Single cell type - EIF5AL1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EIF5AL1
Gene descriptionⁱ Full gene name according to HGNC.	Eukaryotic translation initiation factor 5A like 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Essential proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Protein processing (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Late primary spermatocytes, Enteric transient amplifying cells, Enteric stem cells, Colonocytes, Goblet cells, Esophageal basal cells, Esophageal suprabasal cells, Foveolar cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.68
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Not available
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

Single cell type

Cell type enrichment

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nCPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. * Single nuclei Read more
Single cell type groups RNA single cell type group specificity: Cell type enhanced (Spermatogenic cell types, Proliferating cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas HPA data, as well as data generated by Monaco et al and Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

EIF5AL1 is part of cluster 15 Non-specific - Protein processing with confidenceⁱ 1
232 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
ENSG00000262660	Novel protein	0.6088	54
IMPDH2	Inosine monophosphate dehydrogenase 2	0.5472	15
SNRPD3	Small nuclear ribonucleoprotein D3 polypeptide	0.5428	15
NDUFS7	NADH:ubiquinone oxidoreductase core subunit S7	0.5232	97
ARL6IP4	ADP ribosylation factor like GTPase 6 interacting protein 4	0.5209	15
STEAP1B	STEAP family member 1B	0.5185	15
ADSL	Adenylosuccinate lyase	0.5124	15
MTFP1	Mitochondrial fission process 1	0.5111	15
COX6B2	Cytochrome c oxidase subunit 6B2	0.5047	53
SELENOH	Selenoprotein H	0.4998	15
OOEP	Oocyte expressed protein	0.4997	15
HES1	Hes family bHLH transcription factor 1	0.4991	54
RNASEH2A	Ribonuclease H2 subunit A	0.4952	27
EEF1G	Eukaryotic translation elongation factor 1 gamma	0.4939	15
RPL36A	Ribosomal protein L36a	0.4879	15

IMMUNE CELLS

EIF5AL1 is part of cluster 17 B-cells - Immunoglobulins with confidenceⁱ 1
129 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
YARS2	Tyrosyl-tRNA synthetase 2	0.9762	17
TCF3	Transcription factor 3	0.9524	17
MAP7D3	MAP7 domain containing 3	0.9286	5
CPSF4	Cleavage and polyadenylation specific factor 4	0.9286	17
EDEM1	ER degradation enhancing alpha-mannosidase like protein 1	0.9286	5
BCKDHB	Branched chain keto acid dehydrogenase E1 subunit beta	0.9286	5
BHLHE41	Basic helix-loop-helix family member e41	0.9048	17
BTN1A1	Butyrophilin subfamily 1 member A1	0.9048	17
CPNE5	Copine 5	0.9048	17
IGLL1	Immunoglobulin lambda like polypeptide 1	0.9048	17
DYNC2I2	Dynein 2 intermediate chain 2	0.9048	17
SGO1	Shugoshin 1	0.9048	17
FCRL2	Fc receptor like 2	0.9048	17
E2F5	E2F transcription factor 5	0.9048	17
CAV1	Caveolin 1	0.9048	17