Citing the Human Protein Atlas

To cite us, please use:

The Human Protein Atlas

Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, Olsson I, Edlund K, Lundberg E, Navani S, Szigyarto CA, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist PH, Berling H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, Persson L, Johansson F, Zwahlen M, von Heijne G, Nielsen J, Pontén F.
Tissue-based map of the human proteome.
Science 2015 347(6220):1260419.
PubMed: 25613900 DOI: 10.1126/science.1260419

Brain

Sjöstedt E, Zhong W, Fagerberg L, Karlsson M, Mitsios N, Adori C, Oksvold P, Edfors F, Limiszewska A, Hikmet F, Huang J, Du Y, Lin L, Dong Z, Yang L, Liu X, Jiang H, Xu X, Wang J, Yang H, Bolund L, Mardinoglu A, Zhang C, von Feilitzen K, Lindskog C, Pontén F, Luo Y, Hökfelt T, Uhlén M, Mulder J.
An atlas of the protein-coding genes in the human, pig, and mouse brain.
Science. 2020 367(6482)
PubMed: 32139519 DOI: 10.1126/science.aay5947

Single Cell Type

Karlsson M, Zhang C, Méar L, Zhong W, Digre A, Katona B, Sjöstedt E, Butler L, Odeberg J, Dusart P, Edfors F, Oksvold P, von Feilitzen K, Zwahlen M, Arif M, Altay O, Li X, Ozcan M, Mardinoglu A, Fagerberg L, Mulder J, Luo Y, Ponten F, Uhlén M, Lindskog C.
A single-cell type transcriptomics map of human tissues.
Sci Adv. 2021 7(31):.
PubMed: 34321199 DOI: 10.1126/sciadv.abh2169

Pathology / Cancer

Uhlen M, Zhang C, Lee S, Sjöstedt E, Fagerberg L, Bidkhori G, Benfeitas R, Arif M, Liu Z, Edfors F, Sanli K, von Feilitzen K, Oksvold P, Lundberg E, Hober S, Nilsson P, Mattsson J, Schwenk JM, Brunnström H, Glimelius B, Sjöblom T, Edqvist PH, Djureinovic D, Micke P, Lindskog C, Mardinoglu A, Ponten F.
A pathology atlas of the human cancer transcriptome.
Science. 2017 357(6352)
PubMed: 28818916 DOI: 10.1126/science.aan2507

Immune Cells

Uhlen M, Karlsson MJ, Zhong W, Tebani A, Pou C, Mikes J, Lakshmikanth T, Forsström B, Edfors F, Odeberg J, Mardinoglu A, Zhang C, von Feilitzen K, Mulder J, Sjöstedt E, Hober A, Oksvold P, Zwahlen M, Ponten F, Lindskog C, Sivertsson Å, Fagerberg L, Brodin P.
A genome-wide transcriptomic analysis of protein-coding genes in human blood cells.
Science. 2019 366(6472)
PubMed: 31857451 DOI: 10.1126/science.aax9198

Human Secretome

Uhlén M, Karlsson MJ, Hober A, Svensson AS, Scheffel J, Kotol D, Zhong W, Tebani A, Strandberg L, Edfors F, Sjöstedt E, Mulder J, Mardinoglu A, Berling A, Ekblad S, Dannemeyer M, Kanje S, Rockberg J, Lundqvist M, Malm M, Volk AL, Nilsson P, Månberg A, Dodig-Crnkovic T, Pin E, Zwahlen M, Oksvold P, von Feilitzen K, Häussler RS, Hong MG, Lindskog C, Ponten F, Katona B, Vuu J, Lindström E, Nielsen J, Robinson J, Ayoglu B, Mahdessian D, Sullivan D, Thul P, Danielsson F, Stadler C, Lundberg E, Bergström G, Gummesson A, Voldborg BG, Tegel H, Hober S, Forsström B, Schwenk JM, Fagerberg L, Sivertsson Å.
The human secretome.
Sci Signal. 2019 12(609)
PubMed: 31772123 DOI: 10.1126/scisignal.aaz0274 Free access: Abstract, Full text, Reprint

Subcellular

Thul PJ, Åkesson L, Wiking M, Mahdessian D, Geladaki A, Ait Blal H, Alm T, Asplund A, Björk L, Breckels LM, Bäckström A, Danielsson F, Fagerberg L, Fall J, Gatto L, Gnann C, Hober S, Hjelmare M, Johansson F, Lee S, Lindskog C, Mulder J, Mulvey CM, Nilsson P, Oksvold P, Rockberg J, Schutten R, Schwenk JM, Sivertsson Å, Sjöstedt E, Skogs M, Stadler C, Sullivan DP, Tegel H, Winsnes C, Zhang C, Zwahlen M, Mardinoglu A, Pontén F, von Feilitzen K, Lilley KS, Uhlén M, Lundberg E.
A subcellular map of the human proteome.
Science. 2017 356(6340): eaal3321
PubMed: 28495876 DOI: 10.1126/science.aal3321 Free access: Abstract, Full text, Reprint

The original Human Protein Atlas publication

Uhlén M, Björling E, Agaton C, Szigyarto CA, Amini B, Andersen E, Andersson AC, Angelidou P, Asplund A, Asplund C, Berglund L, Bergström K, Brumer H, Cerjan D, Ekström M, Elobeid A, Eriksson C, Fagerberg L, Falk R, Fall J, Forsberg M, Björklund MG, Gumbel K, Halimi A, Hallin I, Hamsten C, Hansson M, Hedhammar M, Hercules G, Kampf C, Larsson K, Lindskog M, Lodewyckx W, Lund J, Lundeberg J, Magnusson K, Malm E, Nilsson P, Odling J, Oksvold P, Olsson I, Oster E, Ottosson J, Paavilainen L, Persson A, Rimini R, Rockberg J, Runeson M, Sivertsson A, Sköllermo A, Steen J, Stenvall M, Sterky F, Strömberg S, Sundberg M, Tegel H, Tourle S, Wahlund E, Waldén A, Wan J, Wernérus H, Westberg J, Wester K, Wrethagen U, Xu LL, Hober S, Pontén F.
A human protein atlas for normal and cancer tissues based on antibody proteomics.
Mol Cell Proteomics. 2005 4(12):1920-32.
PubMed: 16127175 DOI: 10.1074/mcp.M500279-MCP200

