Brain tissue expression of DST in pons - The Human Protein Atlas

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	366.3	nTPM
FANTOM5:	442.7	Scaled Tags Per Million

Mouse:	144.5	nTPM
Rat:	125.9	nTPM
Pig:	87.2	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	366.3

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 351.5

2188	Female, age 91, both hemispheres	424.2
2090	Male, age 80, both hemispheres	348.8
2301	Female, age 85, both hemispheres	342.8
1984	Male, age 76, both hemispheres	290.3

Dorsal cochlear nucleus
nTPM: 302.9

2187	Female, age 91, both hemispheres	343.8
2058	Male, age 76, both hemispheres	322.5
2378	Male, age 80, both hemispheres	308.9
2802	Male, age 74, right hemisphere	303.0
2370	Male, age 61, both hemispheres	236.3

Dorsal tegmental nucleus
nTPM: 311.4

2083	Male, age 80, both hemispheres	343.0
1936	Male, age 76, left hemisphere	316.7
2326	Male, age 74, both hemispheres	311.7
2358	Male, age 61, both hemispheres	274.3

Dorsolateral tegmental area
nTPM: 315.4

2337	Male, age 61, both hemispheres	353.6
2654	Male, age 80, both hemispheres	348.6
2751	Female, age 85, both hemispheres	345.5
2141	Male, age 76, both hemispheres	265.0
2360	Male, age 74, both hemispheres	264.5

Kolliker-Fuse nucleus
nTPM: 365.9

2793	Female, age 91, left hemisphere	423.4
2315	Male, age 76, right hemisphere	352.5
2163	Male, age 80, both hemispheres	321.7

Lateral lemniscal nuclei
nTPM: 336.0

2320	Female, age 91, left hemisphere	370.4
2169	Male, age 76, both hemispheres	354.4
2746	Female, age 85, left hemisphere	341.2
2453	Male, age 74, right hemisphere	331.0
2036	Male, age 80, both hemispheres	282.9

Lateral parabrachial nucleus
nTPM: 365.7

2792	Male, age 76, both hemispheres	420.1
2790	Male, age 61, both hemispheres	364.8
2013	Male, age 80, both hemispheres	340.1
2139	Female, age 85, right hemisphere	337.8

Lateral vestibular nucleus
nTPM: 319.9

2184	Male, age 76, both hemispheres	335.2
2311	Male, age 80, both hemispheres	304.5

Locus coeruleus
nTPM: 274.5

2788	Male, age 74, unknown	341.4
2014	Male, age 55, unknown	300.7
2720	Male, age 74, both hemispheres	276.1
1980	Male, age 76, both hemispheres	265.6
2162	Male, age 80, both hemispheres	250.0
2317	Female, age 72, unknown	245.8
2123	Female, age 91, both hemispheres	242.0

Medial parabrachial nucleus
nTPM: 326.8

2854	Male, age 80, both hemispheres	346.6
2170	Female, age 91, both hemispheres	329.8
2156	Male, age 61, both hemispheres	322.1
2786	Male, age 76, both hemispheres	319.2
2463	Female, age 85, right hemisphere	316.3

Medial periolivary nuclei
nTPM: 356.4

2458	Female, age 91, both hemispheres	402.0
2063	Male, age 76, both hemispheres	363.8
2171	Female, age 85, both hemispheres	353.8
2081	Male, age 80, both hemispheres	350.9
2791	Male, age 74, right hemisphere	311.2

Motor facial nucleus
nTPM: 332.5

2697	Female, age 85, both hemispheres	376.8
2795	Female, age 91, both hemispheres	372.4
2062	Male, age 76, both hemispheres	346.3
2365	Male, age 74, right hemisphere	311.4
2327	Male, age 80, both hemispheres	296.3
2126	Male, age 61, both hemispheres	291.8

Motor trigeminal nucleus
nTPM: 316.9

2321	Female, age 91, both hemispheres	370.2
2309	Male, age 76, both hemispheres	341.9
2079	Male, age 80, both hemispheres	313.7
2560	Male, age 74, both hemispheres	310.4
2335	Male, age 61, both hemispheres	248.4

Nuclei of the trapezoid body
nTPM: 347.4

2368	Female, age 91, both hemispheres	372.1
2166	Male, age 80, both hemispheres	369.8
2159	Male, age 61, both hemispheres	337.7
1983	Male, age 76, both hemispheres	333.6
2735	Female, age 85, both hemispheres	324.0

Nucleus raphe magnus
nTPM: 339.4

2459	Female, age 91, both hemispheres	389.1
2051	Male, age 76, both hemispheres	357.3
2160	Male, age 61, both hemispheres	334.8
2328	Male, age 80, both hemispheres	328.5
2172	Female, age 85, both hemispheres	314.5
2455	Male, age 74, both hemispheres	312.3

Paramedian reticular nucleus
nTPM: 344.1

2052	Male, age 76, both hemispheres	413.9
2050	Female, age 85, both hemispheres	349.3
2057	Male, age 80, both hemispheres	337.1
2313	Male, age 61, both hemispheres	276.1

