Brain tissue expression of CKB in pons - The Human Protein Atlas

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	817.3	nTPM
FANTOM5:	3032.3	Scaled Tags Per Million

Mouse:	1135.9	nTPM
Rat:	1214.7	nTPM
Pig:	753.8	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	817.3

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 731.8

1984	Male, age 76, both hemispheres	1142.4
2090	Male, age 80, both hemispheres	623.4
2301	Female, age 85, both hemispheres	608.1
2188	Female, age 91, both hemispheres	553.5

Dorsal cochlear nucleus
nTPM: 817.3

2802	Male, age 74, right hemisphere	1014.5
2058	Male, age 76, both hemispheres	937.8
2370	Male, age 61, both hemispheres	804.3
2378	Male, age 80, both hemispheres	669.2
2187	Female, age 91, both hemispheres	660.9

Dorsal tegmental nucleus
nTPM: 646.8

2083	Male, age 80, both hemispheres	807.5
1936	Male, age 76, left hemisphere	729.5
2326	Male, age 74, both hemispheres	688.6
2358	Male, age 61, both hemispheres	361.7

Dorsolateral tegmental area
nTPM: 631.6

2141	Male, age 76, both hemispheres	764.2
2751	Female, age 85, both hemispheres	716.2
2654	Male, age 80, both hemispheres	709.6
2360	Male, age 74, both hemispheres	703.6
2337	Male, age 61, both hemispheres	264.5

Kolliker-Fuse nucleus
nTPM: 632.5

2315	Male, age 76, right hemisphere	653.4
2163	Male, age 80, both hemispheres	644.5
2793	Female, age 91, left hemisphere	599.6

Lateral lemniscal nuclei
nTPM: 690.7

2169	Male, age 76, both hemispheres	998.8
2453	Male, age 74, right hemisphere	670.4
2036	Male, age 80, both hemispheres	611.1
2746	Female, age 85, left hemisphere	606.2
2320	Female, age 91, left hemisphere	566.9

Lateral parabrachial nucleus
nTPM: 585.1

2139	Female, age 85, right hemisphere	877.1
2013	Male, age 80, both hemispheres	619.9
2792	Male, age 76, both hemispheres	497.1
2790	Male, age 61, both hemispheres	346.5

Lateral vestibular nucleus
nTPM: 796.9

2184	Male, age 76, both hemispheres	874.5
2311	Male, age 80, both hemispheres	719.3

Locus coeruleus
nTPM: 671.5

2123	Female, age 91, both hemispheres	903.4
2014	Male, age 55, unknown	740.8
2317	Female, age 72, unknown	707.3
1980	Male, age 76, both hemispheres	667.6
2162	Male, age 80, both hemispheres	620.2
2720	Male, age 74, both hemispheres	607.6
2788	Male, age 74, unknown	453.6

Medial parabrachial nucleus
nTPM: 678.7

2463	Female, age 85, right hemisphere	802.2
2170	Female, age 91, both hemispheres	706.6
2786	Male, age 76, both hemispheres	699.2
2854	Male, age 80, both hemispheres	640.7
2156	Male, age 61, both hemispheres	544.6

Medial periolivary nuclei
nTPM: 657.0

2063	Male, age 76, both hemispheres	951.2
2171	Female, age 85, both hemispheres	676.4
2791	Male, age 74, right hemisphere	587.8
2458	Female, age 91, both hemispheres	560.6
2081	Male, age 80, both hemispheres	509.3

Motor facial nucleus
nTPM: 730.1

2062	Male, age 76, both hemispheres	1123.6
2795	Female, age 91, both hemispheres	819.0
2126	Male, age 61, both hemispheres	690.7
2365	Male, age 74, right hemisphere	626.4
2327	Male, age 80, both hemispheres	601.5
2697	Female, age 85, both hemispheres	519.6

Motor trigeminal nucleus
nTPM: 589.1

2079	Male, age 80, both hemispheres	635.8
2560	Male, age 74, both hemispheres	603.1
2335	Male, age 61, both hemispheres	594.0
2309	Male, age 76, both hemispheres	579.5
2321	Female, age 91, both hemispheres	533.3

Nuclei of the trapezoid body
nTPM: 803.7

1983	Male, age 76, both hemispheres	1029.5
2159	Male, age 61, both hemispheres	958.2
2735	Female, age 85, both hemispheres	702.2
2166	Male, age 80, both hemispheres	670.6
2368	Female, age 91, both hemispheres	657.9

Nucleus raphe magnus
nTPM: 700.6

2051	Male, age 76, both hemispheres	835.9
2455	Male, age 74, both hemispheres	795.9
2328	Male, age 80, both hemispheres	737.3
2160	Male, age 61, both hemispheres	734.6
2172	Female, age 85, both hemispheres	556.4
2459	Female, age 91, both hemispheres	543.3

Paramedian reticular nucleus
nTPM: 622.1

2057	Male, age 80, both hemispheres	707.1
2050	Female, age 85, both hemispheres	679.8
2313	Male, age 61, both hemispheres	669.5
2052	Male, age 76, both hemispheres	432.1

