Single cell type - ZHX1-C8orf76 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZHX1-C8orf76
Gene descriptionⁱ Full gene name according to HGNC.	ZHX1-C8orf76 readthrough
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Skeletal myocytes - Muscle excitation & contraction (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Myonuclei)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.57
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

Single cell type

Single nuclei - Brain

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nCPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. * Single nuclei Read more
Single cell type groups RNA single cell type group specificity: Low cell type specificity

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Low cell type specificity

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas HPA data, as well as data generated by Monaco et al and Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

ZHX1-C8orf76 is part of cluster 36 Skeletal myocytes - Muscle excitation & contraction with confidenceⁱ 0.74
183 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
EIF2B3	Eukaryotic translation initiation factor 2B subunit gamma	0.5016	36
PFKFB1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.4746	89
CACNA2D1	Calcium voltage-gated channel auxiliary subunit alpha2delta 1	0.4655	36
KLHL22	Kelch like family member 22	0.4615	7
CAND2	Cullin associated and neddylation dissociated 2 (putative)	0.4463	36
GHR	Growth hormone receptor	0.4440	89
ZNF248	Zinc finger protein 248	0.4337	59
TBX15	T-box transcription factor 15	0.4336	36
ANGPT1	Angiopoietin 1	0.4301	89
CACNA1S	Calcium voltage-gated channel subunit alpha1 S	0.4284	36
KCNA7	Potassium voltage-gated channel subfamily A member 7	0.4269	36
ALPK3	Alpha kinase 3	0.4199	36
MYOZ3	Myozenin 3	0.4186	36
ITIH6	Inter-alpha-trypsin inhibitor heavy chain family member 6	0.4104	36
RUSC2	RUN and SH3 domain containing 2	0.4077	36

IMMUNE CELLS

ZHX1-C8orf76 is part of cluster 25 Non-specific - Unknown function with confidenceⁱ 0.89
355 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
HARS2	Histidyl-tRNA synthetase 2, mitochondrial	1.0000	25
LFNG	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	1.0000	25
HSD17B1	Hydroxysteroid 17-beta dehydrogenase 1	0.9762	25
KAT5	Lysine acetyltransferase 5	0.9762	25
MELK	Maternal embryonic leucine zipper kinase	0.9762	25
PSMD4	Proteasome 26S subunit ubiquitin receptor, non-ATPase 4	0.9762	25
DOK2	Docking protein 2	0.9762	25
KIF23	Kinesin family member 23	0.9762	25
RBM42	RNA binding motif protein 42	0.9762	36
TSC2	TSC complex subunit 2	0.9762	25
KCNK6	Potassium two pore domain channel subfamily K member 6	0.9762	36
CAPZB	Capping actin protein of muscle Z-line subunit beta	0.9762	25
TBC1D22B	TBC1 domain family member 22B	0.9524	19
ZBTB45	Zinc finger and BTB domain containing 45	0.9524	25
CCDC170	Coiled-coil domain containing 170	0.9524	25