Publications

883 Hikmet F, Rassy M, Backman M, Méar L, Mattsson JSM, Djureinovic D, Botling J, Brunnström H, Micke P, Lindskog C.
Expression of cancer-testis antigens in the immune microenvironment of non-small cell lung cancer.
Mol Oncol. 2023 Epub ahead of print
PubMed: 37341056 DOI: 10.1002/1878-0261.13474
882 Dénes A, Bontell TO, Barchéus H, Vega SF, Carén H, Lindskog C, Jakola AS, Smits A.
The clinical value of proneural, classical and mesenchymal protein signatures in WHO 2021 adult-type diffuse lower-grade gliomas.
PLoS One. 2023 18(5):e0285732.
PubMed: 37192181 DOI: 10.1371/journal.pone.0285732
881 Sountoulidis A, Marco Salas S, Braun E, Avenel C, Bergenstråhle J, Theelke J, Vicari M, Czarnewski P, Liontos A, Abalo X, Andrusivová Ž, Mirzazadeh R, Asp M, Li X, Hu L, Sariyar S, Martinez Casals A, Ayoglu B, Firsova A, Michaëlsson J, Lundberg E, Wählby C, Sundström E, Linnarsson S, Lundeberg J, Nilsson M, Samakovlis C.
A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung.
Nat Cell Biol. 2023 25(2):351-365.
PubMed: 36646791 DOI: 10.1038/s41556-022-01064-x
880 Rossi R, Johansson C, Heywood W, Vinette H, Jensen G, Tegel H, Jiménez-Requena A, Torelli S, Al-Khalili Szigyarto C, Ferlini A.
A Proof of Principle Proteomic Study Detects Dystrophin in Human Plasma: Implications in DMD Diagnosis and Clinical Monitoring.
Int J Mol Sci. 2023 24(6):.
PubMed: 36982290 DOI: 10.3390/ijms24065215
879 Hober A, Rekanovic M, Forsström B, Hansson S, Kotol D, Percy AJ, Uhlén M, Oscarsson J, Edfors F, Miliotis T.
Targeted proteomics using stable isotope labeled protein fragments enables precise and robust determination of total apolipoprotein(a) in human plasma.
PLoS One. 2023 18(2):e0281772.
PubMed: 36791076 DOI: 10.1371/journal.pone.0281772
878 Edfeldt G, Kaldhusdal V, Czarnewski P, Bradley F, Bergström S, Lajoie J, Xu J, Månberg A, Kimani J, Oyugi J, Nilsson P, Tjernlund A, Fowke KR, Kwon DS, Broliden K.
Distinct cervical tissue-adherent and luminal microbiome communities correlate with mucosal host gene expression and protein levels in Kenyan sex workers.
Microbiome. 2023 11(1):67.
PubMed: 37004130 DOI: 10.1186/s40168-023-01502-4
877 Geroldinger-Simić M, Bayati S, Pohjanen E, Sepp N, Nilsson P, Pin E.
Autoantibodies against PIP4K2B and AKT3 Are Associated with Skin and Lung Fibrosis in Patients with Systemic Sclerosis.
Int J Mol Sci. 2023 24(6):.
PubMed: 36982700 DOI: 10.3390/ijms24065629
876 Hauser J, Dale M, Beck O, Schwenk JM, Stemme G, Fredolini C, Roxhed N.
Microfluidic Device for Patient-Centric Multiplexed Assays with Readout in Centralized Laboratories.
Anal Chem. 2023 95(2):1350-1358.
PubMed: 36548393 DOI: 10.1021/acs.analchem.2c04318
875 Allesøe RL, Lundgaard AT, Hernández Medina R, Aguayo-Orozco A, Johansen J, Nissen JN, Brorsson C, Mazzoni G, Niu L, Biel JH, Leal Rodríguez C, Brasas V, Webel H, Benros ME, Pedersen AG, Chmura PJ, Jacobsen UP, Mari A, Koivula R, Mahajan A, Vinuela A, Tajes JF, Sharma S, Haid M, Hong MG, Musholt PB, De Masi F, Vogt J, Pedersen HK, Gudmundsdottir V, Jones A, Kennedy G, Bell J, Thomas EL, Frost G, Thomsen H, Hansen E, Hansen TH, Vestergaard H, Muilwijk M, Blom MT, 't Hart LM, Pattou F, Raverdy V, Brage S, Kokkola T, Heggie A, McEvoy D, Mourby M, Kaye J, Hattersley A, McDonald T, Ridderstråle M, Walker M, Forgie I, Giordano GN, Pavo I, Ruetten H, Pedersen O, Hansen T, Dermitzakis E, Franks PW, Schwenk JM, Adamski J, McCarthy MI, Pearson E, Banasik K, Rasmussen S, Brunak S, IMI DIRECT Consortium.
Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models.
Nat Biotechnol. 2023 41(3):399-408.
PubMed: 36593394 DOI: 10.1038/s41587-022-01520-x
874 Ribet F, Bendes A, Fredolini C, Dobielewski M, Böttcher M, Beck O, Schwenk JM, Stemme G, Roxhed N.
Microneedle Patch for Painless Intradermal Collection of Interstitial Fluid Enabling Multianalyte Measurement of Small Molecules, SARS-CoV-2 Antibodies, and Protein Profiling.
Adv Healthc Mater. 2023 12(13):e2202564.
PubMed: 36748807 DOI: 10.1002/adhm.202202564
873 Kotliar IB, Lorenzen E, Schwenk JM, Hay DL, Sakmar TP.
Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins.
Pharmacol Rev. 2023 75(1):1-34.
PubMed: 36757898 DOI: 10.1124/pharmrev.120.000180
872 Kotliar IB, Ceraudo E, Kemelmakher-Liben K, Oren DA, Lorenzen E, Dodig-Crnković T, Horioka-Duplix M, Huber T, Schwenk JM, Sakmar TP.
Itch receptor MRGPRX4 interacts with the receptor activity-modifying proteins.
J Biol Chem. 2023 299(5):104664.
PubMed: 37003505 DOI: 10.1016/j.jbc.2023.104664
871 Zenlander R, Fredolini C, Schwenk JM, Rydén I, Påhlsson P, Löwbeer C, Eggertsen G, Stål P.
A wide scan of plasma proteins demonstrates thioredoxin reductase 1 as a potential new diagnostic biomarker for hepatocellular carcinoma.
Scand J Gastroenterol. 2023 ():1-11.
PubMed: 37017178 DOI: 10.1080/00365521.2023.2194008
870 Sendic S, Mansouri L, Hong MG, Schwenk JM, Eriksson MJ, Hylander B, Lundahl J, Jacobson SH.
Soluble CD14 and osteoprotegerin associate with ankle-brachial index as a measure of arterial stiffness in patients with mild to moderate chronic kidney disease in a five-year prospective study.
Cardiorenal Med. 2023 ():1.
PubMed: 37231818 DOI: 10.1159/000530985
869 Iglesias MJ, Sanchez-Rivera L, Ibrahim-Kosta M, Naudin C, Munsch G, Goumidi L, Farm M, Smith PM, Thibord F, Kral-Pointner JB, Hong MG, Suchon P, Germain M, Schottmaier W, Dusart P, Boland A, Kotol D, Edfors F, Koprulu M, Pietzner M, Langenberg C, Damrauer SM, Johnson AD, Klarin DM, Smith NL, Smadja DM, Holmström M, Magnusson M, Silveira A, Uhlén M, Renné T, Martinez-Perez A, Emmerich J, Deleuze JF, Antovic J, Soria Fernandez JM, Assinger A, Schwenk JM, Souto Andres JC, Morange PE, Butler LM, Trégouët DA, Odeberg J.
Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism.
Nat Commun. 2023 14(1):3280.
PubMed: 37286573 DOI: 10.1038/s41467-023-38383-y
868 Dahl L, Kotliar IB, Bendes A, Dodig-Crnković T, Fromm S, Elofsson A, Uhlén M, Sakmar TP, Schwenk JM.
Multiplexed selectivity screening of anti-GPCR antibodies.
Sci Adv. 2023 9(18):eadf9297.
PubMed: 37134173 DOI: 10.1126/sciadv.adf9297
867 Digre A, Lindskog C.
The human protein atlas-Integrated omics for single cell mapping of the human proteome.
Protein Sci. 2023 32(2):e4562.
PubMed: 36604173 DOI: 10.1002/pro.4562
866 Battisti UM, Gao C, Nilsson O, Akladios F, Lulla A, Bogucka A, Nain-Perez A, Håversen L, Kim W, Boren J, Hyvönen M, Uhlen M, Mardinoglu A, Grøtli M.
Serendipitous Identification of a Covalent Activator of Liver Pyruvate Kinase.
Chembiochem. 2023 24(1):e202200339.
PubMed: 36250581 DOI: 10.1002/cbic.202200339
865 Battisti UM, Gao C, Akladios F, Kim W, Yang H, Bayram C, Bolat I, Kiliclioglu M, Yuksel N, Tozlu OO, Zhang C, Sebhaoui J, Iqbal S, Shoaie S, Hacimuftuoglu A, Yildirim S, Turkez H, Uhlen M, Boren J, Mardinoglu A, Grøtli M.
Ellagic Acid and Its Metabolites as Potent and Selective Allosteric Inhibitors of Liver Pyruvate Kinase.
Nutrients. 2023 15(3):.
PubMed: 36771285 DOI: 10.3390/nu15030577
864 Turkez H, Altay O, Yildirim S, Li X, Yang H, Bayram C, Bolat I, Oner S, Tozlu OO, Arslan ME, Arif M, Yulug B, Hanoglu L, Cankaya S, Lam S, Velioglu HA, Coskun E, Idil E, Nogaylar R, Ozsimsek A, Hacimuftuoglu A, Shoaie S, Zhang C, Nielsen J, Borén J, Uhlén M, Mardinoglu A.
Combined metabolic activators improve metabolic functions in the animal models of neurodegenerative diseases.
Life Sci. 2023 314():121325.
PubMed: 36581096 DOI: 10.1016/j.lfs.2022.121325
863 Arslan ME, Türkez H, Sevim Y, Selvitopi H, Kadi A, Öner S, Mardinoğlu A.
Costunolide and Parthenolide Ameliorate MPP+ Induced Apoptosis in the Cellular Parkinson's Disease Model.
Cells. 2023 12(7):.
PubMed: 37048065 DOI: 10.3390/cells12070992
862 Rutten MGS, Lei Y, Hoogerland JH, Bloks VW, Yang H, Bos T, Krishnamurthy KA, Bleeker A, Koster MH, Thomas RE, Wolters JC, van den Bos H, Mithieux G, Rajas F, Mardinoglu A, Spierings DCJ, de Bruin A, van de Sluis B, Oosterveer MH.
Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia.
Cancer Metab. 2023 11(1):5.
PubMed: 37085901 DOI: 10.1186/s40170-023-00305-3
861 Battisti UM, Monjas L, Akladios F, Matic J, Andresen E, Nagel CH, Hagkvist M, Håversen L, Kim W, Uhlen M, Borén J, Mardinoğlu A, Grøtli M.
Exploration of Novel Urolithin C Derivatives as Non-Competitive Inhibitors of Liver Pyruvate Kinase.
Pharmaceuticals (Basel). 2023 16(5):.
PubMed: 37242451 DOI: 10.3390/ph16050668
860 Graves OK, Kim W, Özcan M, Ashraf S, Turkez H, Yuan M, Zhang C, Mardinoglu A, Li X.
Discovery of drug targets and therapeutic agents based on drug repositioning to treat lung adenocarcinoma.
Biomed Pharmacother. 2023 161():114486.
PubMed: 36906970 DOI: 10.1016/j.biopha.2023.114486
859 Bayraktar A, Li X, Kim W, Zhang C, Turkez H, Shoaie S, Mardinoglu A.
Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer's disease patients.
J Transl Med. 2023 21(1):332.
PubMed: 37210557 DOI: 10.1186/s12967-023-04192-6
858 Yang H, Li X, Jin H, Turkez H, Ozturk G, Doganay HL, Zhang C, Nielsen J, Uhlén M, Borén J, Mardinoglu A.
Longitudinal metabolomics analysis reveals the acute effect of cysteine and NAC included in the combined metabolic activators.
Free Radic Biol Med. 2023 204():347-358.
PubMed: 37245532 DOI: 10.1016/j.freeradbiomed.2023.05.013
857 Li X, Yang H, Jin H, Turkez H, Ozturk G, Doganay HL, Zhang C, Nielsen J, Uhlén M, Borén J, Mardinoglu A.
The acute effect of different NAD precursors included in the combined metabolic activators.
Free Radic Biol Med. 2023 205():77-89.
PubMed: 37271226 DOI: 10.1016/j.freeradbiomed.2023.05.032
856 Yulug B, Altay O, Li X, Hanoglu L, Cankaya S, Lam S, Velioglu HA, Yang H, Coskun E, Idil E, Nogaylar R, Ozsimsek A, Bayram C, Bolat I, Oner S, Tozlu OO, Arslan ME, Hacimuftuoglu A, Yildirim S, Arif M, Shoaie S, Zhang C, Nielsen J, Turkez H, Borén J, Uhlén M, Mardinoglu A.
Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: a randomised, double-blinded, placebo-controlled phase-II trial.
Transl Neurodegener. 2023 12(1):4.
PubMed: 36703196 DOI: 10.1186/s40035-023-00336-2
855 Omenn GS, Lane L, Overall CM, Pineau C, Packer NH, Cristea IM, Lindskog C, Weintraub ST, Orchard S, Roehrl MHA, Nice E, Liu S, Bandeira N, Chen YJ, Guo T, Aebersold R, Moritz RL, Deutsch EW.
The 2022 Report on the Human Proteome from the HUPO Human Proteome Project.
J Proteome Res. 2023 22(4):1024-1042.
PubMed: 36318223 DOI: 10.1021/acs.jproteome.2c00498
854 Méar L, Sutantiwanichkul T, Östman J, Damdimopoulou P, Lindskog C.
Spatial Proteomics for Further Exploration of Missing Proteins: A Case Study of the Ovary.
J Proteome Res. 2023 22(4):1071-1079.
PubMed: 36108145 DOI: 10.1021/acs.jproteome.2c00392
853 Gilvesy A, Husen E, Magloczky Z, Mihaly O, Hortobágyi T, Kanatani S, Heinsen H, Renier N, Hökfelt T, Mulder J, Uhlen M, Kovacs GG, Adori C.
Spatiotemporal characterization of cellular tau pathology in the human locus coeruleus-pericoerulear complex by three-dimensional imaging.
Acta Neuropathol. 2022 144(4):651-676.
PubMed: 36040521 DOI: 10.1007/s00401-022-02477-6
852 Kovács T, Szinyákovics J, Billes V, Murányi G, Varga VB, Bjelik A, Légrádi Á, Szabó M, Sándor S, Kubinyi E, Szekeres-Paracky C, Szocsics P, Lőke J, Mulder J, Gulyás B, Renner É, Palkovits M, Gulya K, Maglóczky Z, Vellai T.
A conserved MTMR lipid phosphatase increasingly suppresses autophagy in brain neurons during aging.
Sci Rep. 2022 12(1):21817.
PubMed: 36528685 DOI: 10.1038/s41598-022-24843-w
851 Arslan ME, Tatar A, Yıldırım ÖÇ, Şahin İO, Ozdemir O, Sonmez E, Hacımuftuoglu A, Acikyildiz M, Geyikoğlu F, Mardinoğlu A, Türkez H.
In Vitro Transcriptome Analysis of Cobalt Boride Nanoparticles on Human Pulmonary Alveolar Cells.
Materials (Basel). 2022 15(23):.
PubMed: 36500178 DOI: 10.3390/ma15238683
850 Türkez H, Yıldırım ÖÇ, Öner S, Kadı A, Mete A, Arslan ME, Şahin İO, Yapça ÖE, Mardinoğlu A.
Lipoic Acid Conjugated Boron Hybrids Enhance Wound Healing and Antimicrobial Processes.
Pharmaceutics. 2022 15(1):.
PubMed: 36678778 DOI: 10.3390/pharmaceutics15010149
849 Liu Z, Xu J, Que S, Geng L, Zhou L, Mardinoglu A, Zheng S.
Recent Progress and Future Direction for the Application of Multiomics Data in Clinical Liver Transplantation.
J Clin Transl Hepatol. 2022 10(2):363-373.
PubMed: 35528975 DOI: 10.14218/JCTH.2021.00219
848 Nain-Perez A, Foller Füchtbauer A, Håversen L, Lulla A, Gao C, Matic J, Monjas L, Rodríguez A, Brear P, Kim W, Hyvönen M, Borén J, Mardinoglu A, Uhlen M, Grøtli M.
Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase.
Eur J Med Chem. 2022 234():114270.
PubMed: 35290845 DOI: 10.1016/j.ejmech.2022.114270
847 Kori M, Arga KY, Mardinoglu A, Turanli B.
Repositioning of Anti-Inflammatory Drugs for the Treatment of Cervical Cancer Sub-Types.
Front Pharmacol. 2022 13():884548.
PubMed: 35770086 DOI: 10.3389/fphar.2022.884548
846 Emanuelsson EB, Berry DB, Reitzner SM, Arif M, Mardinoglu A, Gustafsson T, Ward SR, Sundberg CJ, Chapman MA.
MRI characterization of skeletal muscle size and fatty infiltration in long-term trained and untrained individuals.
Physiol Rep. 2022 10(14):e15398.
PubMed: 35854646 DOI: 10.14814/phy2.15398
845 Yıldırım ÖÇ, Arslan ME, Öner S, Cacciatore I, Di Stefano A, Mardinoglu A, Turkez H.
Boron Nitride Nanoparticles Loaded with a Boron-Based Hybrid as a Promising Drug Carrier System for Alzheimer's Disease Treatment.
Int J Mol Sci. 2022 23(15):.
PubMed: 35897815 DOI: 10.3390/ijms23158249
844 Turkez H, Yıldırım S, Sahin E, Arslan ME, Emsen B, Tozlu OO, Alak G, Ucar A, Tatar A, Hacimuftuoglu A, Keles MS, Geyikoglu F, Atamanalp M, Saruhan F, Mardinoglu A.
Boron Compounds Exhibit Protective Effects against Aluminum-Induced Neurotoxicity and Genotoxicity: In Vitro and In Vivo Study.
Toxics. 2022 10(8):.
PubMed: 36006107 DOI: 10.3390/toxics10080428
843 Baboota RK, Rawshani A, Bonnet L, Li X, Yang H, Mardinoglu A, Tchkonia T, Kirkland JL, Hoffmann A, Dietrich A, Boucher J, Blüher M, Smith U.
BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of NAFLD/NASH.
Nat Metab. 2022 4(8):1007-1021.
PubMed: 35995996 DOI: 10.1038/s42255-022-00620-x
842 Aydin N, Turkez H, Tozlu OO, Arslan ME, Yavuz M, Sonmez E, Ozpolat OF, Cacciatore I, Di Stefano A, Mardinoglu A.
Ameliorative Effects by Hexagonal Boron Nitride Nanoparticles against Beta Amyloid Induced Neurotoxicity.
Nanomaterials (Basel). 2022 12(15):.
PubMed: 35957121 DOI: 10.3390/nano12152690
841 Tozlu ÖÖ, Türkez H, Okkay U, Ceylan O, Bayram C, Hacımüftüoğlu A, Mardinoğlu A.
Assessment of the neuroprotective potential of d-cycloserine and l-serine in aluminum chloride-induced experimental models of Alzheimer's disease: and studies.
Front Nutr. 2022 9():981889.
PubMed: 36159454 DOI: 10.3389/fnut.2022.981889
840 Zhang C, Shi M, Kim W, Arif M, Klevstig M, Li X, Yang H, Bayram C, Bolat I, Tozlu ÖÖ, Hacımuftuoglu A, Yıldırım S, Sebhaoui J, Iqbal S, Wei Y, Shi X, Nielsen J, Turkez H, Uhlen M, Boren J, Mardinoglu A.
Discovery of therapeutic agents targeting PKLR for NAFLD using drug repositioning.
EBioMedicine. 2022 83():104214.
PubMed: 35988463 DOI: 10.1016/j.ebiom.2022.104214
839 Turkez H, Arslan ME, Barboza JN, Kahraman CY, de Sousa DP, Mardinoğlu A.
Therapeutic Potential of Ferulic Acid in Alzheimer's Disease.
Curr Drug Deliv. 2022 19(8):860-873.
PubMed: 34963433 DOI: 10.2174/1567201819666211228153801
838 Baboota RK, Spinelli R, Erlandsson MC, Brandao BB, Lino M, Yang H, Mardinoglu A, Bokarewa MI, Boucher J, Kahn CR, Smith U.
Chronic hyperinsulinemia promotes human hepatocyte senescence.
Mol Metab. 2022 64():101558.
PubMed: 35872305 DOI: 10.1016/j.molmet.2022.101558
837 Turkez H, Ozdemir Tozlu O, Tatar A, Arslan ME, Cadirci K, Marinelli L, Yapca OE, Cacciatore I, Di Stefano A, Mardinoglu A.
Toxicity of Glycyl-l-Prolyl-l-Glutamate Pseudotripeptides: Cytotoxic, Oxidative, Genotoxic, and Embryotoxic Perspectives.
J Toxicol. 2022 2022():3775194.
PubMed: 36444193 DOI: 10.1155/2022/3775194
836 Cornacchia C, Marinelli L, Di Rienzo A, Dimmito MP, Serra F, Di Biase G, De Filippis B, Turkez H, Mardinoglu A, Bellezza I, Di Stefano A, Cacciatore I.
Development of l-Dopa-containing diketopiperazines as blood-brain barrier shuttle.
Eur J Med Chem. 2022 243():114746.
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835 Smati S, Polizzi A, Fougerat A, Ellero-Simatos S, Blum Y, Lippi Y, Régnier M, Laroyenne A, Huillet M, Arif M, Zhang C, Lasserre F, Marrot A, Al Saati T, Wan J, Sommer C, Naylies C, Batut A, Lukowicz C, Fougeray T, Tramunt B, Dubot P, Smith L, Bertrand-Michel J, Hennuyer N, Pradere JP, Staels B, Burcelin R, Lenfant F, Arnal JF, Levade T, Gamet-Payrastre L, Lagarrigue S, Loiseau N, Lotersztajn S, Postic C, Wahli W, Bureau C, Guillaume M, Mardinoglu A, Montagner A, Gourdy P, Guillou H.
Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target.
Gut. 2022 71(4):807-821.
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834 Sparreman Mikus M, Kolmert J, Andersson LI, Östling J, Knowles RG, Gómez C, Ericsson M, Thörngren JO, Emami Khoonsari P, Dahlén B, Kupczyk M, De Meulder B, Auffray C, Bakke PS, Beghe B, Bel EH, Caruso M, Chanez P, Chawes B, Fowler SJ, Gaga M, Geiser T, Gjomarkaj M, Horváth I, Howarth PH, Johnston SL, Joos G, Krug N, Montuschi P, Musial J, Niżankowska-Mogilnicka E, Olsson HK, Papi A, Rabe KF, Sandström T, Shaw DE, Siafakas NM, Uhlén M, Riley JH, Bates S, Middelveld RJM, Wheelock CE, Chung KF, Adcock IM, Sterk PJ, Djukanovic R, Nilsson P, Dahlén SE, James A, U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease outcome) Study Group and the BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway Disease) Consortium.
Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation.
Eur Respir J. 2022 59(2):.
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833 Blixt L, Bogdanovic G, Buggert M, Gao Y, Hober S, Healy K, Johansson H, Kjellander C, Mravinacova S, Muschiol S, Nilsson P, Palma M, Pin E, Smith CIE, Stromberg O, Sällberg Chen M, Zain R, Hansson L, Österborg A.
Covid-19 in patients with chronic lymphocytic leukemia: clinical outcome and B- and T-cell immunity during 13 months in consecutive patients.
Leukemia. 2022 36(2):476-481.
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832 Havervall S, Ng H, Jernbom Falk A, Greilert-Norin N, Månberg A, Marking U, Laurén I, Gabrielsson L, Salomonsson AC, Aguilera K, Kihlgren M, Månsson M, Rosell A, Hellström C, Andersson E, Olofsson J, Skoglund L, Yousef J, Pin E, Lord M, Åberg M, Hedhammar M, Tegel H, Dönnes P, Phillipson M, Nilsson P, Klingström J, Mangsbo S, Hober S, Thålin C.
Robust humoral and cellular immune responses and low risk for reinfection at least 8 months following asymptomatic to mild COVID-19.
J Intern Med. 2022 291(1):72-80.
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831 Asplund Högelin K, Ruffin N, Pin E, Hober S, Nilsson P, Starvaggi Cucuzza C, Khademi M, Olsson T, Piehl F, Al Nimer F.
B-cell repopulation dynamics and drug pharmacokinetics impact SARS-CoV-2 vaccine efficacy in anti-CD20-treated multiple sclerosis patients.
Eur J Neurol. 2022 29(11):3317-3328.
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830 Moffitt JR, Lundberg E, Heyn H.
The emerging landscape of spatial profiling technologies.
Nat Rev Genet. 2022 23(12):741-759.
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829 Blixt L, Gao Y, Wullimann D, Murén Ingelman-Sundberg H, Muschiol S, Healy K, Bogdanovic G, Pin E, Nilsson P, Kjellander C, Grifoni A, Sette A, Sällberg Chen M, Ljunggren HG, Buggert M, Hansson L, Österborg A.
Hybrid immunity in immunocompromised patients with CLL after SARS-CoV-2 infection followed by booster mRNA vaccination.
Blood. 2022 140(22):2403-2407.
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828 Yu X, Schwenk JM, Xu P, LaBaer J.
