Single cell type - POC1B-GALNT4 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	POC1B-GALNT4
Gene descriptionⁱ Full gene name according to HGNC.	POC1B-GALNT4 readthrough
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Epicardial mesothelial cells - Basic cellular functions (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Epicardial cells, Cardiomyocytes, Endometrial glandular cells, Endometrial luminal cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.96
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Not available
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at transcript level

ASSAYSⁱ

Single cell type

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nCPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. * Single nuclei Read more
Single cell type groups RNA single cell type group specificity: Cell type enhanced (Barrier epithelial cells, Myocytes, Glandular cells)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas HPA data, as well as data generated by Monaco et al and Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

POC1B-GALNT4 is part of cluster 83 Epicardial mesothelial cells - Basic cellular functions with confidenceⁱ 1
118 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IL17REL	Interleukin 17 receptor E like	0.5709	52
INO80	INO80 complex ATPase subunit	0.5540	83
MIDEAS	Mitotic deacetylase associated SANT domain protein	0.5442	83
DPH1	Diphthamide biosynthesis 1	0.5358	83
ERCC1	ERCC excision repair 1, endonuclease non-catalytic subunit	0.5277	83
FAM90A24P	Family with sequence similarity 90 member A24, pseudogene	0.5183	83
RAB6C	RAB6C, member RAS oncogene family	0.5140	83
STX18	Syntaxin 18	0.5106	52
ENSG00000263620	Novel protein	0.5097	83
ELP3	Elongator acetyltransferase complex subunit 3	0.5089	52
PBOV1	Prostate and breast cancer overexpressed 1	0.5045	83
MSLNL	Mesothelin like	0.5024	83
CLDN22	Claudin 22	0.5016	52
RAD54L	RAD54 like	0.4999	52
ZBTB2	Zinc finger and BTB domain containing 2	0.4987	52

IMMUNE CELLS

POC1B-GALNT4 is part of cluster 20 Non-specific - DNA binding with confidenceⁱ 1
266 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
PCGF5	Polycomb group ring finger 5	0.9762	20
GK5	Glycerol kinase 5	0.9524	20
ZNF578	Zinc finger protein 578	0.9048	5
SERPINE1	Serpin family E member 1	0.9048	14
TNKS	Tankyrase	0.9048	20
ENSG00000288681	Novel protein	0.8810	15
TUBA3FP	Tubulin alpha 3f pseudogene	0.8810	20
TMEM213	Transmembrane protein 213	0.8810	20
ZFP42	ZFP42 zinc finger protein	0.8810	20
JAK1	Janus kinase 1	0.8810	5
PUM2	Pumilio RNA binding family member 2	0.8810	35
ZC3H18	Zinc finger CCCH-type containing 18	0.8571	5
PPP3CA	Protein phosphatase 3 catalytic subunit alpha	0.8571	35
TPD52L1	TPD52 like 1	0.8571	20
INSC	INSC spindle orientation adaptor protein	0.8571	20