 60-69 years, male 3.9
GTEX-1JMQJ-0011-R2a-SM-F6493 50-59 years, male 3.9
GTEX-1PPGY-0011-R2b-SM-F33YW 60-69 years, male 3.9
GTEX-ZYY3-0011-R2a-SM-GNTB2 60-69 years, female 3.9
GTEX-13G51-0011-R2b-SM-5LZXS 60-69 years, male 3.8
GTEX-13RTJ-0011-R2a-SM-5PNW9 60-69 years, male 3.8
GTEX-1KD4Q-0011-R2a-SM-F649I 40-49 years, male 3.8
GTEX-1RQED-0011-R2a-SM-F3K5T 60-69 years, male 3.8
GTEX-1F6IF-0011-R2b-SM-9QEHB 60-69 years, male 3.7
GTEX-11UD1-0011-R2b-SM-5BC6O 40-49 years, female 3.6
GTEX-1399T-0011-R2b-SM-5DUXM 60-69 years, male 3.6
GTEX-1R9K4-0011-R2b-SM-G8LLF 60-69 years, male 3.6
GTEX-132Q8-0011-R2b-SM-5EQ5Z 60-69 years, male 3.5
GTEX-13PDP-0011-R2b-SM-5O9DH 60-69 years, male 3.5
GTEX-15DCD-0011-R2b-SM-6LPIE 70-79 years, female 3.5
GTEX-1IY9M-0011-R2a-SM-D4P29 60-69 years, male 3.5
GTEX-1QMI2-0011-R2b-SM-F648R 60-69 years, male 3.5
GTEX-RN5K-0011-R2A-SM-GQ1CA 50-59 years, female 3.5
GTEX-ZV68-0011-R2a-SM-4YCDK 50-59 years, female 3.5
GTEX-13O3Q-0011-R2b-SM-5KM3K 50-59 years, male 3.4
GTEX-17EVP-0011-R2a-SM-7LG4W 40-49 years, male 3.4
GTEX-1EU9M-0011-R2b-SM-9QEH7 60-69 years, male 3.4
GTEX-1GN1U-0011-R2a-SM-CL53A 50-59 years, female 3.4
GTEX-1N2EE-0011-R2a-SM-F649F 60-69 years, male 3.4
GTEX-1N5O9-0011-R2a-SM-G8LM1 60-69 years, male 3.4
GTEX-13O3O-0011-R2b-SM-5P9H1 60-69 years, female 3.3
GTEX-13X6I-0011-R2b-SM-5PNWQ 60-69 years, male 3.3
GTEX-1A3MX-0011-R2b-SM-7EWFL 60-69 years, male 3.3
GTEX-1F6I4-0011-R2a-SM-CL536 60-69 years, male 3.3
GTEX-1GTWX-0011-R2b-SM-ADEH5 60-69 years, male 3.3
GTEX-1NV8Z-0011-R2b-SM-F648N 60-69 years, male 3.3
GTEX-11GSO-0011-R2a-SM-57WDF 60-69 years, male 3.2
GTEX-16GPK-0011-R2a-SM-GRR1F 60-69 years, male 3.2
GTEX-1HBPH-0011-R2a-SM-GQ1DS 40-49 years, female 3.2
GTEX-1LB8K-0011-R2a-SM-EZ6MQ 50-59 years, male 3.2
GTEX-1LKK1-0011-R2b-SM-G8OLT 50-59 years, female 3.2
GTEX-1P4AB-0011-R2a-SM-F649K 50-59 years, male 3.2
GTEX-1RDX4-0011-R2b-SM-F649Z 50-59 years, female 3.2
GTEX-1EKGG-0011-R2a-SM-CE6R8 60-69 years, male 3.1
GTEX-1LG7Y-0011-R2b-SM-G8LMM 50-59 years, male 3.1
GTEX-1MA7X-0011-R2b-SM-EZ6MT 60-69 years, male 3.1
GTEX-R55E-0011-R2A-SM-EYYV9 20-29 years, male 3.1
GTEX-UTHO-0011-R2A-SM-3GIKC 60-69 years, male 3.1
GTEX-13QJC-0011-R2b-SM-5PNUN 60-69 years, female 3.0
GTEX-14PN4-0011-R2a-SM-6EU2Y 50-59 years, male 3.0
GTEX-15RJE-0011-R2b-SM-79OMP 40-49 years, male 3.0
GTEX-1HR98-0011-R2a-SM-ARL7A 60-69 years, male 3.0
GTEX-1JJ6O-0011-R2a-SM-EY5ZO 60-69 years, male 3.0
GTEX-139TS-0011-R2b-SM-5J1MX 60-69 years, male 2.9
GTEX-1KWVE-0011-R2a-SM-G8OLX 30-39 years, male 2.9
GTEX-13FXS-0011-R2b-SM-5K7XX 50-59 years, male 2.8
GTEX-13N2G-0011-R2a-SM-5MR4Q 60-69 years, male 2.8
GTEX-13OVL-0011-R2b-SM-H65ZN 50-59 years, male 2.8
GTEX-17HG3-0011-R2a-SM-7MGVX 30-39 years, female 2.8
GTEX-ZE9C-0011-R2a-SM-4WKGH 60-69 years, male 2.8
GTEX-12696-0011-R2b-SM-GHWPY 60-69 years, male 2.7
GTEX-13NYS-0011-R2b-SM-5MR4G 60-69 years, male 2.7
GTEX-14ASI-0011-R2b-SM-5YY9H 60-69 years, male 2.6
GTEX-14BIM-0011-R2b-SM-69LQ6 60-69 years, female 2.6