Advances in plasma proteomics: Moving from technology to precision medicine.
Proteomics Clin Appl. 2022 16(6):e2200083.
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827 Havervall S, Marking U, Svensson J, Greilert-Norin N, Bacchus P, Nilsson P, Hober S, Gordon M, Blom K, Klingström J, Åberg M, Smed-Sörensen A, Thålin C.
Anti-Spike Mucosal IgA Protection against SARS-CoV-2 Omicron Infection.
N Engl J Med. 2022 387(14):1333-1336.
PubMed: 36103621 DOI: 10.1056/NEJMc2209651
826 Gurke R, Bendes A, Bowes J, Koehm M, Twyman RM, Barton A, Elewaut D, Goodyear C, Hahnefeld L, Hillenbrand R, Hunter E, Ibberson M, Ioannidis V, Kugler S, Lories RJ, Resch E, Rüping S, Scholich K, Schwenk JM, Waddington JC, Whitfield P, Geisslinger G, FitzGerald O, Behrens F, Pennington SR, HIPPOCRATES Consortium.
Omics and Multi-Omics Analysis for the Early Identification and Improved Outcome of Patients with Psoriatic Arthritis.
Biomedicines. 2022 10(10):.
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825 Gyllensten U, Hedlund-Lindberg J, Svensson J, Manninen J, Öst T, Ramsell J, Åslin M, Ivansson E, Lomnytska M, Lycke M, Axelsson T, Liljedahl U, Nordlund J, Edqvist PH, Sjöblom T, Uhlén M, Stålberg K, Sundfeldt K, Åberg M, Enroth S.
Next Generation Plasma Proteomics Identifies High-Precision Biomarker Candidates for Ovarian Cancer.
Cancers (Basel). 2022 14(7):.
PubMed: 35406529 DOI: 10.3390/cancers14071757
824 Malm M, Kuo CC, Barzadd MM, Mebrahtu A, Wistbacka N, Razavi R, Volk AL, Lundqvist M, Kotol D, Tegel H, Hober S, Edfors F, Gräslund T, Chotteau V, Field R, Varley PG, Roth RG, Lewis NE, Hatton D, Rockberg J.
Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins.
Metab Eng. 2022 72():171-187.
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823 Danielsson H, Tebani A, Zhong W, Fagerberg L, Brusselaers N, Hård AL, Uhlén M, Hellström A.
Blood protein profiles related to preterm birth and retinopathy of prematurity.
Pediatr Res. 2022 91(4):937-946.
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822 Li X, Shong K, Kim W, Yuan M, Yang H, Sato Y, Kume H, Ogawa S, Turkez H, Shoaie S, Boren J, Nielsen J, Uhlen M, Zhang C, Mardinoglu A.
Prediction of drug candidates for clear cell renal cell carcinoma using a systems biology-based drug repositioning approach.
EBioMedicine. 2022 78():103963.
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821 Bergman-Larsson J, Gustafsson S, Méar L, Huvila J, Tolf A, Olovsson M, Pontén F, Edqvist PD.
Combined expression of HOXA11 and CD10 identifies endometriosis versus normal tissue and tumors.
Ann Diagn Pathol. 2022 56():151870.
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820 Karlsson M, Sjöstedt E, Oksvold P, Sivertsson Å, Huang J, Álvez MB, Arif M, Li X, Lin L, Yu J, Ma T, Xu F, Han P, Jiang H, Mardinoglu A, Zhang C, von Feilitzen K, Xu X, Wang J, Yang H, Bolund L, Zhong W, Fagerberg L, Lindskog C, Pontén F, Mulder J, Luo Y, Uhlen M.
Genome-wide annotation of protein-coding genes in pig.
BMC Biol. 2022 20(1):25.
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819 Birgersson M, Katona B, Lindskog C, Pontén F, Williams C.
Antibody Validation for Estrogen Receptor Beta.
Methods Mol Biol. 2022 2418():1-23.
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818 Vessby J, Wisniewski JR, Lindskog C, Eriksson N, Gabrysch K, Zettl K, Wanders A, Carlson M, Rorsman F, Åberg M.
AGPAT1 as a Novel Colonic Biomarker for Discriminating Between Ulcerative Colitis With and Without Primary Sclerosing Cholangitis.
Clin Transl Gastroenterol. 2022 13(5):e00486.
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817 Abdulla M, Hollander P, Lindskog C, Sundström C, Enblad G, Saft L, Amini RM.
Outcome in PCNSL patients and its association with PD-L1+ leukocytes in the tumor microenvironment.
Acta Oncol. 2022 61(7):824-829.
PubMed: 35621149 DOI: 10.1080/0284186X.2022.2075239
816 Corell A, Gómez Vecchio T, Ferreyra Vega S, Dénes A, Neimantaite A, Hagerius A, Barchéus H, Solheim O, Lindskog C, Bontell TO, Carén H, Jakola AS, Smits A.
Stemness and clinical features in relation to the subventricular zone in diffuse lower-grade glioma: an exploratory study.
Neurooncol Adv. 2022 4(1):vdac074.
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815 Norreen-Thorsen M, Struck EC, Öling S, Zwahlen M, Von Feilitzen K, Odeberg J, Lindskog C, Pontén F, Uhlén M, Dusart PJ, Butler LM.
A human adipose tissue cell-type transcriptome atlas.
Cell Rep. 2022 40(2):111046.
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814 Lindskog C, Méar L, Virhammar J, Fällmar D, Kumlien E, Hesselager G, Casar-Borota O, Rostami E.
Protein Expression Profile of ACE2 in the Normal and COVID-19-Affected Human Brain.
J Proteome Res. 2022 21(9):2137-2145.
PubMed: 35901083 DOI: 10.1021/acs.jproteome.2c00184
813 Yuan M, Shong K, Li X, Ashraf S, Shi M, Kim W, Nielsen J, Turkez H, Shoaie S, Uhlen M, Zhang C, Mardinoglu A.
A Gene Co-Expression Network-Based Drug Repositioning Approach Identifies Candidates for Treatment of Hepatocellular Carcinoma.
Cancers (Basel). 2022 14(6):.
PubMed: 35326724 DOI: 10.3390/cancers14061573
812 Edfors F, Iglesias MJ, Butler LM, Odeberg J.
Proteomics in thrombosis research.
Res Pract Thromb Haemost. 2022 6(3):e12706.
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811 Ambikan AT, Yang H, Krishnan S, Svensson Akusjärvi S, Gupta S, Lourda M, Sperk M, Arif M, Zhang C, Nordqvist H, Ponnan SM, Sönnerborg A, Treutiger CJ, O'Mahony L, Mardinoglu A, Benfeitas R, Neogi U.
Multi-omics personalized network analyses highlight progressive disruption of central metabolism associated with COVID-19 severity.
Cell Syst. 2022 13(8):665-681.e4.
PubMed: 35933992 DOI: 10.1016/j.cels.2022.06.006
810 Hickey JW, Neumann EK, Radtke AJ, Camarillo JM, Beuschel RT, Albanese A, McDonough E, Hatler J, Wiblin AE, Fisher J, Croteau J, Small EC, Sood A, Caprioli RM, Angelo RM, Nolan GP, Chung K, Hewitt SM, Germain RN, Spraggins JM, Lundberg E, Snyder MP, Kelleher NL, Saka SK.
Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging.
Nat Methods. 2022 19(3):284-295.
PubMed: 34811556 DOI: 10.1038/s41592-021-01316-y
809 Bagheri N, Carpenter AE, Lundberg E, Plant AL, Horwitz R.
The new era of quantitative cell imaging-challenges and opportunities.
Mol Cell. 2022 82(2):241-247.
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808 Melani RD, Gerbasi VR, Anderson LC, Sikora JW, Toby TK, Hutton JE, Butcher DS, Negrão F, Seckler HS, Srzentić K, Fornelli L, Camarillo JM, LeDuc RD, Cesnik AJ, Lundberg E, Greer JB, Fellers RT, Robey MT, DeHart CJ, Forte E, Hendrickson CL, Abbatiello SE, Thomas PM, Kokaji AI, Levitsky J, Kelleher NL.
The Blood Proteoform Atlas: A reference map of proteoforms in human hematopoietic cells.
Science. 2022 375(6579):411-418.
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807 Kustatscher G, Collins T, Gingras AC, Guo T, Hermjakob H, Ideker T, Lilley KS, Lundberg E, Marcotte EM, Ralser M, Rappsilber J.
An open invitation to the Understudied Proteins Initiative.
Nat Biotechnol. 2022 40(6):815-817.
PubMed: 35534555 DOI: 10.1038/s41587-022-01316-z
806 Mund A, Coscia F, Kriston A, Hollandi R, Kovács F, Brunner AD, Migh E, Schweizer L, Santos A, Bzorek M, Naimy S, Rahbek-Gjerdrum LM, Dyring-Andersen B, Bulkescher J, Lukas C, Eckert MA, Lengyel E, Gnann C, Lundberg E, Horvath P, Mann M.
Deep Visual Proteomics defines single-cell identity and heterogeneity.
Nat Biotechnol. 2022 40(8):1231-1240.
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805 Burnum-Johnson KE, Conrads TP, Drake RR, Herr AE, Iyengar R, Kelly RT, Lundberg E, MacCoss MJ, Naba A, Nolan GP, Pevzner PA, Rodland KD, Sechi S, Slavov N, Spraggins JM, Van Eyk JE, Vidal M, Vogel C, Walt DR, Kelleher NL.
New Views of Old Proteins: Clarifying the Enigmatic Proteome.
Mol Cell Proteomics. 2022 21(7):100254.
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804 Andrews B, Chang JB, Collinson L, Li D, Lundberg E, Mahamid J, Manley S, Mhlanga M, Nakano A, Schöneberg J, Van Valen D, Wu T', Zaritsky A.
Imaging cell biology.
Nat Cell Biol. 2022 24(8):1180-1185.
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803 Le T, Winsnes CF, Axelsson U, Xu H, Mohanakrishnan Kaimal J, Mahdessian D, Dai S, Makarov IS, Ostankovich V, Xu Y, Benhamou E, Henkel C, Solovyev RA, Banić N, Bošnjak V, Bošnjak A, Miličević A, Ouyang W, Lundberg E.
Analysis of the Human Protein Atlas Weakly Supervised Single-Cell Classification competition.
Nat Methods. 2022 19(10):1221-1229.
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802 Han L, Wei X, Liu C, Volpe G, Zhuang Z, Zou X, Wang Z, Pan T, Yuan Y, Zhang X, Fan P, Guo P, Lai Y, Lei Y, Liu X, Yu F, Shangguan S, Lai G, Deng Q, Liu Y, Wu L, Shi Q, Yu H, Huang Y, Cheng M, Xu J, Liu Y, Wang M, Wang C, Zhang Y, Xie D, Yang Y, Yu Y, Zheng H, Wei Y, Huang F, Lei J, Huang W, Zhu Z, Lu H, Wang B, Wei X, Chen F, Yang T, Du W, Chen J, Xu S, An J, Ward C, Wang Z, Pei Z, Wong CW, Liu X, Zhang H, Liu M, Qin B, Schambach A, Isern J, Feng L, Liu Y, Guo X, Liu Z, Sun Q, Maxwell PH, Barker N, Muñoz-Cánoves P, Gu Y, Mulder J, Uhlen M, Tan T, Liu S, Yang H, Wang J, Hou Y, Xu X, Esteban MA, Liu L.
Cell transcriptomic atlas of the non-human primate Macaca fascicularis.
Nature. 2022 604(7907):723-731.
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801 Chen A, Liao S, Cheng M, Ma K, Wu L, Lai Y, Qiu X, Yang J, Xu J, Hao S, Wang X, Lu H, Chen X, Liu X, Huang X, Li Z, Hong Y, Jiang Y, Peng J, Liu S, Shen M, Liu C, Li Q, Yuan Y, Wei X, Zheng H, Feng W, Wang Z, Liu Y, Wang Z, Yang Y, Xiang H, Han L, Qin B, Guo P, Lai G, Muñoz-Cánoves P, Maxwell PH, Thiery JP, Wu QF, Zhao F, Chen B, Li M, Dai X, Wang S, Kuang H, Hui J, Wang L, Fei JF, Wang O, Wei X, Lu H, Wang B, Liu S, Gu Y, Ni M, Zhang W, Mu F, Yin Y, Yang H, Lisby M, Cornall RJ, Mulder J, Uhlén M, Esteban MA, Li Y, Liu L, Xu X, Wang J.
Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays.
Cell. 2022 185(10):1777-1792.e21.
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800 Wang F, Ding P, Liang X, Ding X, Brandt CB, Sjöstedt E, Zhu J, Bolund S, Zhang L, de Rooij LPMH, Luo L, Wei Y, Zhao W, Lv Z, Haskó J, Li R, Qin Q, Jia Y, Wu W, Yuan Y, Pu M, Wang H, Wu A, Xie L, Liu P, Chen F, Herold J, Kalucka J, Karlsson M, Zhang X, Helmig RB, Fagerberg L, Lindskog C, Pontén F, Uhlen M, Bolund L, Jessen N, Jiang H, Xu X, Yang H, Carmeliet P, Mulder J, Chen D, Lin L, Luo Y.
Endothelial cell heterogeneity and microglia regulons revealed by a pig cell landscape at single-cell level.
Nat Commun. 2022 13(1):3620.
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799 Zhong W, Barde S, Mitsios N, Adori C, Oksvold P, Feilitzen KV, O'Leary L, Csiba L, Hortobágyi T, Szocsics P, Mechawar N, Maglóczky Z, Renner É, Palkovits M, Uhlén M, Mulder J, Hökfelt T.
The neuropeptide landscape of human prefrontal cortex.
Proc Natl Acad Sci U S A. 2022 119(33):e2123146119.
PubMed: 35947618 DOI: 10.1073/pnas.2123146119
798 Leifsdottir K, Jost K, Siljehav V, Thelin EP, Lassarén P, Nilsson P, Haraldsson Á, Eksborg S, Herlenius E.
The cerebrospinal fluid proteome of preterm infants predicts neurodevelopmental outcome.
Front Pediatr. 2022 10():921444.
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797 Blom K, Marking U, Havervall S, Norin NG, Gordon M, García M, Tecleab T, Christ W, Forsell M, Phillipson M, Nilsson P, Mangsbo S, Hober S, Åberg M, Klingström J, Thålin C.
Immune responses after omicron infection in triple-vaccinated health-care workers with and without previous SARS-CoV-2 infection.
Lancet Infect Dis. 2022 22(7):943-945.
PubMed: 35691303 DOI: 10.1016/S1473-3099(22)00362-0
796 Bradley F, Franzén Boger M, Kaldhusdal V, Åhlberg A, Edfeldt G, Lajoie J, Bergström S, Omollo K, Damdimopoulos A, Czarnewski P, Månberg A, Oyugi J, Kimani J, Nilsson P, Fowke K, Tjernlund A, Broliden K.
Multi-omics analysis of the cervical epithelial integrity of women using depot medroxyprogesterone acetate.
PLoS Pathog. 2022 18(5):e1010494.
PubMed: 35533147 DOI: 10.1371/journal.ppat.1010494
795 Bronge M, Högelin KA, Thomas OG, Ruhrmann S, Carvalho-Queiroz C, Nilsson OB, Kaiser A, Zeitelhofer M, Holmgren E, Linnerbauer M, Adzemovic MZ, Hellström C, Jelcic I, Liu H, Nilsson P, Hillert J, Brundin L, Fink K, Kockum I, Tengvall K, Martin R, Tegel H, Gräslund T, Al Nimer F, Guerreiro-Cacais AO, Khademi M, Gafvelin G, Olsson T, Grönlund H.
Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis.
Sci Adv. 2022 8(17):eabn1823.
PubMed: 35476434 DOI: 10.1126/sciadv.abn1823
794 Havervall S, Marking U, Greilert-Norin N, Gordon M, Ng H, Christ W, Phillipson M, Nilsson P, Hober S, Blom K, Klingström J, Mangsbo S, Åberg M, Thålin C.
Impact of SARS-CoV-2 infection on vaccine-induced immune responses over time.
Clin Transl Immunology. 2022 11(4):e1388.
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793 Laurén I, Havervall S, Ng H, Lord M, Pettke A, Greilert-Norin N, Gabrielsson L, Chourlia A, Amoêdo-Leite C, Josyula VS, Eltahir M, Kerzeli I, Falk AJ, Hober J, Christ W, Wiberg A, Hedhammar M, Tegel H, Burman J, Xu F, Pin E, Månberg A, Klingström J, Christoffersson G, Hober S, Nilsson P, Philipson M, Dönnes P, Lindsay R, Thålin C, Mangsbo S.
Long-term SARS-CoV-2-specific and cross-reactive cellular immune responses correlate with humoral responses, disease severity, and symptomatology.
Immun Inflamm Dis. 2022 10(4):e595.
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792 Marking U, Havervall S, Greilert-Norin N, Ng H, Blom K, Nilsson P, Phillipson M, Hober S, Nilsson C, Mangsbo S, Christ W, Klingström J, Gordon M, Åberg M, Thålin C.
Duration of SARS-CoV-2 Immune Responses Up to Six Months Following Homologous or Heterologous Primary Immunization with ChAdOx1 nCoV-19 and BNT162b2 mRNA Vaccines.
Vaccines (Basel). 2022 10(3):.
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791 Leifsdottir K, Thelin EP, Lassarén P, Siljehav V, Nilsson P, Eksborg S, Herlenius E.
Proteomic profiles in cerebrospinal fluid predicted death and disability in term infants with perinatal asphyxia: A pilot study.
Acta Paediatr. 2022 111(5):961-970.
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790 Healy K, Pin E, Chen P, Söderdahl G, Nowak P, Mielke S, Hansson L, Bergman P, Smith CIE, Ljungman P, Valentini D, Blennow O, Österborg A, Gabarrini G, Al-Manei K, Alkharaan H, Sobkowiak MJ, Yousef J, Mravinacova S, Cuapio A, Xu X, Akber M, Loré K, Hellström C, Muschiol S, Bogdanovic G, Buggert M, Ljunggren HG, Hober S, Nilsson P, Aleman S, Sällberg Chen M.
Salivary IgG to SARS-CoV-2 indicates seroconversion and correlates to serum neutralization in mRNA-vaccinated immunocompromised individuals.
Med (N Y). 2022 3(2):137-153.e3.
PubMed: 35075450 DOI: 10.1016/j.medj.2022.01.001
789 Juanes-Velasco P, Galicia N, Pin E, Jara-Acevedo R, Carabias-Sánchez J, García-Valiente R, Lecrevisse Q, Pedreira CE, Gongora R, Sanchez-Santos JM, Lorenzo-Gil H, Landeira-Viñuela A, Bareke H, Orfao A, Nilsson P, Fuentes M.
Deciphering Biomarkers for Leptomeningeal Metastasis in Malignant Hemopathies (Lymphoma/Leukemia) Patients by Comprehensive Multipronged Proteomics Characterization of Cerebrospinal Fluid.
Cancers (Basel). 2022 14(2):.
PubMed: 35053611 DOI: 10.3390/cancers14020449
788 Havervall S, Jernbom Falk A, Klingström J, Ng H, Greilert-Norin N, Gabrielsson L, Salomonsson AC, Isaksson E, Rudberg AS, Hellström C, Andersson E, Olofsson J, Skoglund L, Yousef J, Pin E, Christ W, Olausson M, Hedhammar M, Tegel H, Mangsbo S, Phillipson M, Månberg A, Hober S, Nilsson P, Thålin C.
SARS-CoV-2 induces a durable and antigen specific humoral immunity after asymptomatic to mild COVID-19 infection.
PLoS One. 2022 17(1):e0262169.
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787 Marabita F, James T, Karhu A, Virtanen H, Kettunen K, Stenlund H, Boulund F, Hellström C, Neiman M, Mills R, Perheentupa T, Laivuori H, Helkkula P, Byrne M, Jokinen I, Honko H, Kallonen A, Ermes M, Similä H, Lindholm M, Widén E, Ripatti S, Perälä-Heape M, Engstrand L, Nilsson P, Moritz T, Miettinen T, Sallinen R, Kallioniemi O.
Multiomics and digital monitoring during lifestyle changes reveal independent dimensions of human biology and health.
Cell Syst. 2022 13(3):241-255.e7.
PubMed: 34856119 DOI: 10.1016/j.cels.2021.11.001
786 Wesolowska-Andersen A, Brorsson CA, Bizzotto R, Mari A, Tura A, Koivula R, Mahajan A, Vinuela A, Tajes JF, Sharma S, Haid M, Prehn C, Artati A, Hong MG, Musholt PB, Kurbasic A, De Masi F, Tsirigos K, Pedersen HK, Gudmundsdottir V, Thomas CE, Banasik K, Jennison C, Jones A, Kennedy G, Bell J, Thomas L, Frost G, Thomsen H, Allin K, Hansen TH, Vestergaard H, Hansen T, Rutters F, Elders P, t'Hart L, Bonnefond A, Canouil M, Brage S, Kokkola T, Heggie A, McEvoy D, Hattersley A, McDonald T, Teare H, Ridderstrale M, Walker M, Forgie I, Giordano GN, Froguel P, Pavo I, Ruetten H, Pedersen O, Dermitzakis E, Franks PW, Schwenk JM, Adamski J, Pearson E, McCarthy MI, Brunak S, IMI DIRECT Consortium.
Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study.
Cell Rep Med. 2022 3(1):100477.
PubMed: 35106505 DOI: 10.1016/j.xcrm.2021.100477
785 Thomas CE, Dahl L, Byström S, Chen Y, Uhlén M, Mälarstig A, Czene K, Hall P, Schwenk JM, Gabrielson M.
Circulating proteins reveal prior use of menopausal hormonal therapy and increased risk of breast cancer.
Transl Oncol. 2022 17():101339.
PubMed: 35033985 DOI: 10.1016/j.tranon.2022.101339
784 Yang Z, Macdonald-Dunlop E, Chen J, Zhai R, Li T, Richmond A, Klarić L, Pirastu N, Ning Z, Zheng C, Wang Y, Huang T, He Y, Guo H, Ying K, Gustafsson S, Prins B, Ramisch A, Dermitzakis ET, Png G, Eriksson N, Haessler J, Hu X, Zanetti D, Boutin T, Hwang SJ, Wheeler E, Pietzner M, Raffield LM, Kalnapenkis A, Peters JE, Viñuela A, Gilly A, Elmståhl S, Dedoussis G, Petrie JR, Polašek O, Folkersen L, Chen Y, Yao C, Võsa U, Pairo-Castineira E, Clohisey S, Bretherick AD, Rawlik K, GenOMICC Consortium†, IMI-DIRECT Consortium†, Esko T, Enroth S, Johansson Å, Gyllensten U, Langenberg C, Levy D, Hayward C, Assimes TL, Kooperberg C, Manichaikul AW, Siegbahn A, Wallentin L, Lind L, Zeggini E, Schwenk JM, Butterworth AS, Michaëlsson K, Pawitan Y, Joshi PK, Baillie JK, Mälarstig A, Reiner AP, Wilson JF, Shen X.
Genetic Landscape of the ACE2 Coronavirus Receptor.
Circulation. 2022 145(18):1398-1411.
PubMed: 35387486 DOI: 10.1161/CIRCULATIONAHA.121.057888
783 Katona B, Lindskog C.
The Human Protein Atlas and Antibody-Based Tissue Profiling in Clinical Proteomics.
Methods Mol Biol. 2022 2420():191-206.
PubMed: 34905175 DOI: 10.1007/978-1-0716-1936-0_15
782 Farfaras S, Roshani L, Mulder J, Mitsios N, Hallström EK, Kartus JT.
Increased levels of inflammatory markers in the subscapularis tendon and joint capsule in patients with subacromial impingement.
Knee Surg Sports Traumatol Arthrosc. 2021 29(7):2228-2236.
PubMed: 32356046 DOI: 10.1007/s00167-020-05992-9
781 Suhre K, McCarthy MI, Schwenk JM.
Genetics meets proteomics: perspectives for large population-based studies.
Nat Rev Genet. 2021 22(1):19-37.
PubMed: 32860016 DOI: 10.1038/s41576-020-0268-2
780 Andersson L, Cinato M, Mardani I, Miljanovic A, Arif M, Koh A, Lindbom M, Laudette M, Bollano E, Omerovic E, Klevstig M, Henricsson M, Fogelstrand P, Swärd K, Ekstrand M, Levin M, Wikström J, Doran S, Hyötyläinen T, Sinisalu L, Orešič M, Tivesten Å, Adiels M, Bergo MO, Proia R, Mardinoglu A, Jeppsson A, Borén J, Levin MC.
Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking.
Eur Heart J. 2021 42(43):4481-4492.
PubMed: 34297830 DOI: 10.1093/eurheartj/ehab412
779 Deutsch EW, Omenn GS, Sun Z, Maes M, Pernemalm M, Palaniappan KK, Letunica N, Vandenbrouck Y, Brun V, Tao SC, Yu X, Geyer PE, Ignjatovic V, Moritz RL, Schwenk JM.
