PUBLICATIONS


Citing the Human Protein Atlas

To cite us, please use:

The Human Protein Atlas

UhlÚn M, Fagerberg L, Hallstr÷m BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson ┼, Kampf C, Sj÷stedt E, Asplund A, Olsson I, Edlund K, Lundberg E, Navani S, Szigyarto CA, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist PH, Berling H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, Persson L, Johansson F, Zwahlen M, von Heijne G, Nielsen J, PontÚn F.
Tissue-based map of the human proteome.
Science 2015 347(6220):1260419.
PubMed: 25613900 DOI: 10.1126/science.1260419

Uhlen M, Oksvold P, Fagerberg L, Lundberg E, Jonasson K, Forsberg M, Zwahlen M, Kampf C, Wester K, Hober S, Wernerus H, Bj÷rling L, Ponten F.
Towards a knowledge-based Human Protein Atlas.
Nat Biotechnol. 2010 28(12):1248-50.
PubMed: 21139605 DOI: 10.1038/nbt1210-1248

The original Human Protein Atlas publication

UhlÚn M, Bj÷rling E, Agaton C, Szigyarto CA, Amini B, Andersen E, Andersson AC, Angelidou P, Asplund A, Asplund C, Berglund L, Bergstr÷m K, Brumer H, Cerjan D, Ekstr÷m M, Elobeid A, Eriksson C, Fagerberg L, Falk R, Fall J, Forsberg M, Bj÷rklund MG, Gumbel K, Halimi A, Hallin I, Hamsten C, Hansson M, Hedhammar M, Hercules G, Kampf C, Larsson K, Lindskog M, Lodewyckx W, Lund J, Lundeberg J, Magnusson K, Malm E, Nilsson P, Odling J, Oksvold P, Olsson I, Oster E, Ottosson J, Paavilainen L, Persson A, Rimini R, Rockberg J, Runeson M, Sivertsson A, Sk÷llermo A, Steen J, Stenvall M, Sterky F, Str÷mberg S, Sundberg M, Tegel H, Tourle S, Wahlund E, WaldÚn A, Wan J, WernÚrus H, Westberg J, Wester K, Wrethagen U, Xu LL, Hober S, PontÚn F.
A human protein atlas for normal and cancer tissues based on antibody proteomics.
Mol Cell Proteomics. 2005 4(12):1920-32.
PubMed: 16127175 DOI: 10.1074/mcp.M500279-MCP200

Pathology

PontÚn F, Jirstr÷m K, Uhlen M.
The Human Protein Atlas - a tool for pathology.
J Pathol. 2008 216(4):387-93.
PubMed: 18853439 DOI: 10.1002/path.2440

Publications

419 Kannan P, Schain M, Kretzschmar WW, Weidner L, Mitsios N, Gulyßs B, Blom H, Gottesman MM, Innis RB, Hall MD, Mulder J.
An automated method measures variability in P-glycoprotein and ABCG2 densities across brain regions and brain matter.
J Cereb Blood Flow Metab. 2016 Epub ahead of print
PubMed: 27488911 DOI: 10.1177/0271678X16660984
418 Musunuri S, Khoonsari PE, Mikus M, Wetterhall M, Hńggmark-Mńnberg A, Lannfelt L, Erlandsson A, Bergquist J, Ingelsson M, Shevchenko G, Nilsson P, Kultima K.
Increased Levels of Extracellular Microvesicle Markers and Decreased Levels of Endocytic/Exocytic Proteins in the Alzheimer's Disease Brain.
J Alzheimers Dis. 2016 54(4):1671-1686.
PubMed: 27636840 DOI: 10.3233/JAD-160271
417 Thelin EP, Just D, Frostell A, Hńggmark-Mňnberg A, Risling M, Svensson M, Nilsson P, Bellander BM.
Protein profiling in serum after traumatic brain injury in rats reveals potential injury markers.
Behav Brain Res. 2016 Epub ahead of print
PubMed: 27591967 DOI: 10.1016/j.bbr.2016.08.058
416 Ayoglu B, Schwenk JM, Nilsson P.
Antigen arrays for profiling autoantibody repertoires.
Bioanalysis. 2016 8(10):1105-26.
PubMed: 27097564 DOI: 10.4155/bio.16.31
415 Schr÷tter A, Park YM, Marcus K, Martins-de-Souza D, Nilsson P, Magraoui FE, Meyer HE, Grinberg LT.
Key players in neurodegenerative disorders in focus-New insights into the proteomic profile of Alzheimer's disease, schizophrenia, ALS, and multiple sclerosis-24th HUPO BPP Workshop: September 29, 2015, Vancouver, Canada.
Proteomics. 2016 16(7):1047-50.
PubMed: 26872682 DOI: 10.1002/pmic.201600047
414 Khoonsari PE, Hńggmark A, L÷nnberg M, Mikus M, Kilander L, Lannfelt L, Bergquist J, Ingelsson M, Nilsson P, Kultima K, Shevchenko G.
Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease.
PLoS One. 2016 11(3):e0150672.
PubMed: 26950848 DOI: 10.1371/journal.pone.0150672
413 Mardinoglu A, Boren J, Smith U.
Confounding Effects of Metformin on the Human Gut Microbiome in Type 2 Diabetes.
Cell Metab. 2016 23(1):10-2.
PubMed: 26771114 DOI: 10.1016/j.cmet.2015.12.012
412 Bj÷rnson E, BorÚn J, Mardinoglu A.
Personalized Cardiovascular Disease Prediction and Treatment-A Review of Existing Strategies and Novel Systems Medicine Tools.
Front Physiol. 2016 7():2.
PubMed: 26858650 DOI: 10.3389/fphys.2016.00002
411 Elsemman IE, Mardinoglu A, Shoaie S, Soliman TH, Nielsen J.
Systems biology analysis of hepatitis C virus infection reveals the role of copy number increases in regions of chromosome 1q in hepatocellular carcinoma metabolism.
Mol Biosyst. 2016 12(5):1496-506.
PubMed: 27040643 DOI: 10.1039/c5mb00827a
410 Lee S, Mardinoglu A, Zhang C, Lee D, Nielsen J.
Dysregulated signaling hubs of liver lipid metabolism reveal hepatocellular carcinoma pathogenesis.
Nucleic Acids Res. 2016 44(12):5529-39.
PubMed: 27216817 DOI: 10.1093/nar/gkw462
409 Zhang C, Lee S, Mardinoglu A, Hua Q.
Investigating the Combinatory Effects of Biological Networks on Gene Co-expression.
Front Physiol. 2016 7():160.
PubMed: 27445830 DOI: 10.3389/fphys.2016.00160
408 Chaudhari A, Hňversen L, Mobini R, Andersson L, Stňhlman M, Lu E, Rutberg M, Fogelstrand P, Ekroos K, Mardinoglu A, Levin M, Perkins R, BorÚn J.
ARAP2 promotes GLUT1-mediated basal glucose uptake through regulation of sphingolipid metabolism.
Biochim Biophys Acta. 2016 1861(11):1643-1651.
PubMed: 27476102 DOI: 10.1016/j.bbalip.2016.07.009
407 Heinonen S, Muniandy M, Buzkova J, Mardinoglu A, RodrÝguez A, FrŘhbeck G, Hakkarainen A, Lundbom J, Lundbom N, Kaprio J, Rissanen A, Pietilńinen KH.
Mitochondria-related transcriptional signature is downregulated in adipocytes in obesity: a study of young healthy MZ twins.
Diabetologia. 2016 Epub ahead of print
PubMed: 27734103 DOI: 10.1007/s00125-016-4121-2
406 Larsson AH, Lehn S, Wangefjord S, Karnevi E, Kuteeva E, Sundstr÷m M, Nodin B, UhlÚn M, Eberhard J, Birgisson H, Jirstr÷m K.
Significant association and synergistic adverse prognostic effect of podocalyxin-like protein and epidermal growth factor receptor expression in colorectal cancer.
J Transl Med. 2016 14(1):128.
PubMed: 27160084 DOI: 10.1186/s12967-016-0882-0
405 Lee S, Zhang C, Kilicarslan M, Piening BD, Bjornson E, Hallstr÷m BM, Groen AK, Ferrannini E, Laakso M, Snyder M, BlŘher M, Uhlen M, Nielsen J, Smith U, Serlie MJ, Boren J, Mardinoglu A.
Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance.
Cell Metab. 2016 24(1):172-84.
PubMed: 27345421 DOI: 10.1016/j.cmet.2016.05.026
404 Mardinoglu A, UhlÚn M.
Liver: Phenotypic and genetic variance: a systems approach to the liver.
Nat Rev Gastroenterol Hepatol. 2016 13(8):439-40.
PubMed: 27329803 DOI: 10.1038/nrgastro.2016.93
403 Mattsson JS, Brunnstr÷m H, Jabs V, Edlund K, Jirstr÷m K, Mindus S, la Fleur L, PontÚn F, Karlsson MG, Karlsson C, Koyi H, BrandÚn E, Botling J, Helenius G, Micke P, Svensson MA.
Inconsistent results in the analysis of ALK rearrangements in non-small cell lung cancer.
BMC Cancer. 2016 16():603.
PubMed: 27495736 DOI: 10.1186/s12885-016-2646-x
402 Delforoush M, Berglund M, Edqvist PH, Sundstr÷m C, Gullbo J, Enblad G.
Expression of possible targets for new proteasome inhibitors in diffuse large B-cell lymphoma.
Eur J Haematol. 2016 Epub ahead of print
PubMed: 27301795 DOI: 10.1111/ejh.12784
401 Boije H, Shirazi Fard S, Edqvist PH, Hallb÷÷k F.
Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease.
Front Neuroanat. 2016 10():77.
PubMed: 27486389 DOI: 10.3389/fnana.2016.00077
400 Stňhl PL, SalmÚn F, Vickovic S, Lundmark A, Navarro JF, Magnusson J, Giacomello S, Asp M, Westholm JO, Huss M, Mollbrink A, Linnarsson S, Codeluppi S, Borg ┼, PontÚn F, Costea PI, SahlÚn P, Mulder J, Bergmann O, Lundeberg J, FrisÚn J.
Visualization and analysis of gene expression in tissue sections by spatial transcriptomics.
Science. 2016 353(6294):78-82.
PubMed: 27365449 DOI: 10.1126/science.aaf2403
399 Wallerius M, Wallmann T, Bartish M, Ístling J, Mezheyeuski A, Tobin NP, Nygren E, Pangigadde P, Pellegrini P, Squadrito ML, PontÚn F, Hartman J, Bergh J, De Milito A, De Palma M, Ístman A, Andersson J, Rolny C.
Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages.
Cancer Res. 2016 76(11):3166-78.
PubMed: 27197153 DOI: 10.1158/0008-5472.CAN-15-2596
398 Mezheyeuski A, Lindh MB, Guren TK, Dragomir A, Pfeiffer P, Kure EH, Ikdahl T, Skovlund E, Corvigno S, Strell C, Pietras K, Ponten F, Mulder J, Qvortrup C, Portyanko A, Tveit KM, Glimelius B, Sorbye H, Ístman A.
Survival-associated heterogeneity of marker-defined perivascular cells in colorectal cancer.
Oncotarget. 2016 Epub ahead of print
PubMed: 27248825 DOI: 10.18632/oncotarget.9632
397 Zetterling M, Roodakker KR, Berntsson SG, Edqvist PH, Latini F, Landtblom AM, PontÚn F, Alafuzoff I, Larsson EM, Smits A.
Extension of diffuse low-grade gliomas beyond radiological borders as shown by the coregistration of histopathological and magnetic resonance imaging data.
J Neurosurg. 2016 ():1-12.
PubMed: 26918468 DOI: 10.3171/2015.10.JNS15583
396 Manojlovic-Gacic E, Skender-Gazibara M, Popovic V, Soldatovic I, Boricic N, Raicevic S, Pekic S, Doknic M, Miljic D, Alafuzoff I, PontÚn F, Casar-Borota O.
Oncogene-Induced Senescence in Pituitary Adenomas--an Immunohistochemical Study.
Endocr Pathol. 2016 27(1):1-11.
PubMed: 26573928 DOI: 10.1007/s12022-015-9405-4
395 Landegren N, Sharon D, Freyhult E, Hallgren ┼, Eriksson D, Edqvist PH, Bensing S, Wahlberg J, Nelson LM, Gustafsson J, Husebye ES, Anderson MS, Snyder M, Kńmpe O.
Proteome-wide survey of the autoimmune target repertoire in autoimmune polyendocrine syndrome type 1.
Sci Rep. 2016 6():20104.
PubMed: 26830021 DOI: 10.1038/srep20104
394 Hellstr÷m-Lindahl E, Danielsson A, Ponten F, Czernichow P, Korsgren O, Johansson L, Eriksson O.
GPR44 is a pancreatic protein restricted to the human beta cell.
Acta Diabetol. 2016 53(3):413-21.
PubMed: 26467464 DOI: 10.1007/s00592-015-0811-3
393 Fredrik Edfors, Frida Danielsson, Bj÷rn M Hallstr÷m, Lukas Kńll, Emma Lundberg, Fredrik Ponten, Bj÷rn Forsstr÷m and Mathias UhlÚn
Gene-specific correlation of RNA and protein levels in human cells and tissues
Molecular Systems Biology 2016 883
DOI: 10.15252/msb.20167144
392 Lindskog C, Asplund A, Catrina A, Nielsen S, RŘtzler M.
A Systematic Characterization of Aquaporin-9 Expression in Human Normal and Pathological Tissues.
J Histochem Cytochem. 2016 64(5):287-300.
PubMed: 27026296 DOI: 10.1369/0022155416641028
391 Hamsten C, Hńggmark A, Grundstr÷m J, Mikus M, Lindskog C, Konradsen JR, Eklund A, Pershagen G, Wickman M, Grunewald J, MelÚn E, Hedlin G, Nilsson P, van Hage M.
Protein profiles of CCL5, HPGDS, and NPSR1 in plasma reveal association with childhood asthma.
Allergy. 2016 71(9):1357-61.
PubMed: 27145233 DOI: 10.1111/all.12927
390 Lindskog C.
The Human Protein Atlas - an important resource for basic and clinical research.
Expert Rev Proteomics. 2016 13(7):627-9.
PubMed: 27276068 DOI: 10.1080/14789450.2016.1199280
389 Vandenbrouck Y, Lane L, Carapito C, Duek P, Rondel K, Bruley C, Macron C, Gonzalez de Peredo A, CoutÚ Y, Chaoui K, Com E, Gateau A, Hesse AM, Marcellin M, MÚar L, Mouton-Barbosa E, Robin T, Burlet-Schiltz O, Cianferani S, Ferro M, FrÚour T, Lindskog C, Garin J, Pineau C.
Looking for Missing Proteins in the Proteome of Human Spermatozoa: An Update.
J Proteome Res. 2016 Epub ahead of print
PubMed: 27444420 DOI: 10.1021/acs.jproteome.6b00400
388 Volk AL, Hu FJ, Berglund MM, Nordling E, Str÷mberg P, Uhlen M, Rockberg J.
Stratification of responders towards eculizumab using a structural epitope mapping strategy.
Sci Rep. 2016 6():31365.
PubMed: 27509843 DOI: 10.1038/srep31365
387 UhlÚn M, Hallstr÷m BM, Lindskog C, Mardinoglu A, PontÚn F, Nielsen J.
Transcriptomics resources of human tissues andáorgans.
Mol Syst Biol. 2016 12(4):862.
PubMed: 27044256
386 Pozniak Y, Balint-Lahat N, Rudolph JD, Lindskog C, Katzir R, Avivi C, PontÚn F, Ruppin E, Barshack I, Geiger T.
System-wide Clinical Proteomics of Breast Cancer Reveals Global Remodeling of Tissue Homeostasis.
Cell Syst. 2016 2(3):172-84.
PubMed: 27135363 DOI: 10.1016/j.cels.2016.02.001
385 Fukuhara M, Agnarsdˇttir M, Edqvist PH, Coter A, Ponten F.
SATB2 is expressed in Merkel cell carcinoma.
Arch Dermatol Res. 2016 308(6):449-54.
PubMed: 27262585 DOI: 10.1007/s00403-016-1655-6
384 Lal S, Nguyen L, Tezone R, Ponten F, Odeberg J, Li A, Dos Remedios C.
Tissue microarray profiling in human heart failure.
Proteomics. 2016 16(17):2319-26.
PubMed: 27364902 DOI: 10.1002/pmic.201600135
383 Fredholm H, Magnusson K, Lindstr÷m LS, Garmo H, Fńlt SE, Lindman H, Bergh J, Holmberg L, PontÚn F, Frisell J, Fredriksson I.
Long-term outcome in young women with breast cancer: a population-based study.
Breast Cancer Res Treat. 2016 160(1):131-143.
PubMed: 27624330 DOI: 10.1007/s10549-016-3983-9
382 Roodakker KR, Elsir T, Edqvist PD, Hńgerstrand D, Carlson J, Lysiak M, Henriksson R, PontÚn F, Rosell J, S÷derkvist P, Stupp R, Tchougounova E, NistÚr M, Malmstr÷m A, Smits A.
PROX1 is a novel pathway-specific prognostic biomarker for high-grade astrocytomas; results from independent glioblastoma cohorts stratified by age and IDH mutation status.
Oncotarget. 2016 Epub ahead of print
PubMed: 27626492 DOI: 10.18632/oncotarget.11957
381 Butler LM, Hallstr÷m BM, Fagerberg L, PontÚn F, UhlÚn M, RennÚ T, Odeberg J.
Analysis of Body-wide Unfractionated Tissue Data to Identify a Core Human Endothelial Transcriptome.
Cell Syst. 2016 3(3):287-301.e3.
PubMed: 27641958 DOI: 10.1016/j.cels.2016.08.001
380 Eriksson O, Asplund A, Hegde G, Edqvist PH, Navani S, PontÚn F, Siegbahn A.
A stromal cell population in the large intestine identified by tissue factor expression that is lost during colorectal cancer progression.
Thromb Haemost. 2016 116(6):.
PubMed: 27656710 DOI: 10.1160/TH16-04-0267
379 Djureinovic D, Hallstr÷m BM, Horie M, Mattsson JS, La Fleur L, Fagerberg L, Brunnstr÷m H, Lindskog C, Madjar K, RahnenfŘhrer J, Ekman S, Stňhle E, Koyi H, BrandÚn E, Edlund K, Hengstler JG, Lambe M, Saito A, Botling J, PontÚn F, UhlÚn M, Micke P.
Profiling cancer testis antigens in non-small-cell lung cancer.
JCI Insight. 2016 1(10):e86837.
PubMed: 27699219 DOI: 10.1172/jci.insight.86837
378 Pin E, Henjes F, Hong MG, Wiklund F, Magnusson P, Bjartell A, UhlÚn M, Nilsson P, Schwenk JM.
Identification Of A Novel Autoimmune Peptide Epitope Of Prostein In Prostate Cancer.
J Proteome Res. 2016 Epub ahead of print
PubMed: 27700103 DOI: 10.1021/acs.jproteome.6b00620
377 Remnestňl J, Just D, Mitsios N, Fredolini C, Mulder J, Schwenk JM, UhlÚn M, Kultima K, Ingelsson M, Kilander L, Lannfelt L, Svenningsson P, Nellgňrd B, Zetterberg H, Blennow K, Nilsson P, Hńggmark-Mňnberg A.
CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease.
Proteomics Clin Appl. 2016 Epub ahead of print
PubMed: 27604409 DOI: 10.1002/prca.201500150
376 Hong MG, Lee W, Nilsson P, Pawitan Y, Schwenk JM.
Multidimensional Normalization to Minimize Plate Effects of Suspension Bead Array Data.
J Proteome Res. 2016 15(10):3473-3480.
PubMed: 27570895 DOI: 10.1021/acs.jproteome.5b01131
375 Hamsten C, Wiklundh E, Gr÷nlund H, Schwenk JM, UhlÚn M, Eklund A, Nilsson P, Grunewald J, Hńggmark-Mňnberg A.
Elevated levels of FN1 and CCL2 in bronchoalveolar lavage fluid from sarcoidosis patients.
Respir Res. 2016 17(1):69.
PubMed: 27259755 DOI: 10.1186/s12931-016-0381-0
374 Mikus M, Drobin K, Gry M, Bachmann J, Lindberg J, Yimer G, Aklillu E, Makonnen E, Aderaye G, Roach J, Fier I, Kampf C, G÷pfert J, Perazzo H, Poynard T, Stephens C, Andrade RJ, Lucena MI, Arber N, UhlÚn M, Watkins PB, Schwenk JM, Nilsson P, Schuppe-Koistinen I.
Elevated levels of circulating CDH5 and FABP1 in association with human drug-induced liver injury.
Liver Int. 2016 Epub ahead of print
PubMed: 27224670 DOI: 10.1111/liv.13174
373 Hńggmark-Mňnberg A, Zandian A, Forsstr÷m B, Khademi M, Lima Bomfim I, Hellstr÷m C, Arnheim-Dahlstr÷m L, Hallb÷÷k T, Darin N, Lundberg IE, UhlÚn M, Partinen M, Schwenk JM, Olsson T, Nilsson P.
