Explore the cell type specificity of genes within human tissues


ERV3-1 - Skin

IYD - Thyroid

The Tissue Cell Type section contains cell type expression specificity predictions for all human protein coding genes, generated using integrated network analysis of publicly available bulk RNAseq data. A specificity classification is used to predict which genes are enriched in each constituent cell type within an individual tissue. The data can be explored on a tissue-by-tissue basis, together with in-house generated immunohistochemically stained tissue sections. In addition, a core cell type analysis focuses on the cell types found in all, or the majority, of the profiled tissues, e.g., endothelial cells or macrophages. Here, genes with predicted specificity in these core cell types in multiple tissues are detailed. More information about the specific content and data analysis in the section can be found in the Methods Summary.


Learn about:

  • if a gene is predicted to have cell type specificity within a given tissue
  • which genes have a common cell type specificity prediction within each tissue
  • the catalogue of genes with predicted specificity in core cell types across tissues



THE TISSUE CELL TYPE PROTEOMESi

Selecting a tissue will show tissue information, the cell types analyzed and which genes had predicted specificity in each, together with example immunohistochemistry protein staining.


CORE CELL TYPE PROTEOMESi

The cell types in this section are analyzed in many of the tissues profiled. Here, you can explore which genes have predicted enriched expression in these cell types, across multiple tissue types.