GTEX-1F75B-0011-R2a-SM-ARL8I 50-59 years, male 2.6
GTEX-1JMPZ-0011-R2a-SM-G8LLS 30-39 years, male 2.6
GTEX-1PWST-0011-R2b-SM-F3K5I 70-79 years, male 2.6
GTEX-X4XX-0011-R2A-SM-3P623 60-69 years, male 2.6
GTEX-1192X-0011-R2b-SM-GI4VV 50-59 years, male 2.5
GTEX-1I1CD-0011-R2a-SM-CM2T3 60-69 years, female 2.5
GTEX-1KD5A-0011-R2b-SM-G9EPP 50-59 years, male 2.5
GTEX-11EMC-0011-R2b-SM-DO114 60-69 years, female 2.4
GTEX-11TUW-0011-R2b-SM-DO92T 60-69 years, male 2.4
GTEX-14BIN-0011-R2a-SM-5S2RJ 50-59 years, female 2.4
GTEX-1RQEC-0011-R2b-SM-EY5ZT 60-69 years, male 2.4
GTEX-1C6VR-0011-R2a-SM-7RHGZ 60-69 years, male 2.3
GTEX-1H3O1-0011-R2b-SM-CKZOT 60-69 years, male 2.3
GTEX-1F48J-0011-R2a-SM-CL535 50-59 years, female 2.2
GTEX-1LVA9-0011-R2a-SM-EZ6MJ 50-59 years, male 2.2
GTEX-X4EP-0011-R2B-SM-3P625 60-69 years, female 2.2
GTEX-YFC4-0011-R2a-SM-4V6DZ 40-49 years, female 2.2
GTEX-11GS4-0011-R2a-SM-DO942 60-69 years, male 2.1
GTEX-11WQC-0011-R2a-SM-DO927 60-69 years, male 2.1
GTEX-12WSF-0011-R2a-SM-5DUVU 70-79 years, male 2.1
GTEX-13NYB-0011-R2a-SM-5MR3C 40-49 years, male 2.1
GTEX-14PJO-0011-R2a-SM-5ZZVF 60-69 years, male 2.1
GTEX-13OW8-0011-R2a-SM-5L3G2 60-69 years, male 2.0
GTEX-1A8G7-0011-R2a-SM-7IGQI 60-69 years, male 2.0
GTEX-1GMR8-0011-R2a-SM-CE6RD 50-59 years, female 2.0
GTEX-1I19N-0011-R2b-SM-GPRYG 70-79 years, male 2.0
GTEX-1IDJH-0011-R2a-SM-GPI9D 70-79 years, male 2.0
GTEX-13X6K-0011-R2b-SM-5P9K3 60-69 years, female 1.9
GTEX-15G19-0011-R2b-SM-H6Q7S 60-69 years, male 1.9
GTEX-1JMQK-0011-R2a-SM-EYYXQ 60-69 years, male 1.9
GTEX-XMD1-0011-R2B-SM-4AT5N 60-69 years, male 1.9
GTEX-ZZPT-0011-R2a-SM-GNTB1 50-59 years, male 1.9
GTEX-11PRG-0011-R2a-SM-69LQ5 50-59 years, male 1.8
GTEX-11TTK-0011-R2b-SM-GJ3PU 60-69 years, female 1.8
GTEX-ZDXO-0011-R2b-SM-4WKFG 60-69 years, male 1.8
GTEX-13CF2-0011-R2a-SM-5L3DC 60-69 years, male 1.7
GTEX-1IGQW-0011-R2b-SM-D4P26 60-69 years, male 1.7
GTEX-1117F-0011-R2b-SM-GI4VL 60-69 years, female 1.6
GTEX-1GZ2Q-0011-R2b-SM-9OSWO 40-49 years, male 1.6
GTEX-1J1OQ-0011-R2b-SM-ARU88 40-49 years, female 1.6
GTEX-YJ89-0011-R2b-SM-4RGLT 60-69 years, male 1.6
GTEX-12WSD-0011-R2a-SM-5LZWB 60-69 years, female 1.5
GTEX-15EO6-0011-R2a-SM-6M46R 50-59 years, male 1.5
GTEX-1IL2U-0011-R2a-SM-ARU6V 60-69 years, male 1.5
GTEX-OHPN-0011-R2A-SM-2I5FB 60-69 years, female 1.4
GTEX-1H23P-0011-R2a-SM-CKZP3 60-69 years, male 1.3
GTEX-1LVAO-0011-R2a-SM-EYYX1 60-69 years, male 1.2
GTEX-1O9I2-0011-R2b-SM-F3K53 50-59 years, male 1.2
GTEX-12WSA-0011-R2a-SM-57WDK 60-69 years, male 1.1
GTEX-1H1ZS-0011-R2b-SM-CL54Q 70-79 years, male 1.1
GTEX-1RLM8-0011-R2a-SM-EZ6N4 50-59 years, male 1.1
GTEX-1H3VE-0011-R2a-SM-CE6SA 40-49 years, male 1.0
GTEX-13SLW-0011-R2b-SM-5O9C6 70-79 years, male 0.8
GTEX-1CB4J-0011-R2a-SM-9WG5N 60-69 years, male 0.7
GTEX-1GN2E-0011-R2a-SM-9WG7D 60-69 years, male 0.7
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MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Max subtype Scaled Tags Per Millioni

Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.

24.5
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 24.5
FF:10158-103A5 76 years, female 24.5

MIDBRAIN - Macaque RNA-seq
Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

34.2
Macaque sample Sample description nTPM
Substantia nigra
nTPM: 34.2
Samples: 1

Max nTPM: 34.2
Min nTPM: 34.2
Sample A 34.2
Midbrain
nTPM: 30.4
Samples: 1

Max nTPM: 30.4
Min nTPM: 30.4
Sample A 30.4
Superior colliculi
nTPM: 30.5
Samples: 1

Max nTPM: 30.5
Min nTPM: 30.5
Sample A 30.5

MIDBRAIN - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM. Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.

Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

42.2
Pig sample Sample description nTPM
Substantia nigra
nTPM: 30.4
Samples: 3

Max nTPM: 37.2
Min nTPM: 18.9
Sample A Female 35.0
Sample B Female 18.9
Sample C Male 37.2
Midbrain
nTPM: 42.2
Samples: 3

Max nTPM: 78.9
Min nTPM: 21.3
Sample B Female 21.3
Sample C Male 78.9
Sample D Male 26.5
Periaqueductal gray
nTPM: 18.0
Samples: 3

Max nTPM: 20.7
Min nTPM: 16.4
Sample B Female 17.0
Sample C Male 20.7
Sample D Male 16.4
Superior colliculi
nTPM: 27.8
Samples: 4

Max nTPM: 46.7
Min nTPM: 16.1
Sample A Female 16.1
Sample B Female 16.5
Sample C Male 46.7
Sample D Male 31.7

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM. Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.

Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

17.8
Mouse sample Sample description nTPM
Midbrain
nTPM: 17.8
Samples: 4

Max nTPM: 19.9
Min nTPM: 14.6
Sample A 17.1
Sample B 14.6
Sample C 19.7
Sample D 19.9

MIDBRAIN - Rat RNA-seq
Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

21.1
Rat sample Sample description nTPM
Midbrain
nTPM: 21.1
Samples: 4

Max nTPM: 22.4
Min nTPM: 20.1
Sample A 22.4
Sample A 20.6
Sample A 20.1
Sample A 21.3

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