MPP6

GENERAL INFORMATION

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Gene name

MPP6

Gene description

Membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in several types of glandular cells and neurons.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA019085 , HPA020456
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

MPP6 (HGNC Symbol)

Synonyms

p55T, PALS2, VAM-1

Description

Membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) (HGNC Symbol)

Entrez gene summary

Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]).[supplied by OMIM, Mar 2008]

Chromosome

7

Cytoband

p15.3

Chromosome location (bp)

24573268 - 24694193

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105926 (version 78.38)

Entrez gene

51678

UniProt

Q9NZW5 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NZW5

Antibodypedia

MPP6 antibodies


PROTEIN BROWSER

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ENST00000222644
 
ENST00000396475
 
ENST00000409761
 
ENST00000430180
 
ENST00000432190
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MPP6-001 ENSP00000222644
ENST00000222644
Q9NZW5
Show all »
Show » Show » 540 61.1 No 0
MPP6-002 ENSP00000379737
ENST00000396475
Q9NZW5
Show all »
Show » Show » 540 61.1 No 0
MPP6-004 ENSP00000395859
ENST00000432190
C9JGI8
Show all »
Show » Show » 217 23.9 No 0
MPP6-006 ENSP00000391020
ENST00000430180
C9J4Q3
Show all »
Show » Show » 307 34.3 No 0
MPP6-008 ENSP00000386262
ENST00000409761
B8ZZG1
Show all »
Show » Show » 428 48.8 No 0