Advances and Utility of the Human Plasma Proteome.
J Proteome Res. 2021 20(12):5241-5263.
PubMed: 34672606 DOI: 10.1021/acs.jproteome.1c00657
778 Papoutsoglou P, Rodrigues-Junior DM, Morén A, Bergman A, Pontén F, Coulouarn C, Caja L, Heldin CH, Moustakas A.
The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor β signaling.
Oncogene. 2021 40(21):3748-3765.
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777 Alhaidan Y, Christesen HT, Lundberg E, Balwi MAA, Brusgaard K.
CRISPR/Cas9 Knockout Stimulates the Insulin Secretion Pathway Leading to Excessive Insulin Secretion.
Front Endocrinol (Lausanne). 2021 12():657873.
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776 Bayraktar A, Lam S, Altay O, Li X, Yuan M, Zhang C, Arif M, Turkez H, Uhlén M, Shoaie S, Mardinoglu A.
Revealing the Molecular Mechanisms of Alzheimer's Disease Based on Network Analysis.
Int J Mol Sci. 2021 22(21):.
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775 Kaynar A, Altay O, Li X, Zhang C, Turkez H, Uhlén M, Shoaie S, Mardinoglu A.
Systems Biology Approaches to Decipher the Underlying Molecular Mechanisms of Glioblastoma Multiforme.
Int J Mol Sci. 2021 22(24):.
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774 Yang H, Arif M, Yuan M, Li X, Shong K, Türkez H, Nielsen J, Uhlén M, Borén J, Zhang C, Mardinoglu A.
A network-based approach reveals the dysregulated transcriptional regulation in non-alcoholic fatty liver disease.
iScience. 2021 24(11):103222.
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773 Razzaq M, Iglesias MJ, Ibrahim-Kosta M, Goumidi L, Soukarieh O, Proust C, Roux M, Suchon P, Boland A, Daiain D, Olaso R, Havervall S, Thalin C, Butler L, Deleuze JF, Odeberg J, Morange PE, Trégouët DA.
An artificial neural network approach integrating plasma proteomics and genetic data identifies PLXNA4 as a new susceptibility locus for pulmonary embolism.
Sci Rep. 2021 11(1):14015.
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772 Lam S, Hartmann N, Benfeitas R, Zhang C, Arif M, Turkez H, Uhlén M, Englert C, Knight R, Mardinoglu A.
Systems Analysis Reveals Ageing-Related Perturbations in Retinoids and Sex Hormones in Alzheimer's and Parkinson's Diseases.
Biomedicines. 2021 9(10):.
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771 Mailer RK, Allende M, Heestermans M, Schweizer M, Deppermann C, Frye M, Pula G, Odeberg J, Gelderblom M, Rose-John S, Sickmann A, Blankenberg S, Huber TB, Kubisch C, Maas C, Gambaryan S, Firsov D, Stavrou EX, Butler LM, Renné T.
Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate.
Blood. 2021 137(10):1392-1405.
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770 Tebani A, Jotanovic J, Hekmati N, Sivertsson Å, Gudjonsson O, Edén Engström B, Wikström J, Uhlèn M, Casar-Borota O, Pontén F.
Annotation of pituitary neuroendocrine tumors with genome-wide expression analysis.
Acta Neuropathol Commun. 2021 9(1):181.
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769 Bergström S, Öijerstedt L, Remnestål J, Olofsson J, Ullgren A, Seelaar H, van Swieten JC, Synofzik M, Sanchez-Valle R, Moreno F, Finger E, Masellis M, Tartaglia C, Vandenberghe R, Laforce R, Galimberti D, Borroni B, Butler CR, Gerhard A, Ducharme S, Rohrer JD, Månberg A, Graff C, Nilsson P, Genetic Frontotemporal Dementia Initiative (GENFI).
A panel of CSF proteins separates genetic frontotemporal dementia from presymptomatic mutation carriers: a GENFI study.
Mol Neurodegener. 2021 16(1):79.
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768 Christopher JA, Stadler C, Martin CE, Morgenstern M, Pan Y, Betsinger CN, Rattray DG, Mahdessian D, Gingras AC, Warscheid B, Lehtiö J, Cristea IM, Foster LJ, Emili A, Lilley KS.
Subcellular proteomics.
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767 Mena J, Alloza I, Tulloch Navarro R, Aldekoa A, Díez García J, Villanueva Etxebarria A, Lindskog C, Antigüedad A, Boyero S, Mendibe-Bilbao MDM, Álvarez de Arcaya A, Sánchez Menoyo JL, Midaglia L, Villarrubia N, Malhotra S, Montalban X, Villar LM, Comabella M, Vandenbroeck K.
Genomic Multiple Sclerosis Risk Variants Modulate the Expression of the - Gene Region in Immature Dendritic Cells.
Front Immunol. 2021 12():816930.
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766 Lundberg E, Funke J, Uhlmann V, Gerlich D, Walter T, Carpenter A, Coehlo LP.
Which image-based phenotypes are most promising for using AI to understand cellular functions and why?
Cell Syst. 2021 12(5):384-387.
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765 Qin Y, Huttlin EL, Winsnes CF, Gosztyla ML, Wacheul L, Kelly MR, Blue SM, Zheng F, Chen M, Schaffer LV, Licon K, Bäckström A, Vaites LP, Lee JJ, Ouyang W, Liu SN, Zhang T, Silva E, Park J, Pitea A, Kreisberg JF, Gygi SP, Ma J, Harper JW, Yeo GW, Lafontaine DLJ, Lundberg E, Ideker T.
A multi-scale map of cell structure fusing protein images and interactions.
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764 Gultekin O, Gonzalez-Molina J, Hardell E, Moyano-Galceran L, Mitsios N, Mulder J, Kokaraki G, Isaksson A, Sarhan D, Lehti K, Carlson JW.
FOXP3+ T cells in uterine sarcomas are associated with favorable prognosis, low extracellular matrix expression and reduced YAP activation.
NPJ Precis Oncol. 2021 5(1):97.
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763 Tura A, Grespan E, Göbl CS, Koivula RW, Franks PW, Pearson ER, Walker M, Forgie IM, Giordano GN, Pavo I, Ruetten H, Dermitzakis ET, McCarthy MI, Pedersen O, Schwenk JM, Adamski J, De Masi F, Tsirigos KD, Brunak S, Viñuela A, Mahajan A, McDonald TJ, Kokkola T, Vangipurapu J, Cederberg H, Laakso M, Rutters F, Elders PJM, Koopman ADM, Beulens JW, Ridderstråle M, Hansen TH, Allin KH, Hansen T, Vestergaard H, Mari A, IMI DIRECT Consortium.
Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study.
Diabetes. 2021 70(9):2092-2106.
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762 Wu C, Borné Y, Gao R, López Rodriguez M, Roell WC, Wilson JM, Regmi A, Luan C, Aly DM, Peter A, Machann J, Staiger H, Fritsche A, Birkenfeld AL, Tao R, Wagner R, Canouil M, Hong MG, Schwenk JM, Ahlqvist E, Kaikkonen MU, Nilsson P, Shore AC, Khan F, Natali A, Melander O, Orho-Melander M, Nilsson J, Häring HU, Renström E, Wollheim CB, Engström G, Weng J, Pearson ER, Franks PW, White MF, Duffin KL, Vaag AA, Laakso M, Stefan N, Groop L, De Marinis Y.
Elevated circulating follistatin associates with an increased risk of type 2 diabetes.
Nat Commun. 2021 12(1):6486.
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761 Bauer W, Weber M, Diehl-Wiesenecker E, Galtung N, Prpic M, Somasundaram R, Tauber R, Schwenk JM, Micke P, Kappert K.
Plasma Proteome Fingerprints Reveal Distinctiveness and Clinical Outcome of SARS-CoV-2 Infection.
Viruses. 2021 13(12):.
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760 Kotol D, Hober A, Strandberg L, Svensson AS, Uhlén M, Edfors F.
Targeted proteomics analysis of plasma proteins using recombinant protein standards for addition only workflows.
Biotechniques. 2021 71(3):473-483.
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759 Digre A, Lindskog C.
The Human Protein Atlas-Spatial localization of the human proteome in health and disease.
Protein Sci. 2021 30(1):218-233.
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758 Jamin SP, Hikmet F, Mathieu R, Jégou B, Lindskog C, Chalmel F, Primig M.
Combined RNA/tissue profiling identifies novel Cancer/testis genes.
Mol Oncol. 2021 15(11):3003-3023.
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757 Egevad L, Delahunt B, Samaratunga H, Tsuzuki T, Olsson H, Ström P, Lindskog C, Häkkinen T, Kartasalo K, Eklund M, Ruusuvuori P.
Interobserver reproducibility of perineural invasion of prostatic adenocarcinoma in needle biopsies.
Virchows Arch. 2021 478(6):1109-1116.
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756 Abdulla M, Alexsson A, Sundström C, Ladenvall C, Mansouri L, Lindskog C, Berglund M, Cavelier L, Enblad G, Hollander P, Amini RM.
PD-L1 and IDO1 are potential targets for treatment in patients with primary diffuse large B-cell lymphoma of the CNS.
Acta Oncol. 2021 60(4):531-538.
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755 Micke P, Strell C, Mattsson J, Martín-Bernabé A, Brunnström H, Huvila J, Sund M, Wärnberg F, Ponten F, Glimelius B, Hrynchyk I, Mauchanski S, Khelashvili S, Garcia-Vicién G, Molleví DG, Edqvist PH, O Reilly A, Corvigno S, Dahlstrand H, Botling J, Segersten U, Krzyzanowska A, Bjartell A, Elebro J, Heby M, Lundgren S, Hedner C, Borg D, Brändstedt J, Sartor H, Malmström PU, Johansson M, Nodin B, Backman M, Lindskog C, Jirström K, Mezheyeuski A.
The prognostic impact of the tumour stroma fraction: A machine learning-based analysis in 16 human solid tumour types.
EBioMedicine. 2021 65():103269.
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754 Olpe C, Khamis D, Chukanova M, Skoufou-Papoutsaki N, Kemp R, Marks K, Tatton C, Lindskog C, Nicholson A, Brunton-Sim R, Malhotra S, Ten Hoopen R, Stanley R, Winton DJ, Morrissey E.
A Diffusion-like Process Accommodates New Crypts During Clonal Expansion in Human Colonic Epithelium.
Gastroenterology. 2021 161(2):548-559.e23.
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753 Backman M, La Fleur L, Kurppa P, Djureinovic D, Elfving H, Brunnström H, Mattsson JSM, Lindberg A, Pontén V, Eltahir M, Mangsbo S, Gulyas M, Isaksson J, Jirström K, Kärre K, Leandersson K, Mezheyeuski A, Pontén F, Strell C, Lindskog C, Botling J, Micke P.
Infiltration of NK and plasma cells is associated with a distinct immune subset in non-small cell lung cancer.
J Pathol. 2021 255(3):243-256.
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752 Omenn GS, Lane L, Overall CM, Paik YK, Cristea IM, Corrales FJ, Lindskog C, Weintraub S, Roehrl MHA, Liu S, Bandeira N, Srivastava S, Chen YJ, Aebersold R, Moritz RL, Deutsch EW.
Progress Identifying and Analyzing the Human Proteome: 2021 Metrics from the HUPO Human Proteome Project.
J Proteome Res. 2021 20(12):5227-5240.
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751 Pablos I, Machado Y, de Jesus HCR, Mohamud Y, Kappelhoff R, Lindskog C, Vlok M, Bell PA, Butler GS, Grin PM, Cao QT, Nguyen JP, Solis N, Abbina S, Rut W, Vederas JC, Szekely L, Szakos A, Drag M, Kizhakkedathu JN, Mossman K, Hirota JA, Jan E, Luo H, Banerjee A, Overall CM.
Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CL substrate degradome.
Cell Rep. 2021 37(4):109892.
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750 Garcia-Alonso L, Handfield LF, Roberts K, Nikolakopoulou K, Fernando RC, Gardner L, Woodhams B, Arutyunyan A, Polanski K, Hoo R, Sancho-Serra C, Li T, Kwakwa K, Tuck E, Lorenzi V, Massalha H, Prete M, Kleshchevnikov V, Tarkowska A, Porter T, Mazzeo CI, van Dongen S, Dabrowska M, Vaskivskyi V, Mahbubani KT, Park JE, Jimenez-Linan M, Campos L, Kiselev VY, Lindskog C, Ayuk P, Prigmore E, Stratton MR, Saeb-Parsy K, Moffett A, Moore L, Bayraktar OA, Teichmann SA, Turco MY, Vento-Tormo R.
Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro.
Nat Genet. 2021 53(12):1698-1711.
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749 Ghoshal B, Hikmet F, Pineau C, Tucker A, Lindskog C.
DeepHistoClass: A Novel Strategy for Confident Classification of Immunohistochemistry Images Using Deep Learning.
Mol Cell Proteomics. 2021 20():100140.
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748 Iglesias MJ, Schwenk JM, Odeberg J.
Affinity Proteomics Assays for Cardiovascular and Atherosclerotic Disease Biomarkers.
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747 Bendes A, Dale M, Mattsson C, Dodig-Crnković T, Iglesias MJ, Schwenk JM, Fredolini C.
Bead-Based Assays for Validating Proteomic Profiles in Body Fluids.
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746 Gummesson A, Björnson E, Fagerberg L, Zhong W, Tebani A, Edfors F, Schmidt C, Lundqvist A, Adiels M, Bäckhed F, Schwenk JM, Jansson PA, Uhlén M, Bergström G.
Longitudinal plasma protein profiling of newly diagnosed type 2 diabetes.
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745 Stockfelt M, Hong MG, Hesselmar B, Adlerberth I, Wold AE, Schwenk JM, Lundell AC, Rudin A.
Circulating proteins associated with allergy development in infants-an exploratory analysis.
Clin Proteomics. 2021 18(1):11.
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744 Roxhed N, Bendes A, Dale M, Mattsson C, Hanke L, Dodig-Crnković T, Christian M, Meineke B, Elsässer S, Andréll J, Havervall S, Thålin C, Eklund C, Dillner J, Beck O, Thomas CE, McInerney G, Hong MG, Murrell B, Fredolini C, Schwenk JM.
Multianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2.
Nat Commun. 2021 12(1):3695.
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743 Zeybel M, Altay O, Arif M, Li X, Yang H, Fredolini C, Akyildiz M, Saglam B, Gonenli MG, Ural D, Kim W, Schwenk JM, Zhang C, Shoaie S, Nielsen J, Uhlén M, Borén J, Mardinoglu A.
Combined metabolic activators therapy ameliorates liver fat in nonalcoholic fatty liver disease patients.
Mol Syst Biol. 2021 17(10):e10459.
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742 Zhong W, Altay O, Arif M, Edfors F, Doganay L, Mardinoglu A, Uhlén M, Fagerberg L.
Next generation plasma proteome profiling of COVID-19 patients with mild to moderate symptoms
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741 Gerrits E, Brouwer N, Kooistra SM, Woodbury ME, Vermeiren Y, Lambourne M, Mulder J, Kummer M, Möller T, Biber K, Dunnen WFAD, De Deyn PP, Eggen BJL, Boddeke EWGM.
Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease.
Acta Neuropathol. 2021 141(5):681-696.
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740 Mulder J, Lindqvist I, Rasmusson AJ, Husén E, Rönnelid J, Kumlien E, Rostami E, Virhammar J, Cunningham JL.
Indirect immunofluorescence for detecting anti-neuronal autoimmunity in CSF after COVID-19 - Possibilities and pitfalls.
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739 Huang J, Lin L, Dong Z, Yang L, Zheng T, Gu W, Zhang Y, Yin T, Sjöstedt E, Mulder J, Uhlén M, Kristiansen K, Bolund L, Luo Y.
A porcine brain-wide RNA editing landscape.
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738 Mulder J, Feresiadou A, Fällmar D, Frithiof R, Virhammar J, Rasmusson A, Rostami E, Kumlien E, Cunningham JL.
Autoimmune Encephalitis Presenting With Malignant Catatonia in a 40-Year-Old Male Patient With COVID-19.
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737 Adori C, Daraio T, Kuiper R, Barde S, Horvathova L, Yoshitake T, Ihnatko R, Valladolid-Acebes I, Vercruysse P, Wellendorf AM, Gramignoli R, Bozoky B, Kehr J, Theodorsson E, Cancelas JA, Mravec B, Jorns C, Ellis E, Mulder J, Uhlén M, Bark C, Hökfelt T.
Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging.
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736 Iglesias MJ, Kruse LD, Sanchez-Rivera L, Enge L, Dusart P, Hong MG, Uhlén M, Renné T, Schwenk JM, Bergstrom G, Odeberg J, Butler LM.
Identification of Endothelial Proteins in Plasma Associated With Cardiovascular Risk Factors.
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735 Gnann C, Cesnik AJ, Lundberg E.
Illuminating Non-genetic Cellular Heterogeneity with Imaging-Based Spatial Proteomics.
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734 Rozenblatt-Rosen O, Shin JW, Rood JE, Hupalowska A, Human Cell Atlas Standards and Technology Working Group, Regev A, Heyn H.
Building a high-quality Human Cell Atlas.
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733 Pinkard H, Stuurman N, Ivanov IE, Anthony NM, Ouyang W, Li B, Yang B, Tsuchida MA, Chhun B, Zhang G, Mei R, Anderson M, Shepherd DP, Hunt-Isaak I, Dunn RL, Jahr W, Kato S, Royer LA, Thiagarajah JR, Eliceiri KW, Lundberg E, Mehta SB, Waller L.
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732 Gómez-de-Mariscal E, García-López-de-Haro C, Ouyang W, Donati L, Lundberg E, Unser M, Muñoz-Barrutia A, Sage D.
DeepImageJ: A user-friendly environment to run deep learning models in ImageJ.
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731 Mikus M, Zandian A, Sjöberg R, Hamsten C, Forsström B, Andersson M, Greiff L, Uhlén M, Levin M, Nilsson P, van Hage M, Ohlin M.
Allergome-wide peptide microarrays enable epitope deconvolution in allergen-specific immunotherapy.
J Allergy Clin Immunol. 2021 147(3):1077-1086.
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730 Hassan SS, Seigerud Å, Abdirahman R, Arroyo Mühr LS, Nordqvist Kleppe S, Pin E, Månberg A, Hober S, Nilsson P, Engstrand L, Miriam Elfström K, Blomqvist J, Conneryd Lundgren K, Dillner J.
SARS-CoV-2 infections amongst personnel providing home care services for older persons in Stockholm, Sweden.
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729 Månberg A, Skene N, Sanders F, Trusohamn M, Remnestål J, Szczepińska A, Aksoylu IS, Lönnerberg P, Ebarasi L, Wouters S, Lehmann M, Olofsson J, von Gohren Antequera I, Domaniku A, De Schaepdryver M, De Vocht J, Poesen K, Uhlén M, Anink J, Mijnsbergen C, Vergunst-Bosch H, Hübers A, Kläppe U, Rodriguez-Vieitez E, Gilthorpe JD, Hedlund E, Harris RA, Aronica E, Van Damme P, Ludolph A, Veldink J, Ingre C, Nilsson P, Lewandowski SA.
Altered perivascular fibroblast activity precedes ALS disease onset.
Nat Med. 2021 27(4):640-646.
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728 Pin E, Petricoin EF, Cortes N, Bowman TG, Andersson E, Uhlén M, Nilsson P, Caswell SV.
Immunoglobulin A Autoreactivity toward Brain Enriched and Apoptosis-Regulating Proteins in Saliva of Athletes after Acute Concussion and Subconcussive Impacts.
J Neurotrauma. 2021 38(17):2373-2383.
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727 Lourido L, Balboa-Barreiro V, Ruiz-Romero C, Rego-Pérez I, Camacho-Encina M, Paz-González R, Calamia V, Oreiro N, Nilsson P, Blanco FJ.
A clinical model including protein biomarkers predicts radiographic knee osteoarthritis: a prospective study using data from the Osteoarthritis Initiative.
Osteoarthritis Cartilage. 2021 29(8):1147-1154.
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726 Alkharaan H, Bayati S, Hellström C, Aleman S, Olsson A, Lindahl K, Bogdanovic G, Healy K, Tsilingaridis G, De Palma P, Hober S, Månberg A, Nilsson P, Pin E, Sällberg Chen M.
Persisting Salivary IgG Against SARS-CoV-2 at 9 Months After Mild COVID-19: A Complementary Approach to Population Surveys.
J Infect Dis. 2021 224(3):407-414.
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725 Kharlamova N, Dunn N, Bedri SK, Jerling S, Almgren M, Faustini F, Gunnarsson I, Rönnelid J, Pullerits R, Gjertsson I, Lundberg K, Månberg A, Pin E, Nilsson P, Hober S, Fink K, Fogdell-Hahn A.
False Positive Results in SARS-CoV-2 Serological Tests for Samples From Patients With Chronic Inflammatory Diseases.
Front Immunol. 2021 12():666114.
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724 Bergström S, Remnestål J, Yousef J, Olofsson J, Markaki I, Carvalho S, Corvol JC, Kultima K, Kilander L, Löwenmark M, Ingelsson M, Blennow K, Zetterberg H, Nellgård B, Brosseron F, Heneka MT, Bosch B, Sanchez-Valle R, Månberg A, Svenningsson P, Nilsson P.
Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease.
Ann Clin Transl Neurol. 2021 8(7):1456-1470.
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723 Hober S, Hellström C, Olofsson J, Andersson E, Bergström S, Jernbom Falk A, Bayati S, Mravinacova S, Sjöberg R, Yousef J, Skoglund L, Kanje S, Berling A, Svensson AS, Jensen G, Enstedt H, Afshari D, Xu LL, Zwahlen M, von Feilitzen K, Hanke L, Murrell B, McInerney G, Karlsson Hedestam GB, Lendel C, Roth RG, Skoog I, Svenungsson E, Olsson T, Fogdell-Hahn A, Lindroth Y, Lundgren M, Maleki KT, Lagerqvist N, Klingström J, Da Silva Rodrigues R, Muschiol S, Bogdanovic G, Arroyo Mühr LS, Eklund C, Lagheden C, Dillner J, Sivertsson Å, Havervall S, Thålin C, Tegel H, Pin E, Månberg A, Hedhammar M, Nilsson P.
