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CTNNB1
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  • CTNNB1
CELL LINE
BILE DUCT CANCER BLADDER CANCER BONE CANCER BRAIN CANCER BREAST CANCER CERVICAL CANCER COLORECTAL CANCER ESOPHAGEAL CANCER GALLBLADDER CANCER GASTRIC CANCER
HEAD AND NECK CANCER KIDNEY CANCER LEUKEMIA LIVER CANCER LUNG CANCER LYMPHOMA MYELOMA NEUROBLASTOMA NON-CANCEROUS OVARIAN CANCER
PANCREATIC CANCER PROSTATE CANCER RHABDOID SARCOMA SKIN CANCER TESTIS CANCER THYROID CANCER UNCATEGORIZED UTERINE CANCER
Human cell lines
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

CTNNB1
Gene descriptioni

Full gene name according to HGNC.

Catenin beta 1
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Cancer-related genes
Disease related genes
Human disease related genes
Plasma proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

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Intracellular
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

43
HUMAN PROTEIN ATLAS INFORMATIONi

Summary of RNA expression based on cell line data from the DepMap portal and cell line data generated within the Human Protein Atlas project.

Cell line expression clusteri

The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.

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Skin cancer - Melanocyte processes (mainly)
Cell line specificityi

RNA specificity category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.

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Low cancer specificity
Tau specificity scorei

Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.

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0.17
Cell line distributioni

RNA distribution category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.

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Detected in all
Protein evidencei

Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.

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Evidence at protein level
CELL LINESi

RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines.The analyzed cell lines are grouped according to cancer type. Detailed information about the groups is revealed by hovering over the corresponding bar in the chart. More information and cell line data can be found in the Cell line section.

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Cell line categories
Alphabetical
Expression
RNA specificity:Low cancer specificity

EXPRESSION CLUSTERING & CORRELATIONi

The RNA data was used to cluster genes according to their expression across samples. The resulting clusters have been manually annotated to describe common features in terms of function and specificity. The annotation of the cluster is displayed together with a confidence score of the gene's assignment to the cluster. The confidence is calculated as the fraction of times the gene was assigned to this cluster in repeated calculations and is reported between 0 to 1, where 1 is the highest possible confidence. The clustering results are shown in a UMAP, where the cluster this gene was assigned to is highlighted as a colored area in which most of the cluster genes reside. A table shows the 15 most similar genes in terms of expression profile.

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CTNNB1 is part of cluster 16 Skin cancer - Melanocyte processes with confidencei

Confidence is the fraction of times a gene was assigned to the cluster in repeated clustering, and therefore reflects how strongly associated it is to the cluster. A confidence of 1 indicates that the gene was assigned to this cluster in all repeated clusterings.

Read more
1
241 genes in cluster
Go to interactive expression cluster page
15 nearest neighbours based on cell line RNA expression
Neighbouri

Gene name according to HGNC.

Descriptioni

Gene description according to HGNC.

Correlationi

Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.

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Clusteri

ID of the expression cluster of the neighboring gene.

Read more
OCA2 OCA2 melanosomal transmembrane protein 0.5063 16
SORBS1 Sorbin and SH3 domain containing 1 0.5030 34
SLC45A2 Solute carrier family 45 member 2 0.5029 16
PMEL Premelanosome protein 0.4965 16
SLC16A6 Solute carrier family 16 member 6 0.4939 16
TBC1D16 TBC1 domain family member 16 0.4938 16
RLBP1 Retinaldehyde binding protein 1 0.4898 19
ZNF697 Zinc finger protein 697 0.4877 16
SMIM4 Small integral membrane protein 4 0.4877 5
OR7A5 Olfactory receptor family 7 subfamily A member 5 0.4819 16
GJB1 Gap junction protein beta 1 0.4819 16
TRIM63 Tripartite motif containing 63 0.4778 16
APOLD1 Apolipoprotein L domain containing 1 0.4774 16
CAPN3 Calpain 3 0.4763 16
ZC3H11B Zinc finger CCCH-type containing 11B 0.4744 2

CELL LINE DATA
Alphabetical
Expression
Bile duct cancer (n=7)
Alphabetical
Expression
Bladder cancer (n=26)
Alphabetical
Expression
Bone cancer (n=19)
Alphabetical
Expression
Brain cancer (n=65)
Alphabetical
Expression
Breast cancer (n=50)
Alphabetical
Expression
Cervical cancer (n=3)
Alphabetical
Expression
Colorectal cancer (n=57)
Alphabetical
Expression
Esophageal cancer (n=27)
Alphabetical
Expression
Gallbladder cancer (n=1)
Alphabetical
Expression
Gastric cancer (n=38)
Alphabetical
Expression
Head and Neck cancer (n=33)
Alphabetical
Expression
Kidney cancer (n=31)
Alphabetical
Expression
Leukemia (n=88)
Alphabetical
Expression
Liver cancer (n=24)
Alphabetical
Expression
Lung cancer (n=196)
Alphabetical
Expression
Lymphoma (n=57)
Alphabetical
Expression
Myeloma (n=34)
Alphabetical
Expression
Neuroblastoma (n=17)
Alphabetical
Expression
Non-cancerous (n=60)
Alphabetical
Expression
Ovarian cancer (n=46)
Alphabetical
Expression
Pancreatic cancer (n=41)
Alphabetical
Expression
Prostate cancer (n=7)
Alphabetical
Expression
Rhabdoid (n=14)
Alphabetical
Expression
Sarcoma (n=14)
Alphabetical
Expression
Skin cancer (n=50)
Alphabetical
Expression
Testis cancer (n=1)
Alphabetical
Expression
Thyroid cancer (n=11)
Alphabetical
Expression
Uncategorized (n=10)
Alphabetical
Expression
Uterine cancer (n=28)

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The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.