Autoantibody targets in vaccine-associated narcolepsy.
Autoimmunity. 2016 ():1-13.
PubMed: 27206786 DOI: 10.1080/08916934.2016.1183655
372 Amit I, Baker D, Barker R, Berger B, Bertozzi C, Bhatia S, Biffi A, Demichelis F, Doudna J, Dowdy SF, Endy D, Helmstaedter M, Junca H, June C, Kamb S, Khvorova A, Kim DH, Kim JS, Krishnan Y, Lakadamyali M, Lappalainen T, Lewin S, Liao J, Loman N, Lundberg E, Lynd L, Martin C, Mellman I, Miyawaki A, Mummery C, Nelson K, Paz J, Peralta-Yahya P, Picotti P, Polyak K, Prather K, Qin J, Quake S, Regev A, Rogers JA, Shetty R, Sommer M, Stevens M, Stolovitzky G, Takahashi M, Tang F, Teichmann S, Torres-Padilla ME, Tripathi L, Vemula P, Verdine G, Vollmer F, Wang J, Ying JY, Zhang F, Zhang T.
Voices of biotech.
Nat Biotechnol. 2016 34(3):270-5.
PubMed: 26963549 DOI: 10.1038/nbt.3502
371 Omenn GS, Lane L, Lundberg EK, Beavis RC, Overall CM, Deutsch EW.
Metrics for the Human Proteome Project 2016: Progress on Identifying and Characterizing the Human Proteome, Including Post-Translational Modifications.
J Proteome Res. 2016 Epub ahead of print
PubMed: 27487407 DOI: 10.1021/acs.jproteome.6b00511
370 Uhlen M, Bandrowski A, Carr S, Edwards A, Ellenberg J, Lundberg E, Rimm DL, Rodriguez H, Hiltke T, Snyder M, Yamamoto T.
A proposal for validation of antibodies.
Nat Methods. 2016 13(10):823-7.
PubMed: 27595404 DOI: 10.1038/nmeth.3995
369 Ayoglu B, Birgersson E, Mezger A, Nilsson M, UhlÚn M, Nilsson P, Schwenk JM.
Multiplexed protein profiling by sequential affinity capture.
Proteomics. 2016 Epub ahead of print
PubMed: 26935855 DOI: 10.1002/pmic.201500398
368 Ayoglu B, Mitsios N, Kockum I, Khademi M, Zandian A, Sj÷berg R, Forsstr÷m B, Bredenberg J, Lima Bomfim I, Holmgren E, Gr÷nlund H, Guerreiro-Cacais AO, Abdelmagid N, UhlÚn M, Waterboer T, Alfredsson L, Mulder J, Schwenk JM, Olsson T, Nilsson P.
Anoctamin 2 identified as an autoimmune target in multiple sclerosis.
Proc Natl Acad Sci U S A. 2016 113(8):2188-93.
PubMed: 26862169 DOI: 10.1073/pnas.1518553113
367 Fredolini C, Bystr÷m S, Pin E, Edfors F, Tamburro D, Iglesias MJ, Hńggmark A, Hong MG, Uhlen M, Nilsson P, Schwenk JM.
Immunocapture strategies in translational proteomics.
Expert Rev Proteomics. 2016 13(1):83-98.
PubMed: 26558424 DOI: 10.1586/14789450.2016.1111141
366 Zhang MD, Barde S, Szodorai E, Josephson A, Mitsios N, Watanabe M, Attems J, Lubec G, Kovßcs GM, UhlÚn M, Mulder J, Harkany T, H÷kfelt T.
Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord.
Brain Struct Funct. 2016 Epub ahead of print
PubMed: 26843217 DOI: 10.1007/s00429-016-1191-3
365 Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS.
Systems Proteomics View of the Endogenous Human Claudin Protein Family.
J Proteome Res. 2016 15(2):339-59.
PubMed: 26680015 DOI: 10.1021/acs.jproteome.5b00769
364 Gustafsson Sheppard N, Jarl L, Mahadessian D, Strittmatter L, Schmidt A, Madhusudan N, TegnÚr J, Lundberg EK, Asplund A, Jain M, Nilsson R.
The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation.
Sci Rep. 2015 5():15029.
PubMed: 26461067 DOI: 10.1038/srep15029
363 Lyu C, Mulder J, Barde S, Sahlholm K, Zeberg H, Nilsson J, ┼rhem P, H÷kfelt T, Fried K, Shi TJ.
G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy.
Mol Pain. 2015 11():44.
PubMed: 26199148 DOI: 10.1186/s12990-015-0044-z
362 Mardinoglu A, Nielsen J.
New paradigms for metabolic modeling of human cells.
Curr Opin Biotechnol. 2015 34():91-7.
PubMed: 25559199 DOI: 10.1016/j.copbio.2014.12.013
361 Zhang C, Ji B, Mardinoglu A, Nielsen J, Hua Q.
Logical transformation of genome-scale metabolic models for gene level applications and analysis.
Bioinformatics. 2015 31(14):2324-31.
PubMed: 25735769 DOI: 10.1093/bioinformatics/btv134
360 Mardinoglu A, Cregg PJ.
Modelling the effect of SPION size in a stent assisted magnetic drug targeting system with interparticle interactions.
ScientificWorldJournal. 2015 2015():618658.
PubMed: 25815370 DOI: 10.1155/2015/618658
359 Shoaie S, Ghaffari P, Kovatcheva-Datchary P, Mardinoglu A, Sen P, Pujos-Guillot E, de Wouters T, Juste C, Rizkalla S, Chilloux J, Hoyles L, Nicholson JK, , Dore J, Dumas ME, Clement K, Bńckhed F, Nielsen J.
Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome.
Cell Metab. 2015 22(2):320-31.
PubMed: 26244934 DOI: 10.1016/j.cmet.2015.07.001
358 Mardinoglu A, Heiker JT, Gńrtner D, Bj÷rnson E, Sch÷n MR, Flehmig G, Kl÷ting N, Krohn K, Fasshauer M, Stumvoll M, Nielsen J, BlŘher M.
Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue.
Sci Rep. 2015 5():14841.
PubMed: 26434764 DOI: 10.1038/srep14841
357 Mardinoglu A, Shoaie S, Bergentall M, Ghaffari P, Zhang C, Larsson E, Bńckhed F, Nielsen J.
The gut microbiota modulates host amino acid and glutathione metabolism in mice.
Mol Syst Biol. 2015 11(10):834.
PubMed: 26475342
356 Adiels M, Mardinoglu A, Taskinen MR, BorÚn J.
Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans.
Front Physiol. 2015 6():342.
PubMed: 26635628 DOI: 10.3389/fphys.2015.00342
355 Ghaffari P, Mardinoglu A, Nielsen J.
Cancer Metabolism: A Modeling Perspective.
Front Physiol. 2015 6():382.
PubMed: 26733270 DOI: 10.3389/fphys.2015.00382
354 Ruiz-Riquelme A, Sßnchez-Iglesias S, Rßbano A, GuillÚn-Navarro E, Domingo-JimÚnez R, Ramos A, Rosa I, Senra A, Nilsson P, GarcÝa ┴, Ara˙jo-Vilar D, Requena JR.
Larger aggregates of mutant seipin in Celia's Encephalopathy, a new protein misfolding neurodegenerative disease.
Neurobiol Dis. 2015 83():44-53.
PubMed: 26282322 DOI: 10.1016/j.nbd.2015.08.006
353 Langenkamp E, Zhang L, Lugano R, Huang H, Elhassan TE, Georganaki M, Bazzar W, L÷÷f J, Trendelenburg G, Essand M, PontÚn F, Smits A, Dimberg A.
Elevated expression of the C-type lectin CD93 in the glioblastoma vasculature regulates cytoskeletal rearrangements that enhance vessel function and reduce host survival.
Cancer Res. 2015 75(21):4504-16.
PubMed: 26363010 DOI: 10.1158/0008-5472.CAN-14-3636
352 Hansen HG, Nilsson CN, Lund AM, Kol S, Grav LM, Lundqvist M, Rockberg J, Lee GM, Andersen MR, Kildegaard HF.
Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells.
Sci Rep. 2015 5():18016.
PubMed: 26657798 DOI: 10.1038/srep18016
351 Zhang L, Kundu S, Feenstra T, Li X, Jin C, Laaniste L, El Hassan TE, Ohlin KE, Yu D, Olofsson T, Olsson AK, PontÚn F, Magnusson PU, Nilsson KF, Essand M, Smits A, Dieterich LC, Dimberg A.
Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas.
Sci Signal. 2015 8(406):ra125.
PubMed: 26645582 DOI: 10.1126/scisignal.aaa1690
350 Sj÷berg R, Mattsson C, Andersson E, Hellstr÷m C, Uhlen M, Schwenk JM, Ayoglu B, Nilsson P.
Exploration of high-density protein microarrays for antibody validation and autoimmunity profiling.
N Biotechnol. 2015 Epub ahead of print
PubMed: 26417875 DOI: 10.1016/j.nbt.2015.09.002
349 Kanatani S, Honda T, Aramaki M, Hayashi K, Kubo K, Ishida M, Tanaka DH, Kawauchi T, Sekine K, Kusuzawa S, Kawasaki T, Hirata T, Tabata H, UhlÚn P, Nakajima K.
The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain.
Proc Natl Acad Sci U S A. 2015 112(36):E4985-94.
PubMed: 26305926 DOI: 10.1073/pnas.1420701112
348 Adori C, Barde S, Vas S, Ebner K, Su J, Svensson C, MathÚ AA, Singewald N, Reinscheid RR, UhlÚn M, Kultima K, Bagdy G, H÷kfelt T.
Exploring the role of neuropeptide S in the regulation of arousal: a functional anatomical study.
Brain Struct Funct. 2015 Epub ahead of print
PubMed: 26462664 DOI: 10.1007/s00429-015-1117-5
347 Zieba A, Sj÷stedt E, Olovsson M, Fagerberg L, Hallstr÷m BM, Oskarsson L, Edlund K, Tolf A, Uhlen M, Ponten F.
The Human Endometrium-Specific Proteome Defined by Transcriptomics and Antibody-Based Profiling.
OMICS. 2015 19(11):659-68.
PubMed: 26488136 DOI: 10.1089/omi.2015.0115
346 Dijksterhuis JP, Arthofer E, Marinescu VD, Nelander S, UhlÚn M, PontÚn F, Mulder J, Schulte G.
High levels of WNT-5A in human glioma correlate with increased presence of tumor-associated microglia/monocytes.
Exp Cell Res. 2015 339(2):280-8.
PubMed: 26511503 DOI: 10.1016/j.yexcr.2015.10.022
345 Bj÷rnson E, Mukhopadhyay B, Asplund A, Pristovsek N, Cinar R, Romeo S, Uhlen M, Kunos G, Nielsen J, Mardinoglu A.
Stratification of Hepatocellular Carcinoma Patients Based on Acetate Utilization.
Cell Rep. 2015 13(9):2014-26.
PubMed: 26655911 DOI: 10.1016/j.celrep.2015.10.045
344 Habuka M, Fagerberg L, Hallstr÷m BM, PontÚn F, Yamamoto T, Uhlen M.
The Urinary Bladder Transcriptome and Proteome Defined by Transcriptomics and Antibody-Based Profiling.
PLoS One. 2015 10(12):e0145301.
PubMed: 26694548 DOI: 10.1371/journal.pone.0145301
343 Ko BK, Lee SY, Lee YH, Hwang IS, Persson H, Rockberg J, Borrebaeck C, Park D, Kim KT, Uhlen M, Lee JS.
Combination of novel HER2-targeting antibody 1E11 with trastuzumab shows synergistic antitumor activity in HER2-positive gastric cancer.
Mol Oncol. 2015 9(2):398-408.
PubMed: 25306393 DOI: 10.1016/j.molonc.2014.09.007
342 Pronk JT, Lee SY, Lievense J, Pierce J, Palsson B, Uhlen M, Nielsen J.
How to set up collaborations between academia and industrial biotech companies.
Nat Biotechnol. 2015 33(3):237-40.
PubMed: 25748909 DOI: 10.1038/nbt.3171
341 Perisic L, Rodriguez PQ, Hultenby K, Sun Y, Lal M, Betsholtz C, UhlÚn M, Wernerson A, Hedin U, Pikkarainen T, Tryggvason K, Patrakka J.
Schip1 is a novel podocyte foot process protein that mediates actin cytoskeleton rearrangements and forms a complex with Nherf2 and ezrin.
PLoS One. 2015 10(3):e0122067.
PubMed: 25807495 DOI: 10.1371/journal.pone.0122067
340 Lundqvist M, Edfors F, Sivertsson ┼, Hallstr÷m BM, Hudson EP, Tegel H, Holmberg A, UhlÚn M, Rockberg J.
Solid-phase cloning for high-throughput assembly of single and multiple DNA parts.
Nucleic Acids Res. 2015 43(7):e49.
PubMed: 25618848 DOI: 10.1093/nar/gkv036
339 Forsstr÷m B, Axnńs BB, Rockberg J, Danielsson H, Bohlin A, Uhlen M.
Dissecting antibodies with regards to linear and conformational epitopes.
PLoS One. 2015 10(3):e0121673.
PubMed: 25816293 DOI: 10.1371/journal.pone.0121673
338 Vńremo L, Scheele C, Broholm C, Mardinoglu A, Kampf C, Asplund A, Nookaew I, UhlÚn M, Pedersen BK, Nielsen J.
Proteome- and transcriptome-driven reconstruction of the human myocyte metabolic network and its use for identification of markers for diabetes.
Cell Rep. 2015 11(6):921-33.
PubMed: 25937284 DOI: 10.1016/j.celrep.2015.04.010
337 KŘrten C, UhlÚn M, SyrÚn PO.
Overexpression of functional human oxidosqualene cyclase in Escherichia coli.
Protein Expr Purif. 2015 115():46-53.
PubMed: 25962741 DOI: 10.1016/j.pep.2015.04.015
336 Huang M, Bai Y, Sjostrom SL, Hallstr÷m BM, Liu Z, Petranovic D, UhlÚn M, Joensson HN, Andersson-Svahn H, Nielsen J.
Microfluidic screening and whole-genome sequencing identifies mutations associated with improved protein secretion by yeast.
Proc Natl Acad Sci U S A. 2015 112(34):E4689-96.
PubMed: 26261321 DOI: 10.1073/pnas.1506460112
335 Adori C, Barde S, Bogdanovic N, UhlÚn M, Reinscheid RR, Kovacs GG, H÷kfelt T.
Neuropeptide S- and Neuropeptide S receptor-expressing neuron populations in the human pons.
Front Neuroanat. 2015 9():126.
PubMed: 26441556 DOI: 10.3389/fnana.2015.00126
334 Romanov RA, Alpßr A, Zhang MD, Zeisel A, Calas A, Landry M, Fuszard M, Shirran SL, Schnell R, Dobolyi ┴, Olßh M, Spence L, Mulder J, Martens H, Palkovits M, Uhlen M, Sitte HH, Botting CH, Wagner L, Linnarsson S, H÷kfelt T, Harkany T.
A secretagogin locus of the mammalian hypothalamus controls stress hormone release.
EMBO J. 2015 34(1):36-54.
PubMed: 25430741 DOI: 10.15252/embj.201488977
333 ┴dori C, GlŘck L, Barde S, Yoshitake T, Kovacs GG, Mulder J, Maglˇczky Z, Havas L, B÷lcskei K, Mitsios N, UhlÚn M, Szolcsßnyi J, Kehr J, R÷nnbńck A, Schwartz T, Rehfeld JF, Harkany T, Palkovits M, Schulz S, H÷kfelt T.
Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer's disease.
Acta Neuropathol. 2015 129(4):541-63.
PubMed: 25676386 DOI: 10.1007/s00401-015-1394-3
332 Qundos U, Drobin K, Mattsson C, Hong MG, Sj÷berg R, Forsstr÷m B, Solomon D, UhlÚn M, Nilsson P, MichaŰlsson K, Schwenk JM.
Affinity proteomics discovers decreased levels of AMFR in plasma from Osteoporosis patients.
Proteomics Clin Appl. 2015 Epub ahead of print
PubMed: 25689831 DOI: 10.1002/prca.201400167
331 Arner P, Henjes F, Schwenk JM, Darmanis S, Dahlman I, Iresj÷ BM, Naredi P, Agustsson T, Lundholm K, Nilsson P, RydÚn M.
Circulating carnosine dipeptidase 1 associates with weight loss and poor prognosis in gastrointestinal cancer.
PLoS One. 2015 10(4):e0123566.
PubMed: 25898255 DOI: 10.1371/journal.pone.0123566
330 Hamsten C, Skattum L, Truedsson L, von D÷beln U, UhlÚn M, Schwenk JM, Hammarstr÷m L, Nilsson P, Neiman M.
Heat differentiated complement factor profiling.
J Proteomics. 2015 126():155-62.
PubMed: 26047714 DOI: 10.1016/j.jprot.2015.05.027
329 Hńggmark A, Schwenk JM, Nilsson P.
Neuroproteomic profiling of human body fluids.
Proteomics Clin Appl. 2015 Epub ahead of print
PubMed: 26286680 DOI: 10.1002/prca.201500065
328 O'Hurley G, Busch C, Fagerberg L, Hallstr÷m BM, Stadler C, Tolf A, Lundberg E, Schwenk JM, Jirstr÷m K, Bjartell A, Gallagher WM, UhlÚn M, PontÚn F.
Analysis of the Human Prostate-Specific Proteome Defined by Transcriptomics and Antibody-Based Profiling Identifies TMEM79 and ACOXL as Two Putative, Diagnostic Markers in Prostate Cancer.
PLoS One. 2015 10(8):e0133449.
PubMed: 26237329 DOI: 10.1371/journal.pone.0133449
327 Horvatovich P, Lundberg EK, Chen YJ, Sung TY, He F, Nice EC, Goode RJ, Yu S, Ranganathan S, Baker MS, Domont GB, Velasquez E, Li D, Liu S, Wang Q, He QY, Menon R, Guan Y, Corrales FJ, Segura V, Casal JI, Pascual-Montano A, Albar JP, Fuentes M, Gonzalez-Gonzalez M, Diez P, Ibarrola N, Degano RM, Mohammed Y, Borchers CH, Urbani A, Soggiu A, Yamamoto T, Salekdeh GH, Archakov A, Ponomarenko E, Lisitsa A, Lichti CF, Mostovenko E, Kroes RA, Rezeli M, VÚgvßri ┴, Fehniger TE, Bischoff R, VizcaÝno JA, Deutsch EW, Lane L, Nilsson CL, Marko-Varga G, Omenn GS, Jeong SK, Lim JS, Paik YK, Hancock WS.
Quest for Missing Proteins: Update 2015 on Chromosome-Centric Human Proteome Project.
J Proteome Res. 2015 Epub ahead of print
PubMed: 26076068 DOI: 10.1021/pr5013009
326 Omenn GS, Lane L, Lundberg EK, Beavis RC, Nesvizhskii AI, Deutsch EW.
Metrics for the Human Proteome Project 2015: Progress on the Human Proteome and Guidelines for High-Confidence Protein Identification.
J Proteome Res. 2015 Epub ahead of print
PubMed: 26155816 DOI: 10.1021/acs.jproteome.5b00499
325 Roy A, Coum A, Marinescu VD, P§lajeva J, Smits A, Nelander S, Uhrbom L, Westermark B, Forsberg-Nilsson K, PontÚn F, Tchougounova E.
Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells.
Oncotarget. 2015 Epub ahead of print
PubMed: 26164207
324 Lindskog C, LinnÚ J, Fagerberg L, Hallstr÷m BM, Sundberg CJ, Lindholm M, Huss M, Kampf C, Choi H, Liem DA, Ping P, Vńremo L, Mardinoglu A, Nielsen J, Larsson E, PontÚn F, UhlÚn M.
The human cardiac and skeletal muscle proteomes defined by transcriptomics and antibody-based profiling.
BMC Genomics. 2015 16():475.
PubMed: 26109061 DOI: 10.1186/s12864-015-1686-y
323 Yu NY, Hallstr÷m BM, Fagerberg L, Ponten F, Kawaji H, Carninci P, Forrest AR, Fantom Consortium T, Hayashizaki Y, UhlÚn M, Daub CO.
Complementing tissue characterization by integrating transcriptome profiling from the Human Protein Atlas and from the FANTOM5 consortium.
Nucleic Acids Res. 2015 43(14):6787-98.
PubMed: 26117540 DOI: 10.1093/nar/gkv608
322 Reyahi A, Nik AM, Ghiami M, Gritli-Linde A, PontÚn F, Johansson BR, Carlsson P.
Foxf2 Is Required for Brain Pericyte Differentiation and Development and Maintenance of the Blood-Brain Barrier.
Dev Cell. 2015 34(1):19-32.