Systematic evaluation of SARS-CoV-2 antigens enables a highly specific and sensitive multiplex serological COVID-19 assay.
Clin Transl Immunology. 2021 10(7):e1312.
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722 Elfström KM, Blomqvist J, Nilsson P, Hober S, Pin E, Månberg A, Pimenoff VN, Arroyo Mühr LS, Lundgren KC, Dillner J.
Differences in risk for SARS-CoV-2 infection among healthcare workers.
Prev Med Rep. 2021 24():101518.
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721 Asplund Högelin K, Ruffin N, Pin E, Månberg A, Hober S, Gafvelin G, Grönlund H, Nilsson P, Khademi M, Olsson T, Piehl F, Al Nimer F.
Development of humoral and cellular immunological memory against SARS-CoV-2 despite B cell depleting treatment in multiple sclerosis.
iScience. 2021 24(9):103078.
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720 Mangsbo SM, Havervall S, Laurén I, Lindsay R, Jernbom Falk A, Marking U, Lord M, Buggert M, Dönnes P, Christoffersson G, Nilsson P, Hober S, Phillipson M, Klingström J, Thålin C.
An evaluation of a FluoroSpot assay as a diagnostic tool to determine SARS-CoV-2 specific T cell responses.
PLoS One. 2021 16(9):e0258041.
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719 San Segundo-Acosta P, Montero-Calle A, Jernbom-Falk A, Alonso-Navarro M, Pin E, Andersson E, Hellström C, Sánchez-Martínez M, Rábano A, Solís-Fernández G, Peláez-García A, Martínez-Useros J, Fernández-Aceñero MJ, Månberg A, Nilsson P, Barderas R.
Multiomics Profiling of Alzheimer's Disease Serum for the Identification of Autoantibody Biomarkers.
J Proteome Res. 2021 20(11):5115-5130.
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718 Just D, Rasmusson AJ, Nilsson P, Noreland M, Malmström E, Brodin P, Månberg A, Cunningham JL.
Autoantibodies against the C-terminus of Lipopolysaccharide binding protein are elevated in young adults with psychiatric disease.
Psychoneuroendocrinology. 2021 126():105162.
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717 Dillner J, Elfström KM, Blomqvist J, Engstrand L, Uhlén M, Eklund C, Boulund F, Lagheden C, Hamsten M, Nordqvist-Kleppe S, Seifert M, Hellström C, Olofsson J, Andersson E, Falk AJ, Bergström S, Hultin E, Pin E, Pimenoff VN, Hassan S, Månberg A, Nilsson P, Hedhammar M, Hober S, Mattsson J, Arroyo Mühr LS, Lundgren KC.
High Amounts of SARS-CoV-2 Precede Sickness Among Asymptomatic Health Care Workers.
J Infect Dis. 2021 224(1):14-20.
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716 Remnestål J, Bergström S, Olofsson J, Sjöstedt E, Uhlén M, Blennow K, Zetterberg H, Zettergren A, Kern S, Skoog I, Nilsson P, Månberg A.
Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds.
Alzheimers Res Ther. 2021 13(1):54.
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715 Paslawski W, Bergström S, Zhang X, Remnestål J, He Y, Boxer A, Månberg A, Nilsson P, Svenningsson P.
Cerebrospinal Fluid Proteins Altered in Corticobasal Degeneration.
Mov Disord. 2021 36(5):1278-1280.
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714 Dillner J, Elfström KM, Blomqvist J, Eklund C, Lagheden C, Nordqvist-Kleppe S, Hellström C, Olofsson J, Andersson E, Jernbom Falk A, Bergström S, Hultin E, Pin E, Månberg A, Nilsson P, Hedhammar M, Hober S, Mattsson J, Mühr LSA, Conneryd Lundgren K.
Antibodies to SARS-CoV-2 and risk of past or future sick leave.
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713 Lourido L, Paz-González R, Ruiz-Romero C, Nilsson P, Blanco FJ.
Serum Proteomic Profiling in Rheumatoid Arthritis by Antibody Suspension Bead Arrays.
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712 Lindblad C, Pin E, Just D, Al Nimer F, Nilsson P, Bellander BM, Svensson M, Piehl F, Thelin EP.
Fluid proteomics of CSF and serum reveal important neuroinflammatory proteins in blood-brain barrier disruption and outcome prediction following severe traumatic brain injury: a prospective, observational study.
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711 Röhl M, Tjernlund A, Lajoie J, Edfeldt G, Bradley F, Bergström S, Kaldhusdal V, Åhlberg A, Månberg A, Omollo K, Boily-Larouche G, Asghar M, Kwon DS, Oyugi J, Kimani J, Nilsson P, Fowke KR, Broliden K.
HIV-Exposed Seronegative Sex Workers Express Low T-Cell Activation and an Intact Ectocervical Tissue Microenvironment.
Vaccines (Basel). 2021 9(3):.
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710 Havervall S, Rosell A, Phillipson M, Mangsbo SM, Nilsson P, Hober S, Thålin C.
Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers.
JAMA. 2021 325(19):2015-2016.
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709 Mikus M, Järnbert-Pettersson H, Johansson C, Nilsson P, Scheynius A, Alm J.
Protein profiles in plasma: Development from infancy to 5 years of age.
Proteomics Clin Appl. 2021 15(4):e2000038.
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708 Klevebro S, Bahram F, Elfström KM, Hellberg U, Hober S, Merid SK, Kull I, Nilsson P, Tornvall P, Wang G, Conneryd Lundgren K, Ponzer S, Dillner J, Melén E.
Risk of SARS-CoV-2 exposure among hospital healthcare workers in relation to patient contact and type of care.
Scand J Public Health. 2021 49(7):707-712.
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707 Havervall S, Marking U, Greilert-Norin N, Ng H, Gordon M, Salomonsson AC, Hellström C, Pin E, Blom K, Mangsbo S, Phillipson M, Klingström J, Hober S, Nilsson P, Åberg M, Thålin C.
Antibody responses after a single dose of ChAdOx1 nCoV-19 vaccine in healthcare workers previously infected with SARS-CoV-2.
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706 Jernbom Falk A, Galletly C, Just D, Toben C, Baune BT, Clark SR, Liu D, Nilsson P, Månberg A, Schubert KO.
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Transl Psychiatry. 2021 11(1):474.
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705 Mravinacova S, Jönsson M, Christ W, Klingström J, Yousef J, Hellström C, Hedhammar M, Havervall S, Thålin C, Pin E, Tegel H, Nilsson P, Månberg A, Hober S.
A cell-free high throughput assay for assessment of SARS-CoV-2 neutralizing antibodies.
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704 Carapito R, Li R, Helms J, Carapito C, Gujja S, Rolli V, Guimaraes R, Malagon-Lopez J, Spinnhirny P, Lederle A, Mohseninia R, Hirschler A, Muller L, Bastard P, Gervais A, Zhang Q, Danion F, Ruch Y, Schenck M, Collange O, Chamaraux-Tran TN, Molitor A, Pichot A, Bernard A, Tahar O, Bibi-Triki S, Wu H, Paul N, Mayeur S, Larnicol A, Laumond G, Frappier J, Schmidt S, Hanauer A, Macquin C, Stemmelen T, Simons M, Mariette X, Hermine O, Fafi-Kremer S, Goichot B, Drenou B, Kuteifan K, Pottecher J, Mertes PM, Kailasan S, Aman MJ, Pin E, Nilsson P, Thomas A, Viari A, Sanlaville D, Schneider F, Sibilia J, Tharaux PL, Casanova JL, Hansmann Y, Lidar D, Radosavljevic M, Gulcher JR, Meziani F, Moog C, Chittenden TW, Bahram S.
Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort.
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703 Altay O, Arif M, Li X, Yang H, Aydın M, Alkurt G, Kim W, Akyol D, Zhang C, Dinler-Doganay G, Turkez H, Shoaie S, Nielsen J, Borén J, Olmuscelik O, Doganay L, Uhlén M, Mardinoglu A.
Combined Metabolic Activators Accelerates Recovery in Mild-to-Moderate COVID-19.
Adv Sci (Weinh). 2021 8(17):e2101222.
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702 Arif M, Zhang C, Li X, Güngör C, Çakmak B, Arslantürk M, Tebani A, Özcan B, Subaş O, Zhou W, Piening B, Turkez H, Fagerberg L, Price N, Hood L, Snyder M, Nielsen J, Uhlen M, Mardinoglu A.
iNetModels 2.0: an interactive visualization and database of multi-omics data.
Nucleic Acids Res. 2021 49(W1):W271-W276.
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701 Arif M, Klevstig M, Benfeitas R, Doran S, Turkez H, Uhlén M, Clausen M, Wikström J, Etal D, Zhang C, Levin M, Mardinoglu A, Boren J.
Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarction.
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700 Li SL, Pereira RHM, Prete CA, Zarebski AE, Emanuel L, Alves PJH, Peixoto PS, Braga CKV, de Souza Santos AA, de Souza WM, Barbosa RJ, Buss LF, Mendrone A, de Almeida-Neto C, Ferreira SC, Salles NA, Marcilio I, Wu CH, Gouveia N, Nascimento VH, Sabino EC, Faria NR, Messina JP.
Higher risk of death from COVID-19 in low-income and non-White populations of São Paulo, Brazil.
BMJ Glob Health. 2021 6(4):.
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699 Keskinkiliç B, Shaikh I, Tekin A, Ursu P, Mardinoglu A, Mese EA.
A Resilient Health System in Response to Coronavirus Disease 2019: Experiences of Turkey.
Front Public Health. 2021 8():577021.
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698 Cinici E, Caglar O, Arslan ME, Dilekmen N, Utlu B, Mardinoglu A, Turkez H.
Targeted Gene Candidates for Treatment and Early Diagnosis of Age-Related Macular Degeneration.
Biomed Res Int. 2021 2021():6620900.
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697 Rosario D, Bidkhori G, Lee S, Bedarf J, Hildebrand F, Le Chatelier E, Uhlen M, Ehrlich SD, Proctor G, Wüllner U, Mardinoglu A, Shoaie S.
Systematic analysis of gut microbiome reveals the role of bacterial folate and homocysteine metabolism in Parkinson's disease.
Cell Rep. 2021 34(9):108807.
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696 Li X, Kim W, Juszczak K, Arif M, Sato Y, Kume H, Ogawa S, Turkez H, Boren J, Nielsen J, Uhlen M, Zhang C, Mardinoglu A.
Stratification of patients with clear cell renal cell carcinoma to facilitate drug repositioning.
iScience. 2021 24(7):102722.
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695 Mahdessian D, Cesnik AJ, Gnann C, Danielsson F, Stenström L, Arif M, Zhang C, Le T, Johansson F, Shutten R, Bäckström A, Axelsson U, Thul P, Cho NH, Carja O, Uhlén M, Mardinoglu A, Stadler C, Lindskog C, Ayoglu B, Leonetti MD, Pontén F, Sullivan DP, Lundberg E.
Spatiotemporal dissection of the cell cycle with single-cell proteogenomics.
Nature. 2021 590(7847):649-654.
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694 Alkurt G, Murt A, Aydin Z, Tatli O, Agaoglu NB, Irvem A, Aydin M, Karaali R, Gunes M, Yesilyurt B, Turkez H, Mardinoglu A, Doganay M, Basinoglu F, Seyahi N, Dinler Doganay G, Doganay HL.
Seroprevalence of coronavirus disease 2019 (COVID-19) among health care workers from three pandemic hospitals of Turkey.
PLoS One. 2021 16(3):e0247865.
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693 Türkez H, Arslan ME, Sönmez E, Tatar A, Geyikoğlu F, Açikyildiz M, Mardinoğlu A.
Safety Assessments of Nickel Boride Nanoparticles on the Human Pulmonary Alveolar Cells by Using Cell Viability and Gene Expression Analyses.
Biol Trace Elem Res. 2021 199(7):2602-2611.
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692 Turkez H, Tozlu OO, Arslan ME, Mardinoglu A.
Safety and Efficacy Assessments to Take Antioxidants in Glioblastoma Therapy: From In Vitro Experiences to Animal and Clinical Studies.
Neurochem Int. 2021 150():105168.
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691 Altay O, Zhang C, Turkez H, Nielsen J, Uhlén M, Mardinoglu A.
Revealing the Metabolic Alterations during Biofilm Development of Based on Genome-Scale Metabolic Modeling.
Metabolites. 2021 11(4):.
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690 Turkez H, Arslan ME, Tatar A, Mardinoglu A.
Promising potential of boron compounds against Glioblastoma: In Vitro antioxidant, anti-inflammatory and anticancer studies.
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689 Yazici A, Marinelli L, Cacciatore I, Emsen B, Eusepi P, Di Biase G, Di Stefano A, Mardinoğlu A, Türkez H.
Potential Anticancer Effect of Carvacrol Codrugs on Human Glioblastoma Cells.
Curr Drug Deliv. 2021 18(3):350-356.
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688 Doran S, Arif M, Lam S, Bayraktar A, Turkez H, Uhlen M, Boren J, Mardinoglu A.
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Brief Bioinform. 2021 22(5):.
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687 van der Kolk BW, Saari S, Lovric A, Arif M, Alvarez M, Ko A, Miao Z, Sahebekhtiari N, Muniandy M, Heinonen S, Oghabian A, Jokinen R, Jukarainen S, Hakkarainen A, Lundbom J, Kuula J, Groop PH, Tukiainen T, Lundbom N, Rissanen A, Kaprio J, Williams EG, Zamboni N, Mardinoglu A, Pajukanta P, Pietiläinen KH.
Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI.
Cell Rep Med. 2021 2(4):100226.
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686 Zhao LJ, Li YY, Zhang YT, Fan QQ, Ren HM, Zhang C, Mardinoglu A, Chen WC, Pang JR, Shen DD, Wang JW, Zhao LF, Zhang JY, Wang ZY, Zheng YC, Liu HM.
Lysine demethylase LSD1 delivered via small extracellular vesicles promotes gastric cancer cell stemness.
EMBO Rep. 2021 22(8):e50922.
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685 Bosley JR, Björnson E, Zhang C, Turkez H, Nielsen J, Uhlen M, Borén J, Mardinoglu A.
Informing Pharmacokinetic Models With Physiological Data: Oral Population Modeling of L-Serine in Humans.
Front Pharmacol. 2021 12():643179.
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684 Arslan ME, Türkez H, Mardinoğlu A.
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683 Turkez H, Cacciatore I, Marinelli L, Fornasari E, Aslan ME, Cadirci K, Kahraman CY, Caglar O, Tatar A, Di Biase G, Hacimuftuoglu A, Di Stefano A, Mardinoglu A.
Glycyl-L-Prolyl-L-Glutamate Pseudotripeptides for Treatment of Alzheimer's Disease.
Biomolecules. 2021 11(1):.
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682 Zhang C, Wei Y, Mardinoglu A, Zhang P.
Editorial: Application of Systems Biology in Molecular Characterization and Diagnosis of Cancer.
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681 Li X, Kim W, Arif M, Gao C, Hober A, Kotol D, Strandberg L, Forsström B, Sivertsson Å, Oksvold P, Turkez H, Grøtli M, Sato Y, Kume H, Ogawa S, Boren J, Nielsen J, Uhlen M, Zhang C, Mardinoglu A.
Discovery of Functional Alternatively Spliced Transcripts in Human Cancers.
Cancers (Basel). 2021 13(2):.
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680 Özdemir Ö, Marinelli L, Cacciatore I, Ciulla M, Emsen B, Di Stefano A, Mardinoglu A, Turkez H.
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Z Naturforsch C J Biosci. 2021 76(7-8):329-335.
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679 Lam S, Doran S, Yuksel HH, Altay O, Turkez H, Nielsen J, Boren J, Uhlen M, Mardinoglu A.
Addressing the heterogeneity in liver diseases using biological networks.
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678 Harzandi A, Lee S, Bidkhori G, Saha S, Hendry BM, Mardinoglu A, Shoaie S, Sharpe CC.
Acute kidney injury leading to CKD is associated with a persistence of metabolic dysfunction and hypertriglyceridemia.
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677 Karlsson M, Zhang C, Méar L, Zhong W, Digre A, Katona B, Sjöstedt E, Butler L, Odeberg J, Dusart P, Edfors F, Oksvold P, von Feilitzen K, Zwahlen M, Arif M, Altay O, Li X, Ozcan M, Mardinoglu A, Fagerberg L, Mulder J, Luo Y, Ponten F, Uhlén M, Lindskog C.
A single-cell type transcriptomics map of human tissues.
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Research on the Human Proteome Reaches a Major Milestone: >90% of Predicted Human Proteins Now Credibly Detected, According to the HUPO Human Proteome Project.
J Proteome Res. 2020 19(12):4735-4746.
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Enhanced Validation of Antibodies Enables the Discovery of Missing Proteins.
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CDX2: A Prognostic Marker in Metastatic Colorectal Cancer Defining a Better Mutated and a Worse Mutated Subgroup.
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Secretome-Based Screening in Target Discovery.
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Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer.
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Phenotypic Screen with the Human Secretome Identifies FGF16 as Inducing Proliferation of iPSC-Derived Cardiac Progenitor Cells.
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611 Robinson JL, Feizi A, Uhlén M, Nielsen J.
A Systematic Investigation of the Malignant Functions and Diagnostic Potential of the Cancer Secretome.
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610 Hober A, Edfors F, Ryaboshapkina M, Malmqvist J, Rosengren L, Percy AJ, Lind L, Forsström B, Uhlén M, Oscarsson J, Miliotis T.
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A Systems-Based Map of Human Brain Cell-Type Enriched Genes and Malignancy-Associated Endothelial Changes.
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608 Ruiz-Romero C, Lam MPY, Nilsson P, Önnerfjord P, Utz PJ, Van Eyk JE, Venkatraman V, Fert-Bober J, Watt FE, Blanco FJ.
Mining the Proteome Associated with Rheumatic and Autoimmune Diseases.
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607 Sahebekhtiari N, Saraswat M, Joenväärä S, Jokinen R, Lovric A, Kaye S, Mardinoglu A, Rissanen A, Kaprio J, Renkonen R, Pietiläinen KH.
Plasma Proteomics Analysis Reveals Dysregulation of Complement Proteins and Inflammation in Acquired Obesity-A Study on Rare BMI-Discordant Monozygotic Twin Pairs.
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606 Zhang C, Aldrees M, Arif M, Li X, Mardinoglu A, Aziz MA.
Elucidating the Reprograming of Colorectal Cancer Metabolism Using Genome-Scale Metabolic Modeling.
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605 Lundgren S, Fagerström-Vahman H, Zhang C, Ben-Dror L, Mardinoglu A, Uhlen M, Nodin B, Jirström K.
Discovery of KIRREL as a biomarker for prognostic stratification of patients with thin melanoma.
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604 Benfeitas R, Bidkhori G, Mukhopadhyay B, Klevstig M, Arif M, Zhang C, Lee S, Cinar R, Nielsen J, Uhlen M, Boren J, Kunos G, Mardinoglu A.
Characterization of heterogeneous redox responses in hepatocellular carcinoma patients using network analysis.
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603 Liu Z, Zhang C, Lee S, Kim W, Klevstig M, Harzandi AM, Sikanic N, Arif M, Ståhlman M, Nielsen J, Uhlen M, Boren J, Mardinoglu A.
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602 Svensson MC, Borg D, Zhang C, Hedner C, Nodin B, Uhlén M, Mardinoglu A, Leandersson K, Jirström K.
Expression of PD-L1 and PD-1 in Chemoradiotherapy-Naïve Esophageal and Gastric Adenocarcinoma: Relationship With Mismatch Repair Status and Survival.
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601 Turanli B, Zhang C, Kim W, Benfeitas R, Uhlen M, Arga KY, Mardinoglu A.
Discovery of therapeutic agents for prostate cancer using genome-scale metabolic modeling and drug repositioning.
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600 Harms MJ, Li Q, Lee S, Zhang C, Kull B, Hallen S, Thorell A, Alexandersson I, Hagberg CE, Peng XR, Mardinoglu A, Spalding KL, Boucher J.
Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes.
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599 Turanli B, Karagoz K, Bidkhori G, Sinha R, Gatza ML, Uhlen M, Mardinoglu A, Arga KY.
Multi-Omic Data Interpretation to Repurpose Subtype Specific Drug Candidates for Breast Cancer.
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598 Mardinoglu A, Ural D, Zeybel M, Yuksel HH, Uhlén M, Borén J.
The Potential Use of Metabolic Cofactors in Treatment of NAFLD.
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597 Altay O, Nielsen J, Uhlen M, Boren J, Mardinoglu A.
