News Articles

The effect of PTMs on astrocyte creatine kinase levels in Alzheimer`s disease


The brain is a high energy consuming tissue that needs a continuous supply of energy substrates from the circulation for optimal neurological function. Astrocytes are important for regulating the relationship between energy consumption and dynamic neuronal activity in the brain and are mainly involved in processes used for efficient transfer of energy substrates to neurons. Changes in astrocyte energy metabolism could therefore potentially disrupt essential neuronal processes, and this cell type has also been shown to undergo structural and biochemical changes in Alzheimer's disease (AD). Here the cell type distribution and cellular levels of the brain enzyme CKB, which is crucial for energy homeostasis and known to have decreased activity in AD, has been investigated to identify changes associated with neurodegenerative processes...Read more

The immunoregulator IDO1


Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the first and rate-limiting step in the kynurenine pathway, which converts the essential amino acid tryptophan into kynurenine and other metabolites (Ball, 2014). This enzymatic activity exerts significant immunoregulatory effects, which has made it an attractive target for immunotherapy research...Read more

Multiplex tissue image of the month - AQP3 in kidney

News image of the month June 2024 AQP3 2.JPG

The difference in spatial distributions of two aquaporin proteins in the cells of collecting ducts in the kidney is illuminated through multiplex immunohistochemistry (mIHC/IF)...Read more

Csaba Adori receives the 2024 Lennart Nilsson Award


The neurobiologist Csaba Adori is awarded the 2024 Lennart Nilsson Award for his scientific 3D photography of tissues. The motivation states that he in the spirit of Lennart Nilsson combines the scientific aspects of tissue structure and its pathology, that contribute to the understanding of tissue anatomy, with the beauty of anatomical details revealed by artistic images...Read more

HPA keynote lecture at the ELIXIR-organized All-Hands-conference


The Director of the Human Protein Atlas program Mathias Uhlen delivered a keynote lecture entitled "HPA - implications for human biology, drug development and precision medicine" at the ELIXIR conference in Uppsala...Read more