PubMed: 26120030 DOI: 10.1016/j.devcel.2015.05.008
321 Sorbye H, Dragomir A, Sundstr÷m M, Pfeiffer P, Thunberg U, Bergfors M, Aaseb° K, Eide GE, Ponten F, Qvortrup C, Glimelius B.
High BRAF Mutation Frequency and Marked Survival Differences in Subgroups According to KRAS/BRAF Mutation Status and Tumor Tissue Availability in a Prospective Population-Based Metastatic Colorectal Cancer Cohort.
PLoS One. 2015 10(6):e0131046.
PubMed: 26121270 DOI: 10.1371/journal.pone.0131046
320 Sj÷stedt E, Fagerberg L, Hallstr÷m BM, Hńggmark A, Mitsios N, Nilsson P, PontÚn F, H÷kfelt T, UhlÚn M, Mulder J.
Defining the Human Brain Proteome Using Transcriptomics and Antibody-Based Profiling with a Focus on the Cerebral Cortex.
PLoS One. 2015 10(6):e0130028.
PubMed: 26076492 DOI: 10.1371/journal.pone.0130028
319 Vizoso M, Ferreira HJ, Lopez-Serra P, Carmona FJ, MartÝnez-Card˙s A, Girotti MR, Villanueva A, Guil S, Moutinho C, Liz J, Portela A, Heyn H, Moran S, Vidal A, Martinez-Iniesta M, Manzano JL, Fernandez-Figueras MT, Elez E, Mu˝oz-Couselo E, Botella-Estrada R, Berrocal A, PontÚn F, Oord Jv, Gallagher WM, Frederick DT, Flaherty KT, McDermott U, Lorigan P, Marais R, Esteller M.
Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR.
Nat Med. 2015 21(7):741-50.
PubMed: 26030178 DOI: 10.1038/nm.3863
318 Kiflemariam S, Ljungstr÷m V, PontÚn F, Sj÷blom T.
Tumor vessel up-regulation of INSR revealed by single-cell expression analysis of the tyrosine kinome and phosphatome in human cancers.
Am J Pathol. 2015 185(6):1600-9.
PubMed: 25864925 DOI: 10.1016/j.ajpath.2015.02.019
317 Ghaffari P, Mardinoglu A, Asplund A, Shoaie S, Kampf C, Uhlen M, Nielsen J.
Identifying anti-growth factors for human cancer cell lines through genome-scale metabolic modeling.
Sci Rep. 2015 5():8183.
PubMed: 25640694 DOI: 10.1038/srep08183
316 Lindskog C.
The potential clinical impact of the tissue-based map of the human proteome.
Expert Rev Proteomics. 2015 12(3):213-5.
PubMed: 25925092 DOI: 10.1586/14789450.2015.1040771
315 Mattsson JS, Bergman B, Grinberg M, Edlund K, Marincevic M, Jirstr÷m K, PontÚn F, Hengstler JG, RahnenfŘhrer J, Karlsson MG, Karlsson C, Helenius G, Botling J, Micke P, Gulyas M.
Prognostic impact of COX-2 in non-small cell lung cancer: a comprehensive compartment-specific evaluation of tumor and stromal cell expression.
Cancer Lett. 2015 356(2 Pt B):837-45.
PubMed: 25449785 DOI: 10.1016/j.canlet.2014.10.032
314 Edqvist PH, Fagerberg L, Hallstr÷m BM, Danielsson A, Edlund K, UhlÚn M, PontÚn F.
Expression of human skin-specific genes defined by transcriptomics and antibody-based profiling.
J Histochem Cytochem. 2015 63(2):129-41.
PubMed: 25411189 DOI: 10.1369/0022155414562646
313 Lindskog C, Edlund K, Mattsson JS, Micke P.
Immunohistochemistry-based prognostic biomarkers in NSCLC: novel findings on the road to clinical use?
Expert Rev Mol Diagn. 2015 15(4):471-90.
PubMed: 25599124 DOI: 10.1586/14737159.2015.1002772
312 Hńggmark A, Hamsten C, Wiklundh E, Lindskog C, Mattsson C, Andersson E, Lundberg IE, Gr÷nlund H, Schwenk JM, Eklund A, Grunewald J, Nilsson P.
Proteomic profiling reveals autoimmune targets in sarcoidosis.
Am J Respir Crit Care Med. 2015 191(5):574-83.
PubMed: 25608002 DOI: 10.1164/rccm.201407-1341OC
311 Edqvist PH, Huvila J, Forsstr÷m B, Talve L, CarpÚn O, Salvesen HB, Krakstad C, GrÚnman S, Johannesson H, Ljungqvist O, UhlÚn M, PontÚn F, Auranen A.
Loss of ASRGL1 expression is an independent biomarker for disease-specific survival in endometrioid endometrial carcinoma.
Gynecol Oncol. 2015 Epub ahead of print
PubMed: 25858696 DOI: 10.1016/j.ygyno.2015.03.055
310 UhlÚn M, Fagerberg L, Hallstr÷m BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson ┼, Kampf C, Sj÷stedt E, Asplund A, Olsson I, Edlund K, Lundberg E, Navani S, Szigyarto CA, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist PH, Berling H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, Persson L, Johansson F, Zwahlen M, von Heijne G, Nielsen J, PontÚn F.
Tissue-based map of the human proteome.
Science 2015 347(6220):1260419.
PubMed: 25613900 DOI: 10.1126/science.1260419
309 Andersson S, Nilsson K, Fagerberg L, Hallstr÷m BM, Sundstr÷m C, Danielsson A, Edlund K, Uhlen M, Asplund A.
The transcriptomic and proteomic landscapes of bone marrow and secondary lymphoid tissues.
PLoS One. 2014 9(12):e115911.
PubMed: 25541736 DOI: 10.1371/journal.pone.0115911
308 Pinnick KE, Nicholson G, Manolopoulos KN, McQuaid SE, Valet P, Frayn KN, Denton N, Min JL, Zondervan KT, Fleckner J, , McCarthy MI, Holmes CC, Karpe F.
Distinct developmental profile of lower-body adipose tissue defines resistance against obesity-associated metabolic complications.
Diabetes. 2014 63(11):3785-97.
PubMed: 24947352 DOI: 10.2337/db14-0385
307 Habuka M, Fagerberg L, Hallstr÷m BM, Kampf C, Edlund K, Sivertsson ┼, Yamamoto T, PontÚn F, UhlÚn M, Odeberg J.
The kidney transcriptome and proteome defined by transcriptomics and antibody-based profiling.
PLoS One. 2014 9(12):e116125.
PubMed: 25551756 DOI: 10.1371/journal.pone.0116125
306 Danielsson A, PontÚn F, Fagerberg L, Hallstr÷m BM, Schwenk JM, UhlÚn M, Korsgren O, Lindskog C.
The human pancreas proteome defined by transcriptomics and antibody-based profiling.
PLoS One. 2014 9(12):e115421.
PubMed: 25546435 DOI: 10.1371/journal.pone.0115421
305 Elfineh L, Classon C, Asplund A, Pettersson U, Kamali-Moghaddam M, Lind SB.
Tyrosine phosphorylation profiling via in situ proximity ligation assay.
BMC Cancer. 2014 14():435.
PubMed: 24928687 DOI: 10.1186/1471-2407-14-435
304 Hu FJ, Uhlen M, Rockberg J.
Generation of HER2 monoclonal antibodies using epitopes of a rabbit polyclonal antibody.
N Biotechnol. 2014 31(1):35-43.
PubMed: 24120493 DOI: 10.1016/j.nbt.2013.10.002
303 Berntsson J, Lundgren S, Nodin B, UhlÚn M, Gaber A, Jirstr÷m K.
Expression and prognostic significance of the polymeric immunoglobulin receptor in epithelial ovarian cancer.
J Ovarian Res. 2014 7(1):26.
PubMed: 24568264 DOI: 10.1186/1757-2215-7-26
302 Alm T, von Feilitzen K, Lundberg E, Sivertsson ┼, UhlÚn M.
A chromosome-centric analysis of antibodies directed toward the human proteome using Antibodypedia.
J Proteome Res. 2014 13(3):1669-76.
PubMed: 24533432 DOI: 10.1021/pr4011525
301 Zhang MD, Tortoriello G, Hsueh B, Tomer R, Ye L, Mitsios N, Borgius L, Grant G, Kiehn O, Watanabe M, UhlÚn M, Mulder J, Deisseroth K, Harkany T, H÷kfelt TG.
Neuronal calcium-binding proteins 1/2 localize to dorsal root ganglia and excitatory spinal neurons and are regulated by nerve injury.
Proc Natl Acad Sci U S A. 2014 111(12):E1149-58.
PubMed: 24616509 DOI: 10.1073/pnas.1402318111
300 Stadler C, Fagerberg L, Sivertsson ┼, Oksvold P, Zwahlen M, Hallstr÷m BM, Lundberg E, UhlÚn M.
RNA- and antibody-based profiling of the human proteome with focus on chromosome 19.
J Proteome Res. 2014 13(4):2019-27.
PubMed: 24579871 DOI: 10.1021/pr401156g
299 Bengtsson E, Nerjovaj P, Wangefjord S, Nodin B, Eberhard J, UhlÚn M, Borgquist S, Jirstr÷m K.
HMG-CoA reductase expression in primary colorectal cancer correlates with favourable clinicopathological characteristics and an improved clinical outcome.
Diagn Pathol. 2014 9():78.
PubMed: 24708688 DOI: 10.1186/1746-1596-9-78
298 Fristedt R, Gaber A, Hedner C, Nodin B, UhlÚn M, Eberhard J, Jirstr÷m K.
Expression and prognostic significance of the polymeric immunoglobulin receptor in esophageal and gastric adenocarcinoma.
J Transl Med. 2014 12():83.
PubMed: 24694107 DOI: 10.1186/1479-5876-12-83
297 Andersson G, Wennersten C, Gaber A, Boman K, Nodin B, UhlÚn M, Segersten U, Malmstr÷m PU, Jirstr÷m K.
Reduced expression of ezrin in urothelial bladder cancer signifies more advanced tumours and an impaired survival: validatory study of two independent patient cohorts.
BMC Urol. 2014 14():36.
PubMed: 24885195 DOI: 10.1186/1471-2490-14-36
296 Liu Z, Liu L, Ísterlund T, Hou J, Huang M, Fagerberg L, Petranovic D, UhlÚn M, Nielsen J.
Improved production of a heterologous amylase in Saccharomyces cerevisiae by inverse metabolic engineering.
Appl Environ Microbiol. 2014 80(17):5542-50.
PubMed: 24973076 DOI: 10.1128/AEM.00712-14
295 Jonsson L, Hedner C, Gaber A, Korkocic D, Nodin B, UhlÚn M, Eberhard J, Jirstr÷m K.
High expression of RNA-binding motif protein 3 in esophageal and gastric adenocarcinoma correlates with intestinal metaplasia-associated tumours and independently predicts a reduced risk of recurrence and death.
Biomark Res. 2014 2():11.
PubMed: 24963396 DOI: 10.1186/2050-7771-2-11
294 Bystr÷m S, Ayoglu B, Hńggmark A, Mitsios N, Hong MG, Drobin K, Forsstr÷m B, Fredolini C, Khademi M, Amor S, UhlÚn M, Olsson T, Mulder J, Nilsson P, Schwenk JM.
Affinity Proteomic Profiling of Plasma, Cerebrospinal Fluid, and Brain Tissue within Multiple Sclerosis.
J Proteome Res. 2014 Epub ahead of print
PubMed: 25231264 DOI: 10.1021/pr500609e
293 Kampf C, Mardinoglu A, Fagerberg L, Hallstr÷m BM, Danielsson A, Nielsen J, PontÚn F, Uhlen M.
Defining the human gallbladder proteome by transcriptomics and affinity proteomics.
Proteomics. 2014 Epub ahead of print
PubMed: 25175928 DOI: 10.1002/pmic.201400201
292 Mardinoglu A, Kampf C, Asplund A, Fagerberg L, Hallstr÷m BM, Edlund K, BlŘher M, PontÚn F, Uhlen M, Nielsen J.
Defining the Human Adipose Tissue Proteome To Reveal Metabolic Alterations in Obesity.
J Proteome Res. 2014 Epub ahead of print
PubMed: 25219818 DOI: 10.1021/pr500586e
291 Libard S, Popova SN, Amini RM, Kńrjń V, Pietilńinen T, Hńmńlńinen KM, Sundstr÷m C, Hesselager G, Bergqvist M, Ekman S, Zetterling M, Smits A, Nilsson P, Pfeifer S, de Stňhl TD, Enblad G, Ponten F, Alafuzoff I.
Human Cytomegalovirus Tegument Protein pp65 Is Detected in All Intra- and Extra-Axial Brain Tumours Independent of the Tumour Type or Grade.
PLoS One. 2014 9(9):e108861.
PubMed: 25268364 DOI: 10.1371/journal.pone.0108861
290 Gardberg M, Heuser VD, Iljin K, Kampf C, Uhlen M, CarpÚn O.
Characterization of Leukocyte Formin FMNL1 Expression in Human Tissues.
J Histochem Cytochem. 2014 62(6):460-470.
PubMed: 24700756 DOI: 10.1369/0022155414532293
289 Sooman L, Freyhult E, Jaiswal A, Navani S, Edqvist PH, PontÚn F, Tchougounova E, Smits A, Elsir T, Gullbo J, Lennartsson J, Bergqvist M, Ekman S.
FGF2 as a potential prognostic biomarker for proneural glioma patients.
Acta Oncol. 2014 ():1-10.
PubMed: 25263081 DOI: 10.3109/0284186X.2014.951492
288 Lindskog C, Fagerberg L, Hallstr÷m B, Edlund K, Hellwig B, RahnenfŘhrer J, Kampf C, UhlÚn M, PontÚn F, Micke P.
The lung-specific proteome defined by integration of transcriptomics and antibody-based profiling.
FASEB J. 2014 Epub ahead of print
PubMed: 25169055 DOI: 10.1096/fj.14-254862
287 Gremel G, Liew M, Hamzei F, Hardell E, Selling J, Ghaderi M, Stemme S, PontÚn F, Carlson JW.
A prognosis based classification of undifferentiated uterine sarcomas: Identification of mitotic index, hormone receptors and YWHAE-FAM22 translocation status as predictors of survival.
Int J Cancer. 2014 Epub ahead of print
PubMed: 25130488 DOI: 10.1002/ijc.29141
286 Hemdan T, LindÚn M, B Lind S, V Namuduri A, Sj÷stedt E, D de Stňhl T, Asplund A, Malmstr÷m PU, Segersten U.
The prognostic value and therapeutic target role of stathmin-1 in urinary bladder cancer.
Br J Cancer. 2014 111(6):1180-7.
PubMed: 25072257 DOI: 10.1038/bjc.2014.427
285 O Leary PC, Terrile M, Bajor M, Gaj P, Hennessy BT, Mills GB, Zagozdzon A, O Connor DP, Brennan DJ, Connor K, Li J, Gonzalez-Angulo AM, Sun HD, Pu JX, PontÚn F, UhlÚn M, Jirstr÷m K, Nowis DA, Crown JP, Zagozdzon R, Gallagher WM.
Peroxiredoxin-1 protects estrogen receptor alpha from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer.
Breast Cancer Res. 2014 16(4):R79.
PubMed: 25011585 DOI: 10.1186/bcr3691
284 Ayoglu B, Chaouch A, LochmŘller H, Politano L, Bertini E, Spitali P, Hiller M, Niks EH, Gualandi F, PontÚn F, Bushby K, Aartsma-Rus A, Schwartz E, Le Priol Y, Straub V, UhlÚn M, Cirak S, 't Hoen PA, Muntoni F, Ferlini A, Schwenk JM, Nilsson P, Al-Khalili Szigyarto C.
Affinity proteomics within rare diseases: a BIO-NMD study for blood biomarkers of muscular dystrophies.
EMBO Mol Med. 2014 6(7):918-36.
PubMed: 24920607 DOI: 10.15252/emmm.201303724
283 Lindskog C, Kuhlwilm M, Davierwala A, Fu N, Hegde G, UhlÚn M, Navani S, Pńńbo S, PontÚn F.
Analysis of candidate genes for lineage-specific expression changes in humans and primates.
J Proteome Res. 2014 13(8):3596-606.
PubMed: 24911366 DOI: 10.1021/pr500045f
282 Gremel G, Wanders A, Cedernaes J, Fagerberg L, Hallstr÷m B, Edlund K, Sj÷stedt E, UhlÚn M, PontÚn F.
The human gastrointestinal tract-specific transcriptome and proteome as defined by RNA sequencing and antibody-based profiling.
J Gastroenterol. 2014 Epub ahead of print
PubMed: 24789573 DOI: 10.1007/s00535-014-0958-7
281 O'Hurley G, Sj÷stedt E, Rahman A, Li B, Kampf C, PontÚn F, Gallagher WM, Lindskog C.
Garbage in, garbage out: a critical evaluation of strategies used for validation of immunohistochemical biomarkers.
Mol Oncol. 2014 8(4):783-98.
PubMed: 24725481 DOI: 10.1016/j.molonc.2014.03.008
280 Dragomir A, de Wit M, Johansson C, Uhlen M, PontÚn F.
The role of SATB2 as a diagnostic marker for tumors of colorectal origin: Results of a pathology-based clinical prospective study.
Am J Clin Pathol. 2014 141(5):630-8.
PubMed: 24713733 DOI: 10.1309/AJCPWW2URZ9JKQJU
279 Micke P, Mattsson JS, Edlund K, Lohr M, Jirstr÷m K, Berglund A, Botling J, Rahnenfuehrer J, Marincevic M, PontÚn F, Ekman S, Hengstler J, W÷ll S, Sahin U, TŘreci O.
Aberrantly activated claudin 6 and 18.2 as potential therapy targets in non-small-cell lung cancer.
Int J Cancer. 2014 135(9):2206-14.
PubMed: 24710653 DOI: 10.1002/ijc.28857
278 Kampf C, Mardinoglu A, Fagerberg L, Hallstr÷m BM, Edlund K, Lundberg E, PontÚn F, Nielsen J, Uhlen M.
The human liver-specific proteome defined by transcriptomics and antibody-based profiling.
FASEB J. 2014 28(7):2901-14.
PubMed: 24648543 DOI: 10.1096/fj.14-250555
277 Agren R, Mardinoglu A, Asplund A, Kampf C, Uhlen M, Nielsen J.
Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling.
Mol Syst Biol. 2014 10():721.
PubMed: 24646661
276 Liem DA, Nsair A, Setty SP, Cadeiras M, Wang D, Maclellan R, Lotz C, Lin AJ, Tabaraki J, Li H, Ge J, Odeberg J, Ponten F, Larson E, Mulder J, Lundberg E, Weiss JN, Uhlen M, Ping P, Deng MC.
Molecular- and organelle-based predictive paradigm underlying recovery by left ventricular assist device support.
Circ Heart Fail. 2014 7(2):359-66.
PubMed: 24643888 DOI: 10.1161/CIRCHEARTFAILURE.113.000250
275 Bozoky B, Savchenko A, Guven H, Ponten F, Klein G, Szekely L.
Decreased decorin expression in the tumor microenvironment.
Cancer Med. 2014 3(3):485-91.
PubMed: 24634138 DOI: 10.1002/cam4.231
274 Djureinovic D, Fagerberg L, Hallstr÷m B, Danielsson A, Lindskog C, UhlÚn M, PontÚn F.
The human testis-specific proteome defined by transcriptomics and antibody-based profiling.
Mol Hum Reprod. 2014 20(6):476-88.
PubMed: 24598113 DOI: 10.1093/molehr/gau018
273 Howat WJ, Lewis A, Jones P, Kampf C, PontÚn F, van der Loos CM, Gray N, Womack C, Warford A.
Antibody validation of immunohistochemistry for biomarker discovery: Recommendations of a consortium of academic and pharmaceutical based histopathology researchers.
Methods. 2014 Epub ahead of print
PubMed: 24525140 DOI: 10.1016/j.ymeth.2014.01.018
272 Sooman L, Ekman S, Tsakonas G, Jaiswal A, Navani S, Edqvist PH, PontÚn F, Bergstr÷m S, Johansson M, Wu X, Blomquist E, Bergqvist M, Gullbo J, Lennartsson J.
PTPN6 expression is epigenetically regulated and influences survival and response to chemotherapy in high-grade gliomas.
Tumour Biol. 2014 35(5):4479-88.
PubMed: 24510345 DOI: 10.1007/s13277-013-1590-5
271 Nilsson R, Jain M, Madhusudhan N, Sheppard NG, Strittmatter L, Kampf C, Huang J, Asplund A, Mootha VK.
Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer.
Nat Commun. 2014 5():3128.
PubMed: 24451681 DOI: 10.1038/ncomms4128
270 Hansson J, Hultenby K, Cramnert C, PontÚn F, Jansson H, Lindgren D, Axelson H, Johansson ME.
Evidence for a morphologically distinct and functionally robust cell type in the proximal tubules of human kidney.
