PROTEIN CLASSESi


Function and compartment basedi

Protein class

No of genes

No of genes with antibodies

Source

Enzymes » 3262 3048
CD markers 374 326 UniProt
Blood group antigen proteins 31 25 UniProt
Nuclear receptors 49 43 NucleaRDB
Transporters » 1163 1005 TCDB
Ribosomal proteins 149 146 UniProt
G-protein coupled receptors » 774 390 UniProt
Voltage-gated ion channels » 132 100 IUPHAR-DB
Predicted membrane proteins » 5455 4433 MDM
Predicted secreted proteins » 2918 2463 HPA
Predicted intracellular proteins 14889 13412 HPA
Plasma proteins 3751 3522 Plasma Proteome Database
Transcription factors » 1499 1356 UMG
RNA polymerase related proteins 31 30 KEGG
RAS pathway related proteins 228 206 KEGG
Citric acid cycle related proteins 30 29 KEGG


Disease and drug relatedi

Protein class

No of genes

No of genes with antibodies

Source

Cancer-related genes » 1706 1612
Candidate cardiovascular disease genes 161 147 Plasma Proteome Institute
Disease related genes 3541 3228 UniProt
FDA approved drug targets » 646 551 Drugbank
Potential drug targets 1129 1043 HPA


Evidence basedi

Protein class

No of genes

No of genes with antibodies

Source

Mapped to UniProt SWISS-PROT » 18881 16625 UniProt
Protein evidence (Kim et al 2014) 12743 11973 Kim et al 2014
Protein evidence (Ezkurdia et al 2014) 11665 11143 Ezkurdia et al 2014