Brain tissue expression of RPS18 in pons

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	520.2	nTPM
FANTOM5:	95.9	Scaled Tags Per Million

Mouse:	0.2	nTPM
Rat:	2.5	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	520.2

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 462.5

2090	Male, age 80, both hemispheres	575.1
2188	Female, age 91, both hemispheres	517.7
1984	Male, age 76, both hemispheres	388.7
2301	Female, age 85, both hemispheres	368.7

Dorsal cochlear nucleus
nTPM: 468.1

2802	Male, age 74, right hemisphere	564.4
2187	Female, age 91, both hemispheres	503.8
2370	Male, age 61, both hemispheres	438.5
2378	Male, age 80, both hemispheres	438.0
2058	Male, age 76, both hemispheres	396.1

Dorsal tegmental nucleus
nTPM: 492.6

2083	Male, age 80, both hemispheres	545.7
2326	Male, age 74, both hemispheres	543.2
2358	Male, age 61, both hemispheres	448.2
1936	Male, age 76, left hemisphere	433.5

Dorsolateral tegmental area
nTPM: 482.4

2654	Male, age 80, both hemispheres	574.5
2337	Male, age 61, both hemispheres	567.3
2751	Female, age 85, both hemispheres	465.6
2360	Male, age 74, both hemispheres	415.2
2141	Male, age 76, both hemispheres	389.5

Kolliker-Fuse nucleus
nTPM: 451.7

2315	Male, age 76, right hemisphere	542.2
2163	Male, age 80, both hemispheres	414.1
2793	Female, age 91, left hemisphere	398.7

Lateral lemniscal nuclei
nTPM: 323.4

2453	Male, age 74, right hemisphere	348.6
2746	Female, age 85, left hemisphere	346.8
2320	Female, age 91, left hemisphere	344.2
2169	Male, age 76, both hemispheres	314.6
2036	Male, age 80, both hemispheres	262.6

Lateral parabrachial nucleus
nTPM: 482.6

2792	Male, age 76, both hemispheres	554.6
2013	Male, age 80, both hemispheres	519.5
2790	Male, age 61, both hemispheres	432.5
2139	Female, age 85, right hemisphere	423.9

Lateral vestibular nucleus
nTPM: 430.0

2311	Male, age 80, both hemispheres	521.3
2184	Male, age 76, both hemispheres	338.7

Locus coeruleus
nTPM: 397.9

2720	Male, age 74, both hemispheres	440.0
2014	Male, age 55, unknown	415.2
2123	Female, age 91, both hemispheres	413.4
2162	Male, age 80, both hemispheres	405.2
2317	Female, age 72, unknown	403.0
2788	Male, age 74, unknown	361.3
1980	Male, age 76, both hemispheres	347.3

Medial parabrachial nucleus
nTPM: 453.0

2170	Female, age 91, both hemispheres	550.0
2463	Female, age 85, right hemisphere	444.6
2786	Male, age 76, both hemispheres	434.3
2156	Male, age 61, both hemispheres	418.5
2854	Male, age 80, both hemispheres	417.6

Medial periolivary nuclei
nTPM: 384.8

2081	Male, age 80, both hemispheres	463.0
2063	Male, age 76, both hemispheres	451.1
2458	Female, age 91, both hemispheres	382.4
2791	Male, age 74, right hemisphere	349.7
2171	Female, age 85, both hemispheres	277.8

Motor facial nucleus
nTPM: 368.8

2126	Male, age 61, both hemispheres	461.6
2795	Female, age 91, both hemispheres	404.3
2365	Male, age 74, right hemisphere	364.4
2062	Male, age 76, both hemispheres	361.8
2697	Female, age 85, both hemispheres	333.6
2327	Male, age 80, both hemispheres	287.3

Motor trigeminal nucleus
nTPM: 413.1

2335	Male, age 61, both hemispheres	460.9
2309	Male, age 76, both hemispheres	424.8
2560	Male, age 74, both hemispheres	415.4
2321	Female, age 91, both hemispheres	398.5
2079	Male, age 80, both hemispheres	366.0

Nuclei of the trapezoid body
nTPM: 357.1

1983	Male, age 76, both hemispheres	476.3
2166	Male, age 80, both hemispheres	361.6
2368	Female, age 91, both hemispheres	335.0
2159	Male, age 61, both hemispheres	333.5
2735	Female, age 85, both hemispheres	279.0

Nucleus raphe magnus
nTPM: 330.4

2459	Female, age 91, both hemispheres	379.1
2051	Male, age 76, both hemispheres	368.3
2455	Male, age 74, both hemispheres	344.0
2328	Male, age 80, both hemispheres	335.7
2160	Male, age 61, both hemispheres	279.6
2172	Female, age 85, both hemispheres	276.0