Pedunculopontine tegmental nucleus
nTPM: 334.0

2338	Male, age 61, both hemispheres	396.0
2334	Male, age 80, both hemispheres	324.5
1921	Female, age 85, both hemispheres	281.5

Pontine nuclei
nTPM: 364.2

2319	Female, age 91, both hemispheres	396.6
2454	Male, age 74, left hemisphere	393.6
1863	Male, age 55, unknown	387.8
2109	Female, age 72, unknown	360.7
1968	Male, age 76, left hemisphere	360.4
2727	Male, age 61, right hemisphere	355.4
2115	Male, age 80, left hemisphere	332.9
2787	Female, age 85, both hemispheres	326.0

Pontine raphe nucleus
nTPM: 316.2

2122	Female, age 85, midline	332.8
2853	Male, age 76, midline	299.7

Posteroventral cochlear nucleus
nTPM: 349.7

2135	Female, age 91, both hemispheres	453.5
2341	Male, age 80, both hemispheres	401.9
2070	Male, age 76, both hemispheres	318.0
2752	Female, age 85, both hemispheres	316.4
2371	Male, age 61, both hemispheres	258.9

Principal sensory trigeminal nucleus
nTPM: 341.5

2367	Female, age 91, left hemisphere	392.5
2324	Male, age 76, both hemispheres	345.0
2158	Male, age 61, both hemispheres	319.9
2008	Male, age 80, left hemisphere	308.7

Reticular pontine nucleus, caudal
nTPM: 362.1

2457	Female, age 91, both hemispheres	427.8
2092	Male, age 76, both hemispheres	366.9
2559	Male, age 74, both hemispheres	354.1
2332	Male, age 80, right hemisphere	299.6

Reticular pontine nucleus, oral
nTPM: 366.3

2366	Female, age 91, both hemispheres	467.9
1939	Male, age 80, both hemispheres	356.6
2361	Male, age 74, both hemispheres	338.2
2012	Female, age 85, both hemispheres	336.0
2167	Male, age 76, both hemispheres	332.7

Reticulotegmental nucleus
nTPM: 316.0

2322	Female, age 91, both hemispheres	332.6
2325	Male, age 76, both hemispheres	316.4
2452	Male, age 74, both hemispheres	313.1
2333	Male, age 80, both hemispheres	301.8

Spinal trigeminal nucleus, oral
nTPM: 291.1

2164	Male, age 80, both hemispheres	297.0
2737	Female, age 85, both hemispheres	288.8
1978	Male, age 76, both hemispheres	287.6

Subcoeruleus area
nTPM: 306.4

2369	Female, age 85, left hemisphere	365.1
1958	Male, age 80, both hemispheres	336.8
2089	Male, age 76, left hemisphere	301.2
2451	Male, age 74, both hemispheres	279.2
2323	Female, age 91, left hemisphere	249.6

Superior olive
nTPM: 351.6

2561	Female, age 91, both hemispheres	388.0
2020	Male, age 76, both hemispheres	366.6
1875	Female, age 85, both hemispheres	359.0
2329	Male, age 80, right hemisphere	340.5
2364	Male, age 74, right hemisphere	304.0

Ventral periolivary nuclei
nTPM: 345.5

2023	Male, age 76, both hemispheres	372.3
2794	Female, age 91, left hemisphere	342.8
2165	Male, age 80, both hemispheres	338.0
2130	Female, age 85, both hemispheres	328.9

Ventrolateral tegmental area, A5 NE cell group
nTPM: 341.7

2840	Female, age 85, both hemispheres	368.6
2359	Male, age 61, both hemispheres	351.7
1959	Male, age 76, both hemispheres	346.8
2456	Female, age 91, both hemispheres	344.2
2161	Male, age 80, both hemispheres	328.7
2449	Male, age 74, both hemispheres	310.0

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	442.7

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 442.7

FF:10182-103D2	60 years, female	499.9
FF:10165-103B3	76 years, female	385.4

Pons
Scaled Tags Per Million: 385.3

FF:10033-101E6

18-54 years, mixed

385.3

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	87.2

Pig sample

Sample description

nTPM

Pons
nTPM: 87.2

Samples: 3

Max nTPM: 94.8
Min nTPM: 83.4

Sample A	Female	94.8
Sample B	Female	83.4
Sample C	Male	83.5

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	144.5

Mouse sample

Sample description

nTPM

Pons
nTPM: 144.5

Samples: 4

Max nTPM: 149.3
Min nTPM: 139.9

Sample A		149.3
Sample B		139.9
Sample C		148.2
Sample D		140.5

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	125.9

Rat sample

Sample description

nTPM

Pons
nTPM: 125.9

Samples: 4

Max nTPM: 136.9
Min nTPM: 116.7

Sample A		129.1
Sample A		116.7
Sample A		121.0
Sample A		136.9