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596 Klevstig M, Arif M, Mannila M, Svedlund S, Mardani I, Ståhlman M, Andersson L, Lindbom M, Miljanovic A, Franco-Cereceda A, Eriksson P, Jeppsson A, Gan LM, Levin M, Mardinoglu A, Ehrenborg E, Borén J.
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Variation in the Plasma Membrane Monoamine Transporter (PMAT) (Encoded by ) and Organic Cation Transporter 1 (OCT1) (Encoded by ) and Gastrointestinal Intolerance to Metformin in Type 2 Diabetes: An IMI DIRECT Study.
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593 Ignjatovic V, Geyer PE, Palaniappan KK, Chaaban JE, Omenn GS, Baker MS, Deutsch EW, Schwenk JM.
Mass Spectrometry-Based Plasma Proteomics: Considerations from Sample Collection to Achieving Translational Data.
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592 Svedberg MM, Varnäs K, Varrone A, Mitsios N, Mulder J, Gulyás B, Beaumont V, Munoz-Sanjuan I, Zaleska MM, Schmidt CJ, Halldin C, Mrzljak L.
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588 Uhlen M, Karlsson MJ, Zhong W, Tebani A, Pou C, Mikes J, Lakshmikanth T, Forsström B, Edfors F, Odeberg J, Mardinoglu A, Zhang C, von Feilitzen K, Mulder J, Sjöstedt E, Hober A, Oksvold P, Zwahlen M, Ponten F, Lindskog C, Sivertsson Å, Fagerberg L, Brodin P.
A genome-wide transcriptomic analysis of protein-coding genes in human blood cells.
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587 Uhlén M, Karlsson MJ, Hober A, Svensson AS, Scheffel J, Kotol D, Zhong W, Tebani A, Strandberg L, Edfors F, Sjöstedt E, Mulder J, Mardinoglu A, Berling A, Ekblad S, Dannemeyer M, Kanje S, Rockberg J, Lundqvist M, Malm M, Volk AL, Nilsson P, Månberg A, Dodig-Crnkovic T, Pin E, Zwahlen M, Oksvold P, von Feilitzen K, Häussler RS, Hong MG, Lindskog C, Ponten F, Katona B, Vuu J, Lindström E, Nielsen J, Robinson J, Ayoglu B, Mahdessian D, Sullivan D, Thul P, Danielsson F, Stadler C, Lundberg E, Bergström G, Gummesson A, Voldborg BG, Tegel H, Hober S, Forsström B, Schwenk JM, Fagerberg L, Sivertsson Å.
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Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium.
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585 Elfving H, Mattsson JSM, Lindskog C, Backman M, Menzel U, Micke P.
Programmed Cell Death Ligand 1 Immunohistochemistry: A Concordance Study Between Surgical Specimen, Biopsy, and Tissue Microarray.
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584 Pineau C, Hikmet F, Zhang C, Oksvold P, Chen S, Fagerberg L, Uhlén M, Lindskog C.
Cell Type-Specific Expression of Testis Elevated Genes Based on Transcriptomics and Antibody-Based Proteomics.
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Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates with multiple sclerosis risk.
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581 Idborg H, Zandian A, Ossipova E, Wigren E, Preger C, Mobarrez F, Checa A, Sohrabian A, Pucholt P, Sandling JK, Fernandes-Cerqueira C, Rönnelid J, Oke V, Grosso G, Kvarnström M, Larsson A, Wheelock CE, Syvänen AC, Rönnblom L, Kultima K, Persson H, Gräslund S, Gunnarsson I, Nilsson P, Svenungsson E, Jakobsson PJ.
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579 Neiman M, Hellström C, Just D, Mattsson C, Fagerberg L, Schuppe-Koistinen I, Gummesson A, Bergström G, Kallioniemi O, Achour A, Sallinen R, Uhlén M, Nilsson P.
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Improved Differential Diagnosis of Alzheimer's Disease by Integrating ELISA and Mass Spectrometry-Based Cerebrospinal Fluid Biomarkers.
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575 Ge C, Xu B, Liang B, Lönnblom E, Lundström SL, Zubarev RA, Ayoglu B, Nilsson P, Skogh T, Kastbom A, Malmström V, Klareskog L, Toes REM, Rispens T, Dobritzsch D, Holmdahl R.
Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.
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Recognition of Amino Acid Motifs, Rather Than Specific Proteins, by Human Plasma Cell-Derived Monoclonal Antibodies to Posttranslationally Modified Proteins in Rheumatoid Arthritis.
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573 Månberg A, Bradley F, Qundos U, Guthrie BL, Birse K, Noël-Romas L, Lindskog C, Bosire R, Kiarie J, Farquhar C, Burgener AD, Nilsson P, Broliden K.
A High-throughput Bead-based Affinity Assay Enables Analysis of Genital Protein Signatures in Women At Risk of HIV Infection.
Mol Cell Proteomics. 2019 18(3):461-476.
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A deep proteome and transcriptome abundance atlas of 29 healthy human tissues.
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567 Aasebø KØ, Dragomir A, Sundström M, Mezheyeuski A, Edqvist PH, Eide GE, Ponten F, Pfeiffer P, Glimelius B, Sorbye H.
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549 Piening BD, Zhou W, Contrepois K, Röst H, Gu Urban GJ, Mishra T, Hanson BM, Bautista EJ, Leopold S, Yeh CY, Spakowicz D, Banerjee I, Chen C, Kukurba K, Perelman D, Craig C, Colbert E, Salins D, Rego S, Lee S, Zhang C, Wheeler J, Sailani MR, Liang L, Abbott C, Gerstein M, Mardinoglu A, Smith U, Rubin DL, Pitteri S, Sodergren E, McLaughlin TL, Weinstock GM, Snyder MP.
Integrative Personal Omics Profiles during Periods of Weight Gain and Loss.
Cell Syst. 2018 6(2):157-170.e8.
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548 Liu Z, Liang S, Que S, Zhou L, Zheng S, Mardinoglu A.
Meta-Analysis of Adiponectin as a Biomarker for the Detection of Metabolic Syndrome.
Front Physiol. 2018 9():1238.
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547 Zhang C, Bidkhori G, Benfeitas R, Lee S, Arif M, Uhlén M, Mardinoglu A.
ESS: A Tool for Genome-Scale Quantification of Essentiality Score for Reaction/Genes in Constraint-Based Modeling.
Front Physiol. 2018 9():1355.
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546 Zhang X, Mardinoglu A, Joosten LAB, Kuivenhoven JA, Li Y, Netea MG, Groen AK.
Identification of Discriminating Metabolic Pathways and Metabolites in Human PBMCs Stimulated by Various Pathogenic Agents.
Front Physiol. 2018 9():139.
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545 Turanli B, Karagoz K, Gulfidan G, Sinha R, Mardinoglu A, Arga KY.
A Network-Based Cancer Drug Discovery: From Integrated Multi-Omics Approaches to Precision Medicine.
Curr Pharm Des. 2018 24(32):3778-3790.
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544 Håversen L, Sundelin JP, Mardinoglu A, Rutberg M, Ståhlman M, Wilhelmsson U, Hultén LM, Pekny M, Fogelstrand P, Bentzon JF, Levin M, Borén J.
Vimentin deficiency in macrophages induces increased oxidative stress and vascular inflammation but attenuates atherosclerosis in mice.
Sci Rep. 2018 8(1):16973.
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543 Bidkhori G, Benfeitas R, Klevstig M, Zhang C, Nielsen J, Uhlen M, Boren J, Mardinoglu A.
Metabolic network-based stratification of hepatocellular carcinoma reveals three distinct tumor subtypes.
Proc Natl Acad Sci U S A. 2018 115(50):E11874-E11883.
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542 Nicholson AM, Olpe C, Hoyle A, Thorsen AS, Rus T, Colombé M, Brunton-Sim R, Kemp R, Marks K, Quirke P, Malhotra S, Ten Hoopen R, Ibrahim A, Lindskog C, Myers MB, Parsons B, Tavaré S, Wilkinson M, Morrissey E, Winton DJ.
Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium.
Cell Stem Cell. 2018 22(6):909-918.e8.
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541 Morin E, Sjöberg E, Tjomsland V, Testini C, Lindskog C, Franklin O, Sund M, Öhlund D, Kiflemariam S, Sjöblom T, Claesson-Welsh L.
VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival.
J Pathol. 2018 246(3):311-322.
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540 Miyashita N, Horie M, Suzuki HI, Yoshihara M, Djureinovic D, Persson J, Brunnström H, Lindskog C, Elfving H, Micke P, Saito A, Nagase T.
An Integrative Analysis of Transcriptome and Epigenome Features of ASCL1-Positive Lung Adenocarcinomas.
J Thorac Oncol. 2018 13(11):1676-1691.
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539 Strakova K, Kowalski-Jahn M, Gybel T, Valnohova J, Dhople VM, Harnos J, Bernatik O, Ganji RS, Zdrahal Z, Mulder J, Lindskog C, Bryja V, Schulte G.
Dishevelled enables casein kinase 1-mediated phosphorylation of Frizzled 6 required for cell membrane localization.
J Biol Chem. 2018 293(48):18477-18493.
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538 Guo J, Grow EJ, Mlcochova H, Maher GJ, Lindskog C, Nie X, Guo Y, Takei Y, Yun J, Cai L, Kim R, Carrell DT, Goriely A, Hotaling JM, Cairns BR.
The adult human testis transcriptional cell atlas.
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537 Reuterswärd P, Bergström S, Orikiiriza J, Lindquist E, Bergström S, Andersson Svahn H, Ayoglu B, Uhlén M, Wahlgren M, Normark J, Ribacke U, Nilsson P.
Levels of human proteins in plasma associated with acute paediatric malaria.
Malar J. 2018 17(1):426.
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536 Quintana MDP, Ch'ng JH, Zandian A, Imam M, Hultenby K, Theisen M, Nilsson P, Qundos U, Moll K, Chan S, Wahlgren M.
SURGE complex of Plasmodium falciparum in the rhoptry-neck (SURFIN4.2-RON4-GLURP) contributes to merozoite invasion.
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535 Frostegård J, Hellström C, Nilsson P, Frostegård AG, Ajeganova S.
Autoantibody profiling reveals four protein candidate autoantigens associated with systemic lupus erythematosus.
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534 Sjöberg R, Andersson E, Hellström C, Mattsson C, Schwenk JM, Nilsson P, Ayoglu B.
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533 Ayoglu B, Nilsson P, Schwenk JM.
Multiplexed Antigen Bead Arrays for the Assessment of Antibody Selectivity and Epitope Mapping.
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532 Bremer HD, Landegren N, Sjöberg R, Hallgren Å, Renneker S, Lattwein E, Leonard D, Eloranta ML, Rönnblom L, Nordmark G, Nilsson P, Andersson G, Lilliehöök I, Lindblad-Toh K, Kämpe O, Hansson-Hamlin H.
ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease.
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531 Garranzo-Asensio M, San Segundo-Acosta P, Martínez-Useros J, Montero-Calle A, Fernández-Aceñero MJ, Häggmark-Månberg A, Pelaez-Garcia A, Villalba M, Rabano A, Nilsson P, Barderas R.
Identification of prefrontal cortex protein alterations in Alzheimer's disease.
Oncotarget. 2018 9(13):10847-10867.
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530 Quintana MDP, Ch'ng JH, Moll K, Zandian A, Nilsson P, Idris ZM, Saiwaew S, Qundos U, Wahlgren M.
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529 Weidner LD, Kannan P, Mitsios N, Kang SJ, Hall MD, Theodore WH, Innis RB, Mulder J.
The expression of inflammatory markers and their potential influence on efflux transporters in drug-resistant mesial temporal lobe epilepsy tissue.
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528 Dos Remedios CG, Lal SP, Li A, McNamara J, Keogh A, Macdonald PS, Cooke R, Ehler E, Knöll R, Marston SB, Stelzer J, Granzier H, Bezzina C, van Dijk S, De Man F, Stienen GJM, Odeberg J, Pontén F, Linke WA, van der Velden J.
Correction to: The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease.
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527 Casar-Borota O, Bollerslev J, Pontén F.
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526 Huvila J, Laajala TD, Edqvist PH, Mardinoglu A, Talve L, Pontén F, Grénman S, Carpén O, Aittokallio T, Auranen A.
Combined ASRGL1 and p53 immunohistochemistry as an independent predictor of survival in endometrioid endometrial carcinoma.
Gynecol Oncol. 2018 149(1):173-180.
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525 Omenn GS, Lane L, Overall CM, Corrales FJ, Schwenk JM, Paik YK, Van Eyk JE, Liu S, Snyder M, Baker MS, Deutsch EW.
Progress on Identifying and Characterizing the Human Proteome: 2018 Metrics from the HUPO Human Proteome Project.
J Proteome Res. 2018 17(12):4031-4041.
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524 Djureinovic D, Dodig-Crnković T, Hellström C, Holgersson G, Bergqvist M, Mattsson JSM, Pontén F, Ståhle E, Schwenk JM, Micke P.
Detection of autoantibodies against cancer-testis antigens in non-small cell lung cancer.
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523 Mönnich M, Borgeskov L, Breslin L, Jakobsen L, Rogowski M, Doganli C, Schrøder JM, Mogensen JB, Blinkenkjær L, Harder LM, Lundberg E, Geimer S, Christensen ST, Andersen JS, Larsen LA, Pedersen LB.
CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium.
Cell Rep. 2018 22(10):2584-2592.
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522 Guala D, Bernhem K, Blal HA, Jans D, Lundberg E, Brismar H, Sonnhammer ELL.
Experimental validation of predicted cancer genes using FRET.
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521 Edfors F, Hober A, Linderbäck K, Maddalo G, Azimi A, Sivertsson Å, Tegel H, Hober S, Szigyarto CA, Fagerberg L, von Feilitzen K, Oksvold P, Lindskog C, Forsström B, Uhlen M.
Enhanced validation of antibodies for research applications.
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520 Lovric A, Granér M, Bjornson E, Arif M, Benfeitas R, Nyman K, Ståhlman M, Pentikäinen MO, Lundbom J, Hakkarainen A, Sirén R, Nieminen MS, Lundbom N, Lauerma K, Taskinen MR, Mardinoglu A, Boren J.
Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome.
Sci Rep. 2018 8(1):14200.
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519 Sjöstedt E, Sivertsson Å, Hikmet Noraddin F, Katona B, Näsström Å, Vuu J, Kesti D, Oksvold P, Edqvist PH, Olsson I, Uhlén M, Lindskog C.
Integration of Transcriptomics and Antibody-Based Proteomics for Exploration of Proteins Expressed in Specialized Tissues.
J Proteome Res. 2018 17(12):4127-4137.
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518 Lee S, Zhang C, Arif M, Liu Z, Benfeitas R, Bidkhori G, Deshmukh S, Al Shobky M, Lovric A, Boren J, Nielsen J, Uhlen M, Mardinoglu A.
TCSBN: a database of tissue and cancer specific biological networks.
Nucleic Acids Res. 2018 46(D1):D595-D600.
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517 Mardinoglu A, Uhlen M, Borén J.
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Cell Syst. 2018 6(1):7-9.
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516 Mardinoglu A, Wu H, Bjornson E, Zhang C, Hakkarainen A, Räsänen SM, Lee S, Mancina RM, Bergentall M, Pietiläinen KH, Söderlund S, Matikainen N, Ståhlman M, Bergh PO, Adiels M, Piening BD, Granér M, Lundbom N, Williams KJ, Romeo S, Nielsen J, Snyder M, Uhlén M, Bergström G, Perkins R, Marschall HU, Bäckhed F, Taskinen MR, Borén J.
An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans.
Cell Metab. 2018 27(3):559-571.e5.
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515 Karnevi E, Dror LB, Mardinoglu A, Elebro J, Heby M, Olofsson SE, Nodin B, Eberhard J, Gallagher W, Uhlén M, Jirström K.
Translational study reveals a two-faced role of RBM3 in pancreatic cancer and suggests its potential value as a biomarker for improved patient stratification.
Oncotarget. 2018 9(5):6188-6200.
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514 Azimi A, Caramuta S, Seashore-Ludlow B, Boström J, Robinson JL, Edfors F, Tuominen R, Kemper K, Krijgsman O, Peeper DS, Nielsen J, Hansson J, Egyhazi Brage S, Altun M, Uhlen M, Maddalo G.
Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors.
Mol Syst Biol. 2018 14(3):e7858.
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513 Lee CY, Wang D, Wilhelm M, Zolg DP, Schmidt T, Schnatbaum K, Reimer U, Pontén F, Uhlén M, Hahne H, Kuster B.
Mining the Human Tissue Proteome for Protein Citrullination.
Mol Cell Proteomics. 2018 17(7):1378-1391.
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512 Mardinoglu A, Boren J, Smith U, Uhlen M, Nielsen J.
Systems biology in hepatology: approaches and applications.
Nat Rev Gastroenterol Hepatol. 2018 15(6):365-377.
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511 Turanli B, Grøtli M, Boren J, Nielsen J, Uhlen M, Arga KY, Mardinoglu A.
Drug Repositioning for Effective Prostate Cancer Treatment.
Front Physiol. 2018 9():500.
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510 Zhang MD, Su J, Adori C, Cinquina V, Malenczyk K, Girach F, Peng C, Ernfors P, Löw P, Borgius L, Kiehn O, Watanabe M, Uhlén M, Mitsios N, Mulder J, Harkany T, Hökfelt T.
Ca2+-binding protein NECAB2 facilitates inflammatory pain hypersensitivity.
J Clin Invest. 2018 128(9):3757-3768.
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509 Rosario D, Benfeitas R, Bidkhori G, Zhang C, Uhlen M, Shoaie S, Mardinoglu A.
Understanding the Representative Gut Microbiota Dysbiosis in Metformin-Treated Type 2 Diabetes Patients Using Genome-Scale Metabolic Modeling.
Front Physiol. 2018 9():775.
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508 Bidkhori G, Benfeitas R, Elmas E, Kararoudi MN, Arif M, Uhlen M, Nielsen J, Mardinoglu A.
Metabolic Network-Based Identification and Prioritization of Anticancer Targets Based on Expression Data in Hepatocellular Carcinoma.
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507 Matic LP, Jesus Iglesias M, Vesterlund M, Lengquist M, Hong MG, Saieed S, Sanchez-Rivera L, Berg M, Razuvaev A, Kronqvist M, Lund K, Caidahl K, Gillgren P, Pontén F, Uhlén M, Schwenk JM, Hansson GK, Paulsson-Berne G, Fagman E, Roy J, Hultgren R, Bergström G, Lehtiö J, Odeberg J, Hedin U.
Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage.
JACC Basic Transl Sci. 2018 3(4):464-480.
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506 Dusart P, Fagerberg L, Perisic L, Civelek M, Struck E, Hedin U, Uhlén M, Trégouët DA, Renné T, Odeberg J, Butler LM.
A systems-approach reveals human nestin is an endothelial-enriched, angiogenesis-independent intermediate filament protein.
Sci Rep. 2018 8(1):14668.
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505 O'Hagan S, Wright Muelas M, Day PJ, Lundberg E, Kell DB.
GeneGini: Assessment via the Gini Coefficient of Reference "Housekeeping" Genes and Diverse Human Transporter Expression Profiles.
Cell Syst. 2018 6(2):230-244.e1.
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504 Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlén M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams ER, Wohlschlager T, Wysocki VH, Yates NA, Young NL, Zhang B.
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Nat Chem Biol. 2018 14(3):206-214.
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503 Sullivan DP, Winsnes CF, Åkesson L, Hjelmare M, Wiking M, Schutten R, Campbell L, Leifsson H, Rhodes S, Nordgren A, Smith K, Revaz B, Finnbogason B, Szantner A, Lundberg E.
Deep learning is combined with massive-scale citizen science to improve large-scale image classification.
Nat Biotechnol. 2018 36(9):820-828.
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502 Danielsson F, Fasterius E, Sullivan D, Hases L, Sanli K, Zhang C, Mardinoglu A, Al-Khalili C, Huss M, Uhlén M, Williams C, Lundberg E.
Transcriptome profiling of the interconnection of pathways involved in malignant transformation and response to hypoxia.
Oncotarget. 2018 9(28):19730-19744.
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501 Sullivan DP, Lundberg E.
Seeing More: A Future of Augmented Microscopy.
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500 Thul PJ, Lindskog C.
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499 Thelin EP, Just D, Frostell A, Häggmark-Månberg A, Risling M, Svensson M, Nilsson P, Bellander BM.
Protein profiling in serum after traumatic brain injury in rats reveals potential injury markers.
