Often referred to as the "powerhouse of the cell", mitochondria are vitally important to you. The mitochondria contains its own DNA coding for 37 genes, while a vast majority of mitochondrial localizing genes are coded in the nuclear DNA. Dysfunction in these genes often cause extreme disorders and have shown to play key roles in diseases including but not limited to: cancers, optical atrophy, mental development, heart, liver and kidney disease, dementia and diabetes (Scharfe C. et al. 2009).
MAOA shown here is a mitochondrial protein and member of the Monoamine oxidase family of proteins. This family of proteins has been implicated in optic atrophy...Read more
For more than 20 years, scientists have characterised the behaviour of cells in different circumstances by analysing the expression of their genes. This is typically done at the level of gene transcripts, and their collective expression (the 'expression profile') is known as the transcriptome. These methods are very powerful, but generate massive amounts of data (mammalian cells typically express some 20,000 gene transcripts). What is needed is a method that provides a simple summary of such data. A team from Manchester, together with colleagues from Sweden, has now come up with one...Read more
Urothelial cancer, also called bladder cancer, typically presents in patients over 50 years and is approximately three times as common in males compared to females. Tobacco is considered an important risk factor for developing bladder cancer. By using a systems level approach to analyze the urothelial cancer proteome based on clinical metadata and genome-wide transcriptomics data, 1093 genes were found to be associated with prognostic outcome...Read more
Some proteins are expressed periodically during a specific stage of the cell cycle or as a response to various stimuli. As a result, at any given time some cells express the protein of interest and some do not. In the Cell Atlas we denote these images as single-cell variation (SCV). An example of a protein with such variations is CCNB1.
CCNB1, shown here in U-251 MG cells, is essential for cellular proliferation. The abundance of CCNB1 oscillates across the cell cycle, and peaks during G2/M phase. CCNB1 is expressed in the cytoplasm during interphase and translocate to the nucleus during G2/M transition...Read more
Gliomas are a group of brain tumors that originate from different types of glial cells in the central nervous system. The prognosis for glioma is generally poor due to limited possibilities for curative treatment. By using a systems level approach to analyze the glioma proteome with respect to clinical outcome based on genome-wide transcriptomics, 263 genes were found to be associated with prognostic outcome...Read more
February 28, 2018 - March 2, 2018
The Wellcome Genome Campus organizes the conference Proteomics in Cell Biology and Disease Mechanisms where Dr. Emma Lundberg will present "Dissecting the spatiotemporal subcellular distribution of the human proteome". Her talk is scheduled on March 2. Draft programme