Brain tissue expression of NOMO2 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:

82.9

nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	82.9

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 47.4

1984	Male, age 76, both hemispheres	56.0
2301	Female, age 85, both hemispheres	47.4
2188	Female, age 91, both hemispheres	43.7
2090	Male, age 80, both hemispheres	42.3

Dorsal cochlear nucleus
nTPM: 50.5

2187	Female, age 91, both hemispheres	56.3
2058	Male, age 76, both hemispheres	54.3
2802	Male, age 74, right hemisphere	52.8
2370	Male, age 61, both hemispheres	45.4
2378	Male, age 80, both hemispheres	43.6

Dorsal tegmental nucleus
nTPM: 56.5

2358	Male, age 61, both hemispheres	71.8
2083	Male, age 80, both hemispheres	65.5
1936	Male, age 76, left hemisphere	51.0
2326	Male, age 74, both hemispheres	37.7

Dorsolateral tegmental area
nTPM: 57.1

2141	Male, age 76, both hemispheres	77.1
2654	Male, age 80, both hemispheres	64.7
2751	Female, age 85, both hemispheres	58.3
2337	Male, age 61, both hemispheres	45.9
2360	Male, age 74, both hemispheres	39.6

Kolliker-Fuse nucleus
nTPM: 57.0

2163	Male, age 80, both hemispheres	67.8
2793	Female, age 91, left hemisphere	64.3
2315	Male, age 76, right hemisphere	38.8

Lateral lemniscal nuclei
nTPM: 72.2

2169	Male, age 76, both hemispheres	88.4
2036	Male, age 80, both hemispheres	82.1
2453	Male, age 74, right hemisphere	81.2
2746	Female, age 85, left hemisphere	59.8
2320	Female, age 91, left hemisphere	49.4

Lateral parabrachial nucleus
nTPM: 55.7

2139	Female, age 85, right hemisphere	75.6
2790	Male, age 61, both hemispheres	57.7
2013	Male, age 80, both hemispheres	57.1
2792	Male, age 76, both hemispheres	32.3

Lateral vestibular nucleus
nTPM: 59.0

2184	Male, age 76, both hemispheres	61.8
2311	Male, age 80, both hemispheres	56.1

Locus coeruleus
nTPM: 81.9

2123	Female, age 91, both hemispheres	98.2
2720	Male, age 74, both hemispheres	95.4
1980	Male, age 76, both hemispheres	81.0
2014	Male, age 55, unknown	81.0
2788	Male, age 74, unknown	78.0
2317	Female, age 72, unknown	72.7
2162	Male, age 80, both hemispheres	66.8

Medial parabrachial nucleus
nTPM: 62.9

2170	Female, age 91, both hemispheres	72.4
2854	Male, age 80, both hemispheres	71.1
2786	Male, age 76, both hemispheres	63.2
2156	Male, age 61, both hemispheres	58.6
2463	Female, age 85, right hemisphere	49.2

Medial periolivary nuclei
nTPM: 65.7

2063	Male, age 76, both hemispheres	90.6
2171	Female, age 85, both hemispheres	86.7
2791	Male, age 74, right hemisphere	61.0
2081	Male, age 80, both hemispheres	48.2
2458	Female, age 91, both hemispheres	42.2

Motor facial nucleus
nTPM: 73.1

2062	Male, age 76, both hemispheres	89.8
2365	Male, age 74, right hemisphere	82.6
2795	Female, age 91, both hemispheres	70.4
2697	Female, age 85, both hemispheres	68.9
2327	Male, age 80, both hemispheres	66.7
2126	Male, age 61, both hemispheres	60.4

Motor trigeminal nucleus
nTPM: 56.1

2560	Male, age 74, both hemispheres	62.9
2335	Male, age 61, both hemispheres	59.8
2079	Male, age 80, both hemispheres	59.3
2309	Male, age 76, both hemispheres	56.6
2321	Female, age 91, both hemispheres	42.1

Nuclei of the trapezoid body
nTPM: 72.2

2159	Male, age 61, both hemispheres	96.3
1983	Male, age 76, both hemispheres	83.0
2735	Female, age 85, both hemispheres	81.9
2166	Male, age 80, both hemispheres	54.9
2368	Female, age 91, both hemispheres	44.7