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498 Carapito C, Duek P, Macron C, Seffals M, Rondel K, Delalande F, Lindskog C, Fréour T, Vandenbrouck Y, Lane L, Pineau C.
Validating Missing Proteins in Human Sperm Cells by Targeted Mass-Spectrometry- and Antibody-based Methods.
J Proteome Res. 2017 16(12):4340-4351.
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497 Sjöstedt E, Bollerslev J, Mulder J, Lindskog C, Pontén F, Casar-Borota O.
A specific antibody to detect transcription factor T-Pit: a reliable marker of corticotroph cell differentiation and a tool to improve the classification of pituitary neuroendocrine tumours.
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496 Omenn GS, Lane L, Lundberg EK, Overall CM, Deutsch EW.
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495 Sastry A, Monk J, Tegel H, Uhlen M, Palsson BO, Rockberg J, Brunk E.
Machine learning in computational biology to accelerate high-throughput protein expression.
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493 Romanov RA, Zeisel A, Bakker J, Girach F, Hellysaz A, Tomer R, Alpár A, Mulder J, Clotman F, Keimpema E, Hsueh B, Crow AK, Martens H, Schwindling C, Calvigioni D, Bains JS, Máté Z, Szabó G, Yanagawa Y, Zhang MD, Rendeiro A, Farlik M, Uhlén M, Wulff P, Bock C, Broberger C, Deisseroth K, Hökfelt T, Linnarsson S, Horvath TL, Harkany T.
Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes.
Nat Neurosci. 2017 20(2):176-188.
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A TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover.
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Tumoral ANXA1 Is a Predictive Marker for Sunitinib Treatment of Renal Cancer Patients.
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A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family.
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Comparative cell cycle transcriptomics reveals synchronization of developmental transcription factor networks in cancer cells.
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Dysregulations in circulating sphingolipids associate with disease activity indices in female patients with systemic lupus erythematosus: a cross-sectional study.
Lupus. 2017 26(10):1023-1033.
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483 Ch'ng JH, Sirel M, Zandian A, Del Pilar Quintana M, Chun Leung Chan S, Moll K, Tellgren-Roth A, Nilsson I, Nilsson P, Qundos U, Wahlgren M.
Epitopes of anti-RIFIN antibodies and characterization of rif-expressing Plasmodium falciparum parasites by RNA sequencing.
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482 Sierra-Sánchez Á, Garrido-Martín D, Lourido L, González-González M, Díez P, Ruiz-Romero C, Sjöber R, Droste C, De Las Rivas J, Nilsson P, Blanco F, Fuentes M.
Screening and Validation of Novel Biomarkers in Osteoarticular Pathologies by Comprehensive Combination of Protein Array Technologies.
J Proteome Res. 2017 16(5):1890-1899.
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481 Ge C, Tong D, Liang B, Lönnblom E, Schneider N, Hagert C, Viljanen J, Ayoglu B, Stawikowska R, Nilsson P, Fields GB, Skogh T, Kastbom A, Kihlberg J, Burkhardt H, Dobritzsch D, Holmdahl R.
Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
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480 Skogs M, Stadler C, Schutten R, Hjelmare M, Gnann C, Björk L, Poser I, Hyman A, Uhlén M, Lundberg E.
Antibody Validation in Bioimaging Applications Based on Endogenous Expression of Tagged Proteins.
J Proteome Res. 2017 16(1):147-155.
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479 Alkasalias T, Alexeyenko A, Hennig K, Danielsson F, Lebbink RJ, Fielden M, Turunen SP, Lehti K, Kashuba V, Madapura HS, Bozoky B, Lundberg E, Balland M, Guvén H, Klein G, Gad AK, Pavlova T.
RhoA knockout fibroblasts lose tumor-inhibitory capacity in vitro and promote tumor growth in vivo.
Proc Natl Acad Sci U S A. 2017 114(8):E1413-E1421.
PubMed: 28174275 DOI: 10.1073/pnas.1621161114
478 Ly T, Whigham A, Clarke R, Brenes-Murillo AJ, Estes B, Madhessian D, Lundberg E, Wadsworth P, Lamond AI.
Proteomic analysis of cell cycle progression in asynchronous cultures, including mitotic subphases, using PRIMMUS.
Elife. 2017 6():.
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477 Brunnström H, Johansson A, Westbom-Fremer S, Backman M, Djureinovic D, Patthey A, Isaksson-Mettävainio M, Gulyas M, Micke P.
PD-L1 immunohistochemistry in clinical diagnostics of lung cancer: inter-pathologist variability is higher than assay variability.
Mod Pathol. 2017 30(10):1411-1421.
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476 Jedlinski A, Garvin S, Johansson AC, Edqvist PH, Ponten F, Roberg K.
Cetuximab sensitivity of head and neck squamous cell carcinoma xenografts is associated with treatment-induced reduction in EGFR, pEGFR, and pSrc.
J Oral Pathol Med. 2017 46(9):717-724.
PubMed: 28036101 DOI: 10.1111/jop.12545
475 Gremel G, Djureinovic D, Niinivirta M, Laird A, Ljungqvist O, Johannesson H, Bergman J, Edqvist PH, Navani S, Khan N, Patil T, Sivertsson Å, Uhlén M, Harrison DJ, Ullenhag GJ, Stewart GD, Pontén F.
A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma.
BMC Cancer. 2017 17(1):9.
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474 Niinivirta M, Enblad G, Edqvist PH, Pontén F, Dragomir A, Ullenhag GJ.
Tumoral cubilin is a predictive marker for treatment of renal cancer patients with sunitinib and sorafenib.
J Cancer Res Clin Oncol. 2017 143(6):961-970.
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473 Grinberg M, Djureinovic D, Brunnström HR, Mattsson JS, Edlund K, Hengstler JG, La Fleur L, Ekman S, Koyi H, Branden E, Ståhle E, Jirström K, Tracy DK, Pontén F, Botling J, Rahnenführer J, Micke P.
Reaching the limits of prognostication in non-small cell lung cancer: an optimized biomarker panel fails to outperform clinical parameters.
Mod Pathol. 2017 30(7):964-977.
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472 Bondeson ML, Ericson K, Gudmundsson S, Ameur A, Pontén F, Wesström J, Frykholm C, Wilbe M.
A nonsense mutation in CEP55 defines a new locus for a Meckel-like syndrome, an autosomal recessive lethal fetal ciliopathy.
Clin Genet. 2017 92(5):510-516.
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471 Roy A, Attarha S, Weishaupt H, Edqvist PH, Swartling FJ, Bergqvist M, Siebzehnrubl FA, Smits A, Pontén F, Tchougounova E.
Serglycin as a potential biomarker for glioma: association of serglycin expression, extent of mast cell recruitment and glioblastoma progression.
Oncotarget. 2017 8(15):24815-24827.
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470 Roy A, Libard S, Weishaupt H, Gustavsson I, Uhrbom L, Hesselager G, Swartling FJ, Pontén F, Alafuzoff I, Tchougounova E.
Mast Cell Infiltration in Human Brain Metastases Modulates the Microenvironment and Contributes to the Metastatic Potential.
Front Oncol. 2017 7():115.
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469 Casar-Borota O, Botling J, Granberg D, Stigare J, Wikström J, Boldt HB, Kristensen BW, Pontén F, Trouillas J.
Serotonin, ATRX, and DAXX Expression in Pituitary Adenomas: Markers in the Differential Diagnosis of Neuroendocrine Tumors of the Sellar Region.
Am J Surg Pathol. 2017 41(9):1238-1246.
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468 Siesing C, Sorbye H, Dragomir A, Pfeiffer P, Qvortrup C, Pontén F, Jirström K, Glimelius B, Eberhard J.
High RBM3 expression is associated with an improved survival and oxaliplatin response in patients with metastatic colorectal cancer.
PLoS One. 2017 12(8):e0182512.
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467 Dos Remedios CG, Lal SP, Li A, McNamara J, Keogh A, Macdonald PS, Cooke R, Ehler E, Knöll R, Marston SB, Stelzer J, Granzier H, Bezzina C, van Dijk S, De Man F, Stienen GJM, Odeberg J, Pontén F, Linke , Linke W, van der Velden J.
The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease.
Biophys Rev. 2017 9(4):431-441.
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466 Fredholm H, Magnusson K, Lindström LS, Tobin NP, Lindman H, Bergh J, Holmberg L, Pontén F, Frisell J, Fredriksson I.
Breast cancer in young women and prognosis: How important are proliferation markers?
Eur J Cancer. 2017 84():278-289.
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465 Guo J, Grow EJ, Yi C, Mlcochova H, Maher GJ, Lindskog C, Murphy PJ, Wike CL, Carrell DT, Goriely A, Hotaling JM, Cairns BR.
Chromatin and Single-Cell RNA-Seq Profiling Reveal Dynamic Signaling and Metabolic Transitions during Human Spermatogonial Stem Cell Development.
Cell Stem Cell. 2017 21(4):533-546.e6.
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464 Bosley J, Boren C, Lee S, Grøtli M, Nielsen J, Uhlen M, Boren J, Mardinoglu A.
Improving the economics of NASH/NAFLD treatment through the use of systems biology.
Drug Discov Today. 2017 22(10):1532-1538.
PubMed: 28736156 DOI: 10.1016/j.drudis.2017.07.005
463 Liu Z, Que S, Mardinoglu A.
Rediscussion on linearity between fibrosis stages and mortality risk in nonalcoholic fatty liver disease patients.
Hepatology. 2017 66(4):1357-1358.
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462 Liu Z, Que S, Zhou L, Zheng S, Romeo S, Mardinoglu A, Valenti L.
The effect of the TM6SF2 E167K variant on liver steatosis and fibrosis in patients with chronic hepatitis C: a meta-analysis.
Sci Rep. 2017 7(1):9273.
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461 Lee S, Zhang C, Liu Z, Klevstig M, Mukhopadhyay B, Bergentall M, Cinar R, Ståhlman M, Sikanic N, Park JK, Deshmukh S, Harzandi AM, Kuijpers T, Grøtli M, Elsässer SJ, Piening BD, Snyder M, Smith U, Nielsen J, Bäckhed F, Kunos G, Uhlen M, Boren J, Mardinoglu A.
Network analyses identify liver-specific targets for treating liver diseases.
Mol Syst Biol. 2017 13(8):938.
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460 Mardinoglu A, Stančáková A, Lotta LA, Kuusisto J, Boren J, Blüher M, Wareham NJ, Ferrannini E, Groop PH, Laakso M, Langenberg C, Smith U.
Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular Disease.
Cell Metab. 2017 26(2):281-283.
PubMed: 28768165 DOI: 10.1016/j.cmet.2017.07.006
459 Benfeitas R, Uhlen M, Nielsen J, Mardinoglu A.
New Challenges to Study Heterogeneity in Cancer Redox Metabolism.
Front Cell Dev Biol. 2017 5():65.
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458 Mardinoglu A, Borén J.
AUP1 (Ancient Ubiquitous Protein 1): A Molecular Link Between Hepatic Lipid Mobilization and VLDL Secretion.
Arterioscler Thromb Vasc Biol. 2017 37(4):609-610.
PubMed: 28330944 DOI: 10.1161/ATVBAHA.117.309152
457 Mardinoglu A, Bjornson E, Zhang C, Klevstig M, Söderlund S, Ståhlman M, Adiels M, Hakkarainen A, Lundbom N, Kilicarslan M, Hallström BM, Lundbom J, Vergès B, Barrett PH, Watts GF, Serlie MJ, Nielsen J, Uhlén M, Smith U, Marschall HU, Taskinen MR, Boren J.
Personal model-assisted identification of NAD(+) and glutathione metabolism as intervention target in NAFLD.
Mol Syst Biol. 2017 13(3):916.
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456 Nilsson A, Mardinoglu A, Nielsen J.
Predicting growth of the healthy infant using a genome scale metabolic model.
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455 Schwenk JM, Omenn GS, Sun Z, Campbell DS, Baker MS, Overall CM, Aebersold R, Moritz RL, Deutsch EW.
The Human Plasma Proteome Draft of 2017: Building on the Human Plasma PeptideAtlas from Mass Spectrometry and Complementary Assays.
J Proteome Res. 2017 16(12):4299-4310.
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454 Zandian A, Wingård L, Nilsson H, Sjöstedt E, Johansson DX, Just D, Hellström C, Uhlén M, Schwenk JM, Häggmark-Månberg A, Norbeck O, Owe-Larsson B, Nilsson P, Persson MAA.
Untargeted screening for novel autoantibodies with prognostic value in first-episode psychosis.
Transl Psychiatry. 2017 7(7):e1177.
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453 Glimelius B, Melin B, Enblad G, Alafuzoff I, Beskow A, Ahlström H, Bill-Axelson A, Birgisson H, Björ O, Edqvist PH, Hansson T, Helleday T, Hellman P, Henriksson K, Hesselager G, Hultdin M, Häggman M, Höglund M, Jonsson H, Larsson C, Lindman H, Ljuslinder I, Mindus S, Nygren P, Pontén F, Riklund K, Rosenquist R, Sandin F, Schwenk JM, Stenling R, Stålberg K, Stålberg P, Sundström C, Thellenberg Karlsson C, Westermark B, Bergh A, Claesson-Welsh L, Palmqvist R, Sjöblom T.
U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.
Acta Oncol. 2017 ():1-8.
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452 Byström S, Fredolini C, Edqvist PH, Nyaiesh EN, Drobin K, Uhlén M, Bergqvist M, Pontén F, Schwenk JM.
Affinity Proteomics Exploration of Melanoma Identifies Proteins in Serum with Associations to T-Stage and Recurrence.
Transl Oncol. 2017 10(3):385-395.
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451 Omazic B, Ayoglu B, Löhr M, Segersvärd R, Verbeke C, Magalhaes I, Potacova Z, Mattsson J, Terman A, Ghazi S, Albiin N, Kartalis N, Nilsson P, Poiret T, Zhenjiang L, Heuchel R, Schwenk JM, Permert J, Maeurer MJ, Ringden O.
A Preliminary Report: Radical Surgery and Stem Cell Transplantation for the Treatment of Patients With Pancreatic Cancer.
J Immunother. 2017 40(4):132-139.
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450 Lourido L, Ayoglu B, Fernández-Tajes J, Oreiro N, Henjes F, Hellström C, Schwenk JM, Ruiz-Romero C, Nilsson P, Blanco FJ.
Discovery of circulating proteins associated to knee radiographic osteoarthritis.
Sci Rep. 2017 7(1):137.
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449 Zandian A, Forsström B, Häggmark-Månberg A, Schwenk JM, Uhlén M, Nilsson P, Ayoglu B.
Whole-Proteome Peptide Microarrays for Profiling Autoantibody Repertoires within Multiple Sclerosis and Narcolepsy.
J Proteome Res. 2017 16(3):1300-1314.
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448 Hellström C, Dodig-Crnković T, Hong MG, Schwenk JM, Nilsson P, Sjöberg R.
High-Density Serum/Plasma Reverse Phase Protein Arrays.
Methods Mol Biol. 2017 1619():229-238.
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447 Birgersson E, Schwenk JM, Ayoglu B.
Bead-Based and Multiplexed Immunoassays for Protein Profiling via Sequential Affinity Capture.
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446 Häggmark-Månberg A, Nilsson P, Schwenk JM.
Neuroproteomic Profiling of Cerebrospinal Fluid (CSF) by Multiplexed Affinity Arrays.
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445 Uhlen M, Zhang C, Lee S, Sjöstedt E, Fagerberg L, Bidkhori G, Benfeitas R, Arif M, Liu Z, Edfors F, Sanli K, von Feilitzen K, Oksvold P, Lundberg E, Hober S, Nilsson P, Mattsson J, Schwenk JM, Brunnström H, Glimelius B, Sjöblom T, Edqvist PH, Djureinovic D, Micke P, Lindskog C, Mardinoglu A, Ponten F.
A pathology atlas of the human cancer transcriptome.
Science. 2017 357(6352)
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444 Thul PJ, Åkesson L, Wiking M, Mahdessian D, Geladaki A, Ait Blal H, Alm T, Asplund A, Björk L, Breckels LM, Bäckström A, Danielsson F, Fagerberg L, Fall J, Gatto L, Gnann C, Hober S, Hjelmare M, Johansson F, Lee S, Lindskog C, Mulder J, Mulvey CM, Nilsson P, Oksvold P, Rockberg J, Schutten R, Schwenk JM, Sivertsson Å, Sjöstedt E, Skogs M, Stadler C, Sullivan DP, Tegel H, Winsnes C, Zhang C, Zwahlen M, Mardinoglu A, Pontén F, von Feilitzen K, Lilley KS, Uhlén M, Lundberg E.
A subcellular map of the human proteome.
Science. 2017 356(6340): eaal3321
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443 Kannan P, Schain M, Kretzschmar WW, Weidner L, Mitsios N, Gulyás B, Blom H, Gottesman MM, Innis RB, Hall MD, Mulder J.
An automated method measures variability in P-glycoprotein and ABCG2 densities across brain regions and brain matter.
J Cereb Blood Flow Metab. 2017 37(6):2062-2075.
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442 Heinonen S, Muniandy M, Buzkova J, Mardinoglu A, Rodríguez A, Frühbeck G, Hakkarainen A, Lundbom J, Lundbom N, Kaprio J, Rissanen A, Pietiläinen KH.
Mitochondria-related transcriptional signature is downregulated in adipocytes in obesity: a study of young healthy MZ twins.
Diabetologia. 2017 60(1):169-181.
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441 Delforoush M, Berglund M, Edqvist PH, Sundström C, Gullbo J, Enblad G.
Expression of possible targets for new proteasome inhibitors in diffuse large B-cell lymphoma.
Eur J Haematol. 2017 98(1):52-56.
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440 Pin E, Henjes F, Hong MG, Wiklund F, Magnusson P, Bjartell A, Uhlén M, Nilsson P, Schwenk JM.
Identification of a Novel Autoimmune Peptide Epitope of Prostein in Prostate Cancer.
J Proteome Res. 2017 16(1):204-216.
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439 Mikus M, Drobin K, Gry M, Bachmann J, Lindberg J, Yimer G, Aklillu E, Makonnen E, Aderaye G, Roach J, Fier I, Kampf C, Göpfert J, Perazzo H, Poynard T, Stephens C, Andrade RJ, Lucena MI, Arber N, Uhlén M, Watkins PB, Schwenk JM, Nilsson P, Schuppe-Koistinen I.
Elevated levels of circulating CDH5 and FABP1 in association with human drug-induced liver injury.
Liver Int. 2017 37(1):132-140.
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438 Malm M, Frejd FY, Ståhl S, Löfblom J.
Targeting HER3 using mono- and bispecific antibodies or alternative scaffolds.
MAbs. 2016 8(7):1195-1209.
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437 Scharaw S, Iskar M, Ori A, Boncompain G, Laketa V, Poser I, Lundberg E, Perez F, Beck M, Bork P, Pepperkok R.
The endosomal transcriptional regulator RNF11 integrates degradation and transport of EGFR.
J Cell Biol. 2016 215(4):543-558.
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436 Sialana FJ, Gulyassy P, Májek P, Sjöstedt E, Kis V, Müller AC, Rudashevskaya EL, Mulder J, Bennett KL, Lubec G.
Mass spectrometric analysis of synaptosomal membrane preparations for the determination of brain receptors, transporters and channels.
Proteomics. 2016 16(22):2911-2920.
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435 Micke P, Mattsson JS, Djureinovic D, Nodin B, Jirström K, Tran L, Jönsson P, Planck M, Botling J, Brunnström H.
The Impact of the Fourth Edition of the WHO Classification of Lung Tumours on Histological Classification of Resected Pulmonary NSCCs.
J Thorac Oncol. 2016 11(6):862-72.
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434 Edfors F, Danielsson F, Hallström BM, Käll L, Lundberg E, Pontén F, Forsström B, Uhlén M.
Gene-specific correlation of RNA and protein levels in human cells and tissues.
Mol Syst Biol. 2016 12(10):883.
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433 van Kempen LC, Redpath M, Elchebly M, Klein KO, Papadakis AI, Wilmott JS, Scolyer RA, Edqvist PH, Pontén F, Schadendorf D, van Rijk AF, Michiels S, Dumay A, Helbling-Leclerc A, Dessen P, Wouters J, Stass M, Greenwood CM, Ghanem GE, van den Oord J, Feunteun J, Spatz A.
The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene.
Sci Transl Med. 2016 8(369):369ra177.
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432 Ten Berge JC, van Rosmalen J, Vermeer J, Hellström C, Lindskog C, Nilsson P, Qundos U, Rothova A, Schreurs MW.
Serum Autoantibody Profiling of Patients with Paraneoplastic and Non-Paraneoplastic Autoimmune Retinopathy.
PLoS One. 2016 11(12):e0167909.
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431 Mardinoglu A, Nielsen J.
Editorial: The Impact of Systems Medicine on Human Health and Disease.
Front Physiol. 2016 7():552.
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430 Casey JR, Mardinoglu A, Nielsen J, Karl DM.
Adaptive Evolution of Phosphorus Metabolism in Prochlorococcus.
mSystems. 2016 1(6):.
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429 Magnusson K, Gremel G, Rydén L, Pontén V, Uhlén M, Dimberg A, Jirström K, Pontén F.
