The core smooth muscle enriched transcriptome
Smooth muscle fibers are composed of smooth muscle cells attached to each other via gap junctions. They are found throughout the body, around blood vessels and hollow organs. They have a synchronized response to stimuli, producing pressure through involuntary muscle contraction, allowing them to perform essential bodily functions, such as the regulation of blood pressure.
In this section we detail the predicted core smooth muscle cell transcriptome, highlighting genes classified as having predicted specificity in smooth muscle cells in multiple tissue types. Such genes could be useful general markers for smooth muscle cells across tissue beds, and are likely critical for smooth muscle specific functions. These genes are sub-divided into 3 categories, based on the number of tissues in which they were independently classified as smooth muscle cell enriched.
Protein expression of genes enriched in smooth muscle cells across tissue types
An example of a protein with enriched expression in smooth muscle cells across multiple tissue types is calponin 1 (CNN1), which is a thin filament-associated protein implicated in the regulation and modulation of cell contraction.
Another example of a protein with enriched expression in smooth muscle cells across multiple tissue types is Leiomodin 1 (LMOD1), a member of the actin filament nucleator family.
Genes enriched in smooth muscle in the bronchus include Caldesmon 1 (CALD1), a protein implicated in the regulation of actin and myosin interactions.
Genes with predicted specificity in smooth muscle cells in individual tissues
A summary table of all genes with predicted high enrichment in smooth muscle cells in profiled tissues is provided below. Identified genes are subdivided into 3 categories in each tissue, based on the difference between the enrichment score in smooth muscle cells, compared to the other cell types profiled (see Methods Summary page for details):