Pedunculopontine tegmental nucleus
nTPM: 587.3

1921	Female, age 85, both hemispheres	766.6
2334	Male, age 80, both hemispheres	641.8
2338	Male, age 61, both hemispheres	353.6

Pontine nuclei
nTPM: 797.2

1863	Male, age 55, unknown	1329.0
1968	Male, age 76, left hemisphere	1048.4
2109	Female, age 72, unknown	916.8
2787	Female, age 85, both hemispheres	802.7
2454	Male, age 74, left hemisphere	611.3
2115	Male, age 80, left hemisphere	574.9
2727	Male, age 61, right hemisphere	555.9
2319	Female, age 91, both hemispheres	538.5

Pontine raphe nucleus
nTPM: 675.4

2122	Female, age 85, midline	704.4
2853	Male, age 76, midline	646.4

Posteroventral cochlear nucleus
nTPM: 670.9

2070	Male, age 76, both hemispheres	798.3
2371	Male, age 61, both hemispheres	787.5
2752	Female, age 85, both hemispheres	754.9
2341	Male, age 80, both hemispheres	552.0
2135	Female, age 91, both hemispheres	461.6

Principal sensory trigeminal nucleus
nTPM: 693.6

2324	Male, age 76, both hemispheres	906.9
2158	Male, age 61, both hemispheres	756.9
2008	Male, age 80, left hemisphere	598.6
2367	Female, age 91, left hemisphere	512.0

Reticular pontine nucleus, caudal
nTPM: 698.5

2092	Male, age 76, both hemispheres	869.1
2332	Male, age 80, right hemisphere	773.4
2457	Female, age 91, both hemispheres	678.3
2559	Male, age 74, both hemispheres	473.3

Reticular pontine nucleus, oral
nTPM: 644.0

1939	Male, age 80, both hemispheres	717.3
2167	Male, age 76, both hemispheres	713.0
2012	Female, age 85, both hemispheres	700.8
2366	Female, age 91, both hemispheres	584.2
2361	Male, age 74, both hemispheres	504.9

Reticulotegmental nucleus
nTPM: 752.6

2322	Female, age 91, both hemispheres	851.9
2333	Male, age 80, both hemispheres	811.3
2325	Male, age 76, both hemispheres	679.9
2452	Male, age 74, both hemispheres	667.2

Spinal trigeminal nucleus, oral
nTPM: 761.5

1978	Male, age 76, both hemispheres	825.4
2737	Female, age 85, both hemispheres	764.7
2164	Male, age 80, both hemispheres	694.4

Subcoeruleus area
nTPM: 671.8

2089	Male, age 76, left hemisphere	777.3
2323	Female, age 91, left hemisphere	709.5
2369	Female, age 85, left hemisphere	655.9
1958	Male, age 80, both hemispheres	609.5
2451	Male, age 74, both hemispheres	606.9

Superior olive
nTPM: 640.4

2020	Male, age 76, both hemispheres	763.7
2329	Male, age 80, right hemisphere	646.9
1875	Female, age 85, both hemispheres	616.7
2364	Male, age 74, right hemisphere	613.9
2561	Female, age 91, both hemispheres	561.0

Ventral periolivary nuclei
nTPM: 638.7

2165	Male, age 80, both hemispheres	793.5
2130	Female, age 85, both hemispheres	702.7
2023	Male, age 76, both hemispheres	607.1
2794	Female, age 91, left hemisphere	451.6

Ventrolateral tegmental area, A5 NE cell group
nTPM: 640.6

1959	Male, age 76, both hemispheres	735.7
2449	Male, age 74, both hemispheres	702.5
2840	Female, age 85, both hemispheres	686.9
2456	Female, age 91, both hemispheres	631.4
2161	Male, age 80, both hemispheres	629.2
2359	Male, age 61, both hemispheres	457.7

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	3032.3

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 2778.6

FF:10182-103D2	60 years, female	3924.2
FF:10165-103B3	76 years, female	1633.0

Pons
Scaled Tags Per Million: 3032.3

FF:10033-101E6

18-54 years, mixed

3032.3

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	753.8

Pig sample

Sample description

nTPM

Pons
nTPM: 753.8

Samples: 3

Max nTPM: 928.1
Min nTPM: 554.2

Sample A	Female	928.1
Sample B	Female	554.2
Sample C	Male	779.1

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	1135.9

Mouse sample

Sample description

nTPM

Pons
nTPM: 1135.9

Samples: 4

Max nTPM: 1252.9
Min nTPM: 1016.4

Sample A		1016.4
Sample B		1138.0
Sample C		1252.9
Sample D		1136.2

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	1214.7

Rat sample

Sample description

nTPM

Pons
nTPM: 1214.7

Samples: 4

Max nTPM: 1271.2
Min nTPM: 1100.1

Sample A		1271.2
Sample A		1265.2
Sample A		1100.1
Sample A		1222.4