Paramedian reticular nucleus
nTPM: 423.7

2052	Male, age 76, both hemispheres	478.3
2057	Male, age 80, both hemispheres	439.9
2313	Male, age 61, both hemispheres	399.1
2050	Female, age 85, both hemispheres	377.4

Pedunculopontine tegmental nucleus
nTPM: 439.0

2338	Male, age 61, both hemispheres	512.1
2334	Male, age 80, both hemispheres	456.5
1921	Female, age 85, both hemispheres	348.5

Pontine nuclei
nTPM: 413.8

2319	Female, age 91, both hemispheres	483.6
1863	Male, age 55, unknown	469.1
2115	Male, age 80, left hemisphere	452.3
2454	Male, age 74, left hemisphere	415.9
1968	Male, age 76, left hemisphere	406.4
2109	Female, age 72, unknown	392.8
2787	Female, age 85, both hemispheres	382.7
2727	Male, age 61, right hemisphere	307.4

Pontine raphe nucleus
nTPM: 380.3

2853	Male, age 76, midline	390.4
2122	Female, age 85, midline	370.2

Posteroventral cochlear nucleus
nTPM: 520.2

2341	Male, age 80, both hemispheres	661.8
2135	Female, age 91, both hemispheres	608.6
2371	Male, age 61, both hemispheres	482.0
2070	Male, age 76, both hemispheres	437.1
2752	Female, age 85, both hemispheres	411.6

Principal sensory trigeminal nucleus
nTPM: 339.0

2367	Female, age 91, left hemisphere	391.3
2324	Male, age 76, both hemispheres	341.3
2158	Male, age 61, both hemispheres	325.2
2008	Male, age 80, left hemisphere	298.1

Reticular pontine nucleus, caudal
nTPM: 428.1

2457	Female, age 91, both hemispheres	496.5
2559	Male, age 74, both hemispheres	482.5
2092	Male, age 76, both hemispheres	448.9
2332	Male, age 80, right hemisphere	284.4

Reticular pontine nucleus, oral
nTPM: 418.6

1939	Male, age 80, both hemispheres	461.4
2366	Female, age 91, both hemispheres	458.6
2167	Male, age 76, both hemispheres	426.9
2361	Male, age 74, both hemispheres	404.3
2012	Female, age 85, both hemispheres	341.8

Reticulotegmental nucleus
nTPM: 412.6

2452	Male, age 74, both hemispheres	501.2
2322	Female, age 91, both hemispheres	410.1
2333	Male, age 80, both hemispheres	399.2
2325	Male, age 76, both hemispheres	339.9

Spinal trigeminal nucleus, oral
nTPM: 387.9

2164	Male, age 80, both hemispheres	416.4
1978	Male, age 76, both hemispheres	383.8
2737	Female, age 85, both hemispheres	363.5

Subcoeruleus area
nTPM: 452.1

2451	Male, age 74, both hemispheres	582.9
2369	Female, age 85, left hemisphere	498.7
1958	Male, age 80, both hemispheres	437.2
2323	Female, age 91, left hemisphere	373.7
2089	Male, age 76, left hemisphere	368.2

Superior olive
nTPM: 361.8

2020	Male, age 76, both hemispheres	455.0
2561	Female, age 91, both hemispheres	389.1
2364	Male, age 74, right hemisphere	355.1
1875	Female, age 85, both hemispheres	307.5
2329	Male, age 80, right hemisphere	302.2

Ventral periolivary nuclei
nTPM: 357.4

2023	Male, age 76, both hemispheres	440.4
2794	Female, age 91, left hemisphere	376.5
2165	Male, age 80, both hemispheres	360.2
2130	Female, age 85, both hemispheres	252.3

Ventrolateral tegmental area, A5 NE cell group
nTPM: 378.2

2359	Male, age 61, both hemispheres	433.6
2161	Male, age 80, both hemispheres	405.5
1959	Male, age 76, both hemispheres	380.3
2456	Female, age 91, both hemispheres	373.0
2449	Male, age 74, both hemispheres	341.8
2840	Female, age 85, both hemispheres	335.1

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	95.9

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 95.9

FF:10182-103D2	60 years, female	102.6
FF:10165-103B3	76 years, female	89.1

Pons
Scaled Tags Per Million: 39.7

FF:10033-101E6

18-54 years, mixed

39.7

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	0.2

Mouse sample

Sample description

nTPM

Pons
nTPM: 0.2

Samples: 4

Max nTPM: 0.4
Min nTPM: 0.0

Sample A		0.0
Sample B		0.4
Sample C		0.3
Sample D		0.1

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	2.5

Rat sample

Sample description

nTPM

Pons
nTPM: 2.5

Samples: 4

Max nTPM: 3.2
Min nTPM: 1.3

Sample A		3.2
Sample A		2.8
Sample A		1.3
Sample A		2.8