Hum Pathol. 2014 45(2):382-93.
PubMed: 24439225 DOI: 10.1016/j.humpath.2013.10.003
269 Mardinoglu A, Agren R, Kampf C, Asplund A, Uhlen M, Nielsen J.
Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease.
Nat Commun. 2014 5():3083.
PubMed: 24419221 DOI: 10.1038/ncomms4083
268 de Wit M, Kant H, Piersma SR, Pham TV, Mongera S, van Berkel MP, Boven E, PontÚn F, Meijer GA, Jimenez CR, Fijneman RJ.
Colorectal cancer candidate biomarkers identified by tissue secretome proteome profiling.
J Proteomics. 2014 99():26-39.
PubMed: 24418523 DOI: 10.1016/j.jprot.2014.01.001
267 Hansson SF, Korsgren S, PontÚn F, Korsgren O.
Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry?
Diabetologia. 2014 57(3):645-6.
PubMed: 24352376 DOI: 10.1007/s00125-013-3138-z
266 Gremel G, Bergman J, Djureinovic D, Edqvist PH, Maindad V, Bharambe BM, Khan WA, Navani S, Elebro J, Jirstr÷m K, Hellberg D, UhlÚn M, Micke P, PontÚn F.
A systematic analysis of commonly used antibodies in cancer diagnostics.
Histopathology. 2014 64(2):293-305.
PubMed: 24330150 DOI: 10.1111/his.12255
265 Fagerberg L, Hallstr÷m BM, Oksvold P, Kampf C, Djureinovic D, Odeberg J, Habuka M, Tahmasebpoor S, Danielsson A, Edlund K, Asplund A, Sj÷stedt E, Lundberg E, Szigyarto CA, Skogs M, Takanen JO, Berling H, Tegel H, Mulder J, Nilsson P, Schwenk JM, Lindskog C, Danielsson F, Mardinoglu A, Sivertsson A, von Feilitzen K, Forsberg M, Zwahlen M, Olsson I, Navani S, Huss M, Nielsen J, Ponten F, UhlÚn M.
Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics.
Mol Cell Proteomics. 2014 13(2):397-406.
PubMed: 24309898 DOI: 10.1074/mcp.M113.035600
264 Sherwood V, Chaurasiya SK, Ekstr÷m EJ, Guilmain W, Liu Q, Koeck T, Brown K, Hansson K, Agnarsdˇttir M, Bergqvist M, Jirstr÷m K, Ponten F, James P, Andersson T.
WNT5A-mediated β-catenin-independent signalling is a novel regulator of cancer cell metabolism.
Carcinogenesis. 2014 35(4):784-94.
PubMed: 24293407 DOI: 10.1093/carcin/bgt390
263 Fei C, Atterby C, Edqvist PH, PontÚn F, Zhang WW, Larsson E, Ryan FP.
Detection of the human endogenous retrovirus ERV3-encoded Env-protein in human tissues using antibody-based proteomics.
J R Soc Med. 2014 107(1):22-9.
PubMed: 24262892 DOI: 10.1177/0141076813509981
262 Popova SN, Bergqvist M, Dimberg A, Edqvist PH, Ekman S, Hesselager G, Ponten F, Smits A, Sooman L, Alafuzoff I.
Subtyping of gliomas of various WHO grades by the application of immunohistochemistry.
Histopathology. 2014 64(3):365-79.
PubMed: 24410805 DOI: 10.1111/his.12252
261 Edfors F, Bostr÷m T, Forsstr÷m B, Zeiler M, Johansson H, Lundberg E, Hober S, Lehti÷ J, Mann M, Uhlen M.
Immunoproteomics using polyclonal antibodies and stable isotope-labeled affinity-purified recombinant proteins.
Mol Cell Proteomics. 2014 13(6):1611-24.
PubMed: 24722731 DOI: 10.1074/mcp.M113.034140
260 Bostr÷m T, Johansson HJ, Lehti÷ J, UhlÚn M, Hober S.
Investigating the Applicability of Antibodies Generated within the Human Protein Atlas as Capture Agents in Immunoenrichment Coupled to Mass Spectrometry.
J Proteome Res. 2014 Epub ahead of print
PubMed: 25231543 DOI: 10.1021/pr500691a
259 Algenńs C, Agaton C, Fagerberg L, Asplund A, Bj÷rling L, Bj÷rling E, Kampf C, Lundberg E, Nilsson P, Persson A, Wester K, PontÚn F, WernÚrus H, UhlÚn M, Ottosson Takanen J, Hober S.
Antibody performance in western blot applications is context-dependent.
Biotechnol J. 2014 9(3):435-45.
PubMed: 24403002 DOI: 10.1002/biot.201300341
258 Forsstr÷m B, Bisławska Axnas B, Stengele KP, BŘhler J, Albert TJ, Richmond TA, Jingxin Hu F, Nilsson P, Hudson EP, Rockberg J, Uhlen M.
Proteome-wide epitope mapping of antibodies using ultra-dense peptide arrays.
Mol Cell Proteomics. 2014 Epub ahead of print
PubMed: 24705123 DOI: 10.1074/mcp.M113.033308
257 Bachmann J, BurtÚ F, Pramana S, Conte I, Brown BJ, Orimadegun AE, Ajetunmobi WA, Afolabi NK, Akinkunmi F, Omokhodion S, Akinbami FO, Shokunbi WA, Kampf C, Pawitan Y, UhlÚn M, Sodeinde O, Schwenk JM, Wahlgren M, Fernandez-Reyes D, Nilsson P.
Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria.
PLoS Pathog. 2014 10(4):e1004038.
PubMed: 24743550 DOI: 10.1371/journal.ppat.1004038
256 Boman K, Larsson AH, Segersten U, Kuteeva E, Johannesson H, Nodin B, Eberhard J, UhlÚn M, Malmstr÷m PU, Jirstr÷m K.
Membranous expression of podocalyxin-like protein is an independent factor of poor prognosis in urothelial bladder cancer.
Br J Cancer. 2013 108(11):2321-8.
PubMed: 23652315 DOI: 10.1038/bjc.2013.215
255 Larsson AH, Nodin B, Syk I, Palmquist I, UhlÚn M, Eberhard J, Jirstr÷m K.
Podocalyxin-like protein expression in primary colorectal cancer and synchronous lymph node metastases.
Diagn Pathol. 2013 8():109.
PubMed: 23819542 DOI: 10.1186/1746-1596-8-109
254 Sernbo S, Borrebaeck CA, UhlÚn M, Jirstr÷m K, Ek S.
Nuclear T-STAR protein expression correlates with HER2 status, hormone receptor negativity and prolonged recurrence free survival in primary breast cancer and decreased cancer cell growth in vitro.
PLoS One. 2013 8(7):e70596.
PubMed: 23923007 DOI: 10.1371/journal.pone.0070596
253 Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P.
Integration of cardiac proteome biology and medicine by a specialized knowledgebase.
Circ Res. 2013 113(9):1043-53.
PubMed: 23965338 DOI: 10.1161/CIRCRESAHA.113.301151
252 Gremel G, Grannas K, Sutton LA, PontÚn F, Zieba A.
In situ Protein Detection for Companion Diagnostics.
Front Oncol. 2013 3():271.
PubMed: 24199171 DOI: 10.3389/fonc.2013.00271
251 Jansson L, Kampf C, Kńllskog O.
Functional stimulation of graft nerves has minor effects on insulin release from transplanted rat pancreatic islets.
Ups J Med Sci. 2013 118(4):209-16.
PubMed: 23977866 DOI: 10.3109/03009734.2013.818601
250 Nilsson CL, Berven F, Selheim F, Liu H, Moskal JR, Kroes RA, Sulman EP, Conrad CA, Lang FF, AndrÚn PE, Nilsson A, Carlsohn E, Lilja H, Malm J, Feny÷ D, Subramaniyam D, Wang X, Gonzales-Gonzales M, Dasilva N, Diez P, Fuentes M, VÚgvßri ┴, Sj÷din K, Welinder C, Laurell T, Fehniger TE, Lindberg H, Rezeli M, Edula G, Hober S, Marko-Varga G.
Chromosome 19 annotations with disease speciation: a first report from the Global Research Consortium.
J Proteome Res. 2013 12(1):135-50.
PubMed: 23249167 DOI: 10.1021/pr3008607
249 Malm J, Fehniger TE, Danmyr P, VÚgvßri A, Welinder C, Lindberg H, Appelqvist R, Sj÷din K, Wieslander E, Laurell T, Hober S, Berven FS, Feny÷ D, Wang X, AndrÚn PE, Edula G, Carlsohn E, Fuentes M, Nilsson CL, Dahlbńck M, Rezeli M, Erlinge D, Marko-Varga G.
Developments in biobanking workflow standardization providing sample integrity and stability.
J Proteomics. 2013 95():38-45.
PubMed: 23856607 DOI: 10.1016/j.jprot.2013.06.035
248 Hńggmark A, Bystr÷m S, Ayoglu B, Qundos U, UhlÚn M, Khademi M, Olsson T, Schwenk JM, Nilsson P.
Antibody-based profiling of cerebrospinal fluid within multiple sclerosis.
Proteomics. 2013 13(15):2256-67.
PubMed: 23696371 DOI: 10.1002/pmic.201200580
247 Ayoglu B, Hńggmark A, Khademi M, Olsson T, UhlÚn M, Schwenk JM, Nilsson P.
Autoantibody profiling in multiple sclerosis using arrays of human protein fragments.
Mol Cell Proteomics. 2013 12(9):2657-72.
PubMed: 23732997 DOI: 10.1074/mcp.M112.026757
246 Drobin K, Nilsson P, Schwenk JM.
Highly multiplexed antibody suspension bead arrays for plasma protein profiling.
Methods Mol Biol. 2013 1023():137-45.
PubMed: 23765623 DOI: 10.1007/978-1-4614-7209-4_8
245 Kremer AN, van der Griendt JC, van der Meijden ED, Honders MW, Ayoglu B, Schwenk JM, Nilsson P, Falkenburg JH, Griffioen M.
Development of a coordinated allo T-cell and auto B-cell response against autosomal PTK2B after allogeneic hematopoietic stem cell transplantation.
Haematologica. 2013 Epub ahead of print
PubMed: 24097630 DOI: 10.3324/haematol.2013.086652
244 Qundos U, Hong MG, Tybring G, Divers M, Odeberg J, Uhlen M, Nilsson P, Schwenk JM.
Profiling post-centrifugation delay of serum and plasma with antibody bead arrays.
J Proteomics. 2013 Epub ahead of print
PubMed: 23631827 DOI: 10.1016/j.jprot.2013.04.020
243 Neiman M, Fredolini C, Johansson H, Lehti÷ J, Nygren PA, UhlÚn M, Nilsson P, Schwenk JM.
Selectivity analysis of single binder assays used in plasma protein profiling.
Proteomics. 2013 Epub ahead of print
PubMed: 24151238 DOI: 10.1002/pmic.201300030
242 Swamidoss IN, Kňrsnńs A, Uhlmann V, Ponnusamy P, Kampf C, Simonsson M, Wńhlby C, Strand R.
Automated classification of immunostaining patterns in breast tissue from the human protein atlas.
J Pathol Inform. 2013 4(Suppl):S14.
PubMed: 23766936 DOI: 10.4103/2153-3539.109881
241 Sooman L, Lennartsson J, Gullbo J, Bergqvist M, Tsakonas G, Johansson F, Edqvist PH, PontÚn F, Jaiswal A, Navani S, Alafuzoff I, Popova S, Blomquist E, Ekman S.
Vandetanib combined with a p38 MAPK inhibitor synergistically reduces glioblastoma cell survival.
Med Oncol. 2013 30(3):638.
PubMed: 23783486 DOI: 10.1007/s12032-013-0638-0
240 Rexhepaj E, Agnarsdˇttir M, Bergman J, Edqvist PH, Bergqvist M, UhlÚn M, Gallagher WM, Lundberg E, Ponten F.
A texture based pattern recognition approach to distinguish melanoma from non-melanoma cells in histopathological tissue microarray sections.
PLoS One. 2013 8(5):e62070.
PubMed: 23690928 DOI: 10.1371/journal.pone.0062070
239 P§lajeva J, Bergstr÷m T, Edqvist PH, Lundequist A, Sj÷sten A, Nilsson G, Smits A, Bergqvist M, PontÚn F, Westermark B, Pejler G, Forsberg Nilsson K, Tchougounova E.
Glioma-derived macrophage migration inhibitory factor (MIF) promotes mast cell recruitment in a STAT5-dependent manner.
Mol Oncol. 2013 Epub ahead of print
PubMed: 24091309 DOI: 10.1016/j.molonc.2013.09.002
238 Perisic L, Hedin E, Razuvaev A, Lengquist M, Osterholm C, Folkersen L, Gillgren P, Paulsson-Berne G, Ponten F, Odeberg J, Hedin U.
Profiling of atherosclerotic lesions by gene and tissue microarrays reveals PCSK6 as a novel protease in unstable carotid atherosclerosis.
Arterioscler Thromb Vasc Biol. 2013 33(10):2432-43.
PubMed: 23908247 DOI: 10.1161/ATVBAHA.113.301743
237 O'Hurley G, Daly E, O'Grady A, Cummins R, Quinn C, Flanagan L, Pierce A, Fan Y, Lynn MA, Rafferty M, Fitzgerald D, PontÚn F, Duffy MJ, Jirstr÷m K, Kay EW, Gallagher WM.
Investigation of Molecular Alterations of AKT-3 in Triple Negative Breast Cancer.
Histopathology. 2013 Epub ahead of print
PubMed: 24138071 DOI: 10.1111/his.12313
236 O Leary PC, Penny SA, Dolan RT, Kelly CM, Madden SF, Rexhepaj E, Brennan DJ, McCann AH, PontÚn F, UhlÚn M, Zagozdzon R, Duffy MJ, Kell MR, Jirstr÷m K, Gallagher WM.
Systematic antibody generation and validation via tissue microarray technology leading to identification of a novel protein prognostic panel in breast cancer.
BMC Cancer. 2013 13():175.
PubMed: 23547718 DOI: 10.1186/1471-2407-13-175
235 Nik AM, Reyahi A, PontÚn F, Carlsson P.
Foxf2 in intestinal fibroblasts reduces numbers of Lgr5(+) stem cells and adenoma formation by inhibiting Wnt signaling.
Gastroenterology. 2013 144(5):1001-11.
PubMed: 23376422 DOI: 10.1053/j.gastro.2013.01.045
234 Mardinoglu A, Agren R, Kampf C, Asplund A, Nookaew I, Jacobson P, Walley AJ, Froguel P, Carlsson LM, Uhlen M, Nielsen J.
Integration of clinical data with a genome-scale metabolic model of the human adipocyte.
Mol Syst Biol. 2013 9():649.
PubMed: 23511207 DOI: 10.1038/msb.2013.5
233 Lindskog C, Ellstr÷m P, Olsen B, PontÚn F, van Riel D, Munster VJ, Gonzßlez-Acu˝a D, Kuiken T, Jourdain E.
European H16N3 gull influenza virus attaches to the human respiratory tract and eye.
PLoS One. 2013 8(4):e60757.
PubMed: 23593303 DOI: 10.1371/journal.pone.0060757
232 Li A, Estigoy C, Raftery M, Cameron D, Odeberg J, PontÚn F, Lal S, Dos Remedios CG.
Heart research advances using database search engines, human protein atlas and the sydney heart bank.
Heart Lung Circ. 2013 22(10):819-26.
PubMed: 23856366 DOI: 10.1016/j.hlc.2013.06.006
231 Huvila J, Talve L, CarpÚn O, Edqvist PH, PontÚn F, GrÚnman S, Auranen A.
Progesterone receptor negativity is an independent risk factor for relapse in patients with early stage endometrioid endometrial adenocarcinoma.
Gynecol Oncol. 2013 130(3):463-9.
PubMed: 23777659 DOI: 10.1016/j.ygyno.2013.06.015
230 Giandomenico V, Modlin IM, PontÚn F, Nilsson M, Landegren U, Bergqvist J, Khan MS, Millar RP, Lňngstr÷m B, Borlak J, Eriksson B, Nielsen B, Baltzer L, Waterton JC, Ahlstr÷m H, Íberg K.
Improving the diagnosis and management of neuroendocrine tumors: utilizing new advances in biomarker and molecular imaging science.
Neuroendocrinology. 2013 98(1):16-30.
PubMed: 23446227 DOI: 10.1159/000348832
229 Geiger T, Velic A, Macek B, Lundberg E, Kampf C, Nagaraj N, Uhlen M, Cox J, Mann M.
Initial quantitative proteomic map of 28 mouse tissues using the SILAC mouse.
Mol Cell Proteomics. 2013 12(6):1709-22.
PubMed: 23436904 DOI: 10.1074/mcp.M112.024919
228 Gedda L, Bj÷rkelund H, Lebel L, Asplund A, Dubois L, Wester K, Penagos N, Malmqvist M, Andersson K.
Evaluation of Real-Time Immunohistochemistry and Interaction Map as an Alternative Objective Assessment of HER2 Expression in Human Breast Cancer Tissue.
Appl Immunohistochem Mol Morphol. 2013 Epub ahead of print
PubMed: 23455178 DOI: 10.1097/PAI.0b013e318281162d
227 Gardberg M, Kaipio K, Lehtinen L, Mikkonen P, Heuser VD, Talvinen K, Iljin K, Kampf C, Uhlen M, GrÚnman R, Koivisto M, CarpÚn O.
FHOD1, a Formin Upregulated in Epithelial-Mesenchymal Transition, Participates in Cancer Cell Migration and Invasion.
PLoS One. 2013 8(9):e74923.
PubMed: 24086398 DOI: 10.1371/journal.pone.0074923
226 Elsir T, Edqvist PH, Carlson J, Ribom D, Bergqvist M, Ekman S, Popova SN, Alafuzoff I, Ponten F, NistÚr M, Smits A.
A study of embryonic stem cell-related proteins in human astrocytomas: Identification of Nanog as a predictor of survival.
Int J Cancer. 2013 Epub ahead of print
PubMed: 24037901 DOI: 10.1002/ijc.28441
225 Edvardsson K, Nguyen-Vu T, Kalasekar SM, PontÚn F, Gustafsson J┼, Williams C.
Estrogen receptor β expression induces changes in the microRNA pool in human colon cancer cells.
Carcinogenesis. 2013 34(7):1431-41.
PubMed: 23436804 DOI: 10.1093/carcin/bgt067
224 Danielsson F, Skogs M, Huss M, Rexhepaj E, O'Hurley G, Klevebring D, PontÚn F, Gad AK, UhlÚn M, Lundberg E.
Majority of differentially expressed genes are down-regulated during malignant transformation in a four-stage model.
Proc Natl Acad Sci U S A. 2013 110(17):6853-8.
PubMed: 23569271 DOI: 10.1073/pnas.1216436110
223 Cepeda D, Ng HF, Sharifi HR, Mahmoudi S, Cerrato VS, Fredlund E, Magnusson K, Nilsson H, Malyukova A, Rantala J, Klevebring D, Vi˝als F, Bhaskaran N, Zakaria SM, Rahmanto AS, Grotegut S, Nielsen ML, Szigyarto CA, Sun D, Lerner M, Navani S, Widschwendter M, UhlÚn M, Jirstr÷m K, PontÚn F, Wohlschlegel J, GrandÚr D, Spruck C, Larsson LG, Sangfelt O.
CDK-mediated activation of the SCF(FBXO) (28) ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer.
EMBO Mol Med. 2013 5(7):999-1018.
PubMed: 23776131 DOI: 10.1002/emmm.201202341
222 Billstr÷m E, Sundstr÷m-Poromaa I, Stňlberg K, Asplund A, Hellberg D.
Socioeconomic characteristics, housing conditions and criminal offences among women with cervical neoplasia.
Acta Obstet Gynecol Scand. 2013 92(8):888-94.
PubMed: 23590762 DOI: 10.1111/aogs.12151
221 Andersson S, Konrad A, Ashok N, PontÚn F, Hober S, Asplund A.
Antibodies Biotinylated Using a Synthetic Z-domain from Protein A Provide Stringent In Situ Protein Detection.
J Histochem Cytochem. 2013 Epub ahead of print
PubMed: 23920108 DOI: 10.1369/0022155413502360
220 Stadler C, Rexhepaj E, Singan VR, Murphy RF, Pepperkok R, UhlÚn M, Simpson JC, Lundberg E.
Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells.
Nat Methods. 2013 Apr;10(4):315-23 2013
PubMed: 23435261 DOI: 10.1038/nmeth.2377
219 LindÚn M, Segersten U, Runeson M, Wester K, Busch C, Pettersson U, Lind SB, Malmstr÷m PU.
Tumour expression of bladder cancer-associated urinary proteins.
BJU Int. 2013 112(3):407-15.
