Single cell type - CRELD1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CRELD1
Gene descriptionⁱ Full gene name according to HGNC.	Cysteine rich with EGF like domains 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	20

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neurons - Neurotransmission & signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Brain inhibitory neurons, Brain excitatory neurons, Astrocytes, Other brain neurons, Bergmann glia, Choroid plexus epithelial cells, Oligodendrocyte progenitor cells, Oligodendrocytes, Ependymal cells, Papillary tip epithelial cells, Microglia, Renal collecting duct intercalated cells, Loop of henle epithelial cells, Podocytes, Renal collecting duct principal cells, Renal connecting tubule cells, Proximal tubule cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.81
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

Single cell type

Cell type enrichment

Single nuclei - Brain

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nCPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. * Single nuclei Read more
Single cell type groups RNA single cell type group specificity: Group enriched (Neuronal cells, Glial cells, Ciliated cells, Renal nephron cells, Ductal cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas HPA data, as well as data generated by Monaco et al and Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

CRELD1 is part of cluster 98 Neurons - Neurotransmission & signaling with confidenceⁱ 1
318 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ALDOC	Aldolase, fructose-bisphosphate C	0.6085	98
TIMM22	Translocase of inner mitochondrial membrane 22	0.5941	98
ENSG00000259066	Novel protein	0.5940	102
ABCF2	ATP binding cassette subfamily F member 2	0.5938	98
SPOUT1	SPOUT domain containing methyltransferase 1	0.5933	28
ZNF502	Zinc finger protein 502	0.5908	98
PDZD9	PDZ domain containing 9	0.5873	98
NFKBIL1	NFKB inhibitor like 1	0.5871	98
RING1	Ring finger protein 1	0.5806	98
KBTBD4	Kelch repeat and BTB domain containing 4	0.5772	98
TMEM249	Transmembrane protein 249	0.5771	2
MIEF2	Mitochondrial elongation factor 2	0.5708	98
NLGN2	Neuroligin 2	0.5707	14
EXOSC4	Exosome component 4	0.5621	98
C1QTNF4	C1q and TNF related 4	0.5603	98

IMMUNE CELLS

CRELD1 is part of cluster 25 Non-specific - Unknown function with confidenceⁱ 0.49
355 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
B3GALT4	Beta-1,3-galactosyltransferase 4	0.9762	25
EDN1	Endothelin 1	0.9762	25
LY6G5C	Lymphocyte antigen 6 family member G5C	0.9762	45
SLC52A2	Solute carrier family 52 member 2	0.9762	45
FNTA	Farnesyltransferase, CAAX box, alpha	0.9762	25
SPG11	SPG11 vesicle trafficking associated, spatacsin	0.9762	25
INTS15	Integrator complex subunit 15	0.9762	25
ACAP3	ArfGAP with coiled-coil, ankyrin repeat and PH domains 3	0.9762	25
SLC30A5	Solute carrier family 30 member 5	0.9762	25
TIMM29	Translocase of inner mitochondrial membrane 29	0.9762	45
JTB	Jumping translocation breakpoint	0.9762	45
TEX261	Testis expressed 261	0.9762	25
IL18BP	Interleukin 18 binding protein	0.9524	25
ADIPOR2	Adiponectin receptor 2	0.9524	45
ORMDL2	ORMDL sphingolipid biosynthesis regulator 2	0.9524	25