TISSUE CELL TYPE SUMMARYi

Tissue Cell type Very highHighModerate Enriched
Adipose subcutaneous Adipocytes (Subcutaneous) 515 70 20 605
Endothelial cells 67 57 43 167
Smooth muscle cells 156 95 80 331
Fibroblasts 25 112 103 240
Macrophages 117 116 107 340
Mast cells 13 8 15 36
T-cells 10 71 80 161
Plasma cells 26 62 12 100
Adipose visceral Adipocytes (Visceral) 462 69 26 557
Mesothelial cells 137 152 127 416
Endothelial cells 46 65 104 215
Smooth muscle cells 57 32 28 117
Fibroblasts 11 56 284 351
Macrophages 78 72 72 222
Neutrophils 34 17 13 64
Mast cells 4 6 6 16
T-cells 18 100 132 250
Plasma cells 79 53 16 148
Breast Breast glandular cells 9 88 609 665
Breast glandular cells (progenitors) 3 5 20 28
Breast myoepithelial cells 0 6 60 66
Adipocytes (Breast) 398 152 100 650
Endothelial cells 89 98 101 288
Smooth muscle cells 0 7 59 66
Fibroblasts 23 75 140 238
Macrophages 51 34 41 126
T-cells 13 70 125 208
Plasma cells 121 77 29 227
Colon Colon enterocytes 180 98 91 369
Colon enteroendocrine cells 195 105 75 375
Enteric glia cells 77 104 59 240
Mitotic cells (Colon) 14 33 38 85
Endothelial cells 5 61 153 219
Smooth muscle cells 94 46 26 166
Fibroblasts 0 5 37 42
Macrophages 26 40 77 143
Neutrophils 7 25 35 67
Mast cells 9 12 8 29
T-cells 2 28 78 108
Plasma cells 12 47 55 114
Heart muscle Cardiomyocytes 34 481 952 1467
Mitotic cells (Heart) 7 15 34 56
Endothelial cells 9 44 129 182
Smooth muscle cells 2 10 26 38
Fibroblasts 12 98 251 361
Macrophages 3 23 187 213
Neutrophils 11 22 19 52
T-cells 6 27 42 75
Plasma cells 28 37 13 78
Kidney Podocytes 43 37 32 112
Proximal tubular cells 372 185 158 657
Ascending Loop of Henle cells 8 21 42 71
Intercalated cells 12 32 31 75
Endothelial cells 14 48 227 289
Fibroblasts 0 33 296 329
Macrophages 18 58 119 195
T-cells 0 8 150 158
Plasma cells 0 1 88 89
Liver Hepatocytes 417 341 511 1264
Cholangiocyte 3 16 38 57
NK-cells (Liver) 8 5 17 30
Erythroid cells 21 5 2 28
Endothelial cells 7 47 283 337
Fibroblasts 52 111 153 316
Macrophages 0 14 83 97
Neutrophils 19 35 148 202
T-cells 1 18 54 73
Plasma cells 14 89 40 143
Lung Respiratory ciliated cells 591 53 37 681
Alveolar cells type 1 43 41 48 132
Alveolar cells type 2 20 122 221 363
Mitotic cells (Lung) 111 26 16 153
NK-cells (Lung) 3 13 39 55
B-cells 4 1 6 11
Endothelial cells 0 9 88 97
Smooth muscle cells 14 13 36 63
Fibroblasts 27 64 162 253
Macrophages 4 51 105 160
Neutrophils 61 52 47 160
Mast cells 10 4 3 17
T-cells 6 29 54 89
Plasma cells 166 15 4 185
Pancreas Alpha cells 37 98 86 221
Beta cells 57 82 61 200
Ductal cells 6 24 91 121
Exocrine glandular cells 32 0 0 32
Endothelial cells 0 13 176 189
Fibroblasts 0 12 60 72
Macrophages 1 11 74 86
T-cells 0 7 31 38
Plasma cells 70 43 8 121
Prostate Prostate glandular cells 261 121 56 438
Prostate basal glandular cells 4 39 196 239
Urothelial cells 19 54 86 159
Endothelial cells 55 55 67 177
Smooth muscle cells 126 117 108 351
Fibroblasts 103 109 149 361
Macrophages 23 42 31 96
T-cells 0 32 150 182
Plasma cells 9 89 45 143
Skeletal muscle Skeletal myocytes 63 107 181 329
Endothelial cells 11 98 387 496
Smooth muscle cells 3 12 26 41
Fibroblasts 6 136 370 512
Macrophages 25 54 97 176
Neutrophils 13 10 12 35
Plasma cells 23 17 1 41
Skin Keratinocyte (other) 125 257 355 737
Keratinocyte (granular) 91 61 56 208
Melanocytes 9 3 5 17
Hair cortex cells 0 27 21 48
Inner root sheath cells 0 4 18 22
Outer root sheath cells 1 14 104 119
Sebaceous gland cells 92 63 51 206
Eccrine sweat gland cells 61 73 112 246
Langerhans cells 2 3 15 20
Adipocytes (Skin) 2 10 14 26
Mitotic cells (Skin) 68 47 75 190
Endothelial cells 3 37 173 213
Smooth muscle cells 6 13 17 36
Fibroblasts 4 23 120 147
Macrophages 2 14 40 56
Mast cells 0 6 6 12
T-cells 3 13 42 58
Plasma cells 38 50 11 99
Stomach Parietal cells 1 25 48 74
Chief cells 0 5 51 56
Gastric mucous cells 0 42 337 379
Gastric enteroendocrine cells 0 15 32 47
Mitotic cells (Stomach) 63 57 50 170
Endothelial cells 0 5 79 84
Fibroblasts 0 5 161 166
Macrophages 10 30 114 154
Neutrophils 4 5 13 22
T-cells 0 0 23 23
Plasma cells 0 0 186 186
Testis Spermatogonia 42 173 331 546
Spermatocytes 91 164 283 538
Early spermatids 269 522 795 1586
Late spermatids 29 178 418 625
Sertoli cells 50 188 376 614
Leydig cells 0 4 16 20
Peritubular cells 0 4 38 42
Endothelial cells 0 12 97 109
Macrophages 0 4 15 19
Thyroid Parafollicular cells 21 4 0 25
Thyroid glandular cells 728 567 343 1638
Mitotic cells (Thyroid) 33 25 11 69
Endothelial cells 8 25 37 70
Smooth muscle cells 15 32 39 86
Fibroblasts 11 126 326 463
Macrophages 45 32 40 117
Neutrophils 19 12 5 36
T-cells 35 119 196 350
Plasma cells 99 39 44 182