Nucleus raphe magnus
nTPM: 81.1

2160	Male, age 61, both hemispheres	111.1
2172	Female, age 85, both hemispheres	99.3
2455	Male, age 74, both hemispheres	85.5
2051	Male, age 76, both hemispheres	75.2
2328	Male, age 80, both hemispheres	64.0
2459	Female, age 91, both hemispheres	51.7

Paramedian reticular nucleus
nTPM: 72.9

2050	Female, age 85, both hemispheres	96.4
2057	Male, age 80, both hemispheres	73.3
2313	Male, age 61, both hemispheres	68.1
2052	Male, age 76, both hemispheres	53.6

Pedunculopontine tegmental nucleus
nTPM: 64.7

2334	Male, age 80, both hemispheres	70.0
1921	Female, age 85, both hemispheres	67.3
2338	Male, age 61, both hemispheres	56.7

Pontine nuclei
nTPM: 74.4

2787	Female, age 85, both hemispheres	110.0
2727	Male, age 61, right hemisphere	90.5
1863	Male, age 55, unknown	88.9
1968	Male, age 76, left hemisphere	85.9
2109	Female, age 72, unknown	73.5
2454	Male, age 74, left hemisphere	61.2
2319	Female, age 91, both hemispheres	44.0
2115	Male, age 80, left hemisphere	41.4

Pontine raphe nucleus
nTPM: 82.9

2122	Female, age 85, midline	84.0
2853	Male, age 76, midline	81.8

Posteroventral cochlear nucleus
nTPM: 44.9

2752	Female, age 85, both hemispheres	63.2
2070	Male, age 76, both hemispheres	54.6
2371	Male, age 61, both hemispheres	41.0
2341	Male, age 80, both hemispheres	37.3
2135	Female, age 91, both hemispheres	28.7

Principal sensory trigeminal nucleus
nTPM: 67.1

2158	Male, age 61, both hemispheres	94.6
2008	Male, age 80, left hemisphere	70.4
2324	Male, age 76, both hemispheres	59.0
2367	Female, age 91, left hemisphere	44.5

Reticular pontine nucleus, caudal
nTPM: 57.2

2092	Male, age 76, both hemispheres	65.5
2332	Male, age 80, right hemisphere	64.6
2457	Female, age 91, both hemispheres	50.8
2559	Male, age 74, both hemispheres	48.0

Reticular pontine nucleus, oral
nTPM: 67.9

2361	Male, age 74, both hemispheres	86.4
2012	Female, age 85, both hemispheres	74.5
1939	Male, age 80, both hemispheres	70.4
2167	Male, age 76, both hemispheres	63.1
2366	Female, age 91, both hemispheres	45.0

Reticulotegmental nucleus
nTPM: 60.2

2325	Male, age 76, both hemispheres	71.2
2333	Male, age 80, both hemispheres	57.2
2322	Female, age 91, both hemispheres	57.0
2452	Male, age 74, both hemispheres	55.3

Spinal trigeminal nucleus, oral
nTPM: 60.1

2737	Female, age 85, both hemispheres	61.2
1978	Male, age 76, both hemispheres	60.6
2164	Male, age 80, both hemispheres	58.5

Subcoeruleus area
nTPM: 64.3

2323	Female, age 91, left hemisphere	85.5
1958	Male, age 80, both hemispheres	73.9
2089	Male, age 76, left hemisphere	67.3
2369	Female, age 85, left hemisphere	55.8
2451	Male, age 74, both hemispheres	39.1

Superior olive
nTPM: 65.7

1875	Female, age 85, both hemispheres	83.6
2364	Male, age 74, right hemisphere	66.9
2020	Male, age 76, both hemispheres	62.9
2561	Female, age 91, both hemispheres	57.8
2329	Male, age 80, right hemisphere	57.0

Ventral periolivary nuclei
nTPM: 73.8

2130	Female, age 85, both hemispheres	107.5
2165	Male, age 80, both hemispheres	75.4
2023	Male, age 76, both hemispheres	57.5
2794	Female, age 91, left hemisphere	54.7

Ventrolateral tegmental area, A5 NE cell group
nTPM: 66.6

2840	Female, age 85, both hemispheres	84.1
1959	Male, age 76, both hemispheres	76.9
2449	Male, age 74, both hemispheres	71.7
2161	Male, age 80, both hemispheres	59.8
2359	Male, age 61, both hemispheres	59.1
2456	Female, age 91, both hemispheres	48.2