ANLN is a prognostic biomarker independent of Ki-67 and essential for cell cycle progression in primary breast cancer.
BMC Cancer. 2016 16(1):904.
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428 Bergman J, Botling J, Fagerberg L, Hallström BM, Djureinovic D, Uhlén M, Pontén F.
The human adrenal gland proteome defined by transcriptomics and antibody-based profiling.
Endocrinology. 2016 ():en20161758.
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427 Musunuri S, Khoonsari PE, Mikus M, Wetterhall M, Häggmark-Mänberg A, Lannfelt L, Erlandsson A, Bergquist J, Ingelsson M, Shevchenko G, Nilsson P, Kultima K.
Increased Levels of Extracellular Microvesicle Markers and Decreased Levels of Endocytic/Exocytic Proteins in the Alzheimer's Disease Brain.
J Alzheimers Dis. 2016 54(4):1671-1686.
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426 Ayoglu B, Schwenk JM, Nilsson P.
Antigen arrays for profiling autoantibody repertoires.
Bioanalysis. 2016 8(10):1105-26.
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425 Schrötter A, Park YM, Marcus K, Martins-de-Souza D, Nilsson P, Magraoui FE, Meyer HE, Grinberg LT.
Key players in neurodegenerative disorders in focus-New insights into the proteomic profile of Alzheimer's disease, schizophrenia, ALS, and multiple sclerosis-24th HUPO BPP Workshop: September 29, 2015, Vancouver, Canada.
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424 Khoonsari PE, Häggmark A, Lönnberg M, Mikus M, Kilander L, Lannfelt L, Bergquist J, Ingelsson M, Nilsson P, Kultima K, Shevchenko G.
Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease.
PLoS One. 2016 11(3):e0150672.
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423 Mardinoglu A, Boren J, Smith U.
Confounding Effects of Metformin on the Human Gut Microbiome in Type 2 Diabetes.
Cell Metab. 2016 23(1):10-2.
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422 Björnson E, Borén J, Mardinoglu A.
Personalized Cardiovascular Disease Prediction and Treatment-A Review of Existing Strategies and Novel Systems Medicine Tools.
Front Physiol. 2016 7():2.
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421 Elsemman IE, Mardinoglu A, Shoaie S, Soliman TH, Nielsen J.
Systems biology analysis of hepatitis C virus infection reveals the role of copy number increases in regions of chromosome 1q in hepatocellular carcinoma metabolism.
Mol Biosyst. 2016 12(5):1496-506.
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420 Lee S, Mardinoglu A, Zhang C, Lee D, Nielsen J.
Dysregulated signaling hubs of liver lipid metabolism reveal hepatocellular carcinoma pathogenesis.
Nucleic Acids Res. 2016 44(12):5529-39.
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419 Zhang C, Lee S, Mardinoglu A, Hua Q.
Investigating the Combinatory Effects of Biological Networks on Gene Co-expression.
Front Physiol. 2016 7():160.
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418 Chaudhari A, Håversen L, Mobini R, Andersson L, Ståhlman M, Lu E, Rutberg M, Fogelstrand P, Ekroos K, Mardinoglu A, Levin M, Perkins R, Borén J.
ARAP2 promotes GLUT1-mediated basal glucose uptake through regulation of sphingolipid metabolism.
Biochim Biophys Acta. 2016 1861(11):1643-1651.
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417 Larsson AH, Lehn S, Wangefjord S, Karnevi E, Kuteeva E, Sundström M, Nodin B, Uhlén M, Eberhard J, Birgisson H, Jirström K.
Significant association and synergistic adverse prognostic effect of podocalyxin-like protein and epidermal growth factor receptor expression in colorectal cancer.
J Transl Med. 2016 14(1):128.
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416 Lee S, Zhang C, Kilicarslan M, Piening BD, Bjornson E, Hallström BM, Groen AK, Ferrannini E, Laakso M, Snyder M, Blüher M, Uhlen M, Nielsen J, Smith U, Serlie MJ, Boren J, Mardinoglu A.
Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance.
Cell Metab. 2016 24(1):172-84.
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415 Mardinoglu A, Uhlén M.
Liver: Phenotypic and genetic variance: a systems approach to the liver.
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Affinity proteomics within rare diseases: a BIO-NMD study for blood biomarkers of muscular dystrophies.
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267 Bachmann J, Burté F, Pramana S, Conte I, Brown BJ, Orimadegun AE, Ajetunmobi WA, Afolabi NK, Akinkunmi F, Omokhodion S, Akinbami FO, Shokunbi WA, Kampf C, Pawitan Y, Uhlén M, Sodeinde O, Schwenk JM, Wahlgren M, Fernandez-Reyes D, Nilsson P.
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A study of embryonic stem cell-related proteins in human astrocytomas: identification of Nanog as a predictor of survival.
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Tissue tumor marker expression in smokers, including serum cotinine concentrations, in women with cervical intraepithelial neoplasia or normal squamous cervical epithelium.
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126 Samir R, Tot T, Asplund A, Pekar G, Hellberg D.
Increased serum progesterone and estradiol correlate to increased COX-2 tissue expression in cervical intraepithelial neoplasia.
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125 Kronqvist N, Malm M, Rockberg J, Hjelm B, Uhlén M, Ståhl S, Löfblom J.
Staphylococcal surface display in combinatorial protein engineering and epitope mapping of antibodies.
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124 Klevebring D, Fagerberg L, Lundberg E, Emanuelsson O, Uhlén M, Lundeberg J.
Analysis of transcript and protein overlap in a human osteosarcoma cell line.
BMC Genomics. 2010 11:684.
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123 Jonasson K, Berglund L, Uhlen M.
The 6th HUPO Antibody Initiative (HAI) workshop: sharing data about affinity reagents and other recent developments. September 2009, Toronto, Canada.
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122 International Cancer Genome Consortium
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121 Mulder J, Spence L, Tortoriello G, Dinieri JA, Uhlén M, Shui B, Kotlikoff MI, Yanagawa Y, Aujard F, Hökfelt T, Hurd YL, Harkany T.
Secretagogin is a Ca2+-binding protein identifying prospective extended amygdala neurons in the developing mammalian telencephalon.
Eur J Neurosci. 2010 31(12):2166-77.
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120 Furusato B, Mohamed A, Uhlén M, Rhim JS.
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Pathol Int. 2010 60(7):497-505.
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119 Bourbeillon J, Orchard S, Benhar I, Borrebaeck C, de Daruvar A, Dübel S, Frank R, Gibson F, Gloriam D, Haslam N, Hiltker T, Humphrey-Smith I, Hust M, Juncker D, Koegl M, Konthur Z, Korn B, Krobitsch S, Muyldermans S, Nygren PA, Palcy S, Polic B, Rodriguez H, Sawyer A, Schlapshy M, Snyder M, Stoevesandt O, Taussig MJ, Templin M, Uhlen M, van der Maarel S, Wingren C, Hermjakob H, Sherman D.
Minimum information about a protein affinity reagent (MIAPAR).
Nat Biotechnol. 2010 28(7):650-3.
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118 Gardberg M, Talvinen K, Kaipio K, Iljin K, Kampf C, Uhlen M, Carpén O.
Characterization of Diaphanous-related formin FMNL2 in human tissues.
BMC Cell Biol. 2010 11:55.
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117 Uhlen M, Oksvold P, Fagerberg L, Lundberg E, Jonasson K, Forsberg M, Zwahlen M, Kampf C, Wester K, Hober S, Wernerus H, Björling L, Ponten F.
Towards a knowledge-based Human Protein Atlas.
Nat Biotechnol. 2010 28(12):1248-50.
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116 Lundberg E, Fagerberg L, Klevebring D, Matic I, Geiger T, Cox J, Algenäs C, Lundeberg J, Mann M, Uhlen M.
Defining the transcriptome and proteome in three functionally different human cell lines.
Mol Syst Biol. 2010 6:450.
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115 Gry M, Oksvold P, Pontén F, Uhlén M.
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114 Agnarsdóttir M, Sooman L, Bolander A, Strömberg S, Rexhepaj E, Bergqvist M, Ponten F, Gallagher W, Lennartsson J, Ekman S, Uhlen M, Hedstrand H.
SOX10 expression in superficial spreading and nodular malignant melanomas.
Melanoma Res. 2010 20(6):468-78.
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113 Brennan DJ, O'Connor DP, Rexhepaj E, Ponten F, Gallagher WM.
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112 Ehlén A, Brennan DJ, Nodin B, O'Connor DP, Eberhard J, Alvarado-Kristensson M, Jeffrey IB, Manjer J, Brändstedt J, Uhlén M, Pontén F, Jirström K.
Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer.
J Transl Med. 2010 8:78.
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111 Lindskog C, Asplund A, Engkvist M, Uhlén M, Korsgren O, Pontén F.
Antibody-based proteomics for discovery and exploration of proteins expressed in pancreatic islets.
Discov Med. 2010 9(49):565-78.
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110 Blokzijl A, Friedman M, Pontén F, Landegren U.
Profiling protein expression and interactions: proximity ligation as a tool for personalized medicine.
J Intern Med. 2010 268(3):232-45.
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109 Ryan D, Rafferty M, Hegarty S, O'Leary P, Faller W, Gremel G, Bergqvist M, Agnarsdottir M, Strömberg S, Kampf C, Pontén F, Millikan RC, Dervan PA, Gallagher WM.
Topoisomerase I amplification in melanoma is associated with more advanced tumours and poor prognosis.
Pigment Cell Melanoma Res. 2010 23(4):542-53.
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108 Brennan DJ, Brändstedt J, Rexhepaj E, Foley M, Pontén F, Uhlén M, Gallagher WM, O'Connor DP, O'Herlihy C, Jirstrom K.
Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer.
BMC Cancer. 2010 10:125.
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107 Nord H, Segersten U, Sandgren J, Wester K, Busch C, Menzel U, Komorowski J, Dumanski JP, Malmström PU, Díaz de Ståhl T.
Focal amplifications are associated with high grade and recurrences in stage Ta bladder carcinoma.
Int J Cancer. 2010 126(6):1390-402.
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106 Borsics T, Lundberg E, Geerts D, Koomoa DL, Koster J, Wester K, Bachmann AS.
Subcellular distribution and expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in malignant glioma: Influence on cell survival and migration.
Cancer Sci. 2010 101(7):1624-31.
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105 Lundberg E, Uhlén M.
Creation of an antibody-based subcellular protein atlas.
Proteomics. 2010 10(22):3984-96.
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104 Schwenk JM, Igel U, Neiman M, Langen H, Becker C, Bjartell A, Ponten F, Wiklund F, Grönberg H, Nilsson P, Uhlen M.
Toward next generation plasma profiling via heat-induced epitope retrieval and array-based assays.
Mol Cell Proteomics. 2010 9(11):2497-507.
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103 Rockberg J, Löfblom J, Hjelm B, Ståhl S, Uhlén M.
Epitope mapping using gram-positive surface display.
Curr Protoc Immunol. 2010 Chapter 9:Unit9.9.
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102 Tassidis H, Brokken LJ, Jirström K, Ehrnström R, Pontén F, Ulmert D, Bjartell A, Härkönen P, Wingren AG.
Immunohistochemical detection of tyrosine phosphatase SHP-1 predicts outcome after radical prostatectomy for localized prostate cancer.
Int J Cancer. 2010 126(10):2296-307.
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101 Holgersson G, Ekman S, Reizenstein J, Bergqvist M, Pontén F, Uhlén M, Magnusson K, Jonnalagadda P, Asplund A, Strömberg S, Linder A, Blomquist E, Liljeholm M, Lödén B, Hellström K, Bergström S.
Molecular profiling using tissue microarrays as a tool to identify predictive biomarkers in laryngeal cancer treated with radiotherapy.
Cancer Genomics Proteomics 2010 7(1):1-7.
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Increased levels of recombinant human proteins with the Escherichia coli strain Rosetta(DE3).
Protein Expr Purif. 2010 69(2):159-67.
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99 Fagerberg L, Jonasson K, von Heijne G, Uhlén M, Berglund L.
Prediction of the human membrane proteome.
Proteomics. 2010 10(6):1141-9.
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98 Schwenk JM, Igel U, Kato BS, Nicholson G, Karpe F, Uhlén M, Nilsson P.
Comparative protein profiling of serum and plasma using an antibody suspension bead array approach.
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97 Stadler C, Skogs M, Brismar H, Uhlén M, Lundberg E.
A single fixation protocol for proteome-wide immunofluorescence localization studies.
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96 Gloriam DE, Orchard S, Bertinetti D, Björling E, Bongcam-Rudloff E, Borrebaeck CA, Bourbeillon J, Bradbury AR, de Daruvar A, Dübel S, Frank R, Gibson TJ, Gold L, Haslam N, Herberg FW, Hiltke T, Hoheisel JD, Kerrien S, Koegl M, Konthur Z, Korn B, Landegren U, Montecchi-Palazzi L, Palcy S, Rodriguez H, Schweinsberg S, Sievert V, Stoevesandt O, Taussig MJ, Ueffing M, Uhlén M, van der Maarel S, Wingren C, Woollard P, Sherman DJ, Hermjakob H.
A community standard format for the representation of protein affinity reagents.
Mol Cell Proteomics. 2010 9(1):1-10.
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95 Szigyarto CA, Sibbons P, Williams G, Uhlen M, Metcalfe SM.
The E3 ligase axotrophin/MARCH-7: protein expression profiling of human tissues reveals links to adult stem cells.
J Histochem Cytochem. 2010 58(4):301-8.
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94 Hjelm B, Fernández CD, Löfblom J, Ståhl S, Johannesson H, Rockberg J, Uhlén M.
Exploring epitopes of antibodies toward the human tryptophanyl-tRNA synthetase.
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93 Paavilainen L, Edvinsson A, Asplund A, Hober S, Kampf C, Pontén F, Wester K.
The impact of tissue fixatives on morphology and antibody-based protein profiling in tissues and cells.
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92 Tchougounova E, Jiang Y, Bråsäter D, Lindberg N, Kastemar M, Asplund A, Westermark B, Uhrbom L.
Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence.
Oncogene. 2009 28(12):1537-48.
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Herbal melanin activates TLR4/NF-kappaB signaling pathway.
Phytomedicine. 2009 16(5):477-84.
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Approaching clinical proteomics: current state and future fields of application in cellular proteomics.
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88 Qu M, Aronica E, Boer K, Fällmar D, Kumlien E, Nistér M, Wester K, Pontén F, Smits A.
DLG3/SAP102 protein expression in malformations of cortical development: a study of human epileptic cortex by tissue microarray.
Epilepsy Res. 2009 84(1):33-41.
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87 Newberg JY, Li J, Rao A, Pontén F, Uhlén M, Lundberg E, Murphy RF.
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86 Gaber A, Johansson M, Stenman UH, Hotakainen K, Pontén F, Glimelius B, Bjartell A, Jirström K, Birgisson H.
High expression of tumour-associated trypsin inhibitor correlates with liver metastasis and poor prognosis in colorectal cancer.
Br J Cancer. 2009 100(10):1540-8.
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85 Paulsson J, Sjöblom T, Micke P, Pontén F, Landberg G, Heldin CH, Bergh J, Brennan DJ, Jirström K, Ostman A.
Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer.
Am J Pathol. 2009 175(1):334-41.
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84 Apweiler R, Aslanidis C, Deufel T, Gerstner A, Hansen J, Hochstrasser D, Kellner R, Kubicek M, Lottspeich F, Maser E, Mewes HW, Meyer HE, Müllner S, Mutter W, Neumaier M, Nollau P, Nothwang HG, Ponten F, Radbruch A, Reinert K, Rothe G, Stockinger H, Tarnok A, Taussig MJ, Thiel A, Thiery J, Ueffing M, Valet G, Vandekerckhove J, Verhuven W, Wagener C, Wagner O, Schmitz G.
Approaching clinical proteomics: current state and future fields of application in fluid proteomics.
Clin Chem Lab Med. 2009 47(6):724-44.
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83 Ghanipour A, Jirström K, Pontén F, Glimelius B, Påhlman L, Birgisson H.
The prognostic significance of tryptophanyl-tRNA synthetase in colorectal cancer.
Cancer Epidemiol Biomarkers Prev. 2009 18(11):2949-56.
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ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth.
PLoS Biol. 2009 7(12):e1000256.
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81 Rimini R, Schwenk JM, Sundberg M, Sjöberg R, Klevebring D, Gry M, Uhlén M, Nilsson P.
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Report on EU-USA workshop: how systems biology can advance cancer research (27 October 2008).
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Discovery of epitopes for targeting the human epidermal growth factor receptor 2 (HER2) with antibodies.
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77 Gry M, Rimini R, Strömberg S, Asplund A, Pontén F, Uhlén M, Nilsson P.
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BMC Genomics. 2009 10:365.
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Nuclear expression of the RNA-binding protein RBM3 is associated with an improved clinical outcome in breast cancer.
Mod Pathol. 2009 22(12):1564-74.
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Endogenous gene and protein expression of drug-transporting proteins in cell lines routinely used in drug discovery programs.
Drug Metab Dispos. 2009 37(12):2275-83.
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Control of iron homeostasis by an iron-regulated ubiquitin ligase.
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Secretagogin is a Ca2+-binding protein specifying subpopulations of telencephalic neurons.
Proc Natl Acad Sci U S A. 2009 106(52):22492-7.
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A novel strategy based on histological protein profiling in-silico for identifying potential biomarkers in urinary bladder cancer.
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Pulmonary autoimmunity as a feature of autoimmune polyendocrine syndrome type 1 and identification of KCNRG as a bronchial autoantigen.
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Selective expression of Syntaxin-7 protein in benign melanocytes and malignant melanoma.
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66 Estigoy CB, Pontén F, Odeberg J, Herbert B, Guilhaus M, Charleston M, Ho JWK, Cameron D, dos Remedios CG.
Intercalated discs: multiple proteins perform multiple functions in non-failing and failing human hearts.
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Extensive expression of craniofacial related homeobox genes in canine mammary sarcomas.
Breast Cancer Res Treat. 2009 118(2):333-43.
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The protein expression of TRP-1 and galectin-1 in cutaneous malignant melanomas.
Cancer Genomics Proteomics 2008 5(6):293-300.
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HMG-CoA reductase expression in breast cancer is associated with a less aggressive phenotype and influenced by anthropometric factors.
Int J Cancer. 2008 123(5):1146-53.
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Breast Cancer Res. 2008 10(5):R79.
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Expression profiling of microdissected cell populations selected from basal cells in normal epidermis and basal cell carcinoma.
Br J Dermatol. 2008 158(3):527-38.
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