PubMed: 23470167 DOI: 10.1111/j.1464-410X.2012.11653.x
218 Danielsson F, Wiking M, Mahdessian D, Skogs M, Ait Blal H, Hjelmare M, Stadler C, UhlÚn M, Lundberg E.
RNA deep sequencing as a tool for selection of cell lines for systematic subcellular localization of all human proteins.
J Proteome Res. 2013 12(1):299-307.
PubMed: 23227862 DOI: 10.1021/pr3009308
217 Liu S, Im H, Bairoch A, Cristofanilli M, Chen R, Deutsch EW, Dalton S, Fenyo D, Fanayan S, Gates C, Gaudet P, Hincapie M, Hanash S, Kim H, Jeong SK, Lundberg E, Mias G, Menon R, Mu Z, Nice E, Paik YK, Uhlen M, Wells L, Wu SL, Yan F, Zhang F, Zhang Y, Snyder M, Omenn GS, Beavis RC, Hancock WS.
A chromosome-centric human proteome project (C-HPP) to characterize the sets of proteins encoded in chromosome 17.
J Proteome Res. 2013 12(1):45-57.
PubMed: 23259914 DOI: 10.1021/pr300985j
216 Pe˝a C, CÚspedes MV, Lindh MB, Kiflemariam S, Mezheyeuski A, Edqvist PH, Hńggl÷f C, Birgisson H, Bojmar L, Jirstr÷m K, Sandstr÷m P, Olsson E, Veerla S, Gallardo A, Sj÷blom T, Chang AC, Reddel RR, Mangues R, Augsten M, Ostman A.
STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer.
Cancer Res. 2013 73(4):1287-1297.
PubMed: 23243022 DOI: 10.1158/0008-5472.CAN-12-1875
215 Osterholm C, Folkersen L, Lengquist M, PontÚn F, RennÚ T, Li J, Hedin U.
Increased expression of heparanase in symptomatic carotid atherosclerosis.
Atherosclerosis. 2013 226(1):67-73.
PubMed: 23137827 DOI: 10.1016/j.atherosclerosis.2012.09.030
214 Botling J, Edlund K, Lohr M, Hellwig B, Holmberg L, Lambe M, Berglund A, Ekman S, Bergqvist M, PontÚn F, K÷nig A, Fernandes O, Karlsson M, Helenius G, Karlsson C, RahnenfŘhrer J, Hengstler JG, Micke P.
Biomarker discovery in non-small cell lung cancer: integrating gene expression profiling, meta-analysis, and tissue microarray validation.
Clin Cancer Res. 2013 19(1):194-204.
PubMed: 23032747 DOI: 10.1158/1078-0432.CCR-12-1139
213 Lohr M, Edlund K, Botling J, Hammad S, Hellwig B, Othman A, Berglund A, Lambe M, Holmberg L, Ekman S, Bergqvist M, PontÚn F, Cadenas C, Marchan R, Hengstler JG, RahnenfŘhrer J, Micke P.
The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer.
Cancer Lett. 2013 333(2):222-8.
PubMed: 23370224 DOI: 10.1016/j.canlet.2013.01.036
212 Hansson SF, Korsgren S, PontÚn F, Korsgren O.
Enteroviruses and the pathogenesis of type 1 diabetes revisited: cross-reactivity of enterovirus capsid protein (VP1) antibodies with human mitochondrial proteins.
J Pathol. 2013 229(5):719-28.
PubMed: 23335350 DOI: 10.1002/path.4166
211 Bozˇky B, Savchenko A, Csermely P, Korcsmßros T, D˙l Z, PontÚn F, SzÚkely L, Klein G.
Novel signatures of cancer-associated fibroblasts.
Int J Cancer. 2013 133(2):286-93.
PubMed: 23319410 DOI: 10.1002/ijc.28035
210 Fagerberg L, Oksvold P, Skogs M, Algenńs C, Lundberg E, PontÚn F, Sivertsson A, Odeberg J, Klevebring D, Kampf C, Asplund A, Sj÷stedt E, Al-Khalili Szigyarto C, Edqvist PH, Olsson I, Rydberg U, Hudson P, Ottosson Takanen J, Berling H, Bj÷rling L, Tegel H, Rockberg J, Nilsson P, Navani S, Jirstr÷m K, Mulder J, Schwenk JM, Zwahlen M, Hober S, Forsberg M, von Feilitzen K, UhlÚn M.
Contribution of antibody-based protein profiling to the human Chromosome-centric Proteome Project (C-HPP).
J Proteome Res. 2013 12(6):2439-48.
PubMed: 23276153 DOI: 10.1021/pr300924j
209 Hudson EP, Nikoshkov A, Uhlen M, Rockberg J.
Automated solid-phase subcloning based on beads brought into proximity by magnetic force.
PLoS One. 2012 7(5):e37429.
PubMed: 22624028 DOI: 10.1371/journal.pone.0037429
208 Hudson EP, Uhlen M, Rockberg J.
Multiplex epitope mapping using bacterial surface display reveals both linear and conformational epitopes.
Sci Rep. 2012 2():706.
PubMed: 23050090 DOI: 10.1038/srep00706
207 Hjelm B, Forsstr÷m B, L÷fblom J, Rockberg J, UhlÚn M.
Parallel immunizations of rabbits using the same antigen yield antibodies with similar, but not identical, epitopes.
PLoS One. 2012 7(12):e45817.
PubMed: 23284606 DOI: 10.1371/journal.pone.0045817
206 Adler B, Bostr÷m T, Ekstr÷m S, Hober S, Laurell T.
Miniaturized and automated high-throughput verification of proteins in the ISET platform with MALDI MS.
Anal Chem. 2012 84(20):8663-9.
PubMed: 22971087 DOI: 10.1021/ac3017983
205 Buus S, Rockberg J, Forsstr÷m B, Nilsson P, Uhlen M, Schafer-Nielsen C.
High-resolution mapping of linear antibody epitopes using ultrahigh-density peptide microarrays.
Mol Cell Proteomics. 2012 11(12):1790-800.
PubMed: 22984286 DOI: 10.1074/mcp.M112.020800
204 LindÚn M, Lind SB, Mayrhofer C, Segersten U, Wester K, Lyutvinskiy Y, Zubarev R, Malmstr÷m PU, Pettersson U.
Proteomic analysis of urinary biomarker candidates for nonmuscle invasive bladder cancer.
Proteomics. 2012 12(1):135-44.
PubMed: 22065568 DOI: 10.1002/pmic.201000810
203 Larance M, Kirkwood KJ, Xirodimas DP, Lundberg E, Uhlen M, Lamond AI.
Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathway.
Mol Cell Proteomics. 2012 11(3):M111.014407.
PubMed: 22038470 DOI: 10.1074/mcp.M111.014407
202 Dengjel J, H°yer-Hansen M, Nielsen MO, Eisenberg T, Harder LM, Schandorff S, Farkas T, Kirkegaard T, Becker AC, Schroeder S, Vanselow K, Lundberg E, Nielsen MM, Kristensen AR, Akimov V, Bunkenborg J, Madeo F, Jńńttelń M, Andersen JS.
Identification of autophagosome-associated proteins and regulators by quantitative proteomic analysis and genetic screens.
Mol Cell Proteomics. 2012 11(3):M111.014035.
PubMed: 22311637 DOI: 10.1074/mcp.M111.014035
201 Bock T, Moest H, Omasits U, Dolski S, Lundberg E, Frei A, Hofmann A, Bausch-Fluck D, Jacobs A, Krayenbuehl N, Uhlen M, Aebersold R, Frei K, Wollscheid B.
Proteomic analysis reveals drug accessible cell surface N-glycoproteins of primary and established glioblastoma cell lines.
J Proteome Res. 2012 11(10):4885-93.
PubMed: 22909291 DOI: 10.1021/pr300360a
200 Solnestam BW, Stranneheim H, Hńllman J, Kńller M, Lundberg E, Lundeberg J, Akan P.
Comparison of total and cytoplasmic mRNA reveals global regulation by nuclear retention and miRNAs.
BMC Genomics. 2012 13():574.
PubMed: 23110385 DOI: 10.1186/1471-2164-13-574
199 Akan P, Alexeyenko A, Costea PI, Hedberg L, Solnestam BW, Lundin S, Hńllman J, Lundberg E, UhlÚn M, Lundeberg J.
Comprehensive analysis of the genome transcriptome and proteome landscapes of three tumor cell lines.
Genome Med. 2012 4(11):86.
PubMed: 23158748 DOI: 10.1186/gm387
198 Li J, Shariff A, Wiking M, Lundberg E, Rohde GK, Murphy RF.
Estimating microtubule distributions from 2D immunofluorescence microscopy images reveals differences among human cultured cell lines.
PLoS One. 2012 7(11):e50292.
PubMed: 23209697 DOI: 10.1371/journal.pone.0050292
197 Li J, Newberg JY, UhlÚn M, Lundberg E, Murphy RF.
Automated analysis and reannotation of subcellular locations in confocal images from the human protein atlas.
PLoS One. 2012 7(11):e50514.
PubMed: 23226299 DOI: 10.1371/journal.pone.0050514
196 Kampf C, Bergman J, Oksvold P, Asplund A, Navani S, Wiking M, Lundberg E, UhlÚn M, Ponten F.
A tool to facilitate clinical biomarker studies--a tissue dictionary based on the Human Protein Atlas.
BMC Med. 2012 10():103.
PubMed: 22971420 DOI: 10.1186/1741-7015-10-103
195 Sillars-Hardebol AH, Carvalho B, BeliŰn JA, de Wit M, Delis-van Diemen PM, Tijssen M, van de Wiel MA, PontÚn F, Meijer GA, Fijneman RJ.
CSE1L, DIDO1 and RBM39 in colorectal adenoma to carcinoma progression.
Cell Oncol (Dordr). 2012 35(4):293-300.
PubMed: 22711543 DOI: 10.1007/s13402-012-0088-2
194 Dieterich LC, Mellberg S, Langenkamp E, Zhang L, Zieba A, Salomńki H, Teichert M, Huang H, Edqvist PH, Kraus T, Augustin HG, Olofsson T, Larsson E, S÷derberg O, Molema G, PontÚn F, Georgii-Hemming P, Alafuzoff I, Dimberg A.
Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization.
J Pathol. 2012 228(3):378-90.
PubMed: 22786655 DOI: 10.1002/path.4072
193 Edqvist PH, Niklasson M, Vidal-Sanz M, Hallb÷÷k F, Forsberg-Nilsson K.
Platelet-derived growth factor over-expression in retinal progenitors results in abnormal retinal vessel formation.
PLoS One. 2012 7(8):e42488.
PubMed: 22880002 DOI: 10.1371/journal.pone.0042488
192 Sj÷berg R, Sundberg M, Gundberg A, Sivertsson A, Schwenk JM, UhlÚn M, Nilsson P.
Validation of affinity reagents using antigen microarrays.
N Biotechnol. 2012 29(5):555-63.
PubMed: 22134247 DOI: 10.1016/j.nbt.2011.11.009
191 Arabi A, Ullah K, Branca RM, Johansson J, Bandarra D, Haneklaus M, Fu J, AriŰs I, Nilsson P, Den Boer ML, Pokrovskaja K, GrandÚr D, Xiao G, Rocha S, Lehti÷ J, Sangfelt O.
Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway.
Nat Commun. 2012 3():976.
PubMed: 22864569 DOI: 10.1038/ncomms1975
190 Medrek C, PontÚn F, Jirstr÷m K, Leandersson K.
The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients.
BMC Cancer. 2012 12(1):306.
PubMed: 22824040 DOI: 10.1186/1471-2407-12-306
189 Smits A, Jin Z, Elsir T, Pedder H, NistÚr M, Alafuzoff I, Dimberg A, Edqvist PH, PontÚn F, Aronica E, Birnir B.
GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome.
PLoS One. 2012 7(5):e37041.
PubMed: 22615883 DOI: 10.1371/journal.pone.0037041
188 Asplund A, Edqvist PH, Schwenk JM, PontÚn F.
Antibodies for profiling the human proteome-The Human Protein Atlas as a resource for cancer research.
Proteomics. 2012 12(13):2067-77.
PubMed: 22623277 DOI: 10.1002/pmic.201100504
187 Wallgard E, Nitzsche A, Larsson J, Guo X, Dieterich LC, Dimberg A, Olofsson T, PontÚn FC, Mńkinen T, KalÚn M, Hellstr÷m M.
Paladin (X99384) is expressed in the vasculature and shifts from endothelial to vascular smooth muscle cells during mouse development.
Dev Dyn. 2012 241(4):770-86.
PubMed: 22354871 DOI: 10.1002/dvdy.23753
186 Sillars-Hardebol AH, Carvalho B, Tijssen M, BeliŰn JA, de Wit M, Delis-van Diemen PM, PontÚn F, van de Wiel MA, Fijneman RJ, Meijer GA.
TPX2 and AURKA promote 20q amplicon-driven colorectal adenoma to carcinoma progression.
Gut. 2012 61(11):1568-75.
PubMed: 22207630 DOI: 10.1136/gutjnl-2011-301153
185 Lindskog C, Korsgren O, PontÚn F, Eriksson JW, Johansson L, Danielsson A.
Novel pancreatic beta cell-specific proteins: antibody-based proteomics for identification of new biomarker candidates.
J Proteomics. 2012 75(9):2611-20.
PubMed: 22465717 DOI: 10.1016/j.jprot.2012.03.008
184 Li A, Ponten F, dos Remedios CG.
The interactome of LIM domain proteins: the contributions of LIM domain proteins to heart failure and heart development.
Proteomics. 2012 12(2):203-25.
PubMed: 22253135 DOI: 10.1002/pmic.201100492
183 Kiflemariam S, Andersson S, Asplund A, PontÚn F, Sj÷blom T.
Scalable in situ hybridization on tissue arrays for validation of novel cancer and tissue-specific biomarkers.
PLoS One. 2012 7(3):e32927.
PubMed: 22412953 DOI: 10.1371/journal.pone.0032927
182 Kampf C, Olsson I, Ryberg U, Sj÷stedt E, PontÚn F.
Production of tissue microarrays, immunohistochemistry staining and digitalization within the human protein atlas.
J Vis Exp. 2012 (63):.
PubMed: 22688270 DOI: 10.3791/3620
181 Edlund K, Lindskog C, Saito A, Berglund A, PontÚn F, G÷ransson-Kultima H, Isaksson A, Jirstr÷m K, Planck M, Johansson L, Lambe M, Holmberg L, Nyberg F, Ekman S, Bergqvist M, Landelius P, Lamberg K, Botling J, Ostman A, Micke P.
CD99 is a novel prognostic stromal marker in non-small cell lung cancer.
Int J Cancer. 2012 131(10):2264-73.
PubMed: 22392539 DOI: 10.1002/ijc.27518
180 Samir R, Asplund A, Tot T, Pekar G, Hellberg D.
Oral contraceptive and progestin-only use correlates to tissue tumor marker expression in women with cervical intraepithelial neoplasia.
Contraception. 2012 85(3):288-93.
PubMed: 22067748 DOI: 10.1016/j.contraception.2011.09.001
179 Stadler C, Hjelmare M, Neumann B, Jonasson K, Pepperkok R, UhlÚn M, Lundberg E
Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy.
J Proteomics. 2012 2236ľ2251
PubMed: 22361696 DOI: 10.1016/j.jprot.2012.01.030
178 UhlÚn M, Oksvold P, ─lgenńs C, Hamsten C, Fagerberg L, Klevebring D, Lundberg E, Odeberg J, PontÚn F, Kondo T, Sivertsson ┼.
Antibody-based protein profiling of the human chromosome 21.
Mol Cell Proteomics. 2012 11(3):M111.013458.
PubMed: 22042635 DOI: 10.1074/mcp.M111.013458
177 de Wit M, Jimenez CR, Carvalho B, Belien JA, Delis-van Diemen PM, Mongera S, Piersma SR, Vikas M, Navani S, PontÚn F, Meijer GA, Fijneman RJ.
Cell surface proteomics identifies glucose transporter type 1 and prion protein as candidate biomarkers for colorectal adenoma-to-carcinoma progression.
Gut. 2012 61(6):855-64.
PubMed: 21890811 DOI: 10.1136/gutjnl-2011-300511
176 Sillars-Hardebol AH, Carvalho B, BeliŰn JA, de Wit M, Delis-van Diemen PM, Tijssen M, van de Wiel MA, PontÚn F, Fijneman RJ, Meijer GA.
BCL2L1 has a functional role in colorectal cancer and its protein expression is associated with chromosome 20q gain.
J Pathol. 2012 226(3):442-50.
PubMed: 22009326 DOI: 10.1002/path.2983
175 Hńggmark A, Neiman M, Drobin K, Zwahlen M, UhlÚn M, Nilsson P, Schwenk JM.
Classification of protein profiles from antibody microarrays using heat and detergent treatment.
N Biotechnol. 2012 29(5):564-70.
PubMed: 22023822 DOI: 10.1016/j.nbt.2011.10.005
174 Ahmad Y, Boisvert FM, Lundberg E, Uhlen M, Lamond AI.
Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization.
Mol Cell Proteomics. 2012 11(3):M111.013680.
PubMed: 22002106 DOI: 10.1074/mcp.M111.013680
173 Alpßr A, Attems J, Mulder J, H÷kfelt T, Harkany T.
The renaissance of Ca2+-binding proteins in the nervous system: secretagogin takes center stage.
Cell Signal. 2012 24(2):378-87.
PubMed: 21982882 DOI: 10.1016/j.cellsig.2011.09.028
172 Zeiler M, Straube WL, Lundberg E, Uhlen M, Mann M.
A Protein Epitope Signature Tag (PrEST) library allows SILAC-based absolute quantification and multiplexed determination of protein copy numbers in cell lines.
Mol Cell Proteomics. 2012 11(3):O111.009613.
PubMed: 21964433 DOI: 10.1074/mcp.O111.009613
171 Wňllberg H, L÷fdahl PK, Tschapalda K, UhlÚn M, Tolmachev V, Nygren PK, Stňhl S.
Affinity recovery of eight HER2-binding affibody variants using an anti-idiotypic affibody molecule as capture ligand.
Protein Expr Purif. 2011 76(1):127-35.
PubMed: 21029777 DOI: 10.1016/j.pep.2010.10.008
170 Malmberg J, Sandstr÷m M, Wester K, Tolmachev V, Orlova A.
Comparative biodistribution of imaging agents for in vivo molecular profiling of disseminated prostate cancer in mice bearing prostate cancer xenografts: focus on 111In- and 125I-labeled anti-HER2 humanized monoclonal trastuzumab and ABY-025 affibody.
Nucl Med Biol. 2011 38(8):1093-102.
PubMed: 22137850 DOI: 10.1016/j.nucmedbio.2011.04.005
169 Gantelius J, Bass T, Sj÷berg R, Nilsson P, Andersson-Svahn H.
A lateral flow protein microarray for rapid and sensitive antibody assays.
Int J Mol Sci. 2011 12(11):7748-59.
PubMed: 22174629 DOI: 10.3390/ijms12117748
168 Stňhl PL, Stranneheim H, Asplund A, Berglund L, PontÚn F, Lundeberg J.
Sun-induced nonsynonymous p53 mutations are extensively accumulated and tolerated in normal appearing human skin.
J Invest Dermatol. 2011 131(2):504-8.
PubMed: 20944651 DOI: 10.1038/jid.2010.302
167 Samir R, Asplund A, Tot T, Pekar G, Hellberg D.
High-risk HPV infection and CIN grade correlates to the expression of c-myc, CD4+, FHIT, E-cadherin, Ki-67, and p16INK4a.
J Low Genit Tract Dis. 2011 15(4):280-6.
PubMed: 21558960 DOI: 10.1097/LGT.0b013e318215170c
166 Lindstr÷m AK, Asplund A, Hellberg D.
Correlation between LRIG1 and LRIG2 expressions and expression of 11 tumor markers, with special reference to tumor suppressors, in CIN and normal cervical epithelium.
Gynecol Oncol. 2011 122(2):372-6.
PubMed: 21632100 DOI: 10.1016/j.ygyno.2011.04.049
165 Kato BS, Nicholson G, Neiman M, Rantalainen M, Holmes CC, Barrett A, Uhlen M, Nilsson P, Spector TD, Schwenk JM.
Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model.
Proteome Sci. 2011 9(1):73.
PubMed: 22093360 DOI: 10.1186/1477-5956-9-73
164 Gremel G, Ryan D, Rafferty M, Lanigan F, Hegarty S, Lavelle M, Murphy I, Unwin L, Joyce C, Faller W, McDermott EW, Sheahan K, Ponten F, Gallagher WM.
Functional and prognostic relevance of the homeobox protein MSX2 in malignant melanoma.
Br J Cancer. 2011 105(4):565-74.
PubMed: 21730974 DOI: 10.1038/bjc.2011.249
163 Wallin U, Glimelius B, Jirstr÷m K, Darmanis S, Nong RY, PontÚn F, Johansson C, Pňhlman L, Birgisson H.
Growth differentiation factor 15: a prognostic marker for recurrence in colorectal cancer.
Br J Cancer. 2011 104(10):1619-27.
PubMed: 21468045 DOI: 10.1038/bjc.2011.112
162 Hjelm B, Brennan DJ, Zendehrokh N, Eberhard J, Nodin B, Gaber A, PontÚn F, Johannesson H, Smaragdi K, Frantz C, Hober S, Johnson LB, Pňhlman S, Jirstr÷m K, Uhlen M.
High nuclear RBM3 expression is associated with an improved prognosis in colorectal cancer.
Proteomics Clin Appl. 2011 5(11-12):624-35.
PubMed: 21956899 DOI: 10.1002/prca.201100020
161 Jonsson L, Gaber A, Ulmert D, UhlÚn M, Bjartell A, Jirstr÷m K.
High RBM3 expression in prostate cancer independently predicts a reduced risk of biochemical recurrence and disease progression.
Diagn Pathol. 2011 6:91.
PubMed: 21955582 DOI: 10.1186/1746-1596-6-91
160 Nishibori Y, Katayama K, Parikka M, Oddsson A, Nukui M, Hultenby K, Wernerson A, He B, Ebarasi L, Raschperger E, Norlin J, UhlÚn M, Patrakka J, Betsholtz C, Tryggvason K.
Glcci1 deficiency leads to proteinuria.
J Am Soc Nephrol. 2011 22(11):2037-46.
PubMed: 21949092 DOI: 10.1681/ASN.2010111147
159 Larsson A, Johansson ME, Wangefjord S, Gaber A, Nodin B, Kucharzewska P, Welinder C, Belting M, Eberhard J, Johnsson A, UhlÚn M, Jirstr÷m K.
Overexpression of podocalyxin-like protein is an independent factor of poor prognosis in colorectal cancer.
Br J Cancer. 2011 105(5):666-72.
PubMed: 21829192 DOI: 10.1038/bjc.2011.295
158 Sistani L, DunÚr F, Udumala S, Hultenby K, Uhlen M, Betsholtz C, Tryggvason K, Wernerson A, Patrakka J.
Pdlim2 is a novel actin-regulating protein of podocyte foot processes.
Kidney Int. 2011 80(10):1045-54.
PubMed: 21814175 DOI: 10.1038/ki.2011.231
157 EhlÚn O, Nodin B, Rexhepaj E, Brńndstedt J, UhlÚn M, Alvarado-Kristensson M, PontÚn F, Brennan DJ, Jirstr÷m K.
RBM3-Regulated Genes Promote DNA Integrity and Affect Clinical Outcome in Epithelial Ovarian Cancer.
Transl Oncol. 2011 4(4):212-21.
PubMed: 21804916
156 Jonsson L, Bergman J, Nodin B, Manjer J, PontÚn F, UhlÚn M, Jirstr÷m K.
Low RBM3 protein expression correlates with tumour progression and poor prognosis in malignant melanoma: an analysis of 215 cases from the Malm÷ Diet and Cancer Study.
J Transl Med. 2011 9():114.
PubMed: 21777469 DOI: 10.1186/1479-5876-9-114
155 Legrain P, Aebersold R, Archakov A, Bairoch A, Bala K, Beretta L, Bergeron J, Borchers CH, Corthals GL, Costello CE, Deutsch EW, Domon B, Hancock W, He F, Hochstrasser D, Marko-Varga G, Salekdeh GH, Sechi S, Snyder M, Srivastava S, UhlÚn M, Wu CH, Yamamoto T, Paik YK, Omenn GS.
The human proteome project: current state and future direction.
Mol Cell Proteomics. 2011 10(7):M111.009993.
PubMed: 21742803 DOI: 10.1074/mcp.M111.009993
154 Fagerberg L, Str÷mberg S, El-Obeid A, Gry M, Nilsson K, Uhlen M, Ponten F, Asplund A.
Large-scale protein profiling in human cell lines using antibody-based proteomics.
J Proteome Res. 2011 10(9):4066-75.
PubMed: 21726073 DOI: 10.1021/pr200259v
153 Larsson K, Hofstr÷m C, Lindskog C, Hansson M, Angelidou P, H÷kfelt T, UhlÚn M, WernÚrus H, Grńslund T, Hober S.
Novel antigen design for the generation of antibodies to G-protein-coupled receptors.
J Immunol Methods. 2011 370(1-2):14-23.
PubMed: 21605562 DOI: 10.1016/j.jim.2011.05.001
152 Stanić D, Mulder J, Watanabe M, H÷kfelt T.
Characterization of NPY Y2 receptor protein expression in the mouse brain. II. Coexistence with NPY, the Y1 receptor, and other neurotransmitter-related molecules.
J Comp Neurol. 2011 519(7):1219-57.
PubMed: 21452195 DOI: 10.1002/cne.22608
151 Lindfors C, Nilsson IA, Garcia-Roves PM, Zuberi AR, Karimi M, Donahue LR, Roopenian DC, Mulder J, UhlÚn M, Ekstr÷m TJ, Davisson MT, H÷kfelt TG, Schalling M, Johansen JE.
Hypothalamic mitochondrial dysfunction associated with anorexia in the anx/anx mouse.
Proc Natl Acad Sci U S A. 2011 108(44):18108-13.
PubMed: 22025706 DOI: 10.1073/pnas.1114863108
150 Colwill K, Persson H, Jarvik NE, Wyrzucki A, Wojcik J, Koide A, Kossiakoff AA, Koide S, Sidhu S, Dyson MR, Pershad K, Pavlovic JD, Karatt-Vellatt A, Schofield DJ, Kay BK, McCafferty J, Mersmann M, Meier D, Mersmann J, Helmsing S, Hust M, DŘbel S, Berkowicz S, Freemantle A, Spiegel M, Sawyer A, Layton D, Nice E, Dai A, Rocks O, Williton K, Fellouse FA, Hersi K, Pawson T, Nilsson P, Sundberg M, Sj÷berg R, Sivertsson ┼, Schwenk JM, Takanen JO, Hober S, UhlÚn M, Dahlgren LG, Flores A, Johansson I, Weigelt J, Crombet L, Loppnau P, Kozieradzki I, Cossar D, Arrowsmith CH, Edwards AM, Grńslund S.
A roadmap to generate renewable protein binders to the human proteome.
Nat Methods. 2011 8(7):551-8.
PubMed: 21572409 DOI: 10.1038/nmeth.1607
149 Schwenk JM, Nilsson P.
Assessment of antibody specificity using suspension bead arrays.
Methods Mol Biol. 2011 785:183-9.
PubMed: 21901600 DOI: 10.1007/978-1-61779-286-1_12
148 Neiman M, Hedberg JJ, D÷nnes PR, Schuppe-Koistinen I, Hanschke S, Schindler R, UhlÚn M, Schwenk JM, Nilsson P.
Plasma profiling reveals human fibulin-1 as candidate marker for renal impairment.
J Proteome Res. 2011 10(11):4925-34.
PubMed: 21888404 DOI: 10.1021/pr200286c
147 PontÚn F, Schwenk JM, Asplund A, Edqvist PH.
The Human Protein Atlas as a proteomic resource for biomarker discovery.
J Intern Med. 2011 270(5):428-46.
PubMed: 21752111 DOI: 10.1111/j.1365-2796.2011.02427.x
146 Tegel H, Yderland L, Bostr÷m T, Eriksson C, Ukkonen K, Vasala A, Neubauer P, Ottosson J, Hober S.
Parallel production and verification of protein products using a novel high-throughput screening method.
Biotechnol J. 2011 6(8):1018-25.
PubMed: 21681961 DOI: 10.1002/biot.201000430
145 Fagerberg L, Stadler C, Skogs M, Hjelmare M, Jonasson K, Wiking M, Abergh A, UhlÚn M, Lundberg E.
Mapping the subcellular protein distribution in three human cell lines.
J Proteome Res. 2011 10(8):3766-77.
PubMed: 21675716 DOI: 10.1021/pr200379a
144 Magnusson K, de Wit M, Brennan DJ, Johnson LB, McGee SF, Lundberg E, Naicker K, Klinger R, Kampf C, Asplund A, Wester K, Gry M, Bjartell A, Gallagher WM, Rexhepaj E, Kilpinen S, Kallioniemi OP, Belt E, Goos J, Meijer G, Birgisson H, Glimelius B, Borrebaeck CA, Navani S, UhlÚn M, O'Connor DP, Jirstr÷m K, PontÚn F.
SATB2 in combination with cytokeratin 20 identifies over 95% of all colorectal carcinomas.
Am J Surg Pathol. 2011 35(7):937-48.
PubMed: 21677534 DOI: 10.1097/PAS.0b013e31821c3dae
143 Hjelm B, Forsstr÷m B, Igel U, Johannesson H, Stadler C, Lundberg E, Ponten F, Sj÷berg A, Rockberg J, Schwenk JM, Nilsson P, Johansson C, UhlÚn M.
Generation of monospecific antibodies based on affinity capture of polyclonal antibodies.
Protein Sci. 2011 20(11):1824-35.
PubMed: 21898641 DOI: 10.1002/pro.716
142 Str÷m CE, Johansson F, UhlÚn M, Szigyarto CA, Erixon K, Helleday T.
Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediate.
Nucleic Acids Res. 2011 39(8):3166-75.
PubMed: 21183466 DOI: 10.1093/nar/gkq1241
141 Hńggarth L, Hńggl÷f C, Jaraj SJ, Wester K, PontÚn F, Ostman A, Egevad L.
Diagnostic biomarkers of prostate cancer.
Scand J Urol Nephrol. 2011 45(1):60-7.
PubMed: 21034352 DOI: 10.3109/00365599.2010.526141
140 Jaraj SJ, Augsten M, Hńggarth L, Wester K, PontÚn F, Ostman A, Egevad L.
GAD1 is a biomarker for benign and malignant prostatic tissue.
Scand J Urol Nephrol. 2011 45(1):39-45.
PubMed: 21091088 DOI: 10.3109/00365599.2010.521189
139 Elkabets M, Gifford AM, Scheel C, Nilsson B, Reinhardt F, Bray MA, Carpenter AE, Jirstr÷m K, Magnusson K, Ebert BL, PontÚn F, Weinberg RA, McAllister SS.
Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice.
J Clin Invest. 2011 121(2):784-99.
PubMed: 21266779 DOI: 10.1172/JCI43757
138 Xu X, Patrakka J, Sistani L, Uhlen M, Jalanko H, Betsholtz C, Tryggvason K.
Expression of novel podocyte-associated proteins sult1b1 and ankrd25.
Nephron Exp Nephrol. 2011 117(2):e39-46.
PubMed: 20720434 DOI: 10.1159/000320049
137 Falk R, Ramstr÷m M, Eriksson C, UhlÚn M, WernÚrus H, Hober S.
Targeted protein pullout from human tissue samples using competitive elution.
Biotechnol J. 2011 6(1):28-37.
PubMed: 21170982
136 Brennan DJ, Laursen H, O'Connor DP, Borgquist S, Uhlen M, Gallagher WM, PontÚn F, Millikan RC, RydÚn L, Jirstr÷m K.
Tumor-specific HMG-CoA reductase expression in primary premenopausal breast cancer predicts response to tamoxifen.
Breast Cancer Res. 2011 13(1):R12.
PubMed: 21281480 DOI: 10.1186/bcr2820
135 Uhlen M, Svahn HA.
Affinity reagents for lab on chips.
Lab Chip. 2011 11(8):1417-9.
PubMed: 21286659 DOI: 10.1039/c1lc90005f
134 Mńlarstig A, Silveira A, Wňgsńter D, Íhrvik J, Bńcklund A, Samnegňrd A, Khademi M, Hellenius ML, Leander K, Olsson T, UhlÚn M, de Faire U, Eriksson P, Hamsten A.
Plasma CD93 concentration is a potential novel biomarker for coronary artery disease.
J Intern Med. 2011 270(3):229-36.
PubMed: 21332844 DOI: 10.1111/j.1365-2796.2011.02364.x
133 Schwenk JM, Nilsson P.
Antibody suspension bead arrays.
Methods Mol Biol. 2011 723:29-36.
PubMed: 21370057 DOI: 10.1007/978-1-61779-043-0_3
132 Ayoglu B, Hńggmark A, Neiman M, Igel U, UhlÚn M, Schwenk JM, Nilsson P.
Systematic antibody and antigen-based proteomic profiling with microarrays.
Expert Rev Mol Diagn. 2011 11(2):219-34.
PubMed: 21405972 DOI: 10.1586/erm.10.110
131 Navani, S.
The Human Protein Atlas
The Journal of Obstetrics and Gynaecology of India 2011 61(1):27-32.
DOI: 10.1007/s13224-011-0013-z
130 Tegel H, Ottosson J, Hober S.
Enhancing the protein production levels in Escherichia coli with a strong promoter.
FEBS J. 2011 278(5):729-39.
PubMed: 21205203 DOI: 10.1111/j.1742-4658.2010.07991.x
129 Gustavsson E, Ek S, Steen J, Kristensson M, ─lgenńs C, UhlÚn M, Wingren C, Ottosson J, Hober S, Borrebaeck CA.
Surrogate antigens as targets for proteome-wide binder selection.
N Biotechnol. 2011 28(4):302-11.
PubMed: 21232647 DOI: 10.1016/j.nbt.2010.12.005
128 Jakobsen L, Vanselow K, Skogs M, Toyoda Y, Lundberg E, Poser I, Falkenby LG, Bennetzen M, Westendorf J, Nigg EA, Uhlen M, Hyman AA, Andersen JS.
Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.
EMBO J. 2011 30(8):1520-35.
PubMed: 21399614 DOI: 10.1038/emboj.2011.63
127 Samir R, Asplund A, Tot T, Pekar G, Hellberg D.
Tissue tumor marker expression in smokers, including serum cotinine concentrations, in women with cervical intraepithelial neoplasia or normal squamous cervical epithelium.
Am J Obstet Gynecol. 2010 202(6):579.e1-7.
PubMed: 20060094 DOI: 10.1016/j.ajog.2009.11.034
126 Samir R, Tot T, Asplund A, Pekar G, Hellberg D.
Increased serum progesterone and estradiol correlate to increased COX-2 tissue expression in cervical intraepithelial neoplasia.
Anticancer Res. 2010 30(4):1217-22.
PubMed: 20530431
125 Kronqvist N, Malm M, Rockberg J, Hjelm B, UhlÚn M, Stňhl S, L÷fblom J.
Staphylococcal surface display in combinatorial protein engineering and epitope mapping of antibodies.
Recent Pat Biotechnol. 2010 4(3):171-82.
PubMed: 21171954 DOI: 10.2174/187220810793611536
124 Klevebring D, Fagerberg L, Lundberg E, Emanuelsson O, UhlÚn M, Lundeberg J.
Analysis of transcript and protein overlap in a human osteosarcoma cell line.
BMC Genomics. 2010 11:684.
PubMed: 21126332 DOI: 10.1186/1471-2164-11-684
123 Jonasson K, Berglund L, Uhlen M.
The 6th HUPO Antibody Initiative (HAI) workshop: sharing data about affinity reagents and other recent developments. September 2009, Toronto, Canada.
Proteomics. 2010 10(11):2066-8.
PubMed: 20514648 DOI: 10.1002/pmic.201090040
122 International Cancer Genome Consortium
International network of cancer genome projects.
Nature. 2010 464(7291):993-8.
PubMed: 20393554 DOI: 10.1038/nature08987
121 Mulder J, Spence L, Tortoriello G, Dinieri JA, UhlÚn M, Shui B, Kotlikoff MI, Yanagawa Y, Aujard F, H÷kfelt T, Hurd YL, Harkany T.
Secretagogin is a Ca2+-binding protein identifying prospective extended amygdala neurons in the developing mammalian telencephalon.
Eur J Neurosci. 2010 31(12):2166-77.
PubMed: 20529129 DOI: 10.1111/j.1460-9568.2010.07275.x
120 Furusato B, Mohamed A, UhlÚn M, Rhim JS.
CXCR4 and cancer.
Pathol Int. 2010 60(7):497-505.
PubMed: 20594270 DOI: 10.1111/j.1440-1827.2010.02548.x
119 Bourbeillon J, Orchard S, Benhar I, Borrebaeck C, de Daruvar A, DŘbel S, Frank R, Gibson F, Gloriam D, Haslam N, Hiltker T, Humphrey-Smith I, Hust M, Juncker D, Koegl M, Konthur Z, Korn B, Krobitsch S, Muyldermans S, Nygren PA, Palcy S, Polic B, Rodriguez H, Sawyer A, Schlapshy M, Snyder M, Stoevesandt O, Taussig MJ, Templin M, Uhlen M, van der Maarel S, Wingren C, Hermjakob H, Sherman D.
Minimum information about a protein affinity reagent (MIAPAR).
Nat Biotechnol. 2010 28(7):650-3.
PubMed: 20622827 DOI: 10.1038/nbt0710-650
118 Gardberg M, Talvinen K, Kaipio K, Iljin K, Kampf C, Uhlen M, CarpÚn O.
Characterization of Diaphanous-related formin FMNL2 in human tissues.
BMC Cell Biol. 2010 11:55.
PubMed: 20633255 DOI: 10.1186/1471-2121-11-55
117 Uhlen M, Oksvold P, Fagerberg L, Lundberg E, Jonasson K, Forsberg M, Zwahlen M, Kampf C, Wester K, Hober S, Wernerus H, Bj÷rling L, Ponten F.
Towards a knowledge-based Human Protein Atlas.
Nat Biotechnol. 2010 28(12):1248-50.
PubMed: 21139605 DOI: 10.1038/nbt1210-1248
116 Lundberg E, Fagerberg L, Klevebring D, Matic I, Geiger T, Cox J, Algenńs C, Lundeberg J, Mann M, Uhlen M.
Defining the transcriptome and proteome in three functionally different human cell lines.
Mol Syst Biol. 2010 6:450.
PubMed: 21179022 DOI: 10.1038/msb.2010.106
115 Gry M, Oksvold P, PontÚn F, UhlÚn M.
Tissue-specific protein expression in human cells, tissues and organs.
J Proteomics Bioinform 2010 3(10):294-301.
DOI: 10.4172/jpb.1000153
114 Agnarsdˇttir M, Sooman L, Bolander A, Str÷mberg S, Rexhepaj E, Bergqvist M, Ponten F, Gallagher W, Lennartsson J, Ekman S, Uhlen M, Hedstrand H.
SOX10 expression in superficial spreading and nodular malignant melanomas.
Melanoma Res. 2010 20(6):468-78.
PubMed: 20890226 DOI: 10.1097/CMR.0b013e3283403ccd
113 Brennan DJ, O'Connor DP, Rexhepaj E, Ponten F, Gallagher WM.
Antibody-based proteomics: fast-tracking molecular diagnostics in oncology.
Nat Rev Cancer. 2010 10(9):605-17.
PubMed: 20720569 DOI: 10.1038/nrc2902
112 EhlÚn A, Brennan DJ, Nodin B, O'Connor DP, Eberhard J, Alvarado-Kristensson M, Jeffrey IB, Manjer J, Brńndstedt J, UhlÚn M, PontÚn F, Jirstr÷m K.
Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer.
J Transl Med. 2010 8:78.
PubMed: 20727170 DOI: 10.1186/1479-5876-8-78
111 Lindskog C, Asplund A, Engkvist M, UhlÚn M, Korsgren O, PontÚn F.
Antibody-based proteomics for discovery and exploration of proteins expressed in pancreatic islets.
Discov Med. 2010 9(49):565-78.
PubMed: 20587347
110 Blokzijl A, Friedman M, PontÚn F, Landegren U.
Profiling protein expression and interactions: proximity ligation as a tool for personalized medicine.
J Intern Med. 2010 268(3):232-45.
PubMed: 20695973 DOI: 10.1111/j.1365-2796.2010.02256.x
109 Ryan D, Rafferty M, Hegarty S, O'Leary P, Faller W, Gremel G, Bergqvist M, Agnarsdottir M, Str÷mberg S, Kampf C, PontÚn F, Millikan RC, Dervan PA, Gallagher WM.
Topoisomerase I amplification in melanoma is associated with more advanced tumours and poor prognosis.
Pigment Cell Melanoma Res. 2010 23(4):542-53.
PubMed: 20465595 DOI: 10.1111/j.1755-148X.2010.00720.x
108 Brennan DJ, Brńndstedt J, Rexhepaj E, Foley M, PontÚn F, UhlÚn M, Gallagher WM, O'Connor DP, O'Herlihy C, Jirstrom K.
Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer.
BMC Cancer. 2010 10:125.
PubMed: 20359358 DOI: 10.1186/1471-2407-10-125
107 Nord H, Segersten U, Sandgren J, Wester K, Busch C, Menzel U, Komorowski J, Dumanski JP, Malmstr÷m PU, DÝaz de Stňhl T.
Focal amplifications are associated with high grade and recurrences in stage Ta bladder carcinoma.
Int J Cancer. 2010 126(6):1390-402.
PubMed: 19821490 DOI: 10.1002/ijc.24954
106 Borsics T, Lundberg E, Geerts D, Koomoa DL, Koster J, Wester K, Bachmann AS.
Subcellular distribution and expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in malignant glioma: Influence on cell survival and migration.
Cancer Sci. 2010 101(7):1624-31.
PubMed: 20412121 DOI: 10.1111/j.1349-7006.2010.01570.x
105 Lundberg E, UhlÚn M.
Creation of an antibody-based subcellular protein atlas.
Proteomics. 2010 10(22):3984-96.
PubMed: 20648481 DOI: 10.1002/pmic.201000125
104 Schwenk JM, Igel U, Neiman M, Langen H, Becker C, Bjartell A, Ponten F, Wiklund F, Gr÷nberg H, Nilsson P, Uhlen M.
Toward next generation plasma profiling via heat-induced epitope retrieval and array-based assays.
Mol Cell Proteomics. 2010 9(11):2497-507.
PubMed: 20682762 DOI: 10.1074/mcp.M110.001560
103 Rockberg J, L÷fblom J, Hjelm B, Stňhl S, UhlÚn M.
Epitope mapping using gram-positive surface display.
Curr Protoc Immunol. 2010 Chapter 9:Unit9.9.
PubMed: 20814943 DOI: 10.1002/0471142735.im0909s90
102 Tassidis H, Brokken LJ, Jirstr÷m K, Ehrnstr÷m R, PontÚn F, Ulmert D, Bjartell A, Hńrk÷nen P, Wingren AG.
Immunohistochemical detection of tyrosine phosphatase SHP-1 predicts outcome after radical prostatectomy for localized prostate cancer.
Int J Cancer. 2010 126(10):2296-307.
PubMed: 19795453 DOI: 10.1002/ijc.24917
101 Holgersson G, Ekman S, Reizenstein J, Bergqvist M, PontÚn F, UhlÚn M, Magnusson K, Jonnalagadda P, Asplund A, Str÷mberg S, Linder A, Blomquist E, Liljeholm M, L÷dÚn B, Hellstr÷m K, Bergstr÷m S.
Molecular profiling using tissue microarrays as a tool to identify predictive biomarkers in laryngeal cancer treated with radiotherapy.
Cancer Genomics Proteomics 2010 7(1):1-7.
PubMed: 20181625
100 Tegel H, Tourle S, Ottosson J, Persson A.
Increased levels of recombinant human proteins with the Escherichia coli strain Rosetta(DE3).
Protein Expr Purif. 2010 69(2):159-67.
PubMed: 19733669 DOI: 10.1016/j.pep.2009.08.017
99 Fagerberg L, Jonasson K, von Heijne G, UhlÚn M, Berglund L.
Prediction of the human membrane proteome.
Proteomics. 2010 10(6):1141-9.
PubMed: 20175080 DOI: 10.1002/pmic.200900258
98 Schwenk JM, Igel U, Kato BS, Nicholson G, Karpe F, UhlÚn M, Nilsson P.
Comparative protein profiling of serum and plasma using an antibody suspension bead array approach.
Proteomics. 2010 10(3):532-40.
PubMed: 19953555 DOI: 10.1002/pmic.200900657
97 Stadler C, Skogs M, Brismar H, UhlÚn M, Lundberg E.
A single fixation protocol for proteome-wide immunofluorescence localization studies.
J Proteomics. 2010 73(6):1067-78.
PubMed: 19896565 DOI: 10.1016/j.jprot.2009.10.012
96 Gloriam DE, Orchard S, Bertinetti D, Bj÷rling E, Bongcam-Rudloff E, Borrebaeck CA, Bourbeillon J, Bradbury AR, de Daruvar A, DŘbel S, Frank R, Gibson TJ, Gold L, Haslam N, Herberg FW, Hiltke T, Hoheisel JD, Kerrien S, Koegl M, Konthur Z, Korn B, Landegren U, Montecchi-Palazzi L, Palcy S, Rodriguez H, Schweinsberg S, Sievert V, Stoevesandt O, Taussig MJ, Ueffing M, UhlÚn M, van der Maarel S, Wingren C, Woollard P, Sherman DJ, Hermjakob H.
A community standard format for the representation of protein affinity reagents.
Mol Cell Proteomics. 2010 9(1):1-10.
PubMed: 19674966 DOI: 10.1074/mcp.M900185-MCP200
95 Szigyarto CA, Sibbons P, Williams G, Uhlen M, Metcalfe SM.
The E3 ligase axotrophin/MARCH-7: protein expression profiling of human tissues reveals links to adult stem cells.
J Histochem Cytochem. 2010 58(4):301-8.
PubMed: 19901269 DOI: 10.1369/jhc.2009.954420
94 Hjelm B, Fernßndez CD, L÷fblom J, Stňhl S, Johannesson H, Rockberg J, UhlÚn M.
Exploring epitopes of antibodies toward the human tryptophanyl-tRNA synthetase.
N Biotechnol. 2010 27(2):129-37.
PubMed: 19913117 DOI: 10.1016/j.nbt.2009.11.001
93 Paavilainen L, Edvinsson A, Asplund A, Hober S, Kampf C, PontÚn F, Wester K.
The impact of tissue fixatives on morphology and antibody-based protein profiling in tissues and cells.
J Histochem Cytochem. 2010 58(3):237-46.
PubMed: 19901271 DOI: 10.1369/jhc.2009.954321
92 Tchougounova E, Jiang Y, Brňsńter D, Lindberg N, Kastemar M, Asplund A, Westermark B, Uhrbom L.
Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence.
Oncogene. 2009 28(12):1537-48.
PubMed: 19219070 DOI: 10.1038/onc.2009.9
91 Oberg F, Haseeb A, Ahnfelt M, PontÚn F, Westermark B, El-Obeid A.
Herbal melanin activates TLR4/NF-kappaB signaling pathway.
Phytomedicine. 2009 16(5):477-84.
PubMed: 19103478 DOI: 10.1016/j.phymed.2008.10.008
90 Apweiler R, Aslanidis C, Deufel T, Gerstner A, Hansen J, Hochstrasser D, Kellner R, Kubicek M, Lottspeich F, Maser E, Mewes HW, Meyer HE, MŘllner S, Mutter W, Neumaier M, Nollau P, Nothwang HG, Ponten F, Radbruch A, Reinert K, Rothe G, Stockinger H, Tßrnok A, Taussig MJ, Thiel A, Thiery J, Ueffing M, Valet G, Vandekerckhove J, Wagener C, Wagner O, Schmitz G.
Approaching clinical proteomics: current state and future fields of application in cellular proteomics.
Cytometry A. 2009 75(10):816-32.
PubMed: 19739086 DOI: 10.1002/cyto.a.20779
89 Leja J, Essaghir A, Essand M, Wester K, Oberg K, T÷tterman TH, Lloyd R, Vasmatzis G, Demoulin JB, Giandomenico V.
Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas.
Mod Pathol. 2009 22(2):261-72.
PubMed: 18953328 DOI: 10.1038/modpathol.2008.174
88 Qu M, Aronica E, Boer K, Fńllmar D, Kumlien E, NistÚr M, Wester K, PontÚn F, Smits A.
DLG3/SAP102 protein expression in malformations of cortical development: a study of human epileptic cortex by tissue microarray.
Epilepsy Res. 2009 84(1):33-41.
PubMed: 19167192 DOI: 10.1016/j.eplepsyres.2008.12.004
87 Newberg JY, Li J, Rao A, PontÚn F, UhlÚn M, Lundberg E, Murphy RF.
Automated Analysis of Human Protein Atlas Immunofluorescence Images.
Proc IEEE Int Symp Biomed Imaging. 2009 5193229:1023-1026.
PubMed: 20628548 DOI: 10.1109/ISBI.2009.5193229
86 Gaber A, Johansson M, Stenman UH, Hotakainen K, PontÚn F, Glimelius B, Bjartell A, Jirstr÷m K, Birgisson H.
High expression of tumour-associated trypsin inhibitor correlates with liver metastasis and poor prognosis in colorectal cancer.
Br J Cancer. 2009 100(10):1540-8.
PubMed: 19384300 DOI: 10.1038/sj.bjc.6605047
85 Paulsson J, Sj÷blom T, Micke P, PontÚn F, Landberg G, Heldin CH, Bergh J, Brennan DJ, Jirstr÷m K, Ostman A.
Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer.
Am J Pathol. 2009 175(1):334-41.
PubMed: 19498003 DOI: 10.2353/ajpath.2009.081030
84 Apweiler R, Aslanidis C, Deufel T, Gerstner A, Hansen J, Hochstrasser D, Kellner R, Kubicek M, Lottspeich F, Maser E, Mewes HW, Meyer HE, MŘllner S, Mutter W, Neumaier M, Nollau P, Nothwang HG, Ponten F, Radbruch A, Reinert K, Rothe G, Stockinger H, Tarnok A, Taussig MJ, Thiel A, Thiery J, Ueffing M, Valet G, Vandekerckhove J, Verhuven W, Wagener C, Wagner O, Schmitz G.
Approaching clinical proteomics: current state and future fields of application in fluid proteomics.
Clin Chem Lab Med. 2009 47(6):724-44.
PubMed: 19527139 DOI: 10.1515/CCLM.2009.167
83 Ghanipour A, Jirstr÷m K, PontÚn F, Glimelius B, Pňhlman L, Birgisson H.
The prognostic significance of tryptophanyl-tRNA synthetase in colorectal cancer.
Cancer Epidemiol Biomarkers Prev. 2009 18(11):2949-56.
PubMed: 19900940 DOI: 10.1158/1055-9965.EPI-09-0456
82 Markljung E, Jiang L, Jaffe JD, Mikkelsen TS, Wallerman O, Larhammar M, Zhang X, Wang L, Saenz-Vash V, Gnirke A, Lindroth AM, BarrÚs R, Yan J, Str÷mberg S, De S, PontÚn F, Lander ES, Carr SA, Zierath JR, Kullander K, Wadelius C, Lindblad-Toh K, Andersson G, Hjńlm G, Andersson L.
ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth.
PLoS Biol. 2009 7(12):e1000256.
PubMed: 20016685 DOI: 10.1371/journal.pbio.1000256
81 Rimini R, Schwenk JM, Sundberg M, Sj÷berg R, Klevebring D, Gry M, UhlÚn M, Nilsson P.
Validation of serum protein profiles by a dual antibody array approach.
J Proteomics 2009 73(2):252-66.
PubMed: 19781670 DOI: 10.1016/j.jprot.2009.09.009
80 Joensson HN, Samuels ML, Brouzes ER, Medkova M, UhlÚn M, Link DR, Andersson-Svahn H.
Detection and analysis of low-abundance cell-surface biomarkers using enzymatic amplification in microfluidic droplets.
Angew Chem Int Ed Engl. 2009 48(14):2518-21.
PubMed: 19235824 DOI: 10.1002/anie.200804326
79 Aebersold R, Auffray C, Baney E, Barillot E, Brazma A, Brett C, Brunak S, Butte A, Califano A, Celis J, Cufer T, Ferrell J, Galas D, Gallahan D, Gatenby R, Goldbeter A, Hace N, Henney A, Hood L, Iyengar R, Jackson V, Kallioniemi O, KlingmŘller U, Kolar P, Kolch W, Kyriakopoulou C, Laplace F, Lehrach H, Marcus F, Matrisian L, Nolan G, Pelkmans L, Potti A, Sander C, Seljak M, Singer D, Sorger P, Stunnenberg H, Superti-Furga G, Uhlen M, Vidal M, Weinstein J, Wigle D, Williams M, Wolkenhauer O, Zhivotovsky B, Zinovyev A, Zupan B.
Report on EU-USA workshop: how systems biology can advance cancer research (27 October 2008).
Mol Oncol. 2009 3(1):9-17.
PubMed: 19383362 DOI: 10.1016/j.molonc.2008.11.003
78 Rockberg J, Schwenk JM, UhlÚn M.
Discovery of epitopes for targeting the human epidermal growth factor receptor 2 (HER2) with antibodies.
Mol Oncol. 2009 3(3):238-47.
PubMed: 19393584 DOI: 10.1016/j.molonc.2009.01.003
77 Gry M, Rimini R, Str÷mberg S, Asplund A, PontÚn F, UhlÚn M, Nilsson P.
Correlations between RNA and protein expression profiles in 23 human cell lines.
BMC Genomics. 2009 10:365.
PubMed: 19660143 DOI: 10.1186/1471-2164-10-365
76 J÷gi A, Brennan DJ, RydÚn L, Magnusson K, Fern÷ M, Stňl O, Borgquist S, Uhlen M, Landberg G, Pňhlman S, PontÚn F, Jirstr÷m K.
Nuclear expression of the RNA-binding protein RBM3 is associated with an improved clinical outcome in breast cancer.
Mod Pathol. 2009 22(12):1564-74.
PubMed: 19734850 DOI: 10.1038/modpathol.2009.124
75 Ahlin G, Hilgendorf C, Karlsson J, Szigyarto CA, UhlÚn M, Artursson P.
Endogenous gene and protein expression of drug-transporting proteins in cell lines routinely used in drug discovery programs.
Drug Metab Dispos. 2009 37(12):2275-83.
PubMed: 19741037 DOI: 10.1124/dmd.109.028654
74 Vashisht AA, Zumbrennen KB, Huang X, Powers DN, Durazo A, Sun D, Bhaskaran N, Persson A, Uhlen M, Sangfelt O, Spruck C, Leibold EA, Wohlschlegel JA.
Control of iron homeostasis by an iron-regulated ubiquitin ligase.
Science. 2009 326(5953):718-21.
PubMed: 19762596 DOI: 10.1126/science.1176333
73 Mulder J, Zilberter M, Spence L, Tortoriello G, UhlÚn M, Yanagawa Y, Aujard F, H÷kfelt T, Harkany T.
Secretagogin is a Ca2+-binding protein specifying subpopulations of telencephalic neurons.
Proc Natl Acad Sci U S A. 2009 106(52):22492-7.
PubMed: 20018755 DOI: 10.1073/pnas.0912484106
72 Segersten MU, Edlund EK, Micke P, de la Torre M, Hamberg H, Edvinsson AE, Andersson SE, Malmstr÷m PU, Wester HK.
A novel strategy based on histological protein profiling in-silico for identifying potential biomarkers in urinary bladder cancer.
BJU Int. 2009 104(11):1780-5.
PubMed: 19522865 DOI: 10.1111/j.1464-410X.2009.08674.x
71 PontÚn F, Gry M, Fagerberg L, Lundberg E, Asplund A, Berglund L, Oksvold P, Bj÷rling E, Hober S, Kampf C, Navani S, Nilsson P, Ottosson J, Persson A, WernÚrus H, Wester K, UhlÚn M.
A global view of protein expression in human cells, tissues, and organs.
Mol Syst Biol. 2009 5:337.
PubMed: 20029370 DOI: 10.1038/msb.2009.93
70 Rockberg J, UhlÚn M.
Prediction of antibody response using recombinant human protein fragments as antigen.
Protein Sci. 2009 18(11):2346-55.
PubMed: 19760667 DOI: 10.1002/pro.245
69 Rodriguez H, Snyder M, UhlÚn M, Andrews P, Beavis R, Borchers C, Chalkley RJ, Cho SY, Cottingham K, Dunn M, Dylag T, Edgar R, Hare P, Heck AJ, Hirsch RF, Kennedy K, Kolar P, Kraus HJ, Mallick P, Nesvizhskii A, Ping P, PontÚn F, Yang L, Yates JR, Stein SE, Hermjakob H, Kinsinger CR, Apweiler R.
Recommendations from the 2008 International Summit on Proteomics Data Release and Sharing Policy: the Amsterdam principles.
J Proteome Res. 2009 8(7):3689-92.
PubMed: 19344107 DOI: 10.1021/pr900023z
68 Alimohammadi M, Dubois N, Sk÷ldberg F, Hallgren A, Tardivel I, Hedstrand H, Haavik J, Husebye ES, Gustafsson J, Rorsman F, Meloni A, Janson C, Vialettes B, Kajosaari M, Egner W, Sargur R, PontÚn F, Amoura Z, Grimfeld A, De Luca F, Betterle C, Perheentupa J, Kńmpe O, Carel JC.
Pulmonary autoimmunity as a feature of autoimmune polyendocrine syndrome type 1 and identification of KCNRG as a bronchial autoantigen.
Proc Natl Acad Sci U S A. 2009 106(11):4396-401.
PubMed: 19251657 DOI: 10.1073/pnas.0809986106
67 Str÷mberg S, Agnarsdˇttir M, Magnusson K, Rexhepaj E, Bolander A, Lundberg E, Asplund A, Ryan D, Rafferty M, Gallagher WM, Uhlen M, Bergqvist M, Ponten F.
Selective expression of Syntaxin-7 protein in benign melanocytes and malignant melanoma.
J Proteome Res. 2009 8(4):1639-46.
PubMed: 19714869 DOI: 10.1021/pr800745e
66 Estigoy CB, PontÚn F, Odeberg J, Herbert B, Guilhaus M, Charleston M, Ho JWK, Cameron D, dos Remedios CG.
Intercalated discs: multiple proteins perform multiple functions in non-failing and failing human hearts.
Biophys Rev 2009 1:43-49.
DOI: 10.1007/s12551-008-0007-y
65 Wensman H, G÷ransson H, Leuchowius KJ, Str÷mberg S, PontÚn F, Isaksson A, Rutteman GR, Heldin NE, Pejler G, HellmÚn E.
Extensive expression of craniofacial related homeobox genes in canine mammary sarcomas.
Breast Cancer Res Treat. 2009 118(2):333-43.
PubMed: 19048371 DOI: 10.1007/s10549-008-0243-7
64 Mulder J, Bj÷rling E, Jonasson K, WernÚrus H, Hober S, H÷kfelt T, UhlÚn M.
Tissue profiling of the mammalian central nervous system using human antibody-based proteomics.
Mol Cell Proteomics. 2009 8(7):1612-22.
PubMed: 19351664 DOI: 10.1074/mcp.M800539-MCP200
63 Larsson K, Eriksson C, Schwenk JM, Berglund L, Wester K, UhlÚn M, Hober S, WernÚrus H.
Characterization of PrEST-based antibodies towards human Cytokeratin-17.
J Immunol Methods. 2009 342(1-2):20-32.
PubMed: 19108777 DOI: 10.1016/j.jim.2008.11.013
62 Steen J, Ramstr÷m M, UhlÚn M, Hober S, Ottosson J.
Automated sample preparation method for mass spectrometry analysis on recombinant proteins.
J Chromatogr A. 2009 1216(20):4457-64.
PubMed: 19345368 DOI: 10.1016/j.chroma.2009.03.041
61 Tegel H, Steen J, Konrad A, Nikdin H, Pettersson K, Stenvall M, Tourle S, Wrethagen U, Xu L, Yderland L, UhlÚn M, Hober S, Ottosson J.
High-throughput protein production - lessons from scaling up from 10 to 288 recombinant proteins per week.
Biotechnol J. 2009 4(1):51-7.
PubMed: 19039781 DOI: 10.1002/biot.200800183
60 Ramstr÷m M, Zuberovic A, Gr÷nwall C, Hanrieder J, Bergquist J, Hober S.
Development of affinity columns for the removal of high-abundance proteins in cerebrospinal fluid.
Biotechnol Appl Biochem. 2009 52(Pt 2):159-66.
PubMed: 18412540 DOI: 10.1042/BA20080015
59 Koomoa DL, Go RC, Wester K, Bachmann AS.
Expression profile of PRAF2 in the human brain and enrichment in synaptic vesicles.
Neurosci Lett. 2008 436(2):171-6.
PubMed: 18395978 DOI: 10.1016/j.neulet.2008.03.030
58 Bolander A, Agnarsdˇttir M, Str÷mberg S, Ponten F, Hesselius P, Uhlen M, Bergqvist M.
The protein expression of TRP-1 and galectin-1 in cutaneous malignant melanomas.
Cancer Genomics Proteomics 2008 5(6):293-300.
PubMed: 19287070
57 Borgquist S, Djerbi S, PontÚn F, Anagnostaki L, Goldman M, Gaber A, Manjer J, Landberg G, Jirstr÷m K.
HMG-CoA reductase expression in breast cancer is associated with a less aggressive phenotype and influenced by anthropometric factors.
Int J Cancer. 2008 123(5):1146-53.
PubMed: 18528862 DOI: 10.1002/ijc.23597
56 Borgquist S, J÷gi A, PontÚn F, RydÚn L, Brennan DJ, Jirstr÷m K.
Prognostic impact of tumour-specific HMG-CoA reductase expression in primary breast cancer.
Breast Cancer Res. 2008 10(5):R79.
PubMed: 18808688 DOI: 10.1186/bcr2146
55 Asplund A, Gry Bj÷rklund M, Sundquist C, Str÷mberg S, Edlund K, Ostman A, Nilsson P, PontÚn F, Lundeberg J.
Expression profiling of microdissected cell populations selected from basal cells in normal epidermis and basal cell carcinoma.
Br J Dermatol. 2008 158(3):527-38.
PubMed: 18241271 DOI: 10.1111/j.1365-2133.2007.08418.x
54 Uhlen M.
A new era for proteomics research?
Genome Biol. 2008 9(11):325.
PubMed: 19014405 DOI: 10.1186/gb-2008-9-11-325
53 Uhlen M, Grńslund S, Sundstr÷m M.
A pilot project to generate affinity reagents to human proteins.
Nat Methods. 2008 5(10):854-5.
PubMed: 18825127 DOI: 10.1038/nmeth1008-854
52 PontÚn F, Jirstr÷m K, Uhlen M.
The Human Protein Atlas - a tool for pathology.
J Pathol. 2008 216(4):387-93.
PubMed: 18853439 DOI: 10.1002/path.2440
51 Rockberg J, L÷fblom J, Hjelm B, UhlÚn M, Stňhl S.
Epitope mapping of antibodies using bacterial surface display.
Nat Methods. 2008 5(12):1039-45.
PubMed: 19029907 DOI: 10.1038/nmeth.1272
50 Berglund L, Bj÷rling E, Oksvold P, Fagerberg L, Asplund A, Szigyarto CA, Persson A, Ottosson J, WernÚrus H, Nilsson P, Lundberg E, Sivertsson A, Navani S, Wester K, Kampf C, Hober S, PontÚn F, UhlÚn M.
A genecentric Human Protein Atlas for expression profiles based on antibodies.
Mol Cell Proteomics. 2008 7(10):2019-27.
PubMed: 18669619 DOI: 10.1074/mcp.R800013-MCP200
49 Bj÷rling E, UhlÚn M.
Antibodypedia, a portal for sharing antibody and antigen validation data.
Mol Cell Proteomics. 2008 7(10):2028-37.
PubMed: 18667413 DOI: 10.1074/mcp.M800264-MCP200
48 UhlÚn M, Hober S.
Generation and validation of affinity reagents on a proteome-wide level.
J Mol Recognit. 2008 22(2):57-64.
PubMed: 18546091 DOI: 10.1002/jmr.891
47 Lundberg E, Gry M, Oksvold P, Kononen J, Andersson-Svahn H, PontÚn F, UhlÚn M, Asplund A.
The correlation between cellular size and protein expression levels - normalization for global protein profiling.
J Proteomics. 2008 71(4):448-60.
PubMed: 18656560 DOI: 10.1016/j.jprot.2008.06.014
46 Schwenk JM, Gry M, Rimini R, UhlÚn M, Nilsson P.
Antibody suspension bead arrays within serum proteomics.
J Proteome Res. 2008 7(8):3168-79.
PubMed: 18588325 DOI: 10.1021/pr700890b
45 Berglund L, Bj÷rling E, Jonasson K, Rockberg J, Fagerberg L, Al-Khalili Szigyarto C, Sivertsson A, UhlÚn M.
A whole-genome bioinformatics approach to selection of antigens for systematic antibody generation.
Proteomics. 2008 8(14):2832-9.
PubMed: 18655051 DOI: 10.1002/pmic.200800203
44 UhlÚn M.
Affinity as a tool in life science.
Biotechniques. 2008 44(5):649-54.
PubMed: 18474040 DOI: 10.2144/000112803
43 Paavilainen L, WernÚrus H, Nilsson P, UhlÚn M, Hober S, Wester K, PontÚn F.
Evaluation of monospecific antibodies: a comparison study with commercial analogs using immunohistochemistry on tissue microarrays.
Appl Immunohistochem Mol Morphol. 2008 16(5):493-502.
PubMed: 18685494 DOI: 10.1097/PAI.0b013e31817c645e
42 Berglund L, Andrade J, Odeberg J, UhlÚn M.
The epitope space of the human proteome.
Protein Sci. 2008 17(4):606-13.
PubMed: 18359855 DOI: 10.1110/ps.073347208
41 Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Bj÷rling E, Asplund A, PontÚn F, Brismar H, UhlÚn M, Andersson-Svahn H.
Toward a confocal subcellular atlas of the human proteome.
Mol Cell Proteomics. 2008 7(3):499-508.
PubMed: 18029348 DOI: 10.1074/mcp.M700325-MCP200
40 Bj÷rling E, Lindskog C, Oksvold P, LinnÚ J, Kampf C, Hober S, UhlÚn M, PontÚn F.
A web-based tool for in silico biomarker discovery based on tissue-specific protein profiles in normal and cancer tissues.
Mol Cell Proteomics. 2008 7(5):825-44.
PubMed: 17913849 DOI: 10.1074/mcp.M700411-MCP200
39 Hober S, UhlÚn M.
Human protein atlas and the use of microarray technologies.
Curr Opin Biotechnol. 2008 19(1):30-5.
PubMed: 18187316 DOI: 10.1016/j.copbio.2007.11.006
38 Mathivanan S, Ahmed M, Ahn NG, Alexandre H, Amanchy R, Andrews PC, Bader JS, Balgley BM, Bantscheff M, Bennett KL, Bj÷rling E, Blagoev B, Bose R, Brahmachari SK, Burlingame AS, Bustelo XR, Cagney G, Cantin GT, Cardasis HL, Celis JE, Chaerkady R, Chu F, Cole PA, Costello CE, Cotter RJ, Crockett D, DeLany JP, De Marzo AM, DeSouza LV, Deutsch EW, Dransfield E, Drewes G, Droit A, Dunn MJ, Elenitoba-Johnson K, Ewing RM, Van Eyk J, Faca V, Falkner J, Fang X, Fenselau C, Figeys D, GagnÚ P, Gelfi C, Gevaert K, Gimble JM, Gnad F, Goel R, Gromov P, Hanash SM, Hancock WS, Harsha HC, Hart G, Hays F, He F, Hebbar P, Helsens K, Hermeking H, Hide W, Hjern° K, Hochstrasser DF, Hofmann O, Horn DM, Hruban RH, Ibarrola N, James P, Jensen ON, Jensen PH, Jung P, Kandasamy K, Kheterpal I, Kikuno RF, Korf U, K÷rner R, Kuster B, Kwon MS, Lee HJ, Lee YJ, Lefevre M, Lehvaslaiho M, Lescuyer P, Levander F, Lim MS, L÷bke C, Loo JA, Mann M, Martens L, Martinez-Heredia J, McComb M, McRedmond J, Mehrle A, Menon R, Miller CA, Mischak H, Mohan SS, Mohmood R, Molina H, Moran MF, Morgan JD, Moritz R, Morzel M, Muddiman DC, Nalli A, Navarro JD, Neubert TA, Ohara O, Oliva R, Omenn GS, Oyama M, Paik YK, Pennington K, Pepperkok R, Periaswamy B, Petricoin EF, Poirier GG, Prasad TS, Purvine SO, Rahiman BA, Ramachandran P, Ramachandra YL, Rice RH, Rick J, Ronnholm RH, Salonen J, Sanchez JC, Sayd T, Seshi B, Shankari K, Sheng SJ, Shetty V, Shivakumar K, Simpson RJ, Sirdeshmukh R, Siu KW, Smith JC, Smith RD, States DJ, Sugano S, Sullivan M, Superti-Furga G, Takatalo M, Thongboonkerd V, Trinidad JC, Uhlen M, Vandekerckhove J, Vasilescu J, Veenstra TD, Vidal-Taboada JM, Vihinen M, Wait R, Wang X, Wiemann S, Wu B, Xu T, Yates JR, Zhong J, Zhou M, Zhu Y, Zurbig P, Pandey A.
Human Proteinpedia enables sharing of human protein data.
Nat Biotechnol. 2008 26(2):164-7.
PubMed: 18259167 DOI: 10.1038/nbt0208-164
37 Nestor M, Ekberg T, Dring J, van Dongen GA, Wester K, Tolmachev V, Anniko M.
Quantification of CD44v6 and EGFR expression in head and neck squamous cell carcinomas using a single-dose radioimmunoassay.
Tumour Biol. 2007 28(5):253-63.
PubMed: 17992053 DOI: 10.1159/000110898
36 Sundqvist G, Stenvall M, Berglund H, Ottosson J, Brumer H.
A general, robust method for the quality control of intact proteins using LC-ESI-MS.
J Chromatogr B Analyt Technol Biomed Life Sci. 2007 852(1-2):188-94.
PubMed: 17267305 DOI: 10.1016/j.jchromb.2007.01.011
35 Alm T, Steen J, Ottosson J, Hober S.
High-throughput protein purification under denaturating conditions by the use of cation exchange chromatography.
Biotechnol J. 2007 2(6):709-16.
PubMed: 17492715 DOI: 10.1002/biot.200700060
34 Renberg B, Nordin J, Merca A, UhlÚn M, Feldwisch J, Nygren PA, Karlstr÷m AE.
Affibody molecules in protein capture microarrays: evaluation of multidomain ligands and different detection formats.
J Proteome Res. 2007 6(1):171-9.
PubMed: 17203961 DOI: 10.1021/pr060316r
33 Mulder J, WernÚrus H, Shi TJ, PontÚn F, Hober S, UhlÚn M, H÷kfelt T.
Systematically generated antibodies against human gene products: high throughput screening on sections from the rat nervous system.
Neuroscience. 2007 146(4):1689-703.
PubMed: 17478047 DOI: 10.1016/j.neuroscience.2007.02.054
32 Orchard S, Heck A, Uhlen M, Ping P.
Publication Committee meeting. HUPO 5th annual World Congress. Long Beach, CA, USA 30 October 2006.
Proteomics. 2007 7(7):1009-11.
PubMed: 17340644 DOI: 10.1002/pmic.200700015
31 Falk R, Ramstr÷m M, Stňhl S, Hober S.
Approaches for systematic proteome exploration.
Biomol Eng. 2007 24(2):155-68.
PubMed: 17376740 DOI: 10.1016/j.bioeng.2007.01.001
30 Str÷mberg S, Bj÷rklund MG, Asplund C, Sk÷llermo A, Persson A, Wester K, Kampf C, Nilsson P, Andersson AC, Uhlen M, Kononen J, Ponten F, Asplund A.
A high-throughput strategy for protein profiling in cell microarrays using automated image analysis.
Proteomics. 2007 7(13):2142-50.
PubMed: 17549799 DOI: 10.1002/pmic.200700199
29 Uhlen M.
Mapping the human proteome using antibodies
Mol Cell Proteomics 2007 6(8):1455-6.
PubMed: 17703056
28 Bengtsson S, Krogh M, Szigyarto CA, Uhlen M, Schedvins K, Silfverswńrd C, Linder S, Auer G, Alaiya A, James P.
Large-scale proteomics analysis of human ovarian cancer for biomarkers.
J Proteome Res. 2007 6(4):1440-50.
PubMed: 17315909 DOI: 10.1021/pr060593y
27 Lofblom J, Kronqvist N, Uhlen M, Stahl S, Wernerus H.
Optimization of electroporation-mediated transformation: Staphylococcus carnosus as model organism.
J Appl Microbiol 2007 102(3):736-47.
PubMed: 17309623 DOI: 10.1111/j.1365-2672.2006.03127.x
26 Lerner M, Corcoran M, Cepeda D, Nielsen ML, Zubarev R, PontÚn F, UhlÚn M, Hober S, GrandÚr D, Sangfelt O.
The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD.
Mol Biol Cell. 2007 18(5):1670-82.
PubMed: 17314412 DOI: 10.1091/mbc.E06-03-0248
25 Lundberg E, Sundberg M, Grńslund T, UhlÚn M, Svahn HA.
A novel method for reproducible fluorescent labeling of small amounts of antibodies on solid phase.
J Immunol Methods. 2007 322(1-2):40-9.
PubMed: 17383674 DOI: 10.1016/j.jim.2007.01.023
24 Patrakka J, Xiao Z, Nukui M, Takemoto M, He L, Oddsson A, Perisic L, Kaukinen A, Szigyarto CA, UhlÚn M, Jalanko H, Betsholtz C, Tryggvason K.
Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik.
J Am Soc Nephrol. 2007 18(3):689-97.
PubMed: 17251388 DOI: 10.1681/ASN.2006060675
23 Taussig MJ, Stoevesandt O, Borrebaeck CA, Bradbury AR, Cahill D, Cambillau C, de Daruvar A, Dubel S, Eichler J, Frank R, Gibson TJ, Gloriam D, Gold L, Herberg FW, Hermjakob H, Hoheisel JD, Joos TO, Kallioniemi O, Koegll M, Konthur Z, Korn B, Kremmer E, Krobitsch S, Landegren U, van der Maarel S, McCafferty J, Muyldermans S, Nygren PA, Palcy S, Pluckthun A, Polic B, Przybylski M, Saviranta P, Sawyer A, Sherman DJ, Skerra A, Templin M, Ueffing M, Uhlen M.
ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome.
Nature Methods 2007 4(1):13-7.
PubMed: 17195019 DOI: 10.1038/nmeth0107-13
22 Schwenk JM, Lindberg J, Sundberg M, UhlÚn M, Nilsson P.
Determination of binding specificities in highly multiplexed bead-based assays for antibody proteomics.
Mol Cell Proteomics. 2007 6(1):125-32.
PubMed: 17060675 DOI: 10.1074/mcp.T600035-MCP200
21 S÷derberg O, Gullberg M, Jarvius M, Ridderstrňle K, Leuchowius KJ, Jarvius J, Wester K, Hydbring P, Bahram F, Larsson LG, Landegren U.
Direct observation of individual endogenous protein complexes in situ by proximity ligation.
Nat Methods. 2006 3(12):995-1000.
PubMed: 17072308 DOI: 10.1038/nmeth947
20 Steen J, UhlÚn M, Hober S, Ottosson J.
High-throughput protein purification using an automated set-up for high-yield affinity chromatography.
Protein Expr Purif. 2006 46(2):173-8.
PubMed: 16483795 DOI: 10.1016/j.pep.2005.12.010
19 Andrade J, Berglund L, UhlÚn M, Odeberg J.
Using Grid technology for computationally intensive applied bioinformatics analyses.
In Silico Biol. 2006 6(6):495-504.
PubMed: 17518760
18 Persson A, Hober S, UhlÚn M.
A human protein atlas based on antibody proteomics.
Curr Opin Mol Ther. 2006 8(3):185-90.
PubMed: 16774037
17 Ek S, AndrÚasson U, Hober S, Kampf C, PontÚn F, UhlÚn M, Merz H, Borrebaeck CA.
From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies.
Mol Cell Proteomics. 2006 5(6):1072-81.
PubMed: 16524965 DOI: 10.1074/mcp.M600077-MCP200
16 Eriksson C, Agaton C, Kňnge R, Sundberg M, Nilsson P, Ek B, UhlÚn M, Gustafsson M, Hober S.
Microfluidic analysis of antibody specificity in a compact disk format.
J Proteome Res. 2006 5(7):1568-74.
PubMed: 16823963 DOI: 10.1021/pr050447c
15 Haab BB, Paulovich AG, Anderson NL, Clark AM, Downing GJ, Hermjakob H, Labaer J, Uhlen M.
A reagent resource to identify proteins and peptides of interest for the cancer community: a workshop report.
Mol Cell Proteomics. 2006 5(10):1996-2007.
PubMed: 16867976 DOI: 10.1074/mcp.T600020-MCP200
14 Larsson K, Wester K, Nilsson P, UhlÚn M, Hober S, WernÚrus H.
Multiplexed PrEST immunization for high-throughput affinity proteomics.
J Immunol Methods. 2006 315(1-2):110-20.
PubMed: 16949094 DOI: 10.1016/j.jim.2006.07.014
13 Andersson AC, Str÷mberg S, Bńckvall H, Kampf C, Uhlen M, Wester K, PontÚn F.
Analysis of protein expression in cell microarrays: a tool for antibody-based proteomics.
J Histochem Cytochem. 2006 54(12):1413-23.
PubMed: 16957166 DOI: 10.1369/jhc.6A7001.2006
12 Rada-Iglesias A, Wallerman O, Koch C, Ameur A, Enroth S, Clelland G, Wester K, Wilcox S, Dovey OM, Ellis PD, Wraight VL, James K, Andrews R, Langford C, Dhami P, Carter N, Vetrie D, PontÚn F, Komorowski J, Dunham I, Wadelius C.
Binding sites for metabolic disease related transcription factors inferred at base pair resolution by chromatin immunoprecipitation and genomic microarrays.
Hum Mol Genet. 2005 14(22):3435-47.
PubMed: 16221759 DOI: 10.1093/hmg/ddi378
11 Janzi M, Odling J, Pan-Hammarstr÷m Q, Sundberg M, Lundeberg J, UhlÚn M, Hammarstr÷m L, Nilsson P.
Serum microarrays for large scale screening of protein levels.
Mol Cell Proteomics. 2005 4(12):1942-7.
PubMed: 16131484 DOI: 10.1074/mcp.M500213-MCP200
10 Nilsson P, Paavilainen L, Larsson K, Odling J, Sundberg M, Andersson AC, Kampf C, Persson A, Al-Khalili Szigyarto C, Ottosson J, Bj÷rling E, Hober S, WernÚrus H, Wester K, PontÚn F, Uhlen M.
Towards a human proteome atlas: high-throughput generation of mono-specific antibodies for tissue profiling.
Proteomics. 2005 5(17):4327-37.
PubMed: 16237735 DOI: 10.1002/pmic.200500072
9 Hedhammar M, Stenvall M, L÷nneborg R, Nord O, Sj÷lin O, Brismar H, UhlÚn M, Ottosson J, Hober S.
A novel flow cytometry-based method for analysis of expression levels in Escherichia coli, giving information about precipitated and soluble protein.
J Biotechnol. 2005 119(2):133-46.
PubMed: 15996784 DOI: 10.1016/j.jbiotec.2005.03.024
8 Stenvall M, Steen J, UhlÚn M, Hober S, Ottosson J.
High-throughput solubility assay for purified recombinant protein immunogens.
Biochim Biophys Acta. 2005 1752(1):6-10.
PubMed: 16084133 DOI: 10.1016/j.bbapap.2005.07.002
7 UhlÚn M, Bj÷rling E, Agaton C, Szigyarto CA, Amini B, Andersen E, Andersson AC, Angelidou P, Asplund A, Asplund C, Berglund L, Bergstr÷m K, Brumer H, Cerjan D, Ekstr÷m M, Elobeid A, Eriksson C, Fagerberg L, Falk R, Fall J, Forsberg M, Bj÷rklund MG, Gumbel K, Halimi A, Hallin I, Hamsten C, Hansson M, Hedhammar M, Hercules G, Kampf C, Larsson K, Lindskog M, Lodewyckx W, Lund J, Lundeberg J, Magnusson K, Malm E, Nilsson P, Odling J, Oksvold P, Olsson I, Oster E, Ottosson J, Paavilainen L, Persson A, Rimini R, Rockberg J, Runeson M, Sivertsson A, Sk÷llermo A, Steen J, Stenvall M, Sterky F, Str÷mberg S, Sundberg M, Tegel H, Tourle S, Wahlund E, WaldÚn A, Wan J, WernÚrus H, Westberg J, Wester K, Wrethagen U, Xu LL, Hober S, PontÚn F.
A human protein atlas for normal and cancer tissues based on antibody proteomics.
Mol Cell Proteomics. 2005 4(12):1920-32.
PubMed: 16127175 DOI: 10.1074/mcp.M500279-MCP200
6 Lindskog M, Rockberg J, Uhlen M, Sterky F.
Selection of protein epitopes for antibody production
Biotechniques 2005 38(5):723-7.
PubMed: 15945371
5 Uhlen M, Ponten F.
Antibody-based proteomics for human tissue profiling.
Mol Cell Proteomics. 2005 4(4):384-93.
PubMed: 15695805 DOI: 10.1074/mcp.R500009-MCP200
4 Kampf C, Andersson A-C, Wester K, Bj÷rling E, Uhlen M, Ponten F
Antibody-based tissue profiling as a tool in clinical proteomics
Clin. Proteomics 2004 1(3-4):285-300.
DOI: 10.1385/CP:1:3-4:285
3 Agaton C, UhlÚn M, Hober S.
Genome-based proteomics.
Electrophoresis. 2004 25(9):1280-8.
PubMed: 15174050 DOI: 10.1002/elps.200405846
2 Agaton C, Falk R, Hoiden Guthenberg I, Gostring L, Uhlen M, Hober S.
Selective enrichment of monospecific polyclonal antibodies for antibody-based proteomics efforts.
J Chromatogr A 2004 16;1043(1):33-40.
PubMed: 15317410
1 Agaton C, Galli J, H÷idÚn Guthenberg I, Janzon L, Hansson M, Asplund A, Brundell E, Lindberg S, Ruthberg I, Wester K, Wurtz D, H÷÷g C, Lundeberg J, Stňhl S, PontÚn F, UhlÚn M.
Affinity proteomics for systematic protein profiling of chromosome 21 gene products in human tissues.
Mol Cell Proteomics. 2003 2(6):405-14.
PubMed: 12796447 DOI: 10.1074/mcp.M300022-MCP200