Single cell type - TMEM276 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TMEM276
Gene descriptionⁱ Full gene name according to HGNC.	Transmembrane protein 276
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Protein processing (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Megakaryocytes, Cholangiocytes, Retinal ganglion cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.78
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Not available
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

Single cell type

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nCPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. * Single nuclei Read more
Single cell type groups RNA single cell type group specificity: Cell type enhanced (Megakaryocytes)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ

HPA datasetⁱ

Lineage

Expression

Alphabetical

Immune cell type specificity: Low immune cell specificity

Monaco datasetⁱ

Lineage

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

TMEM276 is part of cluster 15 Non-specific - Protein processing with confidenceⁱ 1
232 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
RPL41	Ribosomal protein L41	0.5254	97
RPL39	Ribosomal protein L39	0.5162	15
MIF	Macrophage migration inhibitory factor	0.4909	97
RPL17	Ribosomal protein L17	0.4886	15
NEDD8	NEDD8 ubiquitin like modifier	0.4826	97
RPS17	Ribosomal protein S17	0.4811	15
IGLV5-45	Immunoglobulin lambda variable 5-45	0.4588	67
JTB	Jumping translocation breakpoint	0.4571	67
SMIM26	Small integral membrane protein 26	0.4549	97
SELENOH	Selenoprotein H	0.4491	15
EEF1A1	Eukaryotic translation elongation factor 1 alpha 1	0.4473	15
EEF1D	Eukaryotic translation elongation factor 1 delta	0.4427	67
IER3IP1	Immediate early response 3 interacting protein 1	0.4391	67
COX14	Cytochrome c oxidase assembly factor COX14	0.4389	97
KRTCAP2	Keratinocyte associated protein 2	0.4378	67

IMMUNE CELLS

TMEM276 is part of cluster 30 Non-specific - DNA binding with confidenceⁱ 0.99
263 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
SDHAF3	Succinate dehydrogenase complex assembly factor 3	1.0000	30
TIGD6	Tigger transposable element derived 6	1.0000	30
C4BPB	Complement component 4 binding protein beta	0.9762	30
ACBD6	Acyl-CoA binding domain containing 6	0.9762	30
PIGP	Phosphatidylinositol glycan anchor biosynthesis class P	0.9762	30
CHD3	Chromodomain helicase DNA binding protein 3	0.9762	30
TMOD4	Tropomodulin 4	0.9762	30
PTGR2	Prostaglandin reductase 2	0.9762	30
HNRNPD	Heterogeneous nuclear ribonucleoprotein D	0.9762	30
C1orf159	Chromosome 1 open reading frame 159	0.9762	30
OSCP1	Organic solute carrier partner 1	0.9762	30
EXD2	Exonuclease 3'-5' domain containing 2	0.9762	30
ZNF839	Zinc finger protein 839	0.9762	30
LIG3	DNA ligase 3	0.9524	30
DHODH	Dihydroorotate dehydrogenase